Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury by Linzhong Yang, Yuanchen Liu, Cheng Tao, Zichen Cao, Shilin Guo, Zheng Wei, Yanyi Wang, Tao Liu, Lin Chen, Ke Xiong, Xingyu Luo, Jianchuan Ran, Wei Han

“…In addition, the integration of a platelet membrane (PM) has endowed the bionic vesicles with precise targeting and delivery capabilities, ensuring that the drugs can reach the lesion directly and facilitate efficient and precise release. …”
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A consensus statement on child and family health during the COVID-19 pandemic and recommendations for post-pandemic recovery and re-build by Caroline A. B. Redhead, Sergio A. Silverio, Sergio A. Silverio, Elana Payne, Elana Payne, Mari Greenfield, Mari Greenfield, Sara M. Barnett, Anna Chiumento, Beth Holder, Helen Skirrow, Ofelia Torres, Carmen Power, Staci M. Weiss, Laura A. Magee, Soo Downe, Lucy Frith, Claire Cameron

“…IntroductionAs health systems struggled to respond to the catastrophic effects of SARS-CoV-2, infection prevention and control measures significantly impacted on the delivery of non-COVID children's and family health services. …”
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Evaluating the impact of a multicountry interprofessional training programme to improve HIV knowledge and clinical confidence among healthcare workers in sub-Saharan Africa: a coho... by Jehan Z Budak, Ian Couper, Michael Reid, Deborah von Zinkernagel, Elsie Kiguli-Malwadde, Maeve Forster, Shayanne Martin, Evelyn Chilemba, Keneilwe Motlhatlhedi, Jessica Celentano, Clara Haruzivishe, David Sears, Judy N. Khanyola, Mmoloki Molwantwa, Fred Semitala, Marietjie de Villiers, Abigail Kazembe

“…Objective To assess the impact of an interprofessional case-based training programme to enhance clinical knowledge and confidence among clinicians working in high HIV-burden settings in sub-Saharan Africa (SSA).Setting Health professions training institutions and their affiliated clinical training sites in 12 high HIV-burden countries in SSA.Participants Cohort comprising preservice and in-service learners, from diverse health professions, engaged in HIV service delivery.Intervention A standardised, interprofessional, case-based curriculum designed to enhance HIV clinical competency, implemented between October 2019 and April 2020.Main outcome measures The primary outcomes measured were knowledge and clinical confidence related to topics addressed in the curriculum. …”
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Development of a sustainable, green, and solar-powered filtration system for E. coli removal and greywater treatment by R. Abdallat, A.N. Bdour, A. Abu Haifa, F.F. Al-Rawash, L. Almakhadmeh, S. Hazaimeh

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Errors Associated With Medication Administration by a Nurse During Hospitalisation: A Prospective Observational Multicentric Study by Ondrej Tesar, Martin Dosedel, Ales Antonin Kubena, Katerina Mala‐Ladova, Radka Prokesova, Iva Brabcova, Hana Hajduchova, Martin Cerveny, Ivana Chloubova, Jiri Vlcek, Valerie Tothova, Josef Maly

“…The researchers observed nurse care delivery at medical departments acting as passive participants.…”
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Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles by Hanjing Li, Yining Liu, Yuqing Lin, Sijia Li, Chenlu Liu, Ao Cai, Wei Li, Wanyu Zhang, Xinlu Gao, Zhongyu Ren, Haoyu Ji, Yang Yu, Xiuxiu Wang, Wenya Ma, Ning Wang, Dan Zhao, Tianlong Li, Yu Liu, Benzhi Cai

“…We further show that delivery of AR-Neo-EVs by sodium alginate hydrogel microspheres is an effective treatment in myocardial infraction. …”
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Novel predictive biomarkers for atonic postpartum hemorrhage as explored by proteomics and metabolomics by Jiangxue Qu, Hai Jiang, Huifeng Shi, Nana Huang, Jiawen Su, Yan Zhang, Lian Chen, Yangyu Zhao

“…Methods Collection of cervicovaginal fluid (CVF) samples from 27 women with atonic PPH and 32 women with normal delivery was performed for metabolomic (LC-MS/MS) and proteomic (LC-MS/MS) detection and subsequent confirmation experiments in this nested case-control study. …”
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Factors associated with attention-deficit/hyperactivity disorder among Tunisian children by Asma Guedria, Asma Guedria, Asma Guedria, Mohamed Guedria, Manel Ben Fredj, Manel Ben Fredj, Randaline Ayoub, Randaline Ayoub, Randaline Ayoub, Hela Ben Abid, Hela Ben Abid, Hela Ben Abid, Ahmed Mhalla, Ahmed Mhalla, Ahmed Mhalla, Hela Slama, Hela Slama

