Identification of the Key Genes and Pathways in Esophageal Carcinoma by Peng Su, Shiwang Wen, Yuefeng Zhang, Yong Li, Yanzhao Xu, Yonggang Zhu, Huilai Lv, Fan Zhang, Mingbo Wang, Ziqiang Tian

“…The expression level of 8 dysregulated DEGs including CDK4, CCT3, THSD4, SIM2, MYBL2, CENPF, CDCA3, and CDKN3 was validated in EC compared to adjacent nontumor tissues and the results were matched with the microarray analysis. …”
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Comparison of PD-L1 tumor cell expression with 22C3, 28-8, and SP142 IHC assays across multiple tumor types by Jeffrey S Ross, Richard S P Huang, Jake G Maule, Lani K Clinton, Ryon P Graf, Jinpeng Xiao, Geoffrey R Oxnard

“…Background Multiple PD-L1 immunohistochemistry (IHC) assays, including DAKO 22C3, DAKO 28-8, and Ventana SP142 PD-L1 IHC assays, have been approved by the Food and Drug Administration as a companion diagnostic (CDx) for various antiprogrammed death-1 and antiprogrammed death ligand 1 (PD-L1) based cancer immunotherapies. …”
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TRANS-BORDER TRAJECTORIES AND HUMAN SECURITY IN NIGERIA: NORTHEAST AND NORTHWEST IN PERSPECTIVE by JOSHUA OJI ZACHARIAH, ELIAS CHUKWUEMEKA NGWU

“…It further argued that trans-border related insecurity such as banditry, Boko Haram onslaughts impacted negatively on food production, availability, accessibility and stability in the study area. …”
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Immune Dysfunction in Rett Syndrome Patients Revealed by High Levels of Serum Anti-N(Glc) IgM Antibody Fraction by Anna Maria Papini, Francesca Nuti, Feliciana Real-Fernandez, Giada Rossi, Caterina Tiberi, Giuseppina Sabatino, Shashank Pandey, Silvia Leoncini, Cinzia Signorini, Alessandra Pecorelli, Roberto Guerranti, Solange Lavielle, Lucia Ciccoli, Paolo Rovero, Claudio De Felice, Joussef Hayek

“…Rett syndrome (RTT), a neurodevelopmental disorder affecting exclusively (99%) female infants, is associated with loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2) and, more rarely, cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1). In this study, we aimed to evaluate the function of the immune system by measuring serum immunoglobulins (IgG and IgM) in RTT patients (n=53) and, by comparison, in age-matched children affected by non-RTT pervasive developmental disorders (non-RTT PDD) (n=82) and healthy age-matched controls (n=29). …”
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Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells by Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, Atsunori Tsuchiya, Shuji Terai

“…Furthermore, there was a decrease in the number of senescent cells in the liver and the mRNA levels of secrete senescence-associated secretory phenotype factors and Cdkn2a (p16). In vitro, HPE induced macrophage polarization to the anti-inflammatory M2 phenotype. …”
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Modulation of biological activities in adipose derived stem cells by histone deacetylation by Sallam Abdallah, Mouna Tabebi, Sawsan Qanadilo, Neserin Ali, Jing Wang, Pádraig D’Arcy, Wen Zhong, Folke Sjoberg, Moustafa Elmasry, Ahmed El-Serafi

“…Microarray analysis revealed 74 upregulated and 40 downregulated differentially expressed genes, including upregulation of P53 targets, CDKN1A and MDM2. Proteomic analysis identified 631 upregulated and 823 downregulated proteins compared to the vehicle. …”
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Afrika’s Cause Must Triumph: Towards the Hegemony of Lembede’s “Afrika for the Afrikans” as a Political Philosophy of National Liberation in “South Africa”. by Masilo Lepuru

“…The third one is that the broad nationalism of Mda was transformed into the Azanian political tradition by Robert Sobukwe and Steve Biko. The last one is that the triumph of Mda’s idea of Afrika must triumph has contributed to the disastrous dominance of nonracialism in South Africa at the expense of the racial nationalism of Lembede. …”
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La idea de Dios y las preguntas de la razón pura by José Alvarado, Ineida Machado

“…, ¿qué debo hacer?, ¿qué puedo esperar? Se parte de la siguiente premisa: aquello que no cumpla las condiciones impuestas por las intuiciones puras de la sensibilidad no puede ser conocido, por lo que Dios queda negado como problema metafísico; sin embargo, Kant lo justifica dentro del ámbito moral como necesidad para el cumplimiento del bien supremo, en conjunción con la libertad y la felicidad. …”
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EGFR as a biomarker of smoking status and survival in oropharyngeal squamous cell carcinoma by Shanmugappiriya Sivarajah, Morris Kostiuk, Cameron Lindsay, Lakshmi Puttagunta, Daniel A. O’Connell, Jeffrey Harris, Hadi Seikaly, Vincent L. Biron

“…Retrospectively collected tumors were used to construct tissue microarrays (TMAs), which were stained with EGFR, p16, DAPI and Pan-cytokeratin, and digitally quantified. EGFR, CDKN2A and HPV E6/7 levels from prospectively collected OPSCC was measured by droplet digital PCR (ddPCR). …”
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Diagnóstico prenatal citogenético y ultrasonográfico de síndrome de Patau. Presentación de un caso by Pedro Alí Díaz-Véliz Jiménez, Belkis Vidal Hernández, Iliana González Santana

