Prioritizing breast cancer surgeries: insights from the KRONOS SCORE by Lucía Navarro, Lucía Navarro, Lucía Navarro, Luis Perez-Bartivas, Luis Perez-Bartivas, Luis Perez-Bartivas, David Ponferrada, David Ponferrada, David Ponferrada, Javier Cejas, Javier Cejas, Javier Cejas, Juan Adrián Camús, Juan Adrián Camús, Juan Adrián Camús, Natalia Rangel, Natalia Rangel, Natalia Rangel, Maria Porras, Cristina Morales Estevez, Cristina Morales Estevez, Cristina Morales Estevez, Amalia Palacios Eito, Amalia Palacios Eito, Amalia Palacios Eito, Pilar Rioja, Pilar Rioja, Pilar Rioja, Marina Alvarez, Marina Alvarez, Marina Alvarez, Enrique Aranda, Enrique Aranda, Enrique Aranda, Juan De La Haba-Rodríguez, Juan De La Haba-Rodríguez, Juan De La Haba-Rodríguez

“…This study aims to explore the relationship between TTS and clinical outcomes in BC patients, focusing on how TTS influences final tumor stage and lymph node involvement.Materials and methodsA retrospective cohort study was conducted, including 924 women diagnosed with cT1-T3 BC without axillary lymph node involvement between 2014 and 2023. …”
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Low Expression of FFAR2 in Peripheral White Blood Cells May Be a Genetic Marker for Early Diagnosis of Acute Myocardial Infarction by Jianjun Ruan, Heyu Meng, Xue Wang, Weiwei Chen, Xiaomin Tian, Fanbo Meng

“…Logistic regression analysis suggested that the low expression of the FFAR2 gene in peripheral blood may be a risk factor for AMI independent of age, family history of diabetes, fasting blood glucose level, and HDL-C level (p=0.025). …”
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Evaluating the Effectiveness of Cyclin-Dependent Kinase 4/6 Inhibitors in Early- and Very Early-Onset Metastatic Breast Cancer: A Multicenter Study by Akif Doğan, Nurullah İlhan, Goncagül Akdağ, Sedat Yıldırım, Mustafa Seyyar, Zeynep Yüksel Yaşar, Hande Nur Erölmez, Heves Sürmeli, Buğra Öztosun, Özlem Nuray Sever, Hatice Odabaş, Mahmut Emre Yıldırım, Devrim Çabuk, Nedim Turan, Mahmut Gümüş

“…Very early-onset breast cancer, which is diagnosed before the age of 35, was identified as an independent prognostic factor for poor progression-free survival. …”
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Intravenous nicardipine and labetalol use in hypertensive patients with signs or symptoms suggestive of end-organ damage in the emergency department: a subgroup analysis of the CLU... by Brian Hiestand, Phillip Levy, W Frank Peacock, Brigitte M Baumann, Richard M Nowak, Amy Hsu, Joseph Varon, Chad M Cannon, David M Cline, Pierre Borczuk, Abhinav Chandra, Deborah B Diercks, Preeti Jois, Brian Kaminski, Jon W Schrock

“…Nicardipine patients were more likely to have a history of diabetes (41.4% vs 25.7%, p=0.05) but there were no other historical, demographic or laboratory differences between groups. …”
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Artificial intelligence-enhanced comprehensive assessment of the aortic valve stenosis continuum in echocardiographyResearch in context by Jiesuck Park, Jiyeon Kim, Jaeik Jeon, Yeonyee E. Yoon, Yeonggul Jang, Hyunseok Jeong, Youngtaek Hong, Seung-Ah Lee, Hong-Mi Choi, In-Chang Hwang, Goo-Yeong Cho, Hyuk-Jae Chang

“…Summary: Background: Transthoracic echocardiography (TTE) is the primary modality for diagnosing aortic stenosis (AS), yet it requires skilled operators and can be resource-intensive. …”
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Should Echocardiographic Evaluation Be Performed Routinely in the First 72 Hours in Extremely Low Birth Weight Babies? by Ruya Colak, Senem Alkan Ozdemir, Ezgi Yangin Ergon, Ferit Kulali, Oguz Han Kalkanli, Tulin Gokmen Yildirim, Murat Muhtar Yilmazer, Cuneyt Zihni, Sebnem Calkavur

