Comparing Prednisone and Methotrexate to Off-label Biologic Infliximab for Management of Ocular Uveitis: A Cost-minimization Analysis by William V. Padula, Miguel Cordero-Coma, Taygan Yilmaz, William V. Padula, Michéal J. Gallagher, Jonathan D. Campbell

“…**Conclusion:** This cost-effectiveness analysis suggests that despite advances in the use of biologics for treating sight-threatening posterior uveitis and panuveitis, infliximab had lower effectiveness and higher costs compared to both prednisone and methotrexate. …”
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Cohort profile: the BangladEsh Longitudinal Investigation of Emerging Vascular and nonvascular Events (BELIEVE) cohort study by Anisur Rahman, Stephen Sutton, Mahbubur Rahman, Jason Crawte, Tahmeed Ahmed, Md Saimul Islam, Aliya Naheed, Adam S Butterworth, Emanuele Di Angelantonio, Matthew Walker, John Danesh, Angela Wood, Sarah Hawkes, Sadika Akhter, Catherine Perry, Aytalina Azarova, Ruchira T Naved, Meerjady Sabrina Flora, Nusrat Khan, Rajiv Chowdhury, Sohel Reza Choudhury, Nusrat Jahan, Stephen Kaptoge, Md Zahidul Islam, Kaniz Fatema, Kim Robin van Daalen, Shammi Luhar, Roderic L Jones, Abbas Bhuiya, Md Khalequzzaman, Syed Shariful Islam, Henry Taylor, Shamima Akter, Simon Griffin, Khairul Islam, Salma Akter, Ruchira Tabassum Naved, Abdul Malik, Rubhana Raqib, Animesh Talukder, Richard Houghton, Tahmina Shirin, Lawrence King, Kamrun Nahar, Samantha Farrow, Giulia Loffreda, Samsad Rabbani Khan, Valerie Rhenius, Nahida Akter, Md Mostafa Monower, Sabina Akter, Mantaka Rahman, Lisa Pennells, Maria L C Iurilli, Md Taslim Uddin Miah, Khan Mohammad Thouhidur Rahman, Sharraf Samin, Kazi Nazmus Saqeeb, Ishrat Tasmin, Eleanor Farrow, Ank Michielsen, Sarah Spackman, Charlotte van Coeverden, James Ajioka, Khondker Abdul Abdul Awal, Evangelia Chatzidiakou, Jörg Feldmann, Richard Fenner, Tuhin Haque, Sirajul Islam, Kamrul Hasan Khan, Fazila-Tun-Nesa Malik, Olalekan Popoola, Nicholas Mascie Taylor, Md Alfazal Khan, Israt Akter, Laboni Akter, Shoriful Islam, Mohammad Kamruzzaman, Monalisa Moni, A H M Rezwan, K M Thouhidur Rahman, Monjeline Sultana, Jesmin Akhter, Ayasha Akter, Bakul Akter, Jharna Akter, Jesmin Akter, Juba Akter, Khadiza Akter, Khadija Akter, Lipi Akter, Maksuda Akter, Mousumi Akter, Mst Lovely Akter, Nasima Akter, Samima Akter, Sema Akter, Shahida Akter, Shahnaj Akter, Taslima Akter, A T M Zorjis Alam, Mahmuda Atique, Lutfa Begum, Mst Nazma Begum, Farjana Choudhury, Mitali Paul Chowdhury, Robin Reza Chowdhury, Mukul Rani Debnath, Nahid Ferdash, Naima Ferdous, Md Rakib Al Hasan, Khandaker Hashanuzzaman, Shamima Haq, Md Riazul Haque, Alamgir Hossain, Md Ibrahim, Shahi Israt Jahan, Israt Jahan Jarin, Zohora Pradhan Jonaki, Asik Kabir, Tonema Kader, Md Mostafa Kamal, Sayed Kamruzzaman, Sadik Fatima Kanon, Nazmul Karim, Shamsul Karim, Tanuja Khanom, Shamim Ara Khatun, Badrun Nahar Lorin, Mst Sirajum Manira, Farhana Jahan Mary, Kazi Dilruba Mita, Lipi Mitra, Basudeb Mollik, Sudipta Nargis, Nusrat Alam Nawmee, Esrat Zahan Nesa, Mahmuda Akter Nipa, Mehenaz Parvin, Sanjida Parvin, Shahnaj Parvin, Suraiya Parvin, Nayan Rabidash, Rulia Rahman, Madhabi Rani, Shahjalal Sarker, Smriti Sarker, Razia Sultana Shathi, Fatema Shelly, Ireen Sultana, Rovaiya Sultana, Israt Jahan Sumi, Sharmin Tamanna, Khadija Akter Topy, Umme Habiba Urmee, Suraya Yesmin, Julianne Halley, Charlotte van Coeverden, Mahmuda Akther Akhi, Asia Akter, Labony Akter, Ms Mili Akter, Mst Shamima Akter, Setu Akter, Tahmina Akter, Md Sabdar Ali, Mst Jesmin Ara, Edyta Bujnik, Apu Chandra Das, Many Das, Nurjahan Fatema, Md Riyad Hasan, Soniya Jannat, Mst Amena Khatun, Most Nurnahar Khatun, William Mossman, Robyn Murdoch, Zannaton Naeem, Evrikleia Ntasi, Silvia Alonso Rodriguez, Tripty Roy, Most Abida Sultana, Laryssa Amado, Tanya Braune, Eilidh Cowan, Steve Ellis, Ellie Farrow, Hannah Lombardi, Niko Ovenden, Tamara Sabri, Md Khalid Sultan, Jim Ajioka, Khondker Abdul Awal, Arul Baradi, Emanuele Di Angelantonio, Camilla Faidutti, Joerg Feldmann, Louise Hair, Sharifuddin Hasnat, Shahid Akhter Hossain, Md Mominul Islam, Shafiul Islam, Joe Lavallée, Fazila Tun-Nesa Malik, Nick Mascie-Taylor, Md Sirajul Islam, Laurie Savage, Sara Shazad, Lalitha Sundaram, Aloka Tulukdar, Kim Van Daalen, Tanvir Chowdhury, Nurul Huda, Samia Naz Isha, Riaz Hossain Khan, Aliva Salmeen, Zeeba Zahra Sultana

