Engineered biomimetic cisplatin-polyphenol nanocomplex for chemo-immunotherapy of glioblastoma by inducing pyroptosis by Xinyan Hao, Yucheng Tang, Wenjie Xu, Ming Wang, Jiayi Liu, Yongjiang Li, Jun He, Yanjin Peng, Pengcheng Sun, Dehua Liao, Xiongbin Hu, Tiantian Tang, Min Zhou, Ruyue Han, Jiemin Wang, João Conde, Daxiong Xiang, Junyong Wu

“…Notably, cisplatin (CDDP) demonstrated a capacity of inducing pyroptosis by activating caspase-3 to cleave GSDME, coupled with the release of proinflammatory factors, indicating the potential as a viable approach of inducing anti-tumor immune activation. For the effective delivery of CDDP, the CDDP-polyphenol nanocomplexes were prepared, and catalase and copper ions were incorporated to fortify structural integrity, enhance glutathione (GSH) responsiveness, and ameliorate tumor hypoxia. …”
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Services availability and readiness assessment of adolescent sexual and reproductive health in primary healthcare facilities: evidence from selected districts in Ghana by Michel Adurayi Amenah, Jacob Novignon, Ama Pokuaa Fenny, Irene A. Agyepong, Tim Ensor

“…Targeted interventions are necessary to elevate the quality and accessibility of ASRH services, ensuring equitable health care delivery across all regions. Future research should expand to other regions to validate these findings and inform nationwide health strategies.…”
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Vaginal colonization, vertical transmission rate, antimicrobial susceptibility profile, and associated factors of potential neonatal pathogens among pregnant women at public health... by Getnet Shimeles, Getnet Shimeles, Alemu Gedefie, Hilina Motbainor, Chalachew Genet, Chalachew Genet

“…Finally, variables with p < 0.05 and their 95% confidence interval were considered statistically significant.ResultsA total of 348 pregnant women attending vaginal delivery were included in the study. The maternal colonization and vertical transmission rates were 55.5% (193/348) and 53.9% (104/348), respectively. …”
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Meta-synthesizing of Practices of Corporate Social Responsibility: External Stake-holders Approach by Maryam Khalatbari Moazam, Hamidreza Yazdani, Naser Asgari

“…The classifications of actions related to customers are delineated based on the nature of customer interactions, the quality of customer service provided, the intrinsic qualities of the products, and the delivery methods of these products. Additionally, the expectations of stakeholders compel banks not only to act ethically towards their suppliers and competitors but also to avoid any unethical practices. …”
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Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis by Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

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Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells by Annarita Nappi, Vittoria D’Esposito, Caterina Miro, Alessia Parascandolo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Sepehr Torabinejad, Federica Restolfer, Maddalena Raia, Melania Murolo, Emery Di Cicco, Pietro Formisano, Monica Dentice

“…Furthermore, a surgery-free intraductal delivery model, i.e., the Mouse-INtraDuctal (MIND) injection method, was used as a tool for in vivo characterization of breast tumor formation and progression. …”
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Association between childhood immunisation coverage and proximity to health facilities in rural settings: a cross-sectional analysis of Service Provision Assessment 2013–2014 facil... by Ahmad Reza Hosseinpoor, Nicole E Johns, Mike Chisema, M Carolina Danovaro-Holliday, Katherine Kirkby, Anne Schlotheuber, Messeret Shibeshi, Samir V Sodha, Boston Zimba

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Exploring Health Educational Interventions for Children With Congenital Heart Disease: Scoping Review by Neda Barbazi, Ji Youn Shin, Gurumurthy Hiremath, Carlye Anne Lauff

“…The review identifies the types of interventions, target populations, delivery methods, and assessed outcomes. The goal is to consolidate fragmented research, identify gaps, and establish future research agendas. …”
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Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study by Josefin Hagström, Charlotte Blease, Arja Harila, Päivi Lähteenmäki, Isabella Scandurra, Maria Hägglund

“…The findings indicated the importance of increased education, dialogue, and flexibility to uphold confidential and consistent delivery of adolescent health care. Further exploration is needed to understand the experiences of adolescents and parents in diverse clinical and geographic contexts, as well as the perspectives of pediatric health care professionals on restrictive ORA regulations.…”
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Aplikasi Sistem Informasi Manajemen Pengiriman Barang PT. GST by Indra Budi Trisno, Darmanto Darmanto, Dimas Febrian Elvianto

“…The objective of the research was to develop a management information system to give better support for delivery service quality and produce performance report in order to assist management to give better insight about company issues, so they can decide better policy. …”
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Efficacy and safety of ketamine and esketamine in reducing the incidence of postpartum depression: an updated systematic review and meta-analysis by Moaz Yasser Darwish, Abdallah A. Helal, Yousif Ahmed Othman, Manar Alaa Mabrouk, Aya Alrawi, Taha Abd-ElSalam Ashraf, Nada K. Abdelsattar, Fatma Mohammed Sayed, Mohamed Abd-ElGawad

