Establishment of a prognostic signature and immune infiltration characteristics for uterine corpus endometrial carcinoma based on a disulfidptosis/ferroptosis-associated signature by Yong Huang, Huibin Li, Zhifu Wei, Wanshan He, Bin Chen, Shuang Cheng, Zhifang Zhao, Lv Deng, Lv Deng, Xiaohua Chen, Yu Lin, Yu Lin, Xiaoshan Hong, Xiaoshan Hong

“…Finally, we validated the prognostic gene expression profile in clinical samples.ResultsWe identified five optimal DFRGs that were differentially expressed and associated with the prognosis of uterine corpus endometrial carcinoma (UCEC). These genes include CDKN2A, FZD7, LCN2, ACTN4, and MYH10. Based on these DFRGs, we constructed a robust prognostic model with significantly lower overall survival in the high-risk group than in the low-risk group, with differences in tumor burden and immune invasion between the different risk groups. …”
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Biological effectiveness of combined exposure to neutrons and gamma radiation applied in two orders of sequence: Relevance for biological dosimetry after nuclear emergencies by Tomas Palmqvist, Milagrosa Lopez-Riego, Martin Bucher, Ursula Oestreicher, Stefan Pojtinger, Ulrich Giesen, Iuliana Toma-Dasu, Andrzej Wojcik

“…Dicentric chromosomes were analyzed by light microscopy and the expression of six known radiation-responsive genes BBC3, CDKN1A, FDXR, GADD45A, MDM2, and XPC were analyzed by RT-qPCR. …”
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Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line by Mohammed Nihal Hasan, Syed Shoeb Razvi, Hani Choudhry, Mohammed A. Hassan, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Khalid Omer Abualnaja, Majed A. Halwani, Abdulrahman Labeed Al-Malki, Jiannis Ragoussis, Wei Wu, Christian Bronner, Tadao Asami, Mahmoud Alhosin

“…Several epigenetic modulators such as UHRF1, HDAC7, and DNMT1 were also considerably downregulated, and this effect was associated with significant upregulation of various proapoptotic genes including CASP3, TNF-α, CASP7, and CDKN1A (p21). Likewise, damaged DNA repair genes such as RAD51, RAD52, and DDB2 were also significantly downregulated. …”
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Cell Differentiation Trajectory Predicts Prognosis and Immunotherapeutic Response in Clear Cell Renal Cell Carcinoma by Jin Xu, Xi Chen, Yinyu Chen, Qiushuang Wang, Yingliang Jin, Huashuo Zhao

“…Based on machine learning, we identified a prognostic risk model composed of 14 DRGs, including BTG2, CDKN1A, COL6A1, CPM, CYB5D2, FOSB, ID2, ISG15, PLCG2, SECISBP2, SOCS3, TES, ZBTB16, and ZNF704, to predict the survival rate of patients and then constructed a nomogram model integrating clinicopathological characteristics and risk score for clinical practice. …”
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Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population by Dione Aguilar, María Lourdes Garza-Rodríguez, Carolina Elizabeth Muñiz-Garza, Fernando Alcorta Nuñez, Cynthia Mayte Villarreal-Garza, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores

“…The five most frequent non-BRCA genes were CHEK2, PALB2, MUTYH, CDKN2A, and ATM. Among the group of non-BRCA genes, six are involved in the homologous repair pathway (HR), and three are related to DNA damage repair (DDR) pathways. …”
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Правове регулювання цифрової трансформації в Україні: інституційно-технологічні критерії ефективності в умовах європейської інтеграції... by Yu. V. Akulov

“…Проаналізовано роль Міністерства цифрової трансформації та ефективність впровадження посад CDTO в органах державної влади. Визначено необхідність створення спеціалізованих регуляторних органів, зокрема у сфері штучного інтелекту, за аналогією з European Artificial Intelligence Board. …”
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Aprendizagem de vocabulário por meio da leitura de livros digitais: um estudo comparativo by Gianndre Roberto Coelho de Souza Ferreira, Andréia Schmidt

“…Considerando que crianças pré-escolares têm acesso à tecnologia cada vez mais cedo, é fundamental compreender como as histórias digitais podem auxiliar no aprendizado de vocabulário. …”
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Proceso de cuidado enfermero aplicado en un paciente con diabetes mellitus tipo 2 by Vanessa Chero Tapullima, Diana Curo Vasquez, Jennifer Huanca Esquivel, Christian Lázaro Lizano, Susan Haydde Gonzales Saldaña, José Gregorio Molina Torres

“…Caso clínico: Paciente adulto de 59 años, de sexo femenino, con antecedentes de diabetes mellitus tipo 2, previamente hospitalizada para la amputación de dedos en la extremidad inferior del lado derecho. …”
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A Novel Insight into Paraptosis-Related Classification and Signature in Lower-Grade Gliomas by Xi-Feng Qian, Jia-Hao Zhang, Yue-Xue Mai, Xin Yin, Yu-Bin Zheng, Zi-Yuan Yu, Guo-Dong Zhu, Xu-Guang Guo

“…Through least absolute shrinkage and selection operator regression analysis and multivariate Cox regression analysis, 10-paraptosis-related gene (PRG) signatures (CDK4, TNK2, DSTYK, CDKN3, CCR4, CASP9, HSPA5, RGR, LPAR1, and PDCD6IP) were identified to separate LGG patients into high- and low-risk subgroups successfully. …”
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Identification and Validation of Pivotal Genes in Osteoarthritis Combined with WGCNA Analysis by Yang C, Chen X, Liu J, Wang W, Sun L, Xie Y, Chang Q

