The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity by Mustafa Sibai, Sergi Cervilla, Daniela Grases, Eva Musulen, Rossana Lazcano, Chia-Kuei Mo, Veronica Davalos, Arola Fortian, Adrià Bernat, Margarita Romeo, Collin Tokheim, Jordi Barretina, Alexander J. Lazar, Li Ding, Enrique Grande, Francisco X. Real, Manel Esteller, Matthew H. Bailey, Eduard Porta-Pardo, Enrique Grande, Teresa Alonso-Gordoa, Mario Álvarez-Maestro, Elena Andrada, Ainara Azueta, Raquel Benítez Javier Burgos, Daniel Castellano, M. Angel Climent, Mario Domínguez, Ignacio Durán Albert Font, Isabel Galante, Patricia Galván, Juan F. García, Xavier García del Muro, Félix Guerrero-Ramos, Núria Malats, Miriam Marqués, Pablo Maroto, Jaime Martínez de Villarreal, Ane Moreno-Oya, Jesús M. Paramio, Alvaro Pinto, Aleix Prat, Javier Puente, Oscar Reig, Francisco X. Real

Get full text

Effect of Parenting Style on Drug and Substance Abuse Among Teenage Youth in Kabale Municipality. by Ainembabazi, Marion

Get full text

Location of Cynological Units in the Structure of the National Police of Ukraine and in the System of the Ministry of the Internal Affairs by V. V. Garmash

“…For what was analyzed the current state of the legal framework that provides the activities of the canine units of the National Police of Ukraine (NPU), considered the historical features of the development of the canine service in the system of bodies subordinate to the Ministry of Internal Affairs (MIA). …”
Get full text

A Machine Learning Algorithm to Predict Medical Device Recall by the Food and Drug Administration by Victor Barbosa Slivinskis, Isabela Agi Maluli, Joshua Seth Broder

“…Identification of dangerous medical devices as early as possible is necessary to minimize patient harms while avoiding false positives to prevent removal of safe devices from use. While the United States Food and Drug Administration (FDA) employs an adverse event reporting program (MedWatch) and database (MAUDE), other data sources and methods might have utility to identify potentially dangerous medical devices. …”
Get full text

Effects of anti-inflammatory drugs on fever and neutrophilia induced by Clostridium difficile toxin B by R. A. Cardoso, A. A. Melo Filho, M. C. C. Melo, D. M. Lyerly, T. D. Wilkins, A. A. M. Lima, R. A. Ribeiro, G. E. P. Souza

Get full text

Research supporting service transformation: Family Drug and Alcohol Courts and understanding the factors that contribute to their success by Martin Doug

Get full text

Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies by Essam M. Abdelfattah, Essam M. Abdelfattah, Pius S. Ekong, Emmanuel Okello, Emmanuel Okello, Tapakorn Chamchoy, Betsy M. Karle, Randi A. Black, Wagdy ElAshmawy, Wagdy ElAshmawy, David Sheedy, Deniece R. Williams, Terry W. Lehenbauer, Terry W. Lehenbauer, Barbara A. Byrne, Sharif S. Aly, Sharif S. Aly

Get full text

Intravenous push administration of anti-seizure medications by Raniah Aljadeed, Raniah Aljadeed, Brian W. Gilbert, Tallib Karaze, Megan A. Rech

Get full text

Important Things to Know about Medicare Chapter Five: Medicare Part D--Prescription Drug Coverage by Amanda Terminello, Martie Gillen

Get full text

Important Things to Know about Medicare Chapter Five: Medicare Part D--Prescription Drug Coverage by Amanda Terminello, Martie Gillen

Get full text

Deprescribing and Optimal Selection of Proton Pump Inhibitors (Contributions of the 26th United Russian Gastroenterology Week) by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, A. A. Sheptulin, V. I. Simanenkov, T. L. Lapina, I. B. Khlynov, N. N. Dekhnich, O. D. Lopina, O. P. Alekseeva, N. V. Korochanskaya, M. F. Osipenko, P. V. Pavlov, S. S. Pirogov, G. N. Tarasova, Yu. P. Uspenskiy, D. N. Andreev, D. E. Rumyantseva

Get full text

Editorial: Ovarian cancer targeted medication: PARP inhibitors, anti-angiogenic drugs, immunotherapy, and more, volume II by Zhi-Bin Wang, Zhi-Bin Wang, Zhi-Bin Wang, De-Hua Liao, Guang Lei, Zhao-Qian Liu, Zhao-Qian Liu, Nayiyuan Wu, Nayiyuan Wu, Jing Wang, Jing Wang

