Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears by Anastasia A. Artyukh, Mikhail K. Ivanov, Mikhail K. Ivanov, Sergei E. Titov, Sergei E. Titov, Victoria V. Dzyubenko, Sergey E. Krasilnikov, Sergey E. Krasilnikov, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Nikita A. Afanasev, Anastasia V. Malek, Sergei A. Glushkov, Eduard F. Agletdinov

“…Additionally, in the same specimens, the HPV genotyping, viral load assessment, diagnosis of cervicovaginal microbiome imbalance and profiling of some relevant mRNAs and miRNAs were performed by qPCR-based methods.ResultsThe best classifiers were obtained with pairs of mRNAs whose expression changes in opposite directions during lesion progression. With this approach based on a five-mRNA combination (CDKN2A, MAL, TMPRSS4, CRNN, and ECM1), we generated a classifier having ROC AUC 0.935, diagnostic sensitivity 89.7%, and specificity 87.6% for ≥HSIL detection. …”
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Low light reduces saffron corm yield by inhibiting starch synthesis by Weijing Yang, Weijing Yang, Xin Li, Xin Li, Fei Chang, Fei Chang, Xue Qiu, Xulong Huang, Xulong Huang, Zhan Feng, Zhan Feng, Jie Yan, Jie Yan, Qinghua Wu, Qinghua Wu, Feiyan Wen, Feiyan Wen, Jin Pei, Jin Pei, Tao Zhou, Tao Zhou

“…Additionally, the activity of invertase (INV), sucrose synthase in the decomposition direction (SUS) and ADP-glucose pyrophosphorylase (AGPase) in daughter corms were reduced under LL. …”
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Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease? by Maaike Goris, Pieter Ginis, Clint Hansen, Christian Schlenstedt, Christian Schlenstedt, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Nicholas D’Cruz, Wim Vandenberghe, Wim Vandenberghe, Walter Maetzler, Alice Nieuwboer, Moran Gilat

“…Turning on the spot for one minute in alternating directions (360 turn) while performing a cognitive dual-task (DT) is a fast and sensitive way to provoke FOG. …”
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Closing the gap while standing still: clinimetric properties of a low-cost balance platform and a user-friendly app for posturography by Tom Vredeveld, John F. Stins, Annelies J. van Vliet, Vincent C.M. Tuinder, Stephan P.J. Ramaekers, Michel W. Coppieters, Annelies L. Pool-Goudzwaard

“…Power spectra analysis of both force plates revealed larger measurement error by the WBB in medio-lateral direction in tasks requiring minimal postural adjustments. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…Therefore, this study explored the relationship between trophoblast cell aging and oxidative injury and YAP in AMA pregnancy, which not only provided an insight into the mechanisms of trophoblast cell aging, but also provide valuable directions for healthcare during AMA pregnancy.MethodsIn this study, human term placentas were collected from AMA and normal pregnancies for the analysis of aging, oxidative damage and YAP level. …”
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Age-related differences of subjective visual vertical perception in adults—a functional near-infrared spectroscopy study by Jun Lu, Jun Lu, Xiang Gong, Meng-Huan Wang, Ruo-Xin Zhao, Yu-Chen Wang, Ying-Ying Shen, Rong Cao, Guang-Xu Xu, Guang-Xu Xu

“…The study further correlated these neuroimaging findings with behavioral measures.ResultsYoung individuals exhibit superior accuracy and stability in perceiving the subjective visual vertical (SVV) direction. Neuroimaging data, adjusted for multiple comparisons using the false discovery rate, reveal activation of the right supramarginal gyrus (SMG) and the left dorsolateral superior frontal gyrus (SFGdor) in both age groups during SVV tasks. …”
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Global digital elevation model (GDEM) product generation by correcting ASTER GDEM elevation with ICESat-2 altimeter data by B. Li, B. Li, B. Li, B. Li, H. Xie, H. Xie, S. Liu, Z. Ye, Z. Hong, Q. Weng, Q. Weng, Q. Weng, Y. Sun, Q. Xu, X. Tong

