Mechanical characterization of core-shell microcapsules by Xie, Kaili, Leonetti, Marc

“…They not only play an increasing role as artificial models for understanding dynamic behaviors of biological cells in flows, but are also becoming a fundamental class of artificial vehicles at the heart of drug delivery and release in applications. …”
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Cord Entanglement in Monoamniotic Twin Pregnancy: A Case Report and Review of the Literature by Ayşe Figen Türkçapar, Berna Seçkin, Ayla Sargın Oruç

“…There is still no consensus on the antenatal management and timing of delivery of these rarely encountered cases. Here, we present a case of monoamniotic twin pregnancy with cord entanglement diagnosed in labour in a 21-year-old primigravid woman and review the obstetric literature about the management of monoamniotic twin pregnancies. …”
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Subthalamic hGAD65 Gene Therapy and Striatum TH Gene Transfer in a Parkinson’s Disease Rat Model by Deyu Zheng, Xiaohua Jiang, Junpeng Zhao, Deyi Duan, Huanying Zhao, Qunyuan Xu

“…This is combined with the ex vivo gene delivery of tyrosine hydroxylase (TH) by fibroblasts injected into the striatum. …”
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CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses by Milankumar Patel, Sudipta Panja, Lubaba A. Zaman, Pravin Yeapuri, Shaurav Bhattarai, Santhi Gorantla, Linda Chang, Alonso Heredia, Piotr Walczak, Brandon Hanson, Samuel M. Cohen, Bhavesh D. Kevadiya, Howard E. Gendelman

“…These findings offer a role for CCR5-targeted therapeutics in antiretroviral delivery to optimize HIV suppression.…”
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Protocols for translocation processes of flexible polymers through a pore using LAMMPS by Vrinda Garg, Rejoy Mathew, Arindam Chatterjee, Surya K. Ghosh

“…Summary: Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) is an open-source, powerful simulator with a customizable platform for extensive Langevin dynamics simulations. Here, we present a protocol for using LAMMPS to develop coarse-grained models of polymeric systems with macromolecular crowding, an integral part of any soft matter or biophysical system. …”
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Harmful Effects of Hyperoxia in Postcardiac Arrest, Sepsis, Traumatic Brain Injury, or Stroke: The Importance of Individualized Oxygen Therapy in Critically Ill Patients by Jean-Louis Vincent, Fabio Silvio Taccone, Xinrong He

“…Here, we discuss the potentially harmful effects of hyperoxaemia in various groups of critically ill patients, including postcardiac arrest, traumatic brain injury or stroke, and sepsis. …”
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ANFIS robust control application and analysis for load frequency control with nonlinearity by Krishna Kumar, Madhulika Das, Amrendra Kumar Karn

“…Here, dynamics of automatic load frequency control is considered under this case. …”
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Seropositivity for Bovine Viral Diarrhea and Enzootic Bovine Leukemia viruses in Blanco Orejinegro cattle in Colombia and infection associated-factors by A. Saldarriaga-Saldarriaga, M. Londoño-Gil, L. G. González-Herrera, J. C. Rincón-Flórez, A. López-Herrera

“…A cross-sectional study was conducted with a total of 498 animals of all age groups and physiological states of the BON breed were selected, belonging to 14 herds located in 6 states of Colombia, in which a survey with 27 questions was conducted. …”
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Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids by Taisuke Furusho, Ranjan Das, Hideyuki Hakui, Anusha Sairavi, Kei Adachi, Mia S. Galbraith-Liss, Pratheppa Rajagopal, Masahiro Horikawa, Shuhua Luo, Lena Li, Kentaro Yamada, Nicole Andeen, Gregory A. Dissen, Hiroyuki Nakai

“…Abstract AAV vectors show promise for gene therapy; however, kidney gene transfer remains challenging. Here we conduct a barcode-seq-based comparison of 47 AAV capsids administered through different routes in mice, followed by individual validation. …”
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Reversible Ca2+ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads by Jiawei Lin, Chaofeng Qiao, Hao Jiang, Zhihui Liu, Yaxin Hu, Wei Liu, Yu Yong, Fenfang Li

“…Therefore, an improved understanding of how ultrasound evokes Ca2+ signaling in the brain endothelial monolayer, and its correlation to endothelial permeability change is necessary. Here, we examined the effects of SonoVue microbubbles or integrin-targeted microbeads on ultrasound induced bioeffects in brain microvascular endothelial monolayer using an acoustically-coupled microscopy system, where focused ultrasound exposure and real-time recording of Ca2+ signaling and membrane perforation were performed. …”
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Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system by М. М. Gridina

“…In this review, I attempt to describe the currently known information regarding the matter of increasing efciency of targeted insertions into hiPS cells’ genome. Here I will describe the most effective strategies for designing the donor template for homology-directed repair, methods to manipulate the double-strand break repair pathways introduced by a nuclease, including control of CRISPR/Cas9 delivery time. …”
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Bandwidth Reduction via Localized Peer-to-Peer (P2P) Video by Ken Kerpez, Yuanqiu Luo, Frank J. Effenberger

“…Models of video demand and localized P2P serving areas are presented. Detailed simulations of passive optical networks (PON) are run, and these generate statistics of P2P video localization. …”
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On the epistemology of resilience in public health: a novel perspective in a changing world by Alessandro Jatobá, Paula Castro-Nunes, Paulo Victor Rodrigues de Carvalho

“…Resilience, often ambiguously defined, is reexamined here as a critical attribute of public health systems, enabling them to adapt, absorb, and respond to routine and extraordinary demands without compromising universal and equitable service delivery. …”
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Citrate-modified bacterial cellulose as a potential scaffolding material for bone tissue regeneration. by Rabiu Salihu, Saiful Izwan Abd Razak, Mohd Helmi Sani, Mohammed Ahmad Wsoo, Nurliyana Ahmad Zawawi, Shafinaz Shahir

“…Here, hydroxyapatite (HA) was incorporated into a citrate-modified BC (MBC) using the biomimetic synthesis in simulated body fluid (SBF). …”
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Supports d’écriture et gestion de production au quotidien dans le nord de la Gaule (Nerviens, Atrébates) : estampilles et graffiti sur briques et sur tuiles by Christine Hoët-Van Cauwenberghe

“…Some of the items presented here have never been published: two bricks from the Bavay Museum as well as an imbrex recovered during a recent excavation in Bavay (Nord) bear ante cocturam marks, respectively graffiti for the former, a stamp for the latter. …”
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Advanced flow cell design for in vitro release testing of mucoadhesive buccal films by Grilc Blaž, Zdovc Jurij, Planinšek Odon

“…The aim here was to develop an alternative method to the commonly used United States Pharmacopoeia (USP) 2 method, based on the flow-through cell. …”
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Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions by Adil Mardinoglu, P. J. Cregg

“…Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). …”
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

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Occult Spinal Dysraphism in Obstetrics: A Case Report of Caesarean Section with Subarachnoid Anaesthesia after Remifentanil Intravenous Analgesia for Labour by A. Valente, L. Frassanito, L. Natale, G. Draisci

“…She was selected for remifentanil intravenous infusion for labour pain and then underwent urgent operative delivery with spinal anaesthesia with no complications.…”
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