Thrombotic vs. Bleeding Events of Interruption of Dual Antiplatelet Therapy within 12 Months among Patients with Stent-Driven High Ischemic Risk Definition following PCI by Hao-Yu Wang, Bo Xu, Chen-Xi Song, Chang-Dong Guan, Li-Hua Xie, Yan-Yan Zhao, Zhong-Xing Cai, Sheng Yuan, Ke-Fei Dou

“…These findings were consistent across various stent-driven high-ischemic risk subsets with respect to the primary ischemic endpoints, with a greater magnitude of harm among patients with diffuse multivessel diabetic coronary artery disease. Conclusions. In patients undergoing high-risk PCI, interruption of DAPT in the first 12 months occurred infrequently and was associated with a significantly higher adjusted risk of major adverse cardiovascular events and net adverse clinical events. 2017 ESC stent-driven high ischemic risk criteria may help clinicians to discriminate patient selection in the use of long-term DAPT when the ischemic risk certainly overcomes the bleeding one.…”
Get full text

Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…Methods This two-arm, randomized, observer-blind, phase IIb national multicenter clinical trial aims at investigating the long-term neuropsychologic outcomes of pre-emptive mTOR inhibitor treatment in children diagnosed with TSC under four months of age. Sixty participants will be allocated to the trial with a 1:1 randomization ratio. …”
Get full text

Fusidic Acid and Lidocaine-Loaded Electrospun Nanofibers as a Dressing for Accelerated Healing of Infected Wounds by Alsulami KA, Bakr AA, Sirwi A, Elfaky MA, Shaik RA, Alshehri BY, Aodah AH, Al Fayez N, Alshehri AA, Almughem FA, Halwani AA, Tawfik EA

“…Herein, two polymer-based nanofibrous systems were developed using poly-lactic-co-glycolic-acid (PLGA) and polyvinylpyrrolidone (PVP) loaded with a combination of an antibiotic (Fusidic acid, FA) and a local anesthetic (Lidocaine, LDC) via electrospinning technique for an expedited healing process by preventing bacterial infections while reducing the pain sensation.Results: The fabricated nanofibers showed an excellent morphology with an average fiber diameter of 556 ± 71 nm and 291 ± 87 nm for the dual drug-loaded PLGA/PVP and PVP nanofibers, respectively. …”
Get full text

Mangrove biomass productivity and sediment carbon storage assessment at selected sites in Mauritius: the effect of tidal inundation, forest age and mineral availability by M D D Doodee, S D D V Rughooputh, S Jawaheer

“…Using 25m x 25m quadrats and a simple random sampling technique, plant height and diameter at breast height (DBH) were measured in situ with the GLOBE Observer application (The Globe Program, NASA-sponsored) and a measuring tape, respectively. …”
Get full text

SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…The resulting adjuvant system, termed SPA14, appeared as a long-term stable and homogeneous suspension of mostly unilamellar and a few multilamellar vesicles, with an average hydrodynamic diameter of 93 nm, when formulated in citrate buffer at pH 6.0-6.5. …”
Get full text

Geometrical determinants of cerebral artery fenestration for cerebral infarction by Yuqian Mei, Xiaoqin Chen, Yao Zhang, Yanling Wang, Bo Wu, Mingcheng Hu, Quan Bao

“…Methods A cohort comprising 89 patients diagnosed with CAF were enrolled from a total of 9,986 cranial MR angiographies. …”
Get full text

Korean patients with hereditary cancer: a prospective multicentre cohort study protocol exploring psychosocial and health outcomes by Boyoung Park, Sun-young Kong, Dongju Won, Jong Eun Park, Jun-Kyu Kim, Mi-Ae Jang, Jung-Sook Ha, Kyoung-Bo Kim

“…In addition, information on the chronic diseases, cancer diagnoses, medical history and treatment history of participants will be extracted from their electronic medical records to analyse their health status and cancer treatment experiences. …”
Get full text

Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial by Patrick J E Bindels, Arthur M Bohnen, Gijs Elshout, Suzanne G M A Pasmans, Karlijn F van Halewijn

“…Objective To assess the effectiveness of a potent topical corticosteroid (TCS) as an initial treatment in primary care for children with moderate flare-ups of atopic dermatitis (AD), compared to starting on a mild TCS.Design An observational prospective cohort study with an embedded pragmatic multicentre open-label randomised controlled trial.Setting A total of 53 general practices in the southwest of the Netherlands took part in the study.Participants 209 children aged 3 months to 17 years diagnosed with AD (International Classification of Primary Care codes S87 or S88) who visited their general practitioner (GP) for AD or received repeat prescriptions for AD in the previous 12 months were included in the cohort study through the general practices. …”
Get full text

Study of the association of polymorphisms of the folate cycle enzyme gene with the degree of cognitive and affective disorders in patients in the post-covid period by A.A. Shuprovych, O.V. Zinych, N.M. Kushnareva, O.M. Trofymenko, K.P. Komisarenko

“…A small group of individuals with the recessive homozygous T677T genotype (group 3, all men) was distinguished by an older age, the presence of cardiovascular diseases, type 2 diabetes (2 cases out of 3), more severe manifestations of COVID-19, which forces us to pay attention to potentially increased risk of complications in such patients and requires further investigation. …”
Get full text

Involving national stakeholders in a systems approach to map drivers of childhood obesity and actions to prevent childhood obesity in Denmark: the Generation Healthy Kids Study by Knud Ryom, Paul Bloch, Ulla Toft, Didde Høeg, Louise T. Thomsen, Steven Allender, Harry Rutter, Adrian Bauman, Rikke Fredenslund Krølner, Anders Blædel Gottlieb Hansen