“…We included studies which investigated the preventive effect of ketamine or esketamine on PPD among women after giving birth through caesarean or vaginal delivery. We extracted PPD occurrence rate, PPD score, pain score and side effects. …”
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Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy by Linda Tartaglione, Enrico di Stasio, Angelo Sirico, Mauro Di Leo, Salvatore Caputo, Alessandro Rizzi, Agnese Caneschi, Sara De Carolis, Dario Pitocco, Antonio Lanzone

“…After evaluation of one week of SMBG, 21 required diet therapy and 12 required insulin treatment and were followed until the delivery. An increase in gestational weight gain was observed in normal women with normal OGTT but this was not significant. …”
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Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial by Mohamed Abdelrahman, Neil Cowan, Meera Ramcharn, Bassel H Al Wattar, William Parry-Smith, Sarah McRobbie, Michael Rimmer, Nagla Elfaki, Cheryl Dunlop, Damien Coleburt, Olivia Raglan, Jhia Jiat Teh, Maria Fisher, Nilaani Murugesu, Yazid Jibrel, Matthew Wood

“…Videoconferencing technology can facilitate the delivery of JCs, however, there remains no evidence on the role of web-based virtual JCs in promoting the acquisition and retention of medical knowledge. …”
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DNA-based hydrogels for bone regeneration: A promising tool for bone organoids by Xiang Wu, Yan Hu, Shihao Sheng, Huijian Yang, Zuhao Li, Qinglin Han, Qin Zhang, Jiacan Su

“…Furthermore, the bone microenvironment can be finely tuned by leveraging the degradation products, nanostructure, targeting, and delivery capabilities inherent to DNA-based materials. …”
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Glycemic control in women with GDM: insights from a randomized controlled pilot trial on plant-based Nordic healthy diet versus moderately carbohydrate restricted diet by Lisa Torsdatter Markussen, Jemina Kivelä, Jaana Lindström, Miina Ollikainen, Mikko Kytö, Seppo Heinonen, Saila Koivusalo, Jelena Meinilä

“…Methods Forty-two participants were randomized to either HND (n = 20) or MCRD (n = 22) face-to-face nutritional counseling from gestational weeks (GW) 24 + 0—28 + 6 (baseline) until delivery. The HND intervention had no restriction in carbohydrate intake and emphasized plant-based protein sources and Nordic food, while the MCRD had a moderate carbohydrate restriction (~ 40% in proportion to total daily energy consumption, E%). …”
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Preterm preeclampsia screening and prevention: a comprehensive approach to implementation in a real-world setting by Stefania Ronzoni, Shamim Rashid, Aimee Santoro, Elad Mei-Dan, Jon Barrett, Nanette Okun, Tianhua Huang

“…High-risk group for preeclampsia had higher incidences of adverse outcomes, including preterm preeclampsia (7.5 vs 0.4%; p < 0.001), preterm delivery (21.2 vs 6.2%; p < 0.001), low birth weight (23.3 vs 5.6%; p < 0.001) and birthweight < 10th percentile (11% vs 5.6%; p = 0.015) compared to low-risk group. …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…Particular attention is given to electrospun NFs for pharmaceutical applications (e.g., original drug delivery systems) and tissue regeneration (e.g., as tissue scaffolds). …”
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Efficiency enhancement in main path extraction in mRNA vaccine field: A novel approach leveraging intermediate patents, with shielding origin and terminus patent edges by Ting Zhang, Zhongquan Jian, Juan Chen, Dongzi Xu, Xiaoyi Yang, Yan Lu, Shu Yan, Lizi Pan, Qingqiang Wu, Zhaolian Ouyang

“…The patents on the main paths predominantly focus on nucleic acid modifications and delivery systems. The local backward main paths identify a greater number of patents, especially those related to litigation, offering a richer and more diverse set of technological insights. …”
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Conversion from Nonshockable to Shockable Rhythms and Out-of-Hospital Cardiac Arrest Outcomes by Initial Heart Rhythm and Rhythm Conversion Time by Wanwan Zhang, Shengyuan Luo, Daya Yang, Yongshu Zhang, Jinli Liao, Liwen Gu, Wankun Li, Zhihao Liu, Yan Xiong, Ahamed Idris

“…Among 24,849 adult OHCA patients of presumed cardiac etiology with initial asystole or PEA in the Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry (version 3, 2011–2015), we examined the association of shockable rhythm conversion with prehospital return of spontaneous circulation (ROSC), survival, and favorable functional outcome (modified Rankin Scale score ≤3) at hospital discharge by initial rhythm and rhythm conversion time (time from cardiopulmonary resuscitation (CPR) initiation by emergency medical providers to first shock delivery), using logistic regression adjusting for key clinical characteristics. …”
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Polyphenols and pectin enriched golden kiwifruit (Actinidia chinensis) alleviates high fructose-induced glucolipid disorders and hepatic oxidative damage in rats: in association wi... by Aamina Alim, Ting Li, Tanzeela Nisar, Zeshan Ali, Daoyuan Ren, Yueyue Liu, Xingbin Yang

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