“…Study Design:This study was planned retrospectively and observationally.Between June2016 and December2018,36 patients diagnosed with hemodynamically significant PDA(hsPDA) who were hospitalized in the neonatal intensive care unit(NICU),with ≤28Gw or ≤1000g were included in this study.These babies were routinely performed ECHO for PDA between 24-72hours,although they were asymptomatic in the period from June2016 to December2017(n:23).Between January2018 and December2018, patients without PDA symptoms were expected to complete 72hours for routine PDA screening (n:13).The patients were divided into 2 groups as early ECHO group(EEG)(n=23) and late ECHO group (LEG)(n=13).In the presence of at least one of the clinical signs of systemic hypoperfusion and/or pulmonary hyperperfusion, symptomatic PDA was accepted and closure treatment was  applied with ibuprofen(n: 23) or paracetamol(n: 5).While the two groups were compared in terms of demographic features,ECHO findings,and the state of taking closure therapy,patients receiving closure therapy were compared in terms of mortality and premature morbidity. …”
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Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes by Janet Mei, Hamza Adel Salim, Dhairya A. Lakhani, Licia Luna, Aneri Balar, Mona Shahriari, Nathan Z. Hyson, Francis Deng, Adam A. Dmytriw, Adrien Guenego, Vaibhav Vagal, Victor C. Urrutia, Elisabeth B. Marsh, Hanzhang Lu, Risheng Xu, Rich Leigh, Dylan Wolman, Gaurang Shah, Benjamin Pulli, Kambiz Nael, Gregory W. Albers, Max Wintermark, Jeremy J. Heit, Tobias D. Faizy, Argye E. Hillis, Raf Llinas, Vivek Yedavalli

“…After adjusting for age, sex, hypertension, diabetes, atrial fibrillation, administration of intravenous thrombolysis (IVT), Alberta Stroke Program Early CT Scores (ASPECTS), mTICI 2c and/or 3, Tmax >6 s volume, and hemorrhagic transformation, PVT+ was significantly associated with lower NIHSS percent change (B = −0.163, 95%CI −0.326 to −0.001, p = 0.049) and was less likely to achieve higher than 70% NIHSS improvement (OR = 0.331, 95% CI 0.127–0.863, p = 0.024). …”
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Stenotrophomonas maltophilia bacteremia in adult patients with hematological diseases: clinical characteristics and risk factors for 28-day mortality by Wenjing Guo, Qingsong Lin, Jia Li, Xiaomeng Feng, Sisi Zhen, Yingchang Mi, Yizhou Zheng, Fengkui Zhang, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…This study retrospectively analyzed the clinical characteristics and risk factors for 28-day mortality among 140 adult hematological patients diagnosed with SM bacteremia from January 2012 to July 2023. he overall 28-day mortality was 31.43% (44/140), with a median age of 44 years. …”
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Quantification of ecosystem services from mangrove silvofishery by E. Sumarga, D. Rosleine, G.B. Hutajulu, R.P. Plaurint, Tsabita ., M. Basyuni, S.H. Larekeng, M.F. Taqiyudin, N.N. Shohihah, H. Ali

“…During the vegetation survey, data regarding the types of mangrove plants and the diameter of each tree at breast height was gathered. …”
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Role of C5aR2 in prognosis of patients with acute respiratory distress syndrome through negative modulation of C5a: A prospective observational study by Muhammed Rashid, Sreedharan Nair, Pooja Gopal Poojari, Vijetha Shenoy Belle, Vijayanarayana Kunhikatta, Daniel A. Vaz, Vishal Shanbhag, Viji Pulikkel Chandran, Shravya Chitrapady, Girish Thunga

“…Methods: A total of 64 adult patients diagnosed with ARDS were prospectively recruited to the study over a period of one year after obtaining the informed consent. …”
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Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study by Lucian Flavius Herlo, Ioana Golu, Alexandra Herlo, Claudia Raluca Balasa Virzob, Ionescu Alin, Stela Iurciuc, Ionut Eduard Iordache, Luana Alexandrescu, Doina Ecaterina Tofolean, Raluca Dumache

“…Preoperative factors such as elevated C-reactive protein (CRP) levels (<i>p</i> < 0.001), low albumin levels (<i>p</i> = 0.003), a high American Society of Anesthesiologists (ASA) score (<i>p</i> < 0.001), and presence of comorbidities like diabetes and hypertension (<i>p</i> = 0.005) were significantly associated with increased postoperative complications. …”
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The relevance of a multidomain geriatric assessment in older patients with heart failure by Emma E.F. Kleipool, Julia H.I. Wiersinga, Marijke C. Trappenburg, Albert C. vanRossum, Carmen S. vanDam, Su‐San Liem, Mike J.L. Peters, M. Louis Handoko, Majon Muller

“…Logistic regression analyses adjusted for age, sex, diabetes and kidney function assessed 3 month risk of adverse health outcomes (emergency department visits, hospital admissions, and/or death) according to HF severity, physical frailty, and number of affected domains. …”
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Enhancing doctor-patient communication using large language models for pathology report interpretation by Xiongwen Yang, Yi Xiao, Di Liu, Yun Zhang, Huiyin Deng, Jian Huang, Huiyou Shi, Dan Liu, Maoli Liang, Xing Jin, Yongpan Sun, Jing Yao, XiaoJiang Zhou, Wankai Guo, Yang He, WeiJuan Tang, Chuan Xu

