Animal experiments and network pharmacology to explore the anti-inflammatory mechanism of dapagliflozin in the treatment of polycystic ovary syndrome by Yong Liu, He Bai, Huilin Guan, Chunhua Wang, Xueqing Song, Zihao Yong, Xiaomeng Guo, Luxin Li, Zhen Zhang

“…Sodium glucose co-transporter 2 (SGLT2) inhibitors are a class of antidiabetic drugs that can reduce the weight and hyperglycemia of type 2 diabetes patients. Dapagliflozin is a highly selective, orally active and reversible inhibitor of the human SGLT2. …”
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The Role of Immunohistochemistry for AMACR/p504s and p63 in Distinguishing Prostate Cancer from Benign Prostate Tissue Samples in Botswana by Ramatlho P, Rugemalila MM, Tawe L, Pain D, Choga OT, Ndlovu AK, Koobotse MO, Lal P, Rebbeck TR, Paganotti GM, Narasimhamurthy M, Kyokunda LT

“…Chan School of Public Health, Boston, MA, USA; 9Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USACorrespondence: Pleasure Ramatlho, Pleasure Ramatlho School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana, Tel +26777572242, Email pleasureram@gmail.comIntroduction: Prostate cancer (CaP) is the most common malignancy and the second leading cause of cancer-related deaths among men in Botswana. Currently, diagnosing CaP relies on examining prostate biopsy samples, which can be challenging due to benign mimics. …”
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Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients by Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, Mitsuhiro Kitani, Kazuhiro Kawano, Yoshio Taketani, Masataka Sata

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Efficacy of laparoscopic cardiectomy combined with side overlap anastomosis for the treatment of terminal achalasia by Jing-Tao Wang, Yu-Xiang Sun, Rui-Xin Li, Yun-Fei Zhang, Heng-Xuan Ding, Guo-Jun Wang, Bu-Lang Gao

“…The effective rates at 1 month, 6 and 12 months after surgery were 100% (95% CI: 100% -100%), 96% (95% CI: 87.7 -100%), and 92% (95% CI: 80.6 -100%). Two patients were diagnosed with gastroesophageal reflux disease (GERD) at the end of the follow-up. …”
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The Association between ER, PR, HER2, and ER−/PR+ Expression and Lung Cancer Subsequent in Breast Cancer Patients: A Retrospective Cohort Study Based on SEER Database by Hong Yu Shao, Bao Tan Hao, Feng Xiao Gao

“…The study population consisted of 683,336 individuals who were diagnosed with breast cancer (referred to as BC). Various covariates were assessed at baseline, including age, sex, race, marital status, CS tumor size, laterality, radiation, chemotherapy, months from diagnosis to treatment, breast subtype, AJCC 7th edition (2010–2015), and combined summary stage (2004+). …”
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The influence of neurovegetative and psychological characteristics of infertile patients with long-term COVID-19 on the effectiveness of assisted reproductive technologies by O.G. Boichuk, I.S. Golovchak, T.V. Kolomiichenko

“…Vegetative dysfunction is diagnosed in 82.5% of patients. Symptoms that are typical for "long-COVID-19" are most often noted: reduced work capacity/fatigue (82.5%), attack-like headaches (72.5%), difficulty breathing (47.5%), sleep disturbances (47 .5%). …”
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SPEC Process III. Synthesis of a Macroporous Silica-Based Crown Ether-Impregnated Polymeric Composite Modified with 1-Octanol and its Adsorption Capacity for Sr(II) Ions and Some T... by Anyun Zhang, Chunmei Chen, Zhifang Chai, Mikio Kumagai

“…This was achieved by impregnating and immobilizing DtBuCH18C6 and 1-octanol molecules in the pores of macroporous SiO 2 -P particles possessing a mean pore diameter of 50 μm. The adsorption of some fission and non-fission products contained in highly active liquid waste (HLW) such as Ru(III), Mo(VI), Pd(II), Na(I), K(I), Cs(I), Sr(II), Ba(II), La(III) and Y(III) onto (DtBuCH18C6 + Oct)/SiO 2 -P was investigated at 298 K. …”
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Clinical and anamnestic characteristics of patients with clinical manifestations of peripheral artery disease as a function of Т(–786)С polymorphism of the endothelial NO-synthase... by V.I. Tseluyko, L.M. Yakovleva, O.D. Yarova

“…The results of the study indicate that patients with C allele polymorphism Т(–786)С eNOs gene promoter have manifestation of the disease in younger age, clinical manifestations of lower limb ischemia is a severe, concomitant CAD is diagnosed significantly more often.…”
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Dietary supplementation with 15% tomato pomace (Solanum lycopersicum L.) improves sperm production and antioxidant status in aged male broiler breeders by Amir Mosayyeb Zadeh, Seyyed Ali Mirghelenj, Mohsen Daneshyar, Mohsen Eslami, Mohammad Amir Karimi Torshizi, Mahdi Zhandi, Touba Nadri, John Patrick Kastelic, Peyman Hasanloo, Mehdi Nabiloo

