Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…An N-isopropenylimidazole zinc metal complex derivative (laboratory code Pilim-1, prepared in form of gel), reference drug Metrogyl Denta® (M-D, dental gel), as well as the combination Pilim-1 + M-D were applied daily for 14 days on the lower incisors and appropriate gums, and also placed in the gingival pockets and pulp cavities, with pulp partially removed beforehands. …”
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Acute pain pathways: protocol for a prospective cohort study by Christine Lee, Joseph S Ross, Molly Moore Jeffery, Nilay D Shah, David B Page, Nancy Chang, Fernanda Bellolio, Sam Torbati, Jessica D Ritchie, Gregg H Gilbert, Lindsay Emanuel, Mitra Ahadpour, Summer Allen, Richardae Araojo, Laura Ciaccio, Jonathan Fillmore, Patricia Koussis, Heather Lipkind, Celeste Mallama, Tamra Meyer, Megan Moncur, Teryl Nuckols, Michael A Pacanowski, Elektra Papadopoulos, Mat Soukup, Christopher O St. Clair, Stephen Tamang, Douglas W Wallace, Yueqin Zhao, Rebekah Heckmann

“…An essential element to developing evidence-based guidelines is a better understanding of pain management and pain control among individuals experiencing acute pain for various common diagnoses.Methods and analysis This multicentre prospective observational study will recruit 1550 opioid-naïve participants with acute pain seen in diverse clinical settings including primary/urgent care, emergency departments and dental clinics. Participants will be followed for 6 months with the aid of a patient-centred health data aggregating platform that consolidates data from study questionnaires, electronic health record data on healthcare services received, prescription fill data from pharmacies, and activity and sleep data from a Fitbit activity tracker. …”
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T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis by Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D

“…Xiaoshan Yang,1– 3,* Yang Zhou,2,3,* Fuxing Zhou,4,* Lili Bao,2,3 Zhengyan Wang,5 Zihan Li,2,3 Feng Ding,2,3 Huijuan Kuang,6,7 Huan Liu,8 Shenglong Tan,1 Xinyuan Qiu,1 Huan Jing,9 Shiyu Liu,2,3 Dandan Ma1 1Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, People’s Republic of China; 2State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, School of Stomatology, The Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 3State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 4Department of Gynecology and Obstetrics, Xijing Hospital, The Fourth Military Medical University, Xi’an, 710032, People’s Republic of China; 5Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, People’s Republic of China; 6Department of Orthopaedics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China; 7State Key Laboratory for Manufacturing System Engineering, Xi’an Jiaotong University, Xi’an, 710054, People’s Republic of China; 8Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, 100871, People’s Republic of China; 9Department of Endodontics, Guangdong Provincial High-level Clinical Key Specialty, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dandan Ma, Stomatological Hospital, Southern Medical University, S366 Jiangnan Boulevard, Guangzhou, Guangdong, 510280, People’s Republic of China, Tel +86-20-34152996, Email mdd@smu.edu.cn Shiyu Liu, School of Stomatology, The Fourth Military Medical University, No. 145, West Changle Road, Xi’an, Shaanxi, 710032, People’s Republic of China, Tel +86-29-84772645, Email liushiyu@vip.163.comBackground: Osteoporosis is a major public health concern characterized by decreased bone density. …”
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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

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Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem CellsSummary by Kentaro Tominaga, Daniel O. Kechele, J. Guillermo Sanchez, Simon Vales, Ingrid Jurickova, Lizza Roman, Akihiro Asai, Jacob R. Enriquez, Heather A. McCauley, Keishi Kishimoto, Kentaro Iwasawa, Akaljot Singh, Yuko Horio, Jorge O. Múnera, Takanori Takebe, Aaron M. Zorn, Michael A. Helmrath, Lee A. Denson, James M. Wells

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Experiencia en DAC cardiaca en la Comunidad Valenciana: programa de extracción cardiaca extrahospitalaria by Audelio Guevara-Bonilla, Eduardo Tébar-Botí, Claudia Aguirre-Ramón, Alexandra Merino-Orozco, Carlos Domínguez-Massa, Manuel Pérez-Guillén, Ana Bel-Mínguez, Salvador Torregrosa-Puerta, Tomás Heredia-Cambra, Alejandro Rincón-Almanza, María J. Dalmau-Sorli, Iván Martín González, Francisco J. Valera Martínez, Ana Tur-Alonso, Juan B. Martínez León

“…Para ello se ha implementado un protocolo extracción cardiaca extrahospitalaria dentro de la Comunidad Valenciana. Material y método: Desde noviembre de 2022 a abril de 2024 se han realizado 21 valoraciones cardiacas en el contexto de la DAC.Criterios de inclusión: donante < 55 años; consentimiento familiar de donación; previsión de tiempo de isquemia caliente funcional < 30 min.Criterios de exclusión del donante, los propios de una donación cardiaca más: infusión de adrenalina; infusión de dobutamina; infusión de noradrenalina > 0,3 μg/kg/min.Es un estudio descriptivo retrospectivo. …”
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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Institute of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). …”
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New Horizons In The Treatment Of Metastatic Castrate Resistant Prostate Cancer by Zein El Amir

