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5401
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy
Published 2025-02-01“…This study aims to investigate a novel strategy to enhance the therapeutic efficacy against PF by DSS preconditioning MSCs-derived exosomes (DSS-Exo). …”
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5402
High Catalytic Selectivity of Electron/Proton Dual‐Conductive Sulfonated Polyaniline Micropore Encased IrO2 Electrocatalyst by Screening Effect for Oxygen Evolution of Seawater Electrolysis
Published 2025-01-01“…This structure combines electron conductivity from the organic framework and proton conductivity from ‐SO3H, weakens the Cl− adsorption, and suppresses metal‐chlorine coupling, thus enhancing the catalytic activity and selectivity. As a result, the overpotential for the oxygen evolution reaction (OER) is only 283 mV@10 mA cm−2, with a Tafel slope of 16.33 mV dec−1, which reduces 13.8% and 37.8% compared to commercial IrO2, respectively. …”
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<i>Hovenia dulcis Thunb</i>. Honey Exerts Antiviral Effect Against Influenza A Virus Infection Through Mitochondrial Stress-Mediated Enhancement of Innate Immunity
Published 2025-01-01“…HDH treatment significantly reduced IAV infection and viral protein expression. Moreover, it enhanced the production of interferon (IFN)-β, activated the innate immune response through the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway, and upregulated IFN signaling through signal transducer and activator of transcription (STAT)1/2 phosphorylation and interferon-stimulated gene (ISG) expression. …”
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Enhancement of Growth, Antioxidant Activity, and Immunity in Nile Tilapia (<i>Oreochromis niloticus</i>) Through Recombinant <i>Bacillus subtilis</i> Expressing L-Gulonolactone Oxidase
Published 2025-01-01“…Due to its lack of the L-gulonolactone oxidase (<i>GULO</i>) enzyme, Nile tilapia is unable to synthesize vitamin C; thus, it requires an adequate level of exogenous vitamin C in its diet. To enhance antioxidant properties and vitamin C-related effects, we employed recombinant technology to integrate the <i>GULO</i>-encoding gene into the <i>Bacillus subtilis</i> chromosome. …”
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5407
Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma
Published 2021-01-01“…In conclusion, EBV-LMP1 promotes cell autophagy after DDP treatment by activating the MEK1/2/Nrf-2 signaling pathway in lymphoma cells, thus, enhancing the resistance of lymphoma cells to DDP.…”
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5408
State updating of the Xin'anjiang model: joint assimilating streamflow and multi-source soil moisture data via the asynchronous ensemble Kalman filter with enhanced error models
Published 2025-01-01“…<p>Assimilating either soil moisture or streamflow individually has been well demonstrated to enhance the simulation performance of hydrological models. …”
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Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system
Published 2025-02-01“…AI-2 perception by the AsrK-AsrR system remarkably reduces intracellular c-di-GMP levels and enhances tolerance of V. furnissii to oxidative stress and DNA damage by upregulating the transcription of universal stress proteins including UspA1, UspA2, and UspE. …”
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Impact of Motivational Enhanced Adherence Counseling and Point-of-Care Viral Load Monitoring on Viral Load Outcome in Women on Life-Long ART: A Randomized Pilot Study
Published 2022-01-01“…We piloted the combined effectiveness of point-of-care viral load monitoring plus motivational enhanced adherence counseling (intervention) compared with routine care (control) in women identified at risk of virologic failure in the PROMOTE study in Zimbabwe. …”
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Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model
Published 2021-01-01“…Extracellular vesicles (EVs) were equally observed in the hippocampus in the naïve and NEP-enhanced hUC-MSC groups. However, the EVs of NEP-enhanced hUC-MSCs contained higher amounts of NEP as compared to the EVs of naïve hUC-MSCs. …”
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5420
Exploring the Potential of Selenium-Containing Amine (Se-AMA) to Enhance Photosynthesis and Leaf Water Content: New Avenues for Carbonic Anhydrase Modulation in <i>Arabidopsis thaliana</i>
Published 2025-01-01“…Morning treatment with Se-AMA at 300 µM enhanced photosynthetic performances throughout the day, suggesting that the positive effect of Se-AMA lasted for several hours. …”
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