A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women by Bo Anne Daniëlla Frederique Saals, Tessa Helena De Bie, Eral Osmanoglou, Ties van de Laar, Adriaan Willem Tuin, Anne Claire Benedikte van Orten-Luiten, Renger Frederik Witkamp

“…The geometric mean ratio (GMR) of CBD Cmax was 17.4 (90% CI 12.4–24.2 and of the AUC 9.7 (90% CI 7.7–12.3), demonstrating a substantial increase in peak concentration and total CBD exposure under fed conditions. A notable double peak phenomenon was observed after meal consumption, with a less pronounced effect in the fasted state. …”
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A linear filter regularization for POD-based reduced-order models of the quasi-geostrophic equations by Girfoglio, Michele, Quaini, Annalisa, Rozza, Gianluigi

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Safety and Intranasal Retention of a Broad-Spectrum Anti-SARS-CoV-2 Monoclonal Antibody SA55 Nasal Spray in Healthy Volunteers: A Phase I Clinical Trial by Chaoying Hu, Yibo Zhou, Xing Meng, Jianhua Li, Jinxia Chen, Zhifang Ying, Xiaoliang Sunney Xie, Yaling Hu, Yunlong Cao, Ronghua Jin

“…This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure level, and immunogenicity of the SA55 nasal spray in healthy individuals. …”
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Factors influencing livestock ownership and herd intensity among smallholder farmers in the Eastern Cape, South Africa by Jabulile Z. Manyike, Amon Taruvinga, Leocadia Zhou

“…Data were collected through a semi-structured questionnaire and analysed using a double hurdle model. The findings reveal that the decision to own livestock is positively influenced by adherence to African traditional religion, access to climate information, membership in farming organizations, income diversification, possession of formal housing, exposure to high average temperatures, and the likelihood of being in female-headed households. …”
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Transgenic plants as genetic models for studying functions of plant genes by A. V. Kochetov, V. K. Shumny

“…It was also found that these plants were more tolerant to various abiotic stresses (drought, NaCl, cold, toxic heavy metals), which may result from the protective proline effect early in exposure to stress, preventing the cellular gene expression machinery from damage by stress-generated free radicals.…”
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Ex vivo detection of recreational consumed nitrous oxide in exhaled breath by Dinesh Durán Jiménez, Frederick Vinckenbosch, Joris Busink, Jerro van Zijl, Hendrik J. F. Helmerhorst, Desirée van Tuin, Albert Dahan, Johannes Gerardus Ramaekers, Marcel J. van der Schans, Floris J. Bikker

“…Initially, a lung simulator was used to model respiratory mechanics and $$\hbox {N}_{2}$$ O decay, revealing detectable $$\hbox {N}_{2}$$ O levels up to 90 min after exposure. In the final part of this study, a controlled single and double dose of $$\hbox {N}_{2}$$ O gas was administered to 24 volunteers in an operating theatre. …”
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Experimental and Numerical Study on Fracture Characteristics of Interface between In Situ Engineered Cementitious Composites and Steel Deck by Weiwei Han, Shuyin Wu, Xue Gao, Xinyao Zong, Jingsong Shan

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Second-Hand Smoke Increases Bronchial Hyperreactivity and Eosinophilia in a Murine Model of Allergic Aspergillosis by Brian W. P. Seymour, Edward S. Schelegle, Kent E. Pinkerton, Kathleen E. Friebertshauser, Janice L. Peake, Viswanath P. Kurup, Robert L. Coffman, Laurel J. Gershwin

“…The concentration was consistent with that achieved in enclosed public areas or households where multiple people smoke. During exposure, mice were sensitized to Af antigen intranasally. …”
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Insights into corrosion behavior of AlCrFeTi and AlCrFeTiY coating for fuel cladding in static and flowing liquid lead bismuth at 550°C by Jingyi Liang, Wei Zhang, Qingyu Li, Ke Zhao, Jun Xiao, Jijun Yang, Shaoyu Qiu, Sheng Huang