“…Seminiferous tubule diameter (STD) and seminiferous epithelium thickness (SET) were increased in all groups fed TP (P<0.05) and T-10 and T-15 roosters had increases (P<0.05) in tubular differentiation indices (TDI). …”
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Gambaran Fungsi Ginjal pada Pasien Gagal Jantung yang Dirawat di RSUP Dr. M. Djamil Padang Periode 1 Januari 2010-31 Desember 2012 by Putri Reno Indrisia, Saptino Miro, Detty Iryani

“…The objective of this study was to description kidney function among heart failure patients, more than half (about 63.63%) had moderate worsening kidney function, 18.18% mild worsening kidney function and 18.18% severe worsening kidney function. Patients who were diagnosed with CHF I, 40% mild worsening kidney function and 20% moderate worsening kidney function. …”
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Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Methods In total, 60 newly diagnosed PC patients only with GEM-based chemotherapy were recruited. …”
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Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from Low-Back-Related Pain: A Prospective Machine Learning Study by Yang Z, Liang X, Ji Y, Zeng W, Wang Y, Zhang Y, Zhou F

“…Additionally, radiomic wavelet features were correlated with Montreal Cognitive Assessment (MoCA) and Hamilton Anxiety Scale, present pain intensity scores in cognitively impaired LBLP patients (P < 0.05, with Bonferroni correction).Conclusion: Hippocampal functional radiomic features are valuable for diagnosing cognitively impaired patients from LBLP.Keywords: cognitive impairment, resting-state functional MRI, low-back-related leg pain, radiomic, logistic regression algorithm…”
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Patients admitted in an Intensive Care Unit with severe clinical manifestations of Influenza, october-december 2009 by Yenisey Quintero Mendez, Jorge Luis Ulloa Capestani, Rudis Monzón Rodríguez, Francisco García Valdés, Ramón E Álvarez Cepero, Jaime Geroy Gómez, Pablo Rodríguez Díaz, Alfredo Dario Espinosa Brito, Yanli Vázquez Villazón, Diley Moreno Ruiz, Octavio Rivero Rodríguez

“…Personal antecedents were informed by patients suffering arterial hypertension in 31 (28,4%), bronchial asthma and chronic obstructive lung disease in 26 (23,9%), diabetes in 19 (17,4%), ischemic heart disease in 19 (17,4%), alcoholism in 5 (4,6%) and valvulopathies in 4 (3,7%). …”
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Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants by Shujing Ma, Xue Liu, Ruilang Lin, Ye Yao, Min Zhao, Yongfu Yu, Costan G. Magnussen, Bo Xi

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Trisomy 21 screening with αlpha software and the Fetal Medicine Foundation algorithm by L Pistorius, C A Cluver, I Bhorat, L Geerts

“…There were 687 cases of trisomy 21 in 225 021 pregnancies, with only 239 (35%) diagnosed prenatally. The screen positive rates were 11.8% for first trimester biochemistry, 7.6% for second trimester biochemistry, 7.3% for first trimester FMF software ultrasound alone, 3.7% for combined first trimester screening with FMF software, and 3.5% for combined first trimester screening with αlpha software. …”
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Impact of Comorbidities on Prognosis and Treatment Outcomes in Elderly Patients with Hodgkin Lymphoma by Dávid Tóthfalusi, Boglárka Dobó, Fanni Borics, László Imre Pinczés, Árpád Illés, Zsófia Miltényi

“…., platelet count, lactate dehydrogenase (LDH), C-reactive protein (CRP)), PET/CT results and comorbidities (e.g., hypertension, diabetes, cardiovascular diseases), to assess their impact on overall survival (OS) and progression-free survival (PFS). …”
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Removing Excess Iron from Sewage and Natural Waters: Selecting Optimal Sorbent by Ludmila A. Ivanova, Irina V. Timoshchuk, Alena K. Gorelkina, Ekaterina S. Mikhaylova, Nadezhda S. Golubeva, Evgeny N. Neverov, Tamara A. Utrobina

“…The system proved extremely effective and reached 99.0% Fe3+ extraction under the following conditions: flow rate = 1 L/min, loading column height = 0.15 m, column diameter = 0.05 m, initial concentration = 0.5 mg/L (5 MPC). …”
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Pharmacotherapy for AMD: state-of-the-art by I.A. Koroleva, A.A. Gvetadze, T.B. Romanova

“…About 500,000 of new “wet” AMD cases are diagnosed every year worldwide. Agents which prevent neovascularization by inhibiting vascular endothelial growth factor (VEGF) are currently used to manage this rapidly progressing type of AMD. …”
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Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug by Abla KK, Alamoudi MK, Soliman GA, Abdel-Kader MS, Aldawsari MF, Mehanna MM

“…Metformin is an anti-diabetic drug, that can promote hair follicle regeneration via upregulation of the hair-inductive capability. …”
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Sociodemographic characteristics and longitudinal progression of multimorbidity: A multistate modelling analysis of a large primary care records dataset in England. by Sida Chen, Tom Marshall, Christopher Jackson, Jennifer Cooper, Francesca Crowe, Krish Nirantharakumar, Catherine L Saunders, Paul Kirk, Sylvia Richardson, Duncan Edwards, Simon Griffin, Christopher Yau, Jessica K Barrett

“…The study focused on 5 important chronic conditions: cardiovascular disease (CVD), type 2 diabetes (T2D), chronic kidney disease (CKD), heart failure (HF), and mental health (MH) conditions. …”
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