“…This cohort will provide a powerful resource to investigate multidimensional determinants of incident NCDs across diverse settings in Bangladesh, helping to advance scientific discovery and public health action in an archetypal low-middle-income country with pressing public health needs.…”
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Association of the body roundness index with chronic diarrhea and chronic constipation: findings based on the National Health and Nutrition Examination Survey 2005–2010 data by Yinda Wang, Fei Chen, Binzhong Zhang, Zhengwei Song

“…To capture and visualize the nuanced interplay between BRI and gastrointestinal patterns, we utilized advanced nonlinear regression methods, specifically restricted cubic spline (RCS) analyses. …”
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A machine learning framework for short-term prediction of chronic obstructive pulmonary disease exacerbations using personal air quality monitors and lifestyle data by M. Atzeni, G. Cappon, J. K. Quint, F. Kelly, B. Barratt, M. Vettoretti

“…Abstract Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with a variety of symptoms including, persistent coughing and mucus production, shortness of breath, wheezing, and chest tightness. As the disease advances, exacerbations, i.e. acute worsening of respiratory symptoms, may increase in frequency, leading to potentially life-threatening complications. …”
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Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

“…Fap2 is a fusobacteria-specific outer membrane galactose-binding lectin that mediates Fusobacterium adherence to and invasion of CRC tumors. Advances in omics analyses provide an opportunity to profile and identify microbial genomic features that correlate with the cancer-associated bacterial virulence factor Fap2. …”
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The scholarly and practice profile of respiratory therapists in Canada: A cross-sectional survey by Marco Zaccagnini, André Bussières, Peter Nugus, Andrew West, Aliki Thomas

