Virtual primary care for people living with dementia in Canada: cross-sectional surveys of patients, care partners, and family physicians by Vladimir Khanassov, Deniz Cetin-Sahin, Sid Feldman, Saskia Sivananthan, Allan Grill, Isabelle Vedel

“…Abstract Background Virtual care (VC) for dementia in primary care settings is an important aspect of healthcare delivery in Canada. However, the evidence informing optimal and sustainable provision of VC for persons living with dementia (PLWD) and their care partners is scarce. …”
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Synergistic strategies for glioblastoma treatment: CRISPR-based multigene editing combined with immune checkpoint blockade by Xiaolin Liu, Xiao Liu, Xiaonan Luo, Maorong Zhu, Nannan Liu, Juan Li, Qi Zhang, Cheng Zou, Yuxin Wu, Zhengcong Cao, Shuangxin Ma, Weizhong Wang, Guangzhao Yang, Jintao Gu, Wei Liu, Meng Li, Anan Yin, Yalong He, Wei Lin

“…Thus, we have developed an engineered multifunctional extracellular vesicle (EV) delivery system that offers an "all-in-one" strategy for GBM therapy. …”
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Internal Dosimetry in Patients Undergoing Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-[DOTA0-Tyr3] Octerotate: A Single-Center Experience by Elahe Mahmoudi, Mahasti Amoui, Mohammad Reza Deevband, Elahe Pirayesh, Mohammad Reza Asgari, Mehdi Ghorbani

“…It is a form of targeted drug delivery, which is applicable to treat neuroendocrine tumors. …”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…By enhancing CCR, healthcare teams can improve patient outcomes and ensure safer healthcare delivery. Clinical trial number Not required, as this is not a clinical trial and does not involve any healthcare interventions with human participants.…”
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Targeted genome modifcation in protoplasts of a highly regenerable Siberian barley cultivar using RNA-guided Cas9 endonuclease by S. V. Gerasimova, A. M. Korotkova, C. Hertig, S. Hiekel, R. Hofe, N. Budhagatapalli, I. Otto, G. Hensel, V. K. Shumny, A. V. Kochetov, J. Kumlehn, E. K. Khlestkina

“…Site-directed plant genome modifcation by this technology involves the construction of Cas endonuclease- and guide-RNA-encoding vectors, delivery of the plasmid DNA into plant cells, processing of the chosen genomic target site by the corresponding gene products and regeneration of plants from modifed cells. …”
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The analysis of energy efficiency of LNG filling pipeline from choice of thermal insulation structure by A. M. Andreev, A. Yu. Baranov, E. V. Sokolova, T. A. Malysheva, L. V. Ivanov

“…The article presents the numerical analysis of the energy efficiency for one of the stages of large-scale LNG production, namely, the LNG delivery from a storage tank to a LNG carrier vessel via a cryogenic pipeline. …”
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Analisa Tingkat Kematangan Literasi Tik Pada Tenaga Kesehatan Dalam Pelayanan Kesehatan Berbasis TIKDi Puskesmas Kota Palembang by Istiqomah Febrianty, Darius Antoni, Dedy Syamsuar, Diana Diana

“…ICT Literacy is becoming increasingly important for health officer Puskesmas at Palembang City to improving the efficiency and quality of health service, including ICT-based health service applications, use of social media (WhatsApp, Facebook, Instagram, and website) as a medium for information, promotion, communication and delivery of advice to the public. The purpose of this research is to evaluate Maturity Level of ICT Literacy in Health Officers towards ICT-based health service aplications and social media using a quantitative approach analiyzed descriptively. …”
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A Decision Cloud Ranking Approach Based on Privacy and Security in Blockchain E-Health Industry 4.0 Systems by Sarah Qahtan, Khaironi Yatim, Mohd Hafeez Osman, Hazura Zulzalil, Muhammad Luqman Mahamad Zakaria

“…The implications of this study can lead to better decision-making, improved security and privacy, increased competition, and widespread adoption, ultimately contributing to more efficient and effective healthcare delivery. …”
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Building on and tailoring to: Adapting a cancer caregiver psychoeducational intervention for rural settings by Erin E. Kent, Kelly R. Tan, Zev M. Nakamura, Jesse Kovacs, Mindy Gellin, Allison Deal, Eliza M. Park, Maija Reblin

