CD7‐targeting pro‐apoptotic extracellular vesicles: A novel approach for T‐cell haematological malignancy therapy by Bei Zhang, Jianqiang Chen, Jiming Chen, Yingying Shen, Yinghu Chen, Shibo Wang, Chengyan Zhang, Yuzhou He, Huajun Feng, Jiaoli Wang, Zhijian Cai

“…Abstract T‐cell haematological malignancies progress rapidly and have a high mortality rate and effective treatments are still lacking. Here, we developed a drug delivery system utilizing 293T cell‐derived extracellular vesicles (EVs) modified with an anti‐CD7 single‐chain variable fragment (αCD7/EVs). …”
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Targeting Herpetic Keratitis by Gene Therapy by Hossein Mostafa Elbadawy, Marine Gailledrat, Carole Desseaux, Diego Ponzin, Stefano Ferrari

“…By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. …”
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The N-terminus of the Clostridioides difficile transferase A component directs toxin activity and potency by Robin M. Mullard, Michael J. Sheedlo

“…In the future, we expect these mutants will serve as valuable tools to help elucidate the role of CDT during infection.…”
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Surface State Treatment of Carbon Dots Using Sulphur Dioxide Isotherm by L. Natrayan, Dhinakaran Veeman, Pravin P. Patil, V. Swamy Nadh, P. Balamurugan, Muse Degefe Chewaka

“…The water-soluble characteristics of carbon dots help them be involved in biomedicine applications. …”
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Continuous Production of Docetaxel-Loaded Nanostructured Lipid Carriers Using a Coaxial Turbulent Jet Mixer with Heating System by Hyeon Su Lim, Won Il Choi, Jong-Min Lim

“…The continuous synthesis of nanoparticles (NPs) has been actively studied due to its great potential to produce NPs with reproducible and controllable physicochemical properties. Here, we achieved the high throughput production of nanostructured lipid carriers (NLCs) using a coaxial turbulent jet mixer with an added heating system. …”
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Conventional and High-Speed Intravital Multiphoton Laser Scanning Microscopy of Microvasculature, Lymphatics, and Leukocyte-Endothelial Interactions by Timothy P. Padera, Brian R. Stoll, Peter T.C. So, Rakesh K. Jain

“…The ability to determine various functions of genes in an intact host will be an important advance in the postgenomic era. Intravital imaging of gene regulation and the physiological effect of the gene products can play a powerful role in this pursuit. …”
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Novel, low-cost bioreactor for in vitro electrical stimulation of cardiac cells by Joseph P. Licata, Jonathan A. Gerstenhaber, Peter I. Lelkes

“…Finite element analysis and mathematical modeling were used to model the fluid dynamics and to characterize in detail the delivery of pulsatile electrical signals, providing precise control over stimulation parameters such as voltage, current, and charge.ResultsThe bioreactor developed here provides an easy-to-use, inexpensive platform for culturing hiPSC-CMs under the influence of ES and low-shear fluid flow for enhanced nutrient availability, while its “drop-in” design facilitates real-time observation of cultured cells. …”
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Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening by Wei Jin, Yexuan Deng, John E. La Marca, Emily J. Lelliott, Sarah T. Diepstraten, Christina König, Lin Tai, Valentina Snetkova, Kristel M. Dorighi, Luke Hoberecht, Millicent G. Hedditch, Lauren Whelan, Geraldine Healey, Dan Fayle, Kieran Lau, Margaret A. Potts, Moore Z. Chen, Angus P. R. Johnston, Yang Liao, Wei Shi, Andrew J. Kueh, Benjamin Haley, Jean-Philippe Fortin, Marco J. Herold

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Twin Reversed Arterial Perfusion Sequence Diagnosed Late in the Third Trimester: A Case Report and Literature Review by Tafese Dejene, Abdi Kebede, Getahun Fetensa, Delayehu Bekele, Telila Mesfin, Kelil Hussen

“…This condition is associated with 100% mortality in the acardiac twin and a high rate of perinatal morbidity and mortality in the pump twin, primarily due to intrauterine hypoxic injury, heart failure, and prematurity. Following delivery, the surviving pump twin may experience adverse neurodevelopmental outcomes and heart failure, necessitating ongoing follow‐up care. …”
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Immunotherapies to Nano-Immunotherapies: Advances in Immune Targeting in Bladder Cancer by Beatriz Ramos, Dakota Rogers

