Improved Performance of ELISA and Immunochromatographic Tests Using a New Chimeric A2-Based Protein for Human Visceral Leishmaniasis Diagnosis by Maria Marta Figueiredo, Anna R. R. dos Santos, Lara C. Godoi, Natália S. de Castro, Bruno C. de Andrade, Sarah A. R. Sergio, Selma M. B. Jerônimo, Edward J. de Oliveira, Ruth T. Valencia-Portillo, Lucilândia M. Bezerra, Hiro Goto, Maria C. A. Sanchez, Caroline Junqueira, Santuza M. R. Teixeira, Flávio G. da Fonseca, Ricardo T. Gazzinelli, Ana Paula Fernandes

“…Although several VL serological diagnosis advances have been accomplished lately, mainly using recombinant antigens and immunochromatographic tests (ICTs), improvements may still be achieved using multiepitope chimeric proteins in different test platforms. …”
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Efferocytosis-related gene IL33 predicts prognosis and immune response and mediates proliferation and migration in vitro and in vivo of breast cancer by Xiao He, Xianjie Cheng, Zhun Zhang, Lanhui Chen, Changjun Xie, Mengjie Tang

“…IL33 stands out as a significant prognostic marker, crucial in the onset and advancement of BRCA. This highlights the necessity for additional studies and indicates that IL33 might be a potential target for BRCA treatment.…”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Abstract Background Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and treatment options for advanced CRC are limited. The regulatory mechanisms of aberrant NAT10-mediated N4-acetylcytidine (ac4C) modifications in cancer progression remains poorly understood. …”
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SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…Despite significant advances in diagnosis and treatment, the compromised therapeutic effect of chemotherapeutic agents, such as Oxaliplatin (OXA), remains a major clinical challenge. …”
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Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization by Lili Zhang, Dineshi Sewvandi Thalakiriyawa, Jiawei Liu, Shengyan Yang, Yan Wang, Waruna Lakmal Dissanayaka

“…Additionally, a three-dimensional vasculature-on-a-chip microfluidic device was used to investigate the role of M2c macrophage-derived Sema4D in the stabilization of vascular structures. …”
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Global assessment of leukemia care quality: insights from the quality of care index (QCI) from 1990 to 2021Research in context by Yuzhe Pan, Qian Liu, Nan Zhang, Shuang Peng, Xinqi Li, Fuling Zhou

“…Summary: Background: While advancements in leukemia care have been made, the global quality of care remains a concern. …”
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A comparison of new and existing rootstocks to reduce canker of apple trees caused by Neonectria ditissima (Nectriaceae, Hypocreales) by Lucas A. Shuttleworth, Sonia Newman, Ioannis Korkos

“…The current study investigated the effect of rootstock selection on canker and tree death using eight common rootstocks M9 337, M9 337 with Golden Delicious (GD) interstock, M9 EMLA, MM106, M116, M26, Geneva® G11 and G41, in addition to six advanced selections from the NIAB East Malling apple breeding programme EMR-001—EMR-006, all grafted with Gala scions. …”
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Redefining outcomes of ventricular arrhythmia for SGLT2 inhibitor medication in heart failure patients: a meta-analysis of randomized controlled trials by Miao Lin, Shiyu Zhang, Lu Zhang, Chengying Yang, Yang Luo, Yajin Peng, Xiaoqiu Tan, Qiang Wen, Xinrong Fan, Xianhong Ou

“…The participants were non-advanced HF patients, including at-risk for HF, pre-HF, and symptomatic HF, with follow-up duration ranging from 12 to 296 weeks. …”
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Analisa Tingkat Kematangan Literasi Tik Pada Tenaga Kesehatan Dalam Pelayanan Kesehatan Berbasis TIKDi Puskesmas Kota Palembang by Istiqomah Febrianty, Darius Antoni, Dedy Syamsuar, Diana Diana

“…ICT Literacy is becoming increasingly important for health officer Puskesmas at Palembang City to improving the efficiency and quality of health service, including ICT-based health service applications, use of social media (WhatsApp, Facebook, Instagram, and website) as a medium for information, promotion, communication and delivery of advice to the public. The purpose of this research is to evaluate Maturity Level of ICT Literacy in Health Officers towards ICT-based health service aplications and social media using a quantitative approach analiyzed descriptively. …”
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Barriers to healthcare access among female youths in Mozambique: a mixed-effects and spatial analysis using DHS 2022/23 data by Habtu Kifle Negash, Hiwot Tezera Endale, Hailu Aragie, Winta Tesfaye, Mihret Getnet, Tseganesh Asefa, Yibeltal Yismaw Gela, Alebachew Ferede Zegeye

“…Those with no formal education were 2.18 times more likely to face barriers (AOR = 2.18, 95% CI: 1.22, 3.88). …”
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Building National Identity from Within: The Role of Self-Competence in Strengthening National Identity by B. Baydhowi, M. Preston, V. Syahputra, A.D. Cahyani, D. Rabitha

“…These findings provide practical implications for psychological and educational strategies to strengthen national identity formation.…”
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Clinical Evaluation of Faricimab in Real-World Diabetic Macular Edema in India- A Multicenter Observational Study by Chakraborty D, Das S, Maiti A, Sinha TK, Das A, Sheth J, Boral SK, Mondal S, Nandi K

