Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function by Shubhnita Singh, Ariane Bruder, Rafael M. Costa, Juliano V. Alves, Sivakama Bharathi, Eric S. Goetzman, Thiago Bruder‐Nascimento

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Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial. [version 3; peer review... by Pauline Frizelle, Darren Dahly, Aoife O'Shea, Aileen Murphy, Cristina McKean

“…This work has the potential to improve the long-term outcomes and life chances of people living in social disadvantage. …”
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Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial. [version 2; peer review... by Pauline Frizelle, Darren Dahly, Aoife O'Shea, Aileen Murphy, Cristina McKean

“…This work has the potential to improve the long-term outcomes and life chances of people living in social disadvantage. …”
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Short-Term Outcomes of Endoscopic Ultrasound-Guided Pancreatic Cyst Ablation: A Systematic Review and Meta-Analysis by Ahmed Al Qady, Kapil Dev Nayar, Fatima Elmustafa, Mohamed Salih, Joseph Emran, Amir Beirat, Sasmith Menakuru, Dana Harris, Dan J. Echols, Baoan Ji, John M. DeWitt, Zhen Wang, Fernando F. Stancampiano, Yan Bi

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REVOLUTIONIZING LUXURY: THE ROLE OF AI AND MACHINE LEARNING IN ENHANCING MARKETING STRATEGIES WITHIN THE TOURISM AND HOSPITALITY LUXURY SECTORS by Maria Nascimento CUNHA, Manuel PEREIRA, António CARDOSO, Jorge FIGUEIREDO, Isabel OLIVEIRA

“…The study anticipates that the integration of even more immersive technologies such as augmented reality (AR) and virtual reality (VR) will further blur the lines between digital convenience and tangible luxury, suggesting a continued evolution of luxury tourism where technology enhances both the digital and physical aspects of consumer experiences. …”
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The effects of the integrative strategy on fostering reflective thinking and imparting basic basketball offensive techniques to female students by Missaa Nadem, Nadeema Badr Mohammed, Huda Badwe Shbeeb, Iqbal Abdul Hussein Neamah, Najlaa Abbas AL-Zuhairi, Nihad Mohammed Alwan

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Spatiotemporal Changes and Trade-Offs/Synergies of Ecosystem Services in the Qin-Mang River Basin by Jiwei Zhao, Luyao Wang, Dong Jia, Yaowen Wang

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Personalized modeling of gut microbiome metabolism throughout the first year of life by Rola Shaaban, Susheel Bhanu Busi, Paul Wilmes, Jean-Louis Guéant, Almut Heinken

“…Here, we hypothesize that Cesarian section delivery alters not only the composition of the developing infant gut microbiome but also its metabolic capabilities. …”
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SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters by Mingyang Chen, Luexiang Yuan, Binxin Chen, Hui Chang, Jun Luo, Hengbin Zhang, Zhongjian Chen, Jiao Kong, Yaodong Yi, Mengru Bai, Minlei Dong, Hui Zhou, Huidi Jiang

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CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma by Jiaojiao Xu, Zhe Li, Qinli Tong, Sihang Zhang, Jianchen Fang, Aihua Wu, Guoguang Wei, Chen Zhang, Sheng Yu, Binbin Zheng, Hongzheng Lin, Xueling Liao, Zeyu Xiao, Wei Lu

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Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

“…Multiple strategies for viral epitope delivery have been shown to be effective. So far, most of these have relied on a free C-terminus of the immunogenic epitope for extracellular delivery. …”
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Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy by Benjamin L. Franc, Stefanie J. Mandl, Zurab Siprashvili, Paul Wender, Christopher H. Contag

“…In vivo imaging of PTD-mediated gene transfer to cells of the skin has been demonstrated in living animals. Here we review several natural and synthetic PTDs that have evolved in the quest for easier translocation across biological barriers and the application of these peptide domains to in vivo delivery of imaging agents.…”
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Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody by Bin Xie, Shipeng Xu, Sanjeevi Sivasankar

“…Here, we use a combination of biophysical, biochemical, and cell biological methods to demonstrate that trapping the P-cadherin extracellular region in an X-dimer adhesive conformation triggers cadherin endocytosis via an outside-in signaling mechanism. …”
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Increasing Possibilities of Nanosuspension by Kumar Bishwajit Sutradhar, Sabera Khatun, Irin Parven Luna

“…Here, this review describes the methods of pharmaceutical nanosuspension production including advantages and disadvantages, potential benefits, characterization tests, and pharmaceutical applications in drug delivery.…”
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“Clickable” Nanoparticles for Targeted Imaging by Eric Yi Sun, Lee Josephson, Ralph Weissleder

“…Nanomaterials functionalized with targeting ligands are increasingly recognized as useful materials for molecular imaging and drug delivery. Here we describe the development and validation of azide–alkyne reactions (“click chemistry”) for the rapid, site-specific modification of nanoparticles with small molecules. …”
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Comparison of the Infectivity and Transmission of Contemporary Canine and Equine H3N8 Influenza Viruses in Dogs by Heidi L. Pecoraro, Susi Bennett, Kristina Garretson, Ayshea M. Quintana, Katharine F. Lunn, Gabriele A. Landolt

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Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract by Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu

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Progenitor Cell Therapy to Treat Acute Myocardial Infarction: The Promise of High-Dose Autologous CD34+ Bone Marrow Mononuclear Cells by Joseph C. Poole, Arshed A. Quyyumi

“…ST elevation myocardial infarction (STEMI) is associated with an increased risk for congestive heart failure and long-term mortality despite the widespread use of thrombolysis and catheter-based revascularization. …”
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E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer: A Proof-of-Concept Study by Saravanan Yuvaraj, Sa’ad H. Al-Lahham, Rajesh Somasundaram, Patrick A. Figaroa, Maikel P. Peppelenbosch, Nicolaas A. Bos

“…Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. …”
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TEICHI and the Tools Paradox by Sebastian Pape, Christof Schöch, Lutz Wegner

“…We look at these tools from four perspectives: that of the user interacting with the digital edition or archive, of the editor encoding and publishing texts, of the administrator setting up the publishing tool, and of the programmer possibly modifying or enhancing the tool. Our more general aim here is to investigate, from the perspective of tool development in the area of online delivery of TEI-encoded documents, what could be called the “tools paradox”: there is evidence for textual scholars’ need of such tools, and a number of them are available; however, the existing tools are not widely adopted by scholars. …”
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