“…If we talk specifically about the undergraduate medical curriculum, anatomy is a vital component of the basic sciences taught during the first one or two years of medical or dental school. The role these subjects play in the curriculum can be discussed in two categories: the ideal, theoretical role and the less-than-perfect, practical reality. …”
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Anatomy In The Undergraduate Medical Curriculum; Blending The Old And New by Ayesha Yousaf

“…[v]  If we talk specifically about the undergraduate medical curriculum, anatomy is a vital component of the basic sciences taught during the first one or two years of medical or dental school. The role this subject plays in the curriculum can be discussed int two categories: the ideal, theoretical role and the less-than-perfect, practical reality. …”
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Two-year trajectory of functional recovery and quality of life in post-intensive care syndrome: a multicenter prospective observational study on mechanically ventilated patients wi... by Junji Hatakeyama, Kensuke Nakamura, Shigeaki Inoue, Keibun Liu, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto, Naoki Kanda, Shotaro Aso, Shinya Suganuma, Shuhei Maruyama, Yoshitaka Ogata, Akira Takasu, Daisuke Kawakami, Hiroaki Shimizu, Katsura Hayakawa, Takeshi Yoshida, Taku Oshima, Tatsuya Fuchigami, Hironori Yawata, Kyoji Oe, Akira Kawauchi, Hidehiro Yamagata, Masahiro Harada, Yuichi Sato, Tomoyuki Nakamura, Kei Sugiki, Takahiro Hakozaki, Satoru Beppu, Masaki Anraku, Noboru Kato, Tomomi Iwashita, Hiroshi Kamijo, Yuichiro Kitagawa, Michio Nagashima, Hirona Nishimaki, Kentaro Tokuda, Osamu Nishida

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Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MI... by Fiona McNicholas, Dieter Wolke, Jason Madan, Jatinder Singh, Federico Fiori, Paramala Santosh, Jane Warwick, Helena Tuomainen, Swaran Singh, Laura Adams, Mathilde Mastroianni, Natalie Heaney, Kate Lievesley, Ilyas Sagar-Ouriaghli, Giovanni Allibrio, Rebecca Appleton, Nikolina Davidović, Giovanni de Girolamo, Gwen Dieleman, Katarina Dodig-Ćurković, Tomislav Franić, Charlotte Gatherer, Suzanne Gerritsen, Elisa Gheza, Lidia Manenti, Athanasios Maras, Francesco Margari, Adriana Pastore, Moli Paul, Diane Purper-Ouakil, Francesco Rinaldi, Vehbi Sakar, Ulrike Schulze, Giulia Signorini, Cathy Street, Priya Tah, Sabine Tremmery, Amanda Tuffrey, Frank Verhulst, Anna Wilson

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A survey on the implementation of health education among nurses in the stomatology clinic in Guangdong Province (广东省口腔门诊护士健康教育实施现状的调查研究) by SHEN Fang (沈芳), YE Ziwen (叶子文), FENG Xiaowen (冯晓文), SU Wanying (苏婉莹), XIAO Wei (肖炜)

“…Among the 344 nurses surveyed, 85. 47%(294/344)of the nurses in the dental clinic chose armchair preaching in the course of practice, 97. 97%(337/344)of the nurses said that "oral immediate preaching" was the main teaching medium. …”
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La enfermería forense como protagonista de los cuidados en los diversos escenarios de violencia by Zenaide Cavalcanti de Medeiros Kernbeis

“…Desde esta perspectiva, si miramos en la historia verificaremos la evidencia de que el tratamiento forense dentro de la enfermería siempre ha existido. "Las ciencias médico-legales y las ciencias de enfermería surgieron entrelazadas en el siglo 18, cuando los tribunales citaron a las parteras para que dieran su opinión en situaciones de embarazo, virginidad y agresión sexual”.4 La historia de la enfermería forense está ligada a la creciente necesidad de mejorar la atención a la víctima de la violencia, en los diversos tipos de violencia que se encuentran en nuestra sociedad. …”
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Atención primaria de salud como eje fundamental en el cuidado de la salud de la población by Tania de la Caridad García Castellanos

“…Este gran fenómeno pone en detrimento la calidad de la atención brindada a la población, así como la calidad y la cantidad de investigaciones realizadas por los profesionales de la salud en aras de solucionar los problemas existentes; dentro de ellos cabe destacar las enfermedades crónicas, consideradas durante mucho tiempo algo propio de las sociedades prósperas, hoy se han desplazado. …”
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Systematic Review of Lay Responders Educational Outcomes to Identify Life-Threatening Bleeding