“…Creating supportive environments, providing access to resources, and encouraging professional development activities may advance the scholarly practice of RTs. Future national surveys could employ random sampling strategies to achieve a more representative sample of the profession.…”
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Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90% of HIV-Infected Individual... by Prossie Merab Ingabire, Fred Semitala, Moses R. Kamya, Damalie Nakanjako

“…Combination antiretroviral therapy (cART) initiation in hospital settings, where individuals often present with undiagnosed, untreated, advanced HIV disease, is not well understood. Methods. …”
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Gazneliler Dönemine Ait Pirinç Tepsi Üzerindeki Taht Sahnesi by Arslan Durdu

“…Şimdiki Afganistan coğrafyasına hâkim olan Gazneliler 11-12 yüzyıllar arasında bu sanat mirasını devam ettirmiştir. Gaznelilerin kültürel hayatı hakkında yapılan çok fazla çalışma olduğu söylenemez. …”
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Cost Savings in Chronic Pain Patients Initiating Peripheral Nerve Stimulation (PNS) with a 60-Day PNS Treatment by David M. Dickerson, Hemant Kalia, Kevin E. Vorenkamp, Konstantin V. Slavin, Jonathan M. Hagedorn, Candace Gunnarsson, Eric L. Keuffel, Andrew J. Epstein, Mark Stultz, Nathan D. Crosby

“…Estimated PNS-related weighted average costs for the 60-Day PNS cohort [US$17,344; 95% confidence interval (CI): $16,168–$18,527] were lower than the PNS-BT cohort ($24,392; 95% CI $22,865–$25,941) when considering the percent of patients who advanced to a permanently implanted PNS system. The total cost per successful outcome also favored 60-Day PNS ($25,228 per success for the 60-Day PNS cohort vs. $64,502 per success for the PNS-BT cohort) as a first-line approach in PNS treatment. …”
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Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken by Wen Li, Yuxing Luo, Shoujia Zhu, Mengyuan Wang, Xuli Zhao, Zhonghua Ning

“…Collectively, these findings deepen our understanding of how distinct molecular and metabolic pathways in the liver, ovary, and magnum orchestrate yolk proportion and deposition. Such insights may advance future strategies to improve egg quality and productivity in poultry breeding programs.…”
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Personnel Policy Strategy of the National Police of Ukraine in the Context of Updating Administrative and Legal Principles of Protecting Human Rights and Freedoms by A. V. Tanko

“…It is determined that the perspective direction of the studied issue is the development of innovative methods and forms of training and advanced training of personnel capable to meet the professional requirements and ethical standards of policing.…”
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Smoking habits, awareness and support needs for cessation among people with multiple sclerosis in Australia: findings from an online survey by Roshan das Nair, Ron Borland, Claudia H Marck, Isabelle Weld-Blundell, Lisa Grech, Sarah L White

“…Most participants felt they would benefit from smoking cessation advice. MS clinicians, in collaboration with patient organisations, smoking cessation services and general practitioners, should make smoking cessation promotion with people with MS a priority.…”
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Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients by Daniel Y. Chu, Jiancheng Hou, Thomas Hosseini, Veena A. Nair, Nagesh Adluru, Yuri Danilov, Kurt A. Kaczmarek, Mary E. Meyerand, Mitchell Tyler, Mitchell Tyler, Vivek Prabhakaran

“…The current study aimed to extend our previous resting-state functional connectivity (RSFC) study investigating the effects of TLNS intervention on outcome measures related to gait and balance.MethodsAn experimental PoNS device was utilized to deliver the TLNS. The 2-week TLNS intervention program, specifically stimulation during focused physical therapy focused on recovery of gait and balance, included twice-daily treatment in the laboratory and the same program at home during the intervening weekend. …”
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Comparison of air-liquid interface transwell and airway organoid models for human respiratory virus infection studies by Camilla T. Ekanger, Camilla T. Ekanger, Camilla T. Ekanger, Nilima Dinesh Kumar, Rosanne W. Koutstaal, Fan Zhou, Martin Beukema, Joanna Waldock, Simon P. Jochems, Noa Mulder, Cécile A. C. M. van Els, Cécile A. C. M. van Els, Othmar G. Engelhardt, Nathalie Mantel, Kevin P. Buno, Karl Albert Brokstad, Karl Albert Brokstad, Agnete S. T. Engelsen, Agnete S. T. Engelsen, Rebecca J. Cox, Rebecca J. Cox, Barbro N. Melgert, Barbro N. Melgert, Anke L. W. Huckriede, Puck B. van Kasteren

