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  1. 4661
  2. 4662

    SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

    Published 2025-01-01
    “…We recommend utilising this paper alongside the SPIRIT statement, and any relevant extensions, to enhance the development and review of EPDF trial protocols.By facilitating adoption of the SPIRIT-DEFINE statement for EPDF trials, this E&E document can promote enhancement of methodological rigour, patient safety, transparency, and facilitate the generation of high-quality, reproducible evidence that will strengthen the foundation of early phase research and ultimately improve patient outcomes. …”
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  3. 4663
  4. 4664
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  7. 4667

    Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

    Published 2021-10-01
    “…Furthermore, NKAB-ErbB2 synergized with NK-92 cells or primary T cells engineered to express an NKG2D-CD3ζ chimeric antigen receptor (NKAR), leading to targeted cell killing and greatly enhanced antitumor activity, which remained unaffected by soluble MICA known as an inhibitor of NKG2D-mediated natural cytotoxicity. …”
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  8. 4668
  9. 4669

    Research Progress in and Planning Strategies for Multi-scale Measurement of the Efficiency of Urban Blue-Green Infrastructure in Carbon Sink Enhancement and Emission Reduction by Song LIU, Zhaocheng BAI, Dizi LIU, Peiyu SHEN

    Published 2025-01-01
    “…2) What are the mechanisms and pathways through which UBGI enhances carbon sink and reduces carbon emission? 3) How can UBGI be regulated to better enhance its effectiveness in carbon sink enhancement and emission reduction? …”
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  10. 4670
  11. 4671

    Exploring the role of project-based learning in higher education to promote indigenous knowledge through sculpture students’ engagement with Ghanaian Adinkra symbols by Fredrick Boakye-Yiadom, Evans Kwadwo Donkor, Ronald Osei Mensah

    Published 2025-01-01
    “…Abstract This study explores the integration of Project-Based Learning (PBL) within the higher education context, focusing on sculpture learners’ projects based on Ghanaian Adinkra symbols and their engagement with Indigenous Knowledge Systems (IKS). …”
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  12. 4672

    Blasting-Induced Permeability Enhancement of Ore Deposits Associated with Low-Permeability Weakly Weathered Granites Based on the Split Hopkinson Pressure Bar by Lei Yan, Wenhua Yi, Liansheng Liu, Jiangchao Liu, Shenghui Zhang

    Published 2018-01-01
    “…The results demonstrate that the purpose of enhancing permeability and keeping the ore body stable can be achieved by conducting three variable-speed cyclic impacts on the samples.…”
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  13. 4673

    Enhanced corrosion resistance of AM60 alloy with 2.0Ca via thermal oxidation and carbonization under an O₂/CO₂ atmosphere by S.Y. Liu, K. Tang, G.J. Liu, Z.H. Liu, X.Y. Lang, Y.F. Zhu, Q. Jiang

    Published 2025-03-01
    “…Electrochemical impedance spectra and cross-sectional corrosion analysis reveal that the CR is much improved with the optimal O₂/CO₂ ratio of 1:3. This enhancement is attributed to the formation of a high-quality dual-layer protective structure, consisting of an outer MgCO₃/CaCO₃ composite layer and an inner MgO/CaO/Al₂O₃ composite layer. …”
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  14. 4674
  15. 4675

    Biodesulfurization enhancement via targeted re-insertion of the flavin reductase dszD in the genome of the model strain Rhodococcus qingshengii IGTS8 by Olga Martzoukou, Fotios Klenias, Eleni Kopsini, Dimitris G. Hatzinikolaou

    Published 2025-01-01
    “…We conducted a comparative study of the growth and biodesulfurization capabilities of Pkap1-dszD, wild-type and crtIΔ strains, grown on different types and concentrations of carbon and sulfur sources. A significant enhancement of biodesulfurization activity, maximum calculated biomass, and dszD transcript levels in the presence of DBT as the sole sulfur source was achieved for the Pkap1-dszD strain paving the way for further studies that could lead to a more viable commercial biodesulfurization process.…”
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    Advancing Multiple Myeloma Immunotherapy: A Review of Chimeric Antigen Receptor T-Cell and Bispecific T-Cell Engagers Cell Therapies in Revolutionizing Treatment by Rahul Navab, Pragyat Futela, Verkha Kumari, Jayesh Valecha, Ramansh Bandhu Gupta, Rohit Jain

    Published 2025-01-01
    “…Chimeric Antigen Receptor (CAR) T-cell therapy and Bispecific T-cell engagers (BiTEs) are emerging immunotherapies showing promise in MM treatment. …”
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  20. 4680

    Lack of Outer Membrane Protein A Enhances the Release of Outer Membrane Vesicles and Survival of Vibrio cholerae and Suppresses Viability of Acanthamoeba castellanii by Soni Priya Valeru, Salah Shanan, Haifa Alossimi, Amir Saeed, Gunnar Sandström, Hadi Abd

    Published 2014-01-01
    “…Cocultivation with A. castellanii enhanced the survival of both bacterial strains and OmpA protein exhibited no effect on attachment, engulfment, and survival inside the amoebae. …”
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