“…Corrosion resistance of AlCrFeTi and AlCrFeTiY coatings were evaluated in static and flowing lead bismuth with oxygen-controlled precondition at 550 °C, both the oxygen concentration of static and flowing liquid lead bismuth was 1 × 10−5 wt%. Double-layered compact oxide layers were formed on the surface of AlCrFeTi coating which consist of outer Fe/Cr oxide layer and inner Al/Ti oxide layer after exposure in static liquid lead bismuth for 2000 h, while uneven Fe/Cr oxide layers formed on AlCrFeTiY coating and the oxygen content significantly increase inside the coating, indicating the weaker antioxidant properties of AlCrFeTiY. …”
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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…A sensitive and specific bioanalytical method was required to measure the exposure of a LAGA-mutated surrogate mouse IgG2a monoclonal antibody in mouse plasma, but the lack of highly specific reagents for the LAGA mutant hindered the development of a ligand-binding assay. …”
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Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction by Bennett T. Stothers, Andy Hung, Patric E. O. Gonçalves, Lulu X. Pei, Tessa van deKerkhof, Jem I. Arnold, Owen D. Harris, Nadine Borduas‐Dedekind, Andrew W. Sheel, Michael S. Koehle

“…No differences were observed between ozone and room air exposures. There were no significant differences in FeNO response between experimental conditions. …”
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Features of distribution and ecology of the brown bear (Ursus arctos) in the Carpathian National Park (Ukraine) by Oleksandr Kyseliuk, Bohdanna Kalynchuk, Yurii Motruk

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Extraperitoneally Ruptured, Everted, and Prolapsed Bladder: A Very Rare Complication of Pelvic Injury by Rufus Wale Ojewola, Kehinde Habeeb Tijani, Olakunle Olaleke Badmus, Abisola Ekundayo Oliyide, Chukwudi Emmanuel Osegbe

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Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…Cytotoxic properties of the detected mycotoxins were investigated at doses of 31.25, 62.50, 125, 250 and 500 µg/ml following exposure durations of 24 and 48 h in comparison with control. …”
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Identifying high-risk population segments for underweight, overweight, and obesity among reproductive-age women in sub-Saharan Africa by Amare Abera Tareke, Amare Abera Tareke, Anissa Mohammed, Amare Muche, Yeshimebet Ali

“…BackgroundDespite significant progress in addressing underweight in developing countries, the recent rise in the number of overweight and obese individuals has confirmed that the double burden of malnutrition will remain a crucial problem in the foreseeable future. …”
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Knowledge and attitude among Egyptian medical students regarding the role of human papillomavirus vaccine in prevention of oropharyngeal cancer: a questionnaire-based observational... by Mohammed. N. Abdelaziz, Abdullah Hefnawy, Hajer Azzam, Omar Reisha, Omar Hamdy

“…Potential ways of infection are skin warts, sexual activity, exposure, immunization, or oral sex. The growing incidence of OPSCC in Western countries makes vaccination increasingly vital. …”
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Efficacy of Simple Eye Ointment, Polyethylene Cover, and Eyelid Taping in Prevention of Ocular Surface Disorders in Critically Ill Patients: A Randomized Clinical Trial by Mehdi Ahmadinejad, Esmat Karbasi, Yunes Jahani, Maryam Ahmadipour, Maryam Soltaninejad, Zahra Karzari

“…However, patients admitted to the intensive care unit (ICU) for several reasons including loss of consciousness, receiving sedative and neuromuscular blocking agents, and mechanical ventilation may lose eye-protective mechanisms causing exposure keratopathy. Therefore, this study intended to compare three eye care methods to prevent ocular surface disorders (OSDs) in ICU patients. …”
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Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…Participants will be randomly assigned to receive biophilic VR or sham VR (1:1 ratio), all patients have 20 min of exposure per day during the hospital stay. The primary outcome is the impact of VR on the incidence of POCD. …”
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A comparative study of analgesic effect between ultrasound-guided posterior vis-a-vis lateral transversus abdominis plane block in patients undergoing total abdominal hysterectomy... by Rajib Sikder, Sankar Roy, Arunava Biswas, Dipasri Bhattacharya

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Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom by Alice Mentana, Virgilio Quaresima, Pavel Kundrát, Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Andrea Previtali, Giorgia Santi Amantini, Luca Lunati, Virginia Boretti, Livio Narici, Luca Di Fino, Luca Bocchini, Claudio Cipriani, Giorgio Baiocco

“…In particular, two classes of DNA damage were considered: sites and clusters of double-strand breaks (DSBs), which are known to be correlated with cell fate following radiation exposure. …”
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