“…Through the integration of protein-protein interaction (PPI) analysis, validation in animal models and ROC curve analysis, four pivotal genes (GADD45B, CLDN5, HILPDA and CDKN1B) were finally identified.Conclusion: In conclusion, these identified key genes could serve as novel targets for predicting and treating OA, offering fresh insights into its etiology and pathogenesis.Keywords: osteoarthritis, bioinformatics analysis, WGCNA, GSE data…”
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Telangiectasia hemorrágica hereditaria como causa de anemia ferropénica grave de origen oscuro by Jean Pinto Angarita, Fernando García del Risco, Walter Puello Ramos

“…Caso clínico: se presenta el caso de una paciente de 51 años de edad que se presentó con astenia y adinamia en la que se documentó telangiectasias en lengua, labios y dedos y se llegó al diagnóstico de telangiectasia hemorrágica hereditaria luego de la confirmación de malformación arteriovenosa hepática y telangiectasias gástricas. …”
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Influencia de la temperatura durante el quemado sobre el despellejado en aceitunas variedad Aloreña y Manzanilla Sevillana by Julio JUAREZ ROMERO, C. FERNANDEZ, M. DE LA FUENTE

“…En el intervalo de 19-20 °C se consigue un defecto medio de 1% en Manzanilla y 1,25% en Aloreña.…”
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FORMAÇÃO DOCENTE E CURRÍCULO DE CURSOS DE LICENCIATURA EM MATEMÁTICA DO IFCE by Patricia Alves da Silva, Francisco José de Lima

“…Além disso, foi realizada análise documental dos Projetos Político-Pedagógicos dos cursos de Licenciatura em Matemática dos campi de Caucaia; Maranguape; Sobral; Maracanaú; Canindé; Juazeiro do Norte; Cedro; Crateús e Fortaleza do Instituto Federal de Educação, Ciência e Tecnologia do Ceará. …”
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Detection of High- and Low-Risk HPV DNA in Archived Breast Carcinoma Tissues from Ethiopian Women by Endale Gebregzabher, Daniel Seifu, Wondemagegnhu Tigneh, Yonas Bokretsion, Abebe Bekele, Markos Abebe, Gabriella Lillsunde-Larsson, Christina Karlsson, Mats G. Karlsson

“…IHC for p16 was done using an automated system, the Dako Autostainer Link. Results. Out of the 75 valid tests, two were found to be positive (2.7%) for HPV. …”
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Proceso de atención de enfermería aplicado a un adulto mayor con pie diabético by Fatima Del carmen Bernal Corrales, Ximena Alessandra Guevara Sánchez, Liz Katherine Heredia Roalcaba, Lesly Andrea Serrepe Rodas

“…Caso clínico: Adulto mayor internado en el servicio de medicina en un hospital nivel I por presentar una úlcera en el primer dedo del pie derecho, con una profundidad de 0,5 x 0,5 cm de diámetro, de dos meses de evolución, además de un edema en el miembro inferior derecho, con antecedente de diabetes mellitus no controlada. …”
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Cambios en el patrón ecográfico de miembros inferiores en bailarines folclóricos del norte de Chile. Criterios para diseñar un plan de prevención de lesiones by Dayneri León Valladares, Luis Antonio Barrio Mateu

“…<br /><strong>Resultados:</strong> se constataron alteraciones en el patrón de ecogenicidad normal a nivel del menisco lateral, mal alineación del mecanismo de extensión y distensión de la cápsula articular del primer dedo del pie, entre otras. Entre los criterios considerados para la elaboración de un plan profiláctico están: calentamiento, estiramiento, uso adecuado de protección y la aplicación de medios físicos como crioterapia, calor, acupuntura, talasoterapia, entre otros, con énfasis en miembros inferiores, por ser las zonas anatómicas de mayor uso en estos bailarines.…”
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High prevalence of p16 staining in malignant tumors. by Noémi De Wispelaere, Sebastian Dwertmann Rico, Marcus Bauer, Andreas M Luebke, Martina Kluth, Franziska Büscheck, Claudia Hube-Magg, Doris Höflmayer, Natalia Gorbokon, Sören Weidemann, Katharina Möller, Christoph Fraune, Christian Bernreuther, Ronald Simon, Christian Kähler, Anne Menz, Andrea Hinsch, Frank Jacobsen, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Sarah Minner

“…p16 (CDKN2A) is a member of the INK4 class of cell cycle inhibitors, which is often dysregulated in cancer. …”
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O papel do Decreto nº. 70/2017 de 6 de Dezembro e preços de transferência nas indústrias extractivas em Moçambique - Caso de estudo: Sasol Petroleum Temane (SPT) by Torres Filipe Charles

“…O objectivo desta pesquisa é estudar o papel do Decreto 70/2017 de 6 de Dezembro na redução da prática do regime dos preços de transferência abusiva no sector da indústria extractiva em Moçambique. …”
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Noncompaction Cardiomyopathy with Charcot-Marie-Tooth Disease by Sherif Ali Eltawansy, Andrea Bakos, John Checton

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Investigation of the spatial and temporal long-term hydro-climatic trends in Upper Omo Gibe Basin, Ethiopia by Eyasu Tafese Mekuria, Tamene Adugna Demissie, Fekadu Fufa Feyessa

“…The maximum statistically significant increasing trend of rainfall (P < 0.05) was observed at Limugenet station (Z = 3.641, S = 16.484), and a decreasing trend of rainfall was observed in Dedo station (Z = −2.732, S = −31.099). A generally decreasing rainfall trend was observed in the Upper Omo Gibe Basin. …”
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