Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line by Isabella Massimi, Ambra Ciuffetta, Flavia Temperilli, Francesca Ferrandino, Alessandra Zicari, Fabio M. Pulcinelli, Maria Pia Felli

“…In the present paper, we verified whether exposure of human embryonic kidney-293 cells (Hek-293) to aspirin modifies MRP4 gene expression and its correlation with drug elimination and cell toxicity. …”
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Research on Road Adhesion Condition Identification Based on an Improved ALexNet Model by QiMing Wang, JinMing Xu, Tao Sun, ZhiChao Lv, GaoQiang Zong

“…In this paper, considering that the process of manually extracting image features is complicated and that the extraction method is random for everyone, road surface condition identification method based on an improved ALexNet model, namely, the road surface recognition model (RSRM), is proposed. …”
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Sustained Release of Prostaglandin E2 in Fibroblasts Expressing Ectopically Cyclooxygenase 2 Impairs P2Y-Dependent Ca2+-Mobilization by María Pimentel-Santillana, Paqui G. Través, Raquel Pérez-Sen, Esmerilda G. Delicado, Paloma Martín-Sanz, María Teresa Miras-Portugal, Lisardo Boscá

“…We investigated the role of the prostanoid PGE2 in P2Y signaling in mouse embryonic fibroblasts (MEFs), since these cells are involved in different ontogenic and physiopathological processes, among them is tissue repair following proinflammatory activation. …”
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ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure by Qing Liu, Dan Liu, Yuejiao Wang, Xiaowei Wei, Wei Ma, Hui Gu, Shanshan Jia, Yiwen He, Wenting Luo, Songying Cao, Zhonghua Yang, Anhua Wu, Zhengwei Yuan

“…Collectively, these findings highlight the important role of the Zic3-ApoM-Elavl2-Nnt axis in cellular homeostasis during neural tube development, thereby revealing an intracellular molecular regulatory mechanism of ApoM, providing a mechanistic basis for understanding embryonic neural development, and offering experimental evidence for potential therapeutic targets for NTDs.…”
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Proteomic and N-glycosylation analysis of fertile egg white during storage and incubation in chickens by Daqing Dai, Xiqiong Wang, Kexin Wu, Fangren Lan, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Junying Li, Ning Yang, Congjiao Sun

“…Proteins in egg whites play vital roles in embryonic development. Simultaneously, protein modification is affected by the surrounding environment, which ultimately affects the structure and function of proteins. …”
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Establishing a CRISPR/Cas9 genome editing framework in pigeonpea (Cajanus cajan L.) by targeting phytoene desaturase (PDS) gene disruption by Kameshwaran Senthil, Maniraj Rathinam, Manisha Parashar, Narasimham Dokka, Shaily Tyagi, Vandana Mathur, Sandhya Sharma, Kishor Gaikwad, Ramcharan Bhattacharya, Rohini Sreevathsa

“…The system was validated by Agrobacterium tumefaciens-mediated apical meristem-targeted in planta and in vitro embryonic axis explant transformations, with gene knockout confirmed by albino/bleached phenotypes. …”
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Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-known traditional stem cells, such as neural, embryonic, bone marrow mesenchymal, and human umbilical cord blood–derived stem cells, were reported. …”
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Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

“…Regardless of subtype, RMS resembles embryonic skeletal muscle as it expresses the myogenic regulatory factors (MRFs), MYOD1 and MYOG. …”
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CXCR6 Expression Is Important for Retention and Circulation of ILC Precursors by Sylvestre Chea, Cécilie Possot, Thibaut Perchet, Maxime Petit, Ana Cumano, Rachel Golub

“…Circulation was also impaired during embryonic life as fetal liver from CXCR6-deficient embryos displayed decreased numbers of ILC3 precursors. …”
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Reproductive potential of the endangered land crab, Johngarthia lagostoma (H. Milne Edwards, 1837) (Brachyura: Gecarcinidae), from Trindade Island, Brazil by Esli E. D. Mosna, Maria A. M. Oliveira, Marcio C. A. João, Marcelo A. A. Pinheiro

“…A total of 43 ovigerous females in the final stage of embryonic development were analyzed. Their egg masses were removed, weighed, and counted using a volumetric method. …”
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Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes by Shirley Pei Shan Chia, Jeremy Kah Sheng Pang, Winanto Winanto, Boon-Seng Soh

“…To enhance physiological relevance, this study investigated the impact of NPs on human cardiomyocytes (CMs) derived from human embryonic stem cells (hESCs). We observed significantly higher cellular uptake of 50 nm NPs compared to 500 nm particles, with dose-dependent accumulation over 3, 5, and 7 days of treatment. …”
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Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition by Priscila García-Castro, Isabella Giambó-Falian, Ingrid Carvacho, Ricardo Fuentes