“…Changes enhanced fit through the following adaptations: changes to social support domains, session content, interventionist training, resource offerings, screening and recruitment processes, and virtual delivery. Discussion Challenges to establishing successful psychosocial oncology interventions may be improved through participant‐centered approaches and implementation science. …”
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Oncolytic Viruses and Immunotherapy for the Treatment of Uveal Melanoma and Retinoblastoma: The Current Landscape and Novel Advances by Merve Kulbay, Nicolas Tuli, Massimo Mazza, Armaan Jaffer, Sarinee Juntipwong, Emily Marcotte, Stuti Misty Tanya, Anne Xuan-Lan Nguyen, Miguel N. Burnier, Hakan Demirci

“…., virus capsid proteins and encapsulation technologies, vectors for delivery, cell targeting) and immunotherapy. The most recent advances in preclinical- and clinical-phase studies are further summarized. …”
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Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus by Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang

“…Abstract Recombinant adeno-associated virus (rAAV) has emerged as the vector of choice for in vivo gene delivery, with numerous clinical trials underway for the treatment of various human diseases. …”
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Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination by Yue Zhang, Xia Lei, Hongdan Xu, Guoliang Liu, Yeqiu Wang, Huifeng Sun, Fang Geng, Ning Zhang

“…These results provide reliable data support for further study of the pharmacological mechanism of TFDR, formulation of drug delivery schemes, and development of new Chinese medicines in the treatment of AD.…”
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Top health service concerns: a data mining study of the Shanghai health hotline by Lili Shi, Tong Zhao, Shimiao Shi, Tianyu Tan, Aksara Regmi, Yuyang Cai

“…Additionally, the data reveals considerable public concern about the availability and quality of medical services, suggesting that existing policies on resource allocation and service delivery may not adequately meet population needs. …”
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Time to Reconsider the Straddle-Arm Technique: Providing Care for the Conscious Infant who is Choking

“…The practice of straddling the infant’s legs on the rescuer’s upper arm continues to be one method taught to support the infant in the delivery of back blows and chest thrusts in the clearing of a foreign body airway obstruction (FBAO) for a conscious infant. …”
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Non-pharmacological interventions for the reduction and maintenance of blood pressure in people with prehypertension: a systematic review protocol by Paul Rutter, Andrew Clegg, Valerio Benedetto, Caroline Watkins, Nefyn Williams, Joseph Spencer, Lucy Hives, Emma P Bray, Cath Harris, Rachel F Georgiou, Nafisa Iqbal

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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Collectively, our findings suggest that TMEM45A may be a therapeutic target for overcoming palbociclib resistance, and exosomal siRNA delivery could be a viable strategy for precision medicine in HR+ breast cancer.…”
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Congenital cytomegalovirus - current state of knowledge on the treatment and prevention of fetuses and newborns by Katarzyna Miedzińska, Mateusz Grego, Łukasz Stojak, Dariusz Popiela, Karina Urbańska, Filip Kwiatkowski, Mateusz Baczewski, Witold Czyż

“…Importantly, a child who is asymptomatic at the time of delivery is still at risk of developing dysfunctions in the future. …”
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Enhanced membrane protein production in HEK293T cells via ATF4 gene knockout: A CRISPR-Cas9 mediated approach by Byung-Jo Choi, Ba Reum Kim, Ho Joong Choi, Ok-Hee Kim, Say-June Kim

“…Gene editing efficiency was compared between the two delivery systems, with the two-vector system demonstrating higher efficiency based on T7E1 assays. …”
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Highlights of Thirty-Year Experience of CO2 Laser Use at the Florence (Italy) Department of Dermatology by Piero Campolmi, Paolo Bonan, Giovanni Cannarozzo, Andrea Bassi, Nicola Bruscino, Meena Arunachalam, Michela Troiano, Torello Lotti, Silvia Moretti

“…Considering that the continuous wave CO2 laser delivery system and the newer “superpulsed” and scanned CO2 systems have progressively changed our practice and patient satisfaction, a long range documentation can be useful. …”
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Magnitude and Risk of Dying among Low Birth Weight Neonates in Rural Ethiopia: A Community-Based Cross-Sectional Study by Akine Eshete, Abebe Alemu, Taddes Alemu Zerfu

“…The estimated hazard ratios of mortality were higher among neonates whose mothers did not attend antenatal care (ANC) (HR=1.58, 95 % CI: 1.02-2.43), gave birth by assisted or cesarean delivery (HR=1.81 and 3.72; 95% CI: 1.10 - 3.02 and 2.11-6.55), and experienced some form of illness during pregnancy (HH=3.34, 95 % CI: 2.11-5.29), respectively. …”
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