Vaccinating in Different Settings: Best Practices from Italian Regions by Carlo Signorelli, Flavia Pennisi, Anna Carole D’Amelio, Michele Conversano, Sandro Cinquetti, Lorenzo Blandi, Giovanni Rezza

“…Results: In Veneto, where prevention departments were the main actor, herpes zoster vaccination coverage for the 65-year-old cohort increased from 44.4% to 54.9%; in Tuscany, family pediatricians administered 64% of all childhood vaccines; in Liguria, pharmacies delivered 70.1% of COVID-19 vaccines, while vaccinating in schools in Taranto led to higher human papilloma virus vaccination rates compared to regional and national averages. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Here, we aimed to improve efficacy for anti-programmed death ligand 1 (PD-L1) therapy by developing a PD-L1/TLR7 dual-targeting nanobody-drug conjugate (NDC), based on the PD-L1 nanobodies and TLR7 agonist we developed.Methods PD-L1 nanobodies were obtained by phage display screening and identified through T-cell activation bioassay, in vivo imaging and quantitative biodistribution study. …”
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Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a... by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

“…Interpretation: Lipidots® are effective platform for the development of vaccines against cancer based on mRNA delivery. Their combination with immune checkpoint blockers could counter tumour resistance and promote long-term antitumour immunity. …”
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Vagal nerve stimulation dynamically alters anxiety-like behavior in rats by A.G. Butler, J.K. Bassi, A.A. Connelly, M.R. Melo, A.M. Allen, S.J. McDougall

“…The VNS current required to elicit the A-fiber-mediated Hering-Breuer Reflex (HBR) was determined for each animal. …”
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Standardised packaging, minimum excise tax, and RYO focussed tax rise implications for UK tobacco pricing. by Rosemary Hiscock, Nicole H Augustin, J Robert Branston, Anna B Gilmore

“…The beginning and end of the data series were compared in terms of: (a) average monthly price growth, (b) average monthly net revenue growth, and (c) undershifting and overshifting patterns after tax changes. …”
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A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…The cytotoxicity and replication of VVL-m12, VVL-h12 and control VVs were assessed in lung cancer cell lines. Subcutaneous lung cancer mouse models were established to investigate the anti-tumor activity of the viruses after intratumoral delivery in an immunocompetent disease model. …”
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Arthrogryposis Multiplex Congenita: Case Report by Ayla Aktulay, Saliha Sağnıç, Özlem Moraloğlu Tekin, Yaprak Engin Üstün, Elif Gül Yapar Eyi, Leyla Mollamahmutoğlu

“…Prenatal diagnosis of AMC is difficult. Here we report a case with a diagnosis of AMC not diagnosed during antenatal follow-up. …”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

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Artemia sp. as a DNA vaccine vector for common carp Cyprinus carpio larvae by Sri Nuryati, Sekar Sulistyaning Hadiwibowo, . Alimuddin

“…ABSTRACT   Koi herpes virus (KHV) is one of the most common impetuses for disease on common carp Cyprinus carpio. …”
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Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals by Najwa D. Aljehani, Levi Tamming, Muhammad Yasir Khan, Rwaa H. Abdulal, Mohamed A. Alfaleh, Aishah Ghazwani, Asalah Helal, Reem M. Alsulaiman, Mohammad A. Sanki, Khalid Alluhaybi, Farah Ayman Sukareh, Rahaf H. Alharbi, Faris H. Alyami, M-Zaki ElAssouli, Salima Shebbo, Wesam H. Abdulaal, Abdullah Algaissi, Ahmad Bakur Mahmoud, Mohammad Basabrain, Diana Duque, Jegarubee Bavananthasivam, Wangxue Chen, Lisheng Wang, Simon Sauve, Turki S. Abujamel, Tarfa Altorki, Rowa Alhabbab, Anh Tran, Xuguang Li, Anwar M. Hashem

“…Our findings indicate that both vaccinations were effective in stimulating strong and long-lasting immune responses, both locally and across the body, when administered through either IM or IN methods. …”
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Feasibility of HIV self-test implementation among Mizo youths: a field investigation from Northeast India bordering Myanmar by Amrita Rao, Henry Zodinliana Pachuau, Samiran Panda, Richard L. Chawngthu, Rita Zomuanpuii, Pranoti Hemade, Amit Nirmalkar

“…Additionally, only 1% of respondents perceived HIVST as having self-harm potential.ConclusionSustained community engagement, effective networking with HIV program officials, and strategic communication were three critical pillars supporting the successful implementation of HIVST. …”
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An interlaboratory comparison to quantify oxidative potential measurement in aerosol particles: challenges and recommendations for harmonisation by P. A. Dominutti, J.-L. Jaffrezo, A. Marsal, T. Mhadhbi, R. Elazzouzi, C. Rak, F. Cavalli, J.-P. Putaud, A. Bougiatioti, N. Mihalopoulos, N. Mihalopoulos, D. Paraskevopoulou, I. Mudway, I. Mudway, A. Nenes, A. Nenes, K. R. Daellenbach, C. Banach, S. J. Campbell, H. Cigánková, D. Contini, G. Evans, M. Georgopoulou, M. Ghanem, D. A. Glencross, D. A. Glencross, M. R. Guascito, M. R. Guascito, H. Herrmann, S. Iram, M. Jovanović, M. Jovašević-Stojanović, M. Kalberer, I. M. Kooter, S. E. Paulson, A. Patel, A. Patel, A. Patel, E. Perdrix, M. C. Pietrogrande, P. Mikuška, J.-J. Sauvain, K. Seitanidi, P. Shahpoury, E. J. d. S. Souza, S. Steimer, S. Steimer, S. Stevanovic, G. Suarez, P. S. G. Subramanian, B. Utinger, M. F. van Os, V. Verma, X. Wang, R. J. Weber, Y. Yang, X. Querol, G. Hoek, R. M. Harrison, R. M. Harrison, G. Uzu

“…To address this issue, this study engages in an international effort to compare OP measurements using a simplified method (with a dithiothreitol (DTT) assay).</p> <p>Here, we quantify the OP in liquid samples to focus on the protocol measurement itself, while future international OP interlaboratory comparisons (ILCs) should aim to assess the whole chain process, including the sample extraction. …”
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Feasibility of home-based urine collection in children under 5 years in the ORIGINS birth cohort study: mixed method protocol and sample completion results by Courtney D. A. Kidd, Najma A. Moumin, Andrea MacRae, Tim J. Green, Desiree T. Silva, Susan L. Prescott, Nina D’Vaz

“…Uniquely, courier collection and postal kit deliveries were established in response to participant feedback regarding difficulty with in-person sample drop-offs with young children. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Relative value units consider physician work, practice expense, service rendered, and professional liability.[8] Later models, like capitation, were enacted to control costs. Simply put, purely capitated payments consist of flat-term payments for patient care that do not change based on services rendered.[9] Within the past decade, value-based payments, which pay physicians based on patient value, as defined by outcomes divided by costs, became popular.[10] There are other approaches to paying for patient care, such as health savings accounts or direct primary care (patients directly pay physicians without insurance).[11] While these are assuredly interesting areas of study, the financial incentives mimic fee-for-service, in which physicians and organizations receive payments based on direct services rendered and will not be discussed further in this article. …”
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