“…Here, we discuss the immune landscape of bladder cancer, explore the emerging immunotherapies being used as bladder cancer treatment, and discuss the advantages of using nanoparticles as carriers of immunotherapies against bladder cancer. …”
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Novel mitochondrial-targeted alkyl chains act as fungal specific inhibitors of C. neoformans by Elizabeth S. M. Edrich, Luke Young, John Spencer, Andrew McGown, Anthony L. Moore, Campbell W. Gourlay

“…Two derivatives of Colletochlorin B, which we modified to improve delivery to mitochondria, were identified as putative fungal-specific inhibitors. …”
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LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling by Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xie

“…Downregulated MDRL and increased NLRP3 were observed in mouse atherosclerotic plaques, accompanied with the increase of miR-361. …”
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Triple Negative Breast Cancer in Pregnancy and Postpartum: Two Case Reports in Hispanic Women by Ruchi Upadhyay, Qurat-Ul-Ain Butt, Abraham Hamaoui, Cassandra Henderson, Sydney McCalla, Hamid Gilak

“…The patient underwent chemotherapy during the pregnancy and was delivered with a cesarean at 37 weeks for obstetric indication. After delivery, the patient completed her chemotherapy that was followed by radical mastectomy and radiotherapy. …”
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Integrating environmental effects in the benefit-risk assessment of therapeutic products: a proposal and example for sustainable health and healthcare by Emiliano Giovagnoni, Luisa Mattoli, Andrea Cossu, Vitalia Murgia

“…As decision-makers and educators, healthcare providers are in a unique position to make healthcare delivery more sustainable. However, current benefit-risk assessments of therapeutic products do not systematically include environmental risk data. …”
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A vascular endothelial growth factor–loaded chitosan-hyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke by Zhijian Zheng, Xiaohui Lin, Zijun Zhao, Qiang Lin, Ji Liu, Manli Chen, Wenwen Wu, Zhiyun Wu, Nan Liu, Hongbin Chen

“…Both hyaluronic acid and chitosan have the potential to make the microenvironment more hospitable to transplanted stem cells, thereby enhancing the therapeutic effect of mesenchymal stem cell transplantation in the context of stroke. Here, we found that vascular endothelial growth factor significantly improved the activity and paracrine function of adipose-derived stem cells. …”
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Influence of Electrostatic Interactions on the Self-Assembly of Charged Peptides by Xue Sun, Bolan Wu, Na Li, Bo Liu, Shijun Li, Liang Ma, Hangyu Zhang

“…Peptides can be designed to self-assemble into predefined supramolecular nanostructures, which are then employed as biomaterials in a range of applications, including tissue engineering, drug delivery, and vaccination. However, current self-assembling peptide (SAP) hydrogels exhibit inadequate self-healing capacities and necessitate the use of sophisticated printing apparatus, rendering them unsuitable for 3D printing under physiological conditions. …”
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Programmed polymeric integration of gold nanoparticles into multi-material 3D printed hydrogels by Said El Turk, Dileep Chekkaramkodi, Murad Ali, Abdulrahim A. Sajini, Haider Butt

“…The existing residual Olefinic groups (C = C) present in the pHEMA hydrogels matrix were used to label the target sections for producing Au NPs. …”
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Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications by A. P. Budnyk, T. A. Lastovina, A. L. Bugaev, V. A. Polyakov, K. S. Vetlitsyna-Novikova, M. A. Sirota, K. G. Abdulvakhidov, A. G. Fedorenko, E. O. Podlesnaya, A. V. Soldatov

“…An optimum balance between the right particle size and good magnetic response can be reached by a selection of a synthesis method and by doping with rare earth elements. Here, we present a microwave-assisted polyol synthesis of iron oxide MNPs with actual gadolinium (III) doping from 0.5 to 5.1 mol.%. …”
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Digital interventions for self-management of prediabetes: A scoping review. by Melanie Stowell, Rosie Dobson, Katie Garner, Mirza Baig, Norma Nehren, Robyn Whittaker

“…About one-third of studies reported mixed outcomes or early significant outcomes that were not sustained at long-term follow-up. Interventions varied in length, digital modalities, and complexity. …”
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Biomolecular Triconjugates Formed between Gold, Protamine, and Nucleic Acid: Comparative Characterization on the Nanoscale by Robert K. DeLong, Lisa Cillessen, Chris Reynolds, Adam Wanekaya, Tiffany Severs, Kartik Ghosh, Michael Fisher, Stephanie Barber, John Black, Ashley Schaeffer, Kristin J. Flores

“…Given the intense interest in splice-site switching oligomers (SSOs), we utilized a human tumor cell culture system (HeLa pLuc-705), in which SSO-directed splicing repair upregulates luciferase expression, in order to investigate bioactivity of the bionanoconjugates. …”
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