“…Un medio válido para medir estos resultados de aprendizaje permitiría revisar futuras investigaciones y realizar meta-análisis con fines educativos para distinguir la calidad dentro de los programas y entre ellos. En segundo lugar, puede servir como indicador de las conductas de supervivencia en campo, ya que la aplicación de torniquetes sigue siendo poco frecuente. …”
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¡Instagram y más! Instagram Stories Live y videos by Oliver Carrero Márquez

“…Una vez sentadas las bases sobre su idoneidad para comunicar, se da paso a un conocimiento más profundo de Instagram, así como de las aplicaciones que la complementan, dentro del ecosistema digital en el que se desenvuelve. …”
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Variant rs4149584 (R92Q) of the TNFRSF1A gene in patients with familial multiple sclerosis by U. Gomez-Pinedo, J.A. Matías-Guiu, L. Torre-Fuentes, P. Montero-Escribano, L. Hernández-Lorenzo, V. Pytel, P. Maietta, S. Alvarez, I. Sanclemente-Alamán, L. Moreno-Jimenez, D. Ojeda-Hernandez, N. Villar-Gómez, M.S. Benito-Martin, B. Selma-Calvo, L. Vidorreta-Ballesteros, R. Madrid, J. Matías-Guiu

“…También realizamos un estudio funcional para analizar el mecanismo patogénico de la variante rs4149584 (-g.6442643C > G, NM_001065.4:c.362 G > A,R92Q) por transfección plasmídica en células de oligodendroglioma humano (HOG), las cuales se comportan como células de linaje oligodendrocitario; se utilizó marcaje de proteínas para localizar la proteína dentro de las células. También analizamos la capacidad de las células HOG transfectadas para proliferar y diferenciarse en oligodendrocitos. …”
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Variant rs4149584 (R92Q) of the TNFRSF1A gene in patients with familial multiple sclerosis by U. Gomez-Pinedo, J.A. Matías-Guiu, L. Torre-Fuentes, P. Montero-Escribano, L. Hernández-Lorenzo, V. Pytel, P. Maietta, S. Alvarez, I. Sanclemente-Alamán, L. Moreno-Jimenez, D. Ojeda-Hernandez, N. Villar-Gómez, M.S. Benito-Martin, B. Selma-Calvo, L. Vidorreta-Ballesteros, R. Madrid, J. Matías-Guiu

“…También realizamos un estudio funcional para analizar el mecanismo patogénico de la variante rs4149584 (-g.6442643C > G, NM_001065.4:c.362 G > A,R92Q) por transfección plasmídica en células de oligodendroglioma humano (HOG), las cuales se comportan como células de linaje oligodendrocitario; se utilizó marcaje de proteínas para localizar la proteína dentro de las células. También analizamos la capacidad de las células HOG transfectadas para proliferar y diferenciarse en oligodendrocitos. …”
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Associations between degree of food processing and all-cause and cause-specific mortality: a multicentre prospective cohort analysis in 9 European countriesResearch in context by Esther M. González-Gil, Michèle Matta, Fernanda Morales Berstein, Manon Cairat, Geneviève Nicolas, Jessica Blanco, Nathalie Kliemann, Renata Bertazzi Levy, Fernanda Rauber, Inarie Jacobs, Aline Al Nahas, Emine Koc Cakmak, Eszter P. Vamos, Kiara Chang, Sahar G. Yammine, Christopher Millett, Mathilde Touvier, Maria Gabriela Matias Pinho, Konstantinos K. Tsilidis, Alicia K. Heath, Christina M. Lill, Valeria Pala, Conchi Moreno-Iribas, Maria Santucci De Magistris, Christina C. Dahm, Niels Bock, Anja Olsen, Anne Tjønneland, Yvonne T. van der Schouw, Pilar Amiano, Franziska Jannasch, Matthias B. Schulze, Francesca Romana Mancini, Chloé Marques, Claire Cadeau, Catalina Bonet, Daniel Redondo-Sánchez, Kristin Benjaminsen Borch, Magritt Brustad, Guri Skeie, Jesús Humberto-Gómez, Alessandra Macciotta, Pietro Ferrari, Laure Dossus, Marc J. Gunter, Inge Huybrechts

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O diagnóstico e o tratamento de problemas de aprendizagem em questão by Lúcia Gracia Ferreira

“…Embora, faca parte da psicopedagogia se preocupar com o fortalecimento dos processos sintético do ego e facilitação do desenvolvimento das funções cognitivas, Paín opta por uma psicopedagogia que permite ao sujeito que não aprende fazer-se cargo de sua marginalização e aprender, a apartir da mesma, transformando-se para integrar-se na sociedade, mas dentro da perspectiva da necessidade de transformá-la. …”
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