Get full text

Integrating Hybrid Team-Based and Case-Based Learning in Dental Education Transformation by Sidra Abid, Humna Rafiq

“…The CBL is another way to fill the TBL ‘gap’ which is a student-centered learning method in which regular clinical scenarios are solved as case reports, responsibilities of Student-to-Student teaching in particular topics to promote professional diagnosing, and ethical practice planning. The CBL helps students step closer to actual dental practice by allowing them to immerse themselves in genuine cases. …”
Get full text

Biosynthesis, characterization, and in-vitro anticancer effect of plant-mediated silver nanoparticles using Acalypha indica Linn: In-silico approach by Luailik Madaniyah, Saidun Fiddaroini, Elok Kamilah Hayati, Moh. Farid Rahman, Akhmad Sabarudin

“…Characterization of the synthesized AgNPs was conducted using various techniques, including UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), particle size analysis (PSA), and transmission electron microscopy (TEM), confirming the successful synthesis, stability, and spherical morphology of the nanoparticles, with an average diameter of 7 nm and a zeta potential of −24.51 mV. …”
Get full text

Dyslipidemia and metabolic syndrome in childhood-onset systemic lupus erythematosus: is it time to screen? by Sirin Nuntasri, Sirirat Charuvanij, Kraisoon Lomjansook, Puthita Saengpanit, Kwanjai Chotipanang, Maynart Sukharomana

“…Patients aged 10–19 years with cSLE diagnosed before 18 years and at least 1 year follow-up were enrolled, excluding those with other autoimmune disorders, chronic kidney disease, infections, receiving lipid lowering drugs prior, and pregnancy. …”
Get full text

Intestinal protozoa infections and associated factors among diarrheal under-five children in Borena district, central Ethiopia by Alebie Mesfin, Woynshet Gelaye, Getaneh Alemu

“…These findings revealed that Giardia lamblia and Entamoeba histolytica are public health problems causing diarrhea among under-five children in the study area, and their transmission is associated with the illiteracy of mothers/guardians, the absence of functional toilets, not using soap/ash during hand washing, and frequent contact with domestic animals. Therefore, when diagnosing, treating, and educating patients about diarrhea, healthcare professionals should take these protozoans into account.…”
Get full text

Study on the changes and influencing factors of depression in Chinese women with cancer: an analysis based on CHARLS panel data by Na Wang, Mengran Chang, Shidong Liu, Bing Chen

“…Among these influencing factors, age, having a spouse, high educational level, good performance in the activity of daily living (ADL), frequent visits to neighbors, and regular exercise are protective factors against depression, while diabetes, dyslipidemia, frequent outpatient visits, frequent hospitalizations, smoking, and low life satisfaction are risk factors for depression.ConclusionThe depressive state among Chinese women with cancer is alarming. …”
Get full text

Analysis of the clinicopathological and imaging features in breast intraductal papillary lesions with or without pathological nipple discharge by Qian Pu, Peng Li, Minghui Su, Dezong Gao

“…Meanwhile, these characteristics were analyzed in malignant papillary patients with PND or not. 267 patients were pathologically diagnosed with IDPL during three years, accounting for 15.4% of surgical cases of the same period. …”
Get full text

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects by Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Marion Bankstahl, Jens P. Bankstahl

“…New approaches to early diagnose this disease are crucial to facilitate the translation of novel treatment strategies to the clinic. …”
Get full text

Serum Soluble Interleukin-2 Receptor Does Not Differentiate Complex Regional Pain Syndrome from Other Pain Conditions in a Tertiary Referral Setting by K. D. Bharwani, M. Dirckx, D. L. Stronks, W. A. Dik, F. J. P. M. Huygen

“…In order to further validate this marker in the diagnostic workup of CRPS, we conducted this prospective cohort study in which we determined sIL-2R levels in patients that were referred to our tertiary referral center with a suspicion of CRPS in a limb, and subsequently compared sIL-2R levels between the patients that were diagnosed with CRPS (CRPS group) and those who were not (no CRPS group). …”
Get full text

Prevalence and Factors Associated with Iron Deficiency Among Children Aged 6 Months to 12 Years Attending the Sickle Cell Clinic at Kitete Hospital Tanzania. by Lubeja, Amos Charles (M.D)

“…Methods: A cross-sectional study was conducted among children aged 6 months to 12 years diagnosed with Sickle Cell Anaemia by using Hb Electrophoresis and who were attending the Sickle Cell Clinic at Kitete Regional Referral Hospital in Tabora, Tanzania. …”
Get full text

Modelling and Analysis of Bioretention Systems for Removal of Stormwater Pollutants by Nuwagaba, Emmanuel, Abdulkadir, Taofeeq Sholagberu, Agwe, Michael Tobby, Philip, Tibenderana, Ako, Terseer, Moses N., Twesigye-omwe

“…Physical model of two Columns: B and C of 102 mm diameter were developed. Each of the Columns has four layers arranged as follows: Column B (Layer 1 for fine sand of 0.063 – 1.18 mm; Layer 2 for Coarse Sand of 1.18-4.75; Layer 3 for fine aggregate AASHTO M43, 4.75-9.5mm; and Layer 4 for Coarse aggregate >9.5mm), and Column C (Layer 1 for black soil with mulch and plants; fine Sand of 1.18-0.063; Layer 3 for fine aggregate AASHTO M43, 4.75-9.5mm; and Layer 4 for Coarse aggregate >9.5mm). …”
Get full text