“…Univariate then multivariate analyses were conducted to identify factors associated with ADHD.ResultsSeveral factors were more prevalent in children with ADHD than in controls: disturbed family dynamics, low socio-economic status, family history of psychiatric and organic pathologies, and particularly several early environmental factors, including passive smoking during pregnancy, prematurity, fetal distress, caesarean delivery and low birth weight. In the early childhood period, early exposure to television was also strongly associated with ADHD. …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…These findings provide valuable insights for policymakers to keep enhancing digital health infrastructure and mental healthcare delivery. The SMARC model offers a promising framework for implementing similar digital referral systems globally to improve mental healthcare coordination and accessibility.Keywords: mental health, psychiatry, referral systems, acceptance rates, health policy, Saudi Arabia, regional variation, Saudi Medical Referral Center…”
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Cardiovascular disease risk in cancer survivors: a population-based cohort study from the UK Biobank, and meta-analysis of cohort studies by Hong Li, Yazhou He, Zubing Mei, Hong Wu, Yang Shen, Ziqiang Wang, Jichun Zhao, Chuan Xu, Yanhong Zhou, Chi Shu, Botao Yu, Xiran Wang, Changtao Li, Yiqiang Liu

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Thrombus composition and its implication in ischemic stroke assessment and revascularization treatments by Juan Marta-Enguita, Florencio J.D. Machado, Josune Orbe, Roberto Muñoz

“…However, other factors such as clot formation time, associated inflammatory status, or activation of additional immune and coagulation pathways (neutrophil extracellular trap [NET] delivery, platelet aggregation, endothelial activation, and von Willebrand Factor release) have been described as determinants in thrombus characteristics. …”
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Healthy at home for COPD: an integrated digital monitoring, treatment, and pulmonary rehabilitation intervention by Laurel O’Connor, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Biqi Wang, Brandon Savage, Thomas Scornavacca, Jeanne Shirshac, Tracey Wilkie, Michael Hyder, Adrian Zai, Shaun Toomey, Marie Mullen, Kimberly Fisher, Emil Tigas, Steven Wong, David D. McManus, Eric Alper, Peter K. Lindenauer, Eric Dickson, John P. Broach, Vik Kheterpal, Apurv Soni

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Electrocardiographic signs of cardiac ischemia at rest and during exercise in patients with COPD traveling to 3,100 m: data from a randomized trial of acetazolamide by Marla Christen, Marla Christen, Aline Buergin, Aline Buergin, Maamed Mademilov, Maamed Mademilov, Laura Mayer, Laura Mayer, Simon R. Schneider, Simon R. Schneider, Mona Lichtblau, Mona Lichtblau, Talant M. Sooronbaev, Talant M. Sooronbaev, Silvia Ulrich, Silvia Ulrich, Konrad E. Bloch, Konrad E. Bloch, Michael Furian, Michael Furian

“…IntroductionIn patients with chronic obstructive pulmonary disease (COPD), oxygen delivery to the heart may be impaired during travel at altitude. …”
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Emerging burden of post-cancer therapy complications on unplanned hospitalisation and costs among Australian cancer patients: a retrospective cohort study over 14 years by Rashidul Alam Mahumud, Md. Shahjalal, Padam Kanta Dahal, Md. Parvez Mosharaf, Sabuj Kanti Mistry, Kamrun Nahar Koly, Sujana Haque Chowdhury, Andre M. N. Renzaho, Jeff Gow, Khorshed Alam, Olivia Wawryk

“…The results highlight the need for better-customized treatment delivery strategies to address this burden and optimise resources in cancer care.…”
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Pilot study of a ketogenic diet in bipolar disorder: a process evaluation by Benjamin P. Rigby, Nicole Needham, Helen Grossi, Ivana Kamenska, Iain H. Campbell, Ben Meadowcroft, Frances Creasy, Cheryl Fisher, Pankaj Bahuguna, John Norrie, Gerard Thompson, Melissa C. Gibbs, Maja Mitchell-Grigorjeva, Ailsa McLellan, Tessa Moses, Karl Burgess, Rachel Brown, Michael J. Thrippleton, Harry Campbell, Daniel J. Smith, Sharon A. Simpson

