Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…These side-effects can be overcome by using a tumor-specific delivery system. Here, we report a method of targeted immunotherapy using an attenuated Salmonella typhimurium (SAM-FC) engineered to release dual payloads: cytolysin A (ClyA), a cytolytic anti-cancer agent, and Vibrio vulnificus flagellin B (FlaB), a potent inducer of anti-tumor innate immunity. …”
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Phosphatidylserine-Targeted Nanotheranostics for Brain Tumor Imaging and Therapeutic Potential by Lulu Wang MD, PhD, Amyn A. Habib MD, Akiva Mintz MD, PhD, King C. Li MD, Dawen Zhao MD, PhD

“…Advantages of using the nanodelivery system, in particular, lipid-based nanocarriers, are discussed here. We also describe our recent research interest in developing PS-targeted nanotheranostics for potential image-guided drug delivery to treat brain tumors.…”
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Management of Records and Clients Satisfaction at Magistrate Court at Kabale. by Atukwase, Sarah Loynet

“…The findings from the study revealed that tere were several types of records generated at Magistrate Court, Kabale and among others include, administration and withdrawal register record, financial records, and administrative records. …”
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On Computation of Edge Degree-Based Banhatti Indices of a Certain Molecular Network by Jiang-Hua Tang, Muhammad Abid, Kashif Ali, Asfand Fahad, Muhammad Anwar Chaudhry, Muhammad Imran Qureshi, Jia-Bao Liu

“…Our results prove to be very significant to understand the behaviour of water-soluble dendritic unimolecular polyether micelle as a drug-delivery agent.…”
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A Surgical Opinion in a 36-Week Pregnant with Tibia Fracture: Intramedullary Nailing by Celal Bozkurt, Baran Sarikaya

“…The patient underwent a successful surgery, and no harm or adverse events to either the mother or the foetus were reported during or after the procedure. …”
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Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease by Delna Joy, Jobin Jose, Shabana Bibi, Akshay Bandiwadekar, Gopika Gopan, Clara Mariana Gonçalves Lima, Talha Bin Emran, Fahad A. Alhumaydhi, Harsha Ashtekar, Sandeep D. S, Carlos Adam Conte-Junior

“…Compared to systemic delivery systems, such an MN method can achieve a considerably lower effective dose and allow long-term home-based treatment.…”
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MRI-guided focused ultrasound for treating Parkinson’s disease with human mesenchymal stem cells by Sheng-Kai Wu, Chia-Lin Tsai, Aisha Mir, Kullervo Hynynen

“…Stem cells were identified in the sonicated brain regions using surface markers, indicating the feasibility of MSC delivery via MRgFUS. …”
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Composition, determinants, and risk factors of low birth weight in Sri Lanka. by Sachith Mettananda, Himali Herath, Ayesha Thewage, Kumudu Nanayakkara, Indeewari Liyanage, K S Udani, Rajika Savanadasa, Sampatha Goonewardena, Nimesha Gamhewage, Asiri Hewamalage, Dhammica Rowel, Abner Elkan Daniel, Chithramalee de Silva, Susie Perera

“…Birth weight was measured immediately after the birth by trained healthcare personnel attending the delivery.<h4>Results</h4>A total of 9130 live-born neonates were recruited, of which 52% were males. …”
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Neurobiology of Major Depressive Disorder by Rosa Villanueva

“…Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations. …”
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Nongravitational Forces in Planetary Systems by David Jewitt

“…In the solar system, the morphologies of comets, the delivery of meteorites, and the shapes and dynamics of asteroids and binaries are all affected by nongravitational forces. …”
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Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement by Anastasia Mikuscheva, Adel Mekhail, Benjamin J. Wheeler

“…‘Maturity-Onset Diabetes of the Young’ (MODY) or monogenic diabetes accounts for approximately 1–2% of diabetes and is frequently misdiagnosed as type 1 or type 2 diabetes. Here we report a case of a 19-year-old pregnant woman with a MODY 3 diabetes expecting a child to a father with MODY 2 diabetes. …”
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Noncanonical calcium binding motif controls folding of HopQ1, a Pseudomonas syringae type III secretion effector, in a pH-dependent manner by Fabian Giska, Wojciech Rymaszewski, Malgorzata Lichocka, Marcin Piechocki, Jakub Kwiatkowski, Jarosław Poznański, Magdalena Górecka, Magdalena Krzymowska

