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    Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts by Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao

    Published 2025-02-01
    “…Here, plasmid DNA (pDNA) encoding COUP‐TFII is incorporated into decellularized allografts to realize localized delivery. Comprehensive in vitro investigation complemented by a bone marrow transplantation model on genetic‐lineage‐tracing mouse revealed the underlying mechanisms of COUP‐TFII in regulating vascular regeneration and remodeling. …”
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    A thermo-responsive chitosan-based injectable hydrogel for delivery of curcumin-loaded polycaprolactone microspheres to articular cartilage: in-vitro and in-vivo assessments by Farnoosh Kalantarnia, Sasan Maleki, Amir Shamloo, Kazem Akbarnataj, Sayed Navid Tavoosi

    Published 2025-03-01
    “…Additionally, polycaprolactone microspheres, prepared by solid/oil/water method, were used to enhance the bio-availability of curcumin and its sustained delivery. The hydrogel system containing drug-loaded microspheres showed ∼23.55 % drug released by day 7. …”
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    Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

    Published 2025-01-01
    “…Abstract Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinical challenges. …”
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