“…Results Five themes were identified in the qualitative data: (1) ‘Encouraging entry and supporting exit’ (e.g. recognising and managing participants’ varied motives and expectations, including around weight loss and symptom alleviation); (2) ‘Challenging but potentially transformational,’ which reflects that while it can be difficult to initiate and maintain a ketogenic diet day-to-day, many participants perceived physical and psychological benefits (e.g. significant weight loss, mood stability and enhanced ability to focus); (3) ‘Intervention facilitators,’ including a range of behavioural (e.g. goal setting), social (e.g. family and dietitians) and technological (e.g. apps for monitoring) support mechanisms; (4) ‘Intervention barriers’ (e.g. dietary preferences, concerns about the diet and its impact, the testing burden and capacity of the delivery team); and (5) ‘The wider context’ (e.g. the cost of living and sociocultural expectations) was a crucial factor explaining differential experiences. …”
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Administration of Sex Hormone Preparations as a Risk Factor in the Development of Intrahepatic Cholestasis of Pregnancy and Biliary Sludge in Pregnant Women by Yu. B. Uspenskaya, I. V. Kuznetsova, A. A. Sheptulin, N. V. Goncharenko, A. N. Gerasimov, M. M. Amiraslanova

“…Patients with ICP were treated with UDCA in a dose of 500–2000 mg until delivery. Biochemical laboratory parameters in the ICP group were evaluated after 1 and 2 weeks of treatment.Results.  …”
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Incidence of unintended pregnancies and pregnancy experience among adolescents living with perinatally-acquired HIV in West Africa: a mixed-method study by Désiré Lucien Dahourou, Clément Tisseron, Caroline Yonaba, Joël Djaha, Marie-Sylvie N’Gbeche, Corinne Moh, Kouakou Kouadio, Patricia Nindjin, François Eboua, Belinda Bouah, Karen Malateste, Jean-Claude Azani, Eulalie Kangah, Elisabeth Thio, Philippe Msellati, Julie Jesson, Valériane Leroy, for the IeDEA West-African Collaboration

“…They reported major financial challenges associated with their pregnancy that forced them to find a job rather than going back to school after delivery. Conclusions In West Africa, the incidence of unintended pregnancy was high among female ALHIV and resulted in negative socioeconomic outcomes. …”
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What are the barriers to the diagnosis and management of chronic respiratory disease in sub-Saharan Africa? A qualitative study with healthcare workers, national and regional polic... by Angela Obasi, Rachel Tolhurst, Kingsley Rex Chikaphupha, Miriam Taegtmeyer, Kevin Mortimer, Louis Niessen, Maia Lesosky, Jahangir Khan, William Worodria, Jamie Rylance, Lindsay Zurba, Imelda Bates, Stellah G Mpagama, Elizabeth Henry Shayo, Rose Oronje, Emmanuel Addo-Yobo, Brian Allwood, Hastings Banda, Amsalu Binegdie, Adegoke Falade, Bertrand Mbatchou, Beatrice Mutayoba, Nyanda Elias Ntinginya, Heather Zar, Eliya Zulu, Helen Meme, Uzochukwu Egere, Asma Elsony, Martha Chinouya, S Bertel Squire, Stephen Mulupi, Irene Ayakaka, Nicole Kozak, Elhafiz Abdalla, Rashid Osman

“…At the healthcare facility level, inadequate budgetary allocations constrained diagnostic capacity, quality of service delivery and collection of appropriate data, compounding the lack of routine data on burden of disease.Conclusion Health systems in the five countries are ill-equipped to respond to CRD, an issue that has been brought into sharp focus as countries plan for post-COVID-19 lung diseases. …”
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MANIFESTATION OF COVID-19 IN THE SECOND TRIMESTER OF PREGNANCY: FEATURES OF GESTATION, OBSTETRIC AND PERINATAL OUTCOMES by Людмила Станиславовна Ищенко, Екатерина Евгеньевна Воропаева, Элла Алексеевна Казачкова, Евгений Леонидович Казачков, Татьяна Николаевна Шамаева, Елена Романовна Вейсенборн, Юлия Сергеевна Ищенко

“…During the period of convalescence after severe COVID-19, a statistically significantly higher incidence of diabetes mellitus that developed during pregnancy is recorded (p < 0.001; p1.3 = 0.001; p2.3 = 0.002; p3.5 < 0.001). Delivery is associated with a statistically significant increase in the rate of cesarean section in convalescents with mild and moderate COVID-19 compared with uninfected pregnant women (p = 0.002; p1.5 = 0.001; p2.5 < 0.001). …”
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The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018. by May Nawal Lutfiyya, Linda Feng Chang, Cynthia McGrath, Clark Dana, Martin S Lipsky

“…Primary care was the most common care delivery setting and measures related to chronic disease the most commonly measured outcomes. …”
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