“…Our collaborative efforts to harmonize infection experiments and compare ALI transwell and airway organoid models described here aid in advancing our understanding and improving the standardization of these complex in vitro respiratory models for future studies.…”
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Cosmetic Appeal, HRQoL, and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer by Ijeoma N. C. Chibuzo, Augustine O. Takure, Olayiwola B. Shittu, Linus I. Okeke

“…Orchidectomy is the most cost-effective means of hormonal therapy for locally advanced or metastatic prostate cancer (LAMP). However, cost-effectiveness should not detract from health-related quality of life (HRQoL) considerations. …”
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Facilitators and barriers to reach and enrollment into a medically tailored meals program within a section 1115 Medicaid pilot: clinic staff perspectives by Sara C. Folta, Jessica Burch, Matthew Alcusky, Arlene S. Ash, Kurt Hager, Jean Terranova, Fang Fang Zhang, Oyedolapo Anyanwu, Zhongyu Li, Dariush Mozaffarian

“…IntroductionMedically tailored meals (MTMs) are home-delivered, nutritionally tailored meals for individuals living with complex or advanced diet-sensitive medical conditions. In 2020, Massachusetts Medicaid implemented the Flexible Services Program (FSP) through a Section 1115 Demonstration, which funded novel nutrition programs, including MTMs, for high-risk patients through Accountable Care Organizations (ACOs). …”
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Prospective Application of the Erythrocyte Sedimentation Rate (ESR) as a Possible Inflammatory Marker in Feline Patients by Eleonora Gori, Anna Pasquini, Saverio Paltrinieri, George Lubas, Carlo Militello, Daniela Diamanti, Carlo Carletti, Marianna Pantoli, Veronica Marchetti

“…The ESR was performed with MINI-PET using the same K3-EDTA tubes used for CBC, with no additional sample required. …”
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Disruption of zinc homeostasis reverses tigecycline resistance in Klebsiella pneumoniae by Jinyu Wang, Jinyu Wang, Cuiping Xia, Cuiping Xia, Zhaoxin Xia, Zhaoxin Xia, Jilu Shen, Jilu Shen

“…However, bacteria have evolved mechanisms to expel excess zinc ions from their cells, enabling them to thrive in environments rich in metal ions at high concentrations. This evolutionary advancement limits the clinical application of metal ions as antimicrobial agents. …”
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Comparing the cost-benefit of breast cancer screening programs in rural and urban areas across four economic zones in China: a Markov modeling analysis by Dachuang Zhou, Kejia Zhou, Wenjuan Wang, Hanqiao Shao, Hongliu Zhang, Wenxi Tang

“…Except for the rural central region, where the cost-effective strategy had suboptimal outcomes compared to status quo, the recommended strategies in the other seven regions could prevent 41.12–58.80% and 8.08–35.39% of advanced breast cancer cases, and 18.83–29.27% and 2.71–14.06% of breast cancer deaths, when compared to no screening and status quo, respectively. …”
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mRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against Klebsiella pneumoniae by Ting Huang, Siyou Che, Zheng Lv, Danrui Hao, Runyu Wang, Qinxuan Yi, Ling Mei, Yang Yuan, Hang Zou, Yidong Guo, Xinrong Wang, Yiwen Chu, Kelei Zhao

“…To date, messenger RNA (mRNA) vaccine is one of the most advancing technologies and are extensively investigated for viral infection, while infrequently applied for prevention of bacterial infections. …”
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