“…Postoperative pathology reports, which are essential for diagnosing and determining treatment strategies for surgical patients, frequently include complex data that can be challenging for patients to comprehend. …”
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The Linda Kizazi study: a comparison of morbidity and mortality from birth to 2 years between children who are HIV-unexposed and HIV-exposed, uninfected in the era of universal ant... by John Kinuthia, Dara A Lehman, Dalton Wamalwa, Brenda Wandika, Emily R Begnel, Ednah Ojee, Judy Adhiambo, Eliza Mabele, Vincent Ogweno, Efrem S Lim, Soren Gantt, Jennifer Slyker

“…We followed the mother–infant pairs for 2 years post partum and collected data on symptoms of illness, clinical visits and diagnoses, and infant feeding every 3 months; a self-selected subset of participants also received weekly data collection for up to 1 year. …”
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Multimodal Deep Learning for Differentiating Bacterial and Fungal Keratitis Using Prospective Representative Data by N.V. Prajna, MD, Jad Assaf, MD, Nisha R. Acharya, MD, MS, Jennifer Rose-Nussbaumer, MD, Thomas M. Lietman, MD, J. Peter Campbell, MD, MPH, Jeremy D. Keenan, MD, MPH, Xubo Song, PhD, Travis K. Redd, MD, MPH

“…Participants: Five hundred ninety-nine subjects diagnosed with acute infectious keratitis at Aravind Eye Hospital in Madurai, India. …”
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Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regenera... by Zhaoyang Gong, Zhenhao Chen, Dachuan Li, Xiao Lu, Jianwei Wu, Hanqiu Sun, Ximeng Wang, Siyang Liu, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Chi Sun, Hongli Wang, Feng Zeng, Xiaosheng Ma

“…Size uniformity, biocompatibility, and catalytic activity were assessed via hydrodynamic diameter, zeta potential, and elemental analysis. The Lightgel/NGF/CeMn NP-PEG composite was synthesized and characterized via electron microscopy, compression testing, rheological analysis, NGF release kinetics, and 30-day degradation studies. …”
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Towards a histological diagnosis of childhood small vessel CNS vasculitis by Maryam Nabavi Nouri, Anastasia Dropol, Pascal N. Tyrrell, Sheila Sheikh, Marinka Twilt, Jean Michaud, Benjamin Ellezam, Harvey B. Sarnat, Christopher Dunham, Peter W. Schutz, Julia Keith, David G. Munoz, Harry V. Vinters, Cynthia Hawkins, Susanne M. Benseler

“…This study aims to develop and validate a histological scoring tool for diagnosing small vessel CNS vasculitis. Methods A standardized brain biopsy scoring instrument was developed and applied to consecutive full-thickness brain biopsies of pediatric cases and controls at a single center. …”
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Titanium nanotubes modulate immunophenotyping and cytokine secretion of T cells via IL-17A: a bioinformatic analysis and experimental validation by Jingju Yin, Jingju Yin, Jingju Yin, Jingju Yin, Yunyang Liao, Yunyang Liao, Yunyang Liao, Yunyang Liao, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Shaofeng Liu, Bangwei Che, Hanghang Zhu, Hanghang Zhu, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bingbing Yang, Bin Shi, Bin Shi

“…T cells from activated rat were cultured on titanium nanotubes that were prepared by anodization with different diameters (P-0, NT15-30 nm, NT40-100 nm, NT70-200 nm). …”
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NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8+ T cell antitumor activity by Yingying Xiong, Yiming Weng, Shan Zhu, Jian Qin, Jia Feng, Xiaopeng Jing, Chao Luo, Wei Gong, Rui Sun, Min Peng

“…IntroductionBreast cancer is the most frequently diagnosed malignancy and a leading cause of cancer-related mortality among women worldwide. …”
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Characterizing executive functioning and associated behaviors in individuals with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) syndrome by Hannah M. Rea, Sara Jane Webb, Sara Jane Webb, Evangeline C. Kurtz-Nelson, Caitlin M. Hudac, Caitlin M. Hudac, Raphael A. Bernier, Conor Miles, Rachel Earl, Alana Whiting, Curtis Eayrs, Margaret Johansson, Tianyun Wang, Tianyun Wang, Tianyun Wang, Evan E. Eichler, Evan E. Eichler, Emily Neuhaus, Emily Neuhaus

“…Only two participants had existing ADHD diagnoses; however, 5 participants (out of 10 participants with data) exceeded the cutoff on the BRIEF, 13 individuals (out of 27 with data) exceeded the cutoff on the ASEBA ADHD subscale, and 18 exceeded the cutoff on the ASEBA attention subscale. …”
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