“…El informe de anatomía patológica refirió a nivel del labio superior un orificio que se continuaba hacia la porción superior de la boca por ausencia del paladar duro (labio leporino acompañado de paladar hendido), polidactilia en mano izquierda (seis dedos); cardiopatía congénita dada por aorta disminuida de calibre y dextropuesta, hipoplasia en cavidades izquierdas, comunicación intraventricular basal media con ductus amplio y permeable, así como prominencia en el macizo facial o probóscide.…”
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CHURCH RESPONSE TO SECURITY CHALLENGES IN THE 21ST CENTURY: THE NIGERIAN EXPERIENCE by Oyebode Paul Jegede, Abare Yunuwa Kallah

“…Kidnapping has become a lucrative business in which ransoms running to several billions of naira are being demanded. The emergence of Boko Haram, banditry, and herdsmen altered the already battered image of the country in the comity of nations as one of the countries to abstain from. …”
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Deletions of N33, STK11 and TP53 Are Involved in the Development of Lymph Node Metastasis in Larynx and Pharynx Carcinomas by Marta Alonso Guervós, César Álvarez Marcos, Mario Hermsen, Andrés Sampedro Nuño, Carlos Suárez, José Luis Llorente

“…Methods: Thirty-seven genes were analysed by MLPA in 34 larynx and 22 pharynx carcinomas. Results: Losses of CDKN2A (9p21) and MLH1 (3p22) and gains of CCND1, EMS1 (both at 11q13), RECQL4 and PTP4A3 (both at 8q24) were the most frequent aberrations in both larynx and pharynx carcinomas. …”
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Antología de crítica literaria de Gabriela Pólit (compiladora) by Eduardo Kingman

“…Eso tiene sus desventajas, pero también sus ventajas. …”
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BEHAVIOUR AMONG FEMALE MIGRANTS IN MAKURDI, BENUE STATE by ONYEMA ANGELA ABEL

“…Benue state is one of the states in Nigeria which is worse hit by insurgency (BokoHaram) and comfits (Farmers-Herders conflict),leading to Migration of people. …”
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Review of presentations and radiotherapy outcomes of patients with malignant spinal cord compression by Louisa M. Mbokazi, Sheynaz Bassa, Krishanthavathie Pillay

“…Setting: The study was conducted at Steve Biko Academic Hospital, Radiation Oncology. Methods: This is a retrospective review of 110 patients who were treated for MSCC between January 2022 and November 2023. …”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…Corresponding targeted medications such as Abatacept, chemokine receptor (CCR) inhibitors, CDDO-Im (2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide), adenosine monophosphate-activated protein kinase (AMPK) activators, and Adalimumab are currently under investigation. …”
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High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis by Soon Sang Park, Tae Hoon Roh, Yoshiaki Tanaka, Young Hwa Kim, So Hyun Park, Tae-Gyu Kim, So Yeong Eom, Tae Jun Park, In-Hyun Park, Se-Hyuk Kim, Jang-Hee Kim

“…Previous studies have identified a few prognostic markers for GBM, including the methylation status of O6-methylguanine-DNA methyltransferase (MGMT) promoter, TERT promoter mutation, EGFR amplification, and CDKN2A/2B deletion. However, the classification of GBM remains incomplete, necessitating a comprehensive analysis. …”
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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Subsequent molecular analysis of the osteosarcoma tissue revealed homozygous loss of the CDKN2A gene locus, warranting treatment with CDK4/6 inhibitor palbociclib. …”
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An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma by Michele Massimino, Elena Tirrò, Stefania Stella, Cristina Tomarchio, Sebastiano Di Bella, Silvia Rita Vitale, Chiara Conti, Marialuisa Puglisi, Rosa Maria Di Crescenzo, Silvia Varricchio, Francesco Merolla, Giuseppe Broggi, Federica Martorana, Alice Turdo, Miriam Gaggianesi, Livia Manzella, Andrea Russo, Giorgio Stassi, Rosario Caltabiano, Stefania Staibano, Paolo Vigneri

“…Methods: Following the findings published by “The Cancer Genome Atlas–UM” (TCGA-UM) study, we developed an NGS-based gene panel (called the UMpanel) that classifies mutation sets in four categories: initiating alterations (<i>CYSLTR2</i>, <i>GNA11</i>, <i>GNAQ</i> and <i>PLCB4</i>), prognostic alterations (<i>BAP1</i>, <i>EIF1AX</i>, <i>SF3B1</i> and <i>SRSF2</i>), emergent biomarkers (<i>CDKN2A</i>, <i>CENPE</i>, <i>FOXO1</i>, <i>HIF1A</i>, <i>RPL5</i> and <i>TP53</i>) and chromosomal abnormalities (imbalances in chromosomes 1, 3 and 8). …”
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Features of expression of immunohistochemical markers in local and generalized clear cell kidney cancer by E. M. Frantsiyants, A. N. Shevchenko, E. A. Dzhenkova, N. S. Karnaukhov, T. A. Gudtskova, A. A. Breus, E. V. Filatova, D. A. Shvyrev

“…Antibodies used: E‑cadherin (EP700Y) Cell Marque, 1: 100; CD 44 (EPR1013Y) Cell Marque 1:150; Ki‑67 (SP6) Spring Bio, 1:200; P53 (DO‑7) Cell Marque, 1:200; cyclin D1 (EP12) Dako, 1:200; VEGF Termo Fisher, 1:100; Vimentin (V9) Dako, 1:150; MMP‑9 (EP100902) Epitomics, 1:100. …”
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