Get full text

Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process by Breanne Stewart, Pirkko Lepola, Gunter F. Egger, Fahimeda Ali, Albert J. Allen, Albert J. Allen, Alysha K. Croker, Andrew J. Davidson, Pamela Dicks, Saul N. Faust, Saul N. Faust, Dionna Green, Collin Hovinga, Collin Hovinga, Agnes V. Klein, Robyn Langham, Hidefumi Nakamura, Laura Pioppo, Shiva Ramroop, Michiyo Sakiyama, Isabel Sanchez Vigil de la Villa, Junko Sato, Donna L. Snyder, Mark A. Turner, Mark A. Turner, Sarah Zaidi, Kanecia Zimmerman, Kanecia Zimmerman, Thierry Lacaze-Masmonteil

“…This work, undertaken by the Working Group (WG) on International Collaborations at the European Network of Pediatric Research at the European Medicines Agency (Enpr-EMA) aims to describe the research ethics review requirements including any pediatric specific requirements, as well as current or upcoming changes across six jurisdictions – the European Union (EU), United Kingdom (UK), United States of America (USA), Canada, Japan, and Australia.MethodsAn open questionnaire developed by the WG and directed at both the Competent Authorities (CA) and the national pediatric clinical trial networks arranged by jurisdictions.ResultsA synopsis of the current regulatory requirements covers centralized versus independent review, comparisons between investigator initiated and industry sponsored clinical trials, timelines, review board members requirements and the consenting/assent process for clinical trial (CT) applications, application submission processes and application requirements for each of the six jurisdictions. …”
Get full text

Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

Get full text

Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients by Bridgette M. Cumming, Kelvin W. Addicott, Fernanda Maruri, Fernanda Maruri, Vanessa Pillay, Rukaya Asmal, Sashen Moodley, Beatriz Barreto-Durate, Beatriz Barreto-Durate, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Matilda Mazibuko, Zoey Mhlane, Nikiwe Mbatha, Khadija Khan, Senamile Makhari, Farina Karim, Lauren Peetluk, Alexander S. Pym, Mahomed Yunus S. Moosa, Yuri F. van der Heijden, Yuri F. van der Heijden, Yuri F. van der Heijden, Timothy S. Sterling, Timothy S. Sterling, Bruno B. Andrade, Bruno B. Andrade, Alasdair Leslie, Alasdair Leslie, Alasdair Leslie, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

Get full text

Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy by K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev

“…This opens up the prospect of using SCID mice as an animal model for smallpox to develop antiviral drugs intended for people with severe immuno­suppressive states.…”
Get full text

Corrigendum: Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients by Bridgette M. Cumming, Kelvin W. Addicott, Fernanda Maruri, Fernanda Maruri, Vanessa Pillay, Rukaya Asmal, Sashen Moodley, Beatriz Barreto-Durate, Beatriz Barreto-Durate, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Matilda Mazibuko, Zoey Mhlane, Nikiwe Mbatha, Khadija Khan, Senamile Makhari, Farina Karim, Lauren Peetluk, Alexander S. Pym, Mahomed Yunus S. Moosa, Yuri F. van der Heijden, Yuri F. van der Heijden, Yuri F. van der Heijden, Timothy S. Sterling, Timothy S. Sterling, Bruno B. Andrade, Bruno B. Andrade, Alasdair Leslie, Alasdair Leslie, Alasdair Leslie, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

Get full text

Boosting disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment by introducing stimuli‐responsive drug‐mates by Wenzhe Xu, Ruixu Yang, Yingke Xue, Yang Chen, Shuwei Liu, Songling Zhang, Yonggang Wang, Yi Liu, Hao Zhang

Get full text

EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives by Antonio Rossi, Ettore Mari

Get full text

Linear IgA bullous dermatosis secondary to drugs: a real-world pharmacovigilance study of the FDA adverse event reporting system by Yixuan Yang, Hanzhang Xie, Shuhan Liu, Ying Jia, Bingnan Cui, Zhanshuo Xiao

“…The gender distribution of reports was relatively balanced, with the highest proportion in the 66–85 age group. The United States had the highest number of reports. Vancomycin and Amoxicillin were the most frequently reported drugs, with 559 and 58 reports, respectively. …”
Get full text