“…Debdulal Chakraborty,1 Sudipta Das,2 Aniruddha Maiti,3 Tushar Kanti Sinha,1 Arnab Das,1 Jay Sheth,4 Subhendu Kumar Boral,1 Soumen Mondal,1 Krishnendu Nandi2 1Disha Eye Hospitals, Kolkata, India; 2Nethralayam Superspeciality Eye Care, Kolkata, India; 3Global Eye Hospitals, Kolkata, India; 4Department of Retina Services, Shantilal Shanghvi Eye Institute (SSEI), Mumbai, IndiaCorrespondence: Debdulal Chakraborty, Department of Vitreo-retinal Services, Disha Eye Hospitals, 88 Ghosh Para Road Barrackpore, Kolkata, West Bengal, 700120, India, Tel +91 33 6636 0000, Email devdc@rediffmail.comPurpose: To evaluate the efficacy of faricimab in real-world clinical settings in India for treating diabetic macular edema (DME) in treatment-naïve and recalcitrant eyes.Patients and Methods: This retrospective study involved 39 eyes (16 treatment-naive and 23 recalcitrant) treated with intravitreal faricimab at four centers in India. …”
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Tüketicilerin E-Ticaret Algılarının İncelenmesi (Gaziantep ve Adıyaman Örneği) - A Research On the E-Commerce Perception of Consumer (The Sample of Gaziantep and Adıyaman) by Sabiha Annaç Göv, Yavuz Akçi

“…Böyle olmasına rağmen çeşitli nedenlerden dolayı bazı tüketiciler geleneksel tüketime devam etmekte, e-ticarete direnmektedirler. Bu araştırmada özellikle farklı demografik özelliklere sahip tüketicilerin elektronik ticarete ilişkin algıları belirlenmeye çalışılmıştır. …”
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GENETIC VARIABILITY AND DROUGHT PARAMETERS AMONG SOME GRAIN SORGHUM GENOTYPES USING QUANTITATIVE TRAITS AND RAPD MARKERS by Bahaa A. Zarea, M.E.M. El-Sagheer, H.M. Hafez, A.Y.M. Ahmed

“…These genotypes will be testing in a large scale. High genetic advance as a percentage of mean (Δg%) was obtained for plant height and 1000 grain weight and moderate for 50% flowering and grain yield/plant. …”
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The prognostic utility of the ratio of lymphocyte to monocyte in patients with metastatic colorectal cancer: a systematic review and meta-analysis by Pingping Mei, Li Huang, Lu Lin, Yan Chen, Xiutian Guo

“…BackgroundAlthough advancements in treatment have resulted in improved overall outcomes for patients diagnosed with colorectal cancer, the prognosis remains unfavorable for individuals with metastatic colorectal cancer (mCRC). …”
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Machine Learning–Based Risk Factor Analysis and Prediction Model Construction for the Occurrence of Chronic Heart Failure: Health Ecologic Study by Qian Xu, Xue Cai, Ruicong Yu, Yueyue Zheng, Guanjie Chen, Hui Sun, Tianyun Gao, Cuirong Xu, Jing Sun

“…Future research should focus on prospective studies, diverse data, advanced techniques, longitudinal studies, and exploring factor interactions for better CHF prevention and management.…”
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MECHANISMS FOR ENSURING THE ECONOMIC DEVELOPMENT OF RURAL AREAS THROUGH THE FORMATION OF THEIR ENERGY DEPENDENCE BASED ON THE INTENSIFICATION OF BIOFUEL PRODUCTION by Yuliia Okhota, Denys Titov, Svitlana Dotsiuk

“…The study puts forward a series of proposals for the advancement of Ukraine's bioenergy sector. These include the enhancement of financing mechanisms and the promotion of private initiatives. …”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…Yintao Wu,* Jianyong Zhu,* Hong Zhang, Nianxin Xia Senior Department of Hepato-Pancreato-Biliary Surgery, the First Medical Center of PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nianxin Xia, Senior Department of Hepato-Pancreato-Biliary Surgery, the First Medical Center of PLA General Hospital, Beijing, 100853, People’s Republic of China, Email doctorxnx@163.comPurpose: This study was developed to compare the efficacy of combined D-TACE-HAIC + lenvatinib + PD-1 inhibitor treatment to that of TACE + sorafenib treatment for patients with intermediate and advanced HCC.Patients and Methods: Here, a retrospective analysis of patients with unresectable HCC who underwent transarterial chemoembolization (TACE) from March 2018 to March 2022 at the our hospital was conducted. …”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…The combination treatment did not result in consistent increase in Th1 immune polarity.ConclusionIn conclusion, the maximum tolerated dose of ibrutinib in combination with pembrolizumab in patients with advanced or metastatic melanoma was established at 420 mg by mouth once daily. …”
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Acute Clinical Features and Persistence of Joint Pain in Probable Cases of Chikungunya Fever in Eritrea by Frezgi O, Berhane A, Ghebrewelde G, Tekie H, Kiflezgi T, Mohamedsied A, Tekie Y, Asrat MM, Gebrejesus T

“…Persistent arthralgia following chikungunya fever is common and requires advanced pharmacological interventions as pain does not respond well to analgesics.Objective: The study aimed to describe the acute clinical features of probable cases of chikungunya fever and risk factors associated with the persistence of joint pain.Methods: A prospective, descriptive cohort study was conducted on probable cases of chikungunya fever from October 2018 to March 2019 in the Tesseney subzone of Eritrea.Results: A total of 203 probable cases of chikungunya fever were enrolled, majority being males (68%) with a mean age of 39.2 years. …”
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