Cancer, Natural Products and Nanodrug Delivery Systems by Yong Sze Ong, Loh Teng-Hern Tan

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Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments by Amit Verma, Vikas Pandey, Catherine Sherry, Taylor Humphrey, Christopher James, Kailie Matteson, Jason T. Smith, Alena Rudkouskaya, Xavier Intes, Margarida Barroso

“…Abstract Trastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is clinically used for the treatment of HER2‐positive breast tumors. …”
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Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

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Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation by Farnaz Khaleseh, Abbas Hemmati Azandaryani, Fatemeh Fathian Kolahkaj, Mozafar Khazaei, Katayoun Derakhshandeh

“…The in vitro cell toxicity and cellular uptake of optimum formulation against HER2+ and HER2− cancer cell lines were evaluated. …”
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WLAN Technologies for Audio Delivery by Nicolas-Alexander Tatlas, Andreas Floros, Thomas Zarouchas, John Mourjopoulos

“…Audio delivery and reproduction for home or professional applications may greatly benefit from the adoption of digital wireless local area network (WLAN) technologies. …”
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Postvaginal Delivery Caecal Volvulus and Perforation by M. M. Abdullah Agha

“…High index of suspicion is needed to diagnose it as initial presentation is nonspecific and that is critical to avoid adverse outcomes. We presented here one of these cases that followed vaginal delivery and ended with caecal perforation and hemicolectomy.…”
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The Dominance of Homeopathic Medicine in Yoruba Healthcare Delivery by Richard Taye Oyelakin

Subjects: “…Yoruba Indigenous Medicine, Orthodox Medicine, Homeopathic, Healing, Healthcare Delivery, Medicine…”
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Approaches and applications in transdermal and transpulmonary gene drug delivery by Anni Zhang, Xuran Zhang, Jiahui Chen, Xianbao Shi, Xijuan Yu, Zhonggui He, Zhonggui He, Jin Sun, Jin Sun, Mengchi Sun, Mengchi Sun, Zhijun Liu

“…Considering the rapid development of gene therapeutics via transdermal and transpulmonary administration, here we aim to summarize the nearest advances in transdermal and transpulmonary gene drug delivery. …”
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Molecular Dynamics Insights into Peptide-Based Tetrodotoxin Delivery Nanostructures by Shenghan Song, Xinyu Xia, Temair Shorty, Tongtong Li, Amy O. Stevens, Chao Zhao, Yi He

“…The results reported here may provide fundamental information to drive future research and enhance the development of TTX-based drug delivery systems.…”
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Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery by Thomas Smytheman, Tiffany Pecor, Dana E. Miller, Debora Ferede, Suhavi Kaur, Matthew H. Harband, Hazem F. M. Abdelaal, Carlos A. Guerrero-Bustamante, Krista G. Freeman, Whitney E. Harrington, Lisa M. Frenkel, Graham F. Hatfull, Rhea N. Coler, Sasha E. Larsen

“…We found that aerosol delivery disperses phage across all lung lobes where M.tb is also found after experimental infection by the same route. …”
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Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery by Yuqiong Guo, Xinni He, Gareth R. Williams, Yue Zhou, Xinying Liao, Ziyi Xiao, Cuiyun Yu, Yang Liu

“…Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties render them very suitable for anti-tumor drug delivery. Recently, exploiting the specific characteristics of the tumor microenvironment, a range of multifunctional HBPs responsive to the tumor microenvironment have emerged. …”
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Anesthetic Management and Considerations for Cesarean Delivery in a Patient With Cystic Fibrosis by Richard Pham, Chris Mehdizadeh, Christopher Baker, Leonard J. Soloniuk, Ioana Pasca, Ashish Sinha

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LEGAL REGULATION OF MEASURES OF STATE SUPPORT IN THE PROCESS OF THE IMPLEMENTATION OF NORTHERN DELIVERY by Galina V. Goncharuk

“…The relevance of the issue investigated in the article lies in the need to provide state support measures for the implementation of northern delivery measures to the territory of the Arctic zone of the Russian Federation in order to ensure the preservation of human capital here. …”
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Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA by Stephanie He, Davindra Singh, Brandon Helfield

“…Focused ultrasound presents a non-viral, image-guided technique in which circulating intravascular microbubble contrast agents can reversibly enhance vascular permeability and gene penetration. Here, we explore the influence of flow rate on the microbubble-assisted delivery of miR-126, a potent pro-angiogenic biologic, using a custom acoustically coupled pressurized mesenteric artery model. …”
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NET formation-mediated in situ protein delivery to the inflamed central nervous system by Yina Wu, Jinwon Park, Quoc-Viet Le, Junho Byun, Jaehyun Choi, Enzhen Xu, Jaiwoo Lee, Yu-Kyoung Oh

“…Abstract Delivering protein drugs to the central nervous system (CNS) is challenging due to the blood-brain and blood-spinal cord barrier. Here we show that neutrophils, which naturally migrate through these barriers to inflamed CNS sites and release neutrophil extracellular traps (NETs), can be leveraged for therapeutic delivery. …”
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Chitosan-DNA nanoparticles: synthesis and optimization for long-term storage and effective delivery by Aigul Raimbekova, Ulpan Kart, Akbayan Yerishova, Timur Elebessov, Sergey Yegorov, Tri Thanh Pham, Gonzalo Hortelano

“…HEK293 cells were transfected with CsNPs, and expression of H2B-CMV-mScarlet plasmid was assessed by flow cytometry. …”
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The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…While previous strategies have focused on small molecules that modulate blood-brain barrier permeability or penetrate the barrier, there is an increased focus on biomedical devices—external or implanted—for improving drug delivery. Here, we review device-assisted drug delivery across the blood–brain barrier, emphasizing its application in glioblastoma, an aggressively malignant primary brain cancer in which the blood-brain barrier plays a central role. …”
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Tumor-specific cytosol-penetrating antibodies for antigen- and TME-dependent intracellular cargo delivery by Carolin Sophie Dombrowsky, Felix Klaus Geyer, Diana Zakharchuk, Harald Kolmar

“…In addition, presence of the masking moiety to prevent non-specific surface binding, as well as the activation of cytosol-penetrating capabilities in the tumor microenvironment upon release by tumor-specific proteases was confirmed using the catalytic domain of Pseudomonas exotoxin as model cargo for cytosol delivery. Tumor microenvironment-dependent as well as tumor-associated antigen-specific cytosol-penetrating antibodies of the type developed here have the potential to serve as a modular platform to deliver macromolecular cargoes for addressing intracellular targets in tumor cells.…”
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Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements by Sanshita, Taneja Ayushi, Sangnim Tanikan, Huanbutta Kampanart, Sindhu Rakesh K., Singh Inderbir

“…Liquorice is one of the widely used Chinese herb since ancient times due to its medicinal properties. …”
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