All-fiber delivery of 100 W single-frequency laser through 100 m anti-resonant hollow-core fiber without stimulated Brillouin scattering by Shoufei Gao, Wenxiang Zha, Yujun Feng, Zhixi Liang, Yizhi Sun, Xiaobo Yang, Yingying Wang

“…Here we present the successful delivery of 100 W single-frequency laser power through 100 m of anti-resonant hollow-core fiber (AR-HCF) in an all-fiber configuration, with the absence of SBS. …”
Get full text

Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates by Mengping Liu, Erica Cook, Yanshan Dai, Erich Ehlert, Francois du Plessis, Jacek Lubelski, Bogdan G. Sleczka, Petia Shipkova, Zhuyin Li, Joshua Gamse, David Gordon, Leonard P. Adam, Paul C. Levesque, Glen B. Banks

Get full text

Using Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania by Simon Martin Nzilibili, Hellen Maziku, Awet Araya, Ruthbetha Kateule, Millenium Anthony Malamla, Suna Salum, Furaha Kyesi, Lotalis Gadau, Tumaini Menson Haonga, Florian Tinuga, Rashid Mfaume, Zaitun Hamza, Georgina Joachim, Alice Geofrey Mwiru, Alex Benson, Oscar Kapela, Ona Machangu, Norman Jonas, Ntuli Kapologwe

“…However, Tanzania still has a significant number of zero-dose and under-vaccinated children and was ranked among the top ten African countries with the highest numbers of zero-dose children in 2022. …”
Get full text

Recent advances of antibody-drug conjugates in treating breast cancer with different HER2 status by Yue Qiu, Yaqin Shi, Zhujun Chao, Xinyu Zhu, Yan Chen, Linlin Lu

“…This review presents an updated and comprehensive overview of emerging investigational ADCs for treating breast cancer patients with various HER2 subtypes. These ADCs are spearheading a new era in targeted cancer therapy, promising to innovate treatment paradigms for both HER2-positive and HER2-low breast cancers.…”
Get full text

Evaluation of Carboxymethyl-Hexanoyl Chitosan as a Protein Nanocarrier by Mikael Larsson, Annika Borde, Emma Mattisson, Dean-Mo Liu, Anette Larsson

Get full text

Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research by Yujie Gao, Tianqi Xu, Yu Wang, Yanjinhui Hu, Shaoping Yin, Zhiguo Qin, Hua Yu

“…Nanotechnology-, microneedle- and dressing-based systems have demonstrated the potential for improved skin penetration, enhanced bioavailability, or extended retention time. Here, we will focus on the latest insights into the etiology, diagnostic methodologies, and therapeutic approaches for psoriasis, with a particular emphasis on the evolution and challenges of novel transdermal drug delivery systems.…”
Get full text

Protocol for prognosticating PPD using EEG changes during labor pain by uterine contractions: a prospective cohort study in the first stage of labor by Yan Wang, Wan-Ying He, Chang’ an A. Zhan, Shi-Lei Pan, Wen Wu, Feng-Xian Li, Hong-Fei Zhang

“…The results from this study may act as a predictor for the development of PPD which may enhance long-term quality of life for the parturient and her offspring. …”
Get full text

Fully integrated wearable control system for micro/nanorobot navigation by Zhanxiang Zhang, Lin Wang, Fengqi Jiang, Shimin Yu, Fengtong Ji, Tianhao Sun, He Zhang, Yanhe Zhu, Hao Chang, Tianlong Li, Jie Zhao

“…Micro/nanorobots have exhibited excellent application potential in the biomedical field, such as drug delivery, minimally invasive surgery, and bio-sensing. …”
Get full text

Colony-Forming and Cell Viability Assay to Assess Nanotoxicity of Maleic Acid and N-vinyl Caprolactam-Based Nanoarchitectures by Bekar Buse, Akar Burcu, Akan Handan Sevim, Can Hatice Kaplan