“…To address this challenge, integrating GDEM and satellite laser altimeter data (global coverage and high-accuracy ranging) is an important research direction, in addition to the technological enhancement of the main data source. …”
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La responsabilisation des usagers, une modalité contestée de gouvernance des déchets ménagers : étude de la réception d’une politique locale de réduction des déchets par la populat... by Maxence Mautray

“…L’étude sociologique, par entretiens semi-directifs menés auprès des habitants, de la mise en place d’une telle politique dans un territoire rural et précaire permet de mettre en lumière une réception contestée de la part de la population. …”
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Beyond reliability: assessing rater competence when using a behavioural marker system by Samantha Eve Smith, Scott McColgan-Smith, Fiona Stewart, Julie Mardon, Victoria Ruth Tallentire

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MANAGING FRAUD IN CONTEMPORARY BUSINESS ENVIRONMENT, THE ROLE OF INFORMATION SECURITY MANAGEMENT: A STUDY OF QUOTED DEPOSIT MONEY BANKS (DMBs) IN NIGERIA by Onajero Kensington OHWO

“…The study recommended that the board of directors of DMBs as part of its oversight function should periodically review the overall fraud risk management framework of the bank to ensure it is current, adequate and effective.…”

Capacidades emprendedoras de mujeres empresarias de mypes chilenas by Luperfina Rojas Escobar, Patricia Cortés Iturrieta, Lilian Alvarado Varas, Cristian Blanco Alfaro

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Potential Impacts of Future Climate Changes on Crop Productivity of Cereals and Legumes in Tamil Nadu, India: A Mid-Century Time Slice Approach by Vellingiri Geethalakshmi, Ramasamy Gowtham, Radhakrishnan Gopinath, Shanmugavel Priyanka, Marimuthu Rajavel, Kandasamy Senthilraja, Manickam Dhasarathan, Raj Rengalakshmi, Kulanthaivel Bhuvaneswari

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Impacts du changement climatique sur les itinéraires d’alpinisme du massif des Écrins (Alpes occidentales, France) by Mathis Arnaud, Jacques Mourey, Philippe Bourdeau, Richard Bonet, Ludovic Ravanel

“…L’ensemble des processus qui les affectent ont été cartographiés sous SIG et une analyse statistique a été réalisée pour mieux comprendre l’évolution des itinéraires, en parallèle d’entretiens semi-directifs auprès d’expert·es et praticien•nes de terrain. …”
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Longitudinal Range of the Eastward‐Traveling Equatorial Plasma Bubble Inducing Ionospheric Scintillation by P. Abadi, Y. Otsuka, S. Saito, M. Yamamoto, S. Perwitasari, I. N. Muafiry, A. Y. Putra, A. Faturahman

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Pregnant women’s retention and associated health facility characteristics in the prevention of mother-to-child HIV transmission in Indonesia: cross-sectional study by Michelle Kermode, Margaret Kelaher, Christina Lumbantoruan, Endang Budihastuti

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Detection of genomic loci associated with days to heading in tropical japonica rice through QTL-seq by Khairul Yusuf Nasution, Dani Satyawan, Muhamad Yunus, Azri Kusuma Dewi, Puput Melati, Marina Yuniawati Maryono, Ita Dwimahyani, Wening Enggarini, Sobrizal

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Epidemiological Study of Hepatitis B, C and HIV Cases among the Foreigners Visiting Sulaimani City from 2013 Through 2016 by Mohammed Omer Mohammed, Asan Baram Hasan, Fenk Bakir Maarouf

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“We’re all in the same storm, but not all of us are in the same boat”: qualitative exploration of UK response-focused civil servants experiences of working from home during COVID-1... by Charlotte E. Hall, Samantha K. Brooks, Neil Greenberg, Dale Weston

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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

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Editorial: The Artificial Intelligence in Translational Medicine and Biomedical Research, How Future Can be Shaped?!! by Karzan Abdulmuhsin Mohammad

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