“…Abstract Virulence of many gram-negative bacteria relies upon delivery of type three effectors into host cells. To pass through the conduit of secretion machinery the effectors need to acquire an extended conformation, and in many bacterial species specific chaperones assist in this process. …”
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The curated Lactobacillus acidophilus NCFM genome provides insights into strain specificity and microevolution by Meichen Pan, Sarah O’Flaherty, Ashley Hibberd, Svetlana Gerdes, Wesley Morovic, Rodolphe Barrangou

“…Of particular interest is Lactobacillus acidophilus NCFM, an extensively studied strain that has been widely commercialized for decades and is being used for the delivery of vaccines and therapeutics. Results Here, we revisit the L. acidophilus genome, which was sequenced twenty years ago, and determined the core and pan genomes of 114 publicly available L. acidophilus strains, spanning commercial isolates, academic strains and clones from the scientific literature. …”
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Anaesthetic Management of Parturient with Acute Atrial Fibrillation for Emergency Caesarean Section by Madhu Gupta, Shalini Subramanian, Preeti Adlakha

“…She was given a combined spinal epidural (CSE) anaesthesia and her arrhythmia was successfully managed after delivery of the baby with intravenous calcium channel blocker. …”
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Hereditary Hemorrhagic Telangiectasia Presenting as High Output Cardiac Failure during Pregnancy by Tareq Goussous, Alex Haynes, Katherine Najarian, Marcos Daccarett, Shukri David

“…High-output cardiac failure secondary to hepatic involvement is a rare complication of hereditary hemorrhagic telangiectasia (HHT). Here we report a 43-year-old woman who presented at 29 weeks gestation of her second pregnancy with complications of right-sided heart failure and preterm labor. …”
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Case Series of Intrauterine Subamniotic Hemorrhage by Momoko Owada, Yoshie Shibata, Shunji Suzuki

“…In the cases, severe fetal growth restriction and preterm delivery were recognized in 2 (29%) and 4 cases (57%), respectively. …”
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Ulipristal Acetate in Myomectomy Optimization in an Infertile Patient with Giant Myomas by Elena de la Fuente, María Dolores Borrás, Miriam Rubio, Nuria Abril

“…In addition to myoma reduction and a better control of preoperative bleeding, the treatment with UPA reduced the duration and complexity of the surgery, as well as the area of uterine wall involved and the resulting scar. No side effects were observed and the patient became pregnant 6 months after the surgery and had a normal pregnancy and delivery. …”
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Recurring Facial Erythema in an Infant by Sam Hassan, Mary Jacqueline Saviour

“…There is a rare condition called Auriculotemporal nerve syndrome that is characterized by recurrent episodes of gustatory facial flushing and sweating along the cutaneous distribution of Auriculotemporal nerve: the so-called Frey syndrome. …”
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Imaging Molecular Expression on Vascular Endothelial Cells by In Vivo Immunofluorescence Microscopy by Judith M. Runnels, Parisa Zamiri, Joel A. Spencer, Isreal Veilleux, Xunbin Wei, Alexei Bogdanov, Charles P. Lin

“…Molecular targets on the EC are increasingly being explored for tissue-specific delivery of therapeutic and imaging agents. Here we use in vivo immunofluorescence microscopy to visualize the endothelial molecular expression in the vasculature of live animals. …”
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A universal method for the purification of C2H2 zinc finger arrays. by Jingchang Liang, Maia Azubel, Guanqiao Wang, Yan Nie, Roger D Kornberg, Andrew J Beel, Pierre-Jean Mattei

“…Despite recent advances in both the design and application of ZF-containing proteins, there is still a lack of a general method for their expression and purification. Here we describe a simple method, involving two chromatographic steps, for the production of homogeneous, functional ZF proteins in high yield (one milligram per liter of bacterial culture), and we demonstrate the generality of this method by applying it to a diverse set of eight C2H2-type ZF proteins. …”
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