Get full text

A Case of Pregnancy Complicated with ATIII Deficiency in a Patient Who Developed Severe Venous Thromboembolism in Her Fourth Pregnancy and Had a Favourable Outcome in Her Subsequen... by Mie Sakai, Jumpei Ogura, Koji Yamanoi, Takahiro Hirayama, Tsutomu Ohara, Haruka Suzuki, Yoshihide Inayama, Koji Yasumoto, Koh Suginami

“…An inferior vena cava thrombus and pulmonary embolism were found. Because VTE was very severe, artificial abortion was performed, and VTE disappeared rapidly. …”
Get full text

Individual and community level maternal factors for zero-dose children in Ethiopia using mini-EDHS 2019: a mixed effects model by Anteneh Kassa Yalew, Werkneh Melkie Tilahun, Meron Asmamaw Alemayehu, Tigabu Kidie Tesfie, Muluken Chanie Agimas, Mekuriaw Nibret Aweke, Worku Necho Asferie, Moges Tadesse Abebe

“…Variables like urban residence, no education, home delivery, poor wealth index, no antenatal care(ANC) visit and women from low proportions of community media exposure were the risk factors for zero-dose children in Ethiopia. …”
Get full text

Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies by Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao

Get full text

Assessment of Herpes Simplex Virus Type 1 and 2 by IHC in Association with CD14 Antigen in Placental Tissues from Women with Miscarriage by Zainab A. Hamid, Solaf J. Ali, Ali Hattem Hussain

“…Immunohistochemistry technique assay was used to detect placental infection with HSV-1& HSV-2 as well as CD14 in 40 women with spontaneous miscarriage and in 40 healthy deliveries in Baghdad/Iraq. The IHC- expressions of HSV-1, HSV-2, and CD14 proteins were detected in 4(10%), 15(37.5%), 15(37.5%) in placental tissues from miscarriage women, respectively. …”
Get full text

Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations by Joel Heisler, Daniel Kovner, Saeed Izadi, Jonathan Zarzar, Paul J. Carter

“…In contrast, the impact of Fc mutations on antibody viscosity has been minimally explored. Here, we studied the effect of a panel of common and clinically validated Fc mutations on the viscosity of two closely related humanized IgG1, κ antibodies, omalizumab (anti-IgE) and trastuzumab (anti-HER2). …”
Get full text

Modelling chemistry and biology after implantation of a drug-eluting stent. Part Ⅱ: Cell proliferation by Adam Peddle, William Lee, Tuoi Vo

Get full text

Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor by Alessia Lamolinara, Lorenzo Stramucci, Albana Hysi, Manuela Iezzi, Cristina Marchini, Marianna Mariotti, Augusto Amici, Claudia Curcio

“…Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice. …”
Get full text

Geographic Information System-Based Framework for Sustainable Small and Medium-Sized Enterprise Logistics Operations by Jonathan Agoo, Renz Joshua Lanuza, Jonathan Lee, Paul Anthony Rivera, Neil Oliver Velasco, Marielet Guillermo, Arvin Fernando

“…In this study, the authors propose a framework leveraging geographic information to sustain logistics operations, specifically in terms of managing last-mile delivery and return trip orders. …”
Get full text

Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody by Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh, Paul J. Carter

“…The methods described here may be useful in the optimization of other antibodies to facilitate their therapeutic administration at high concentration.…”
Get full text

Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…Rg3-Lip-OXA/CaO2 was prepared through a thin-film hydration approach and characterized; additionally, its stability and release behavior were studied. The O2, H2O2, and Ca2+ generation ability of Rg3-Lip-OXA/CaO2 in solution and HCT116 cells were measured. …”
Get full text

Geospatial mapping to assess the distribution and determinants of zero dose vaccination status hot spots among children in Ethiopia using EDHS 2019: Spatial and geographical weight... by Muluken Chanie Agimas, Meron Asmamaw, Melese Kebede Hailu, Tigabu Kidie, Habtamu Wagnew Abuhay, Getaneh Awoke Yismaw, Nebiyu Mekonnen Derseh

“…Stata-14, Arc geographic information system-10.3, and Sat Scan software were used to analyze the data. Moran's I statistic was used to assess the non-random distribution of zero-dose vaccination status. …”
Get full text