“…Zebrafish has emerged as a pivotal model for understanding the evolving genetic regulation and molecular mechanisms underlying CG biology, providing valuable insights into fertility and early embryonic development.…”
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Nephrogenic Adenoma of the Urinary Bladder after Kidney Transplantation: Long-Term Follow-Up by Iftikhar Khan, Mahmoud Obeid, Nasreen Hasan, Fayyad Jaradat, Bodhisatwa Sengupta, Mahmoud Tabbal, Abdullah Alsaif, Mansour Tawfeeq, Mohammad Al Qahtani

“…The origin of cells in nephrogenic adenoma is debated and has been postulated to arise from cells of embryonic origin or from metaplasia secondary to chronic irritation or from implantation of allograft cells in patients with kidney transplantation. …”
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RNA modifications: emerging players in the regulation of reproduction and development by Wen Junfei, Zhu Qifan, Liu Yong, Gou Lan-Tao

“…In this review, we focus on the regulatory roles and biological functions of a panel of dominant RNA modifications (including m⁶A, m⁵C, Ψ, ac⁴C, m¹A, and m⁷G) on three RNA types—mRNA, tRNA, and rRNA—in mammalian development, particularly in the context of reproduction as well as embryonic development. We discuss in detail how those modifications, along with their regulatory proteins, affect RNA processing, structure, localization, stability, and translation efficiency. …”
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Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals by Tomoyuki Niimi, Nanae Miyazaki, Hironobu Oiki, Mami Uemura, Shihan Zeng, Watcharapon Promsut, Noriaki Ota, Shunji Nonaka, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Shohei Takami, Jun Fujishiro, Yoshiakira Kanai

“…Abstract An aqueous solution of a common food dye, Fast Green FCF (FG), mimics cholyl-lysyl-fluorescein to visualize embryonic bile flow via single peritoneal injection into intrauterine mouse embryos. …”
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Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells by Hidehito Saito, Keisuke Okita, Noemi Fusaki, Michael S. Sabel, Alfred E. Chang, Fumito Ito

“…TIL-derived iPSCs display embryonic stem cell-like morphology, have normal karyotype, express stem cell-specific surface antigens and pluripotency-associated transcription factors, and have the capacity to differentiate in vitro and in vivo. …”
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Accelerated dynamic light sheet microscopy: unifying time-varying patterned illumination and low-rank and sparsity constrained reconstruction by Marco Tobia Vitali, Alessia Candeo, Andrea Farina, Paolo Pozzi, Alessia Brix, Andrea Bassi, Teresa M Correia

“…This method was applied to the volumetric imaging of embryonic zebrafish hearts, achieving an improvement in imaging speed of 4-fold compared to standard LSFM and a 2-fold improvement compared to traditional compressed sensing approaches, while preserving reconstruction accuracy and enabling the visualization of fast dynamic events with a resolution of a few tens of milliseconds. …”
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Intraspinal Grafting of Serotonergic Neurons Modifies Expression of Genes Important for Functional Recovery in Paraplegic Rats by Krzysztof Miazga, Hanna Fabczak, Ewa Joachimiak, Małgorzata Zawadzka, Łucja Krzemień-Ojak, Marek Bekisz, Anna Bejrowska, Larry M. Jordan, Urszula Sławińska

“…Our results indicate that SCI at the thoracic level leads to changes in Htr2a and Htr7 gene expression, whereas transplantation of embryonic serotonergic neurons modifies these changes in motoneurons innervating hindlimb muscles but not those innervating tail muscles. …”
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LEVEL OF KNOWLEDGE AND MOTIVATION ON THEUSE DENTURES BY PEOPLE WHO LOSE TEETH IN PUSAKA RAKYAT VILLAGE BEKASI by Didik Marsigid, Mujiwati, Iin Alpadari

“…Using dentures is one of the right ways to deal with missing teeth, but not everyone wants to replace missing teeth with dentures. …”
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Endurance Exercise Mobilizes Developmentally Early Stem Cells into Peripheral Blood and Increases Their Number in Bone Marrow: Implications for Tissue Regeneration by Krzysztof Marycz, Katarzyna Mierzejewska, Agnieszka Śmieszek, Ewa Suszynska, Iwona Malicka, Magda Kucia, Mariusz Z. Ratajczak

“…We therefore became interested in whether endurance exercise has the same effect on very small embryonic-like stem cells (VSELs), which have been described as a population of developmentally early stem cells residing in BM. …”
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