Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…In H9C2 cell models, our results demonstrated that YQFM partially prevented defects in SERCA2. Conclusion: Our study demonstrated that YQFM may function as a positive cardiac contractility modulator and therapeutic agent for cardiac protection by restoring SERCA2 expression in cardiomyocytes in HF after myocardial infarction (MI).…”
Get full text

Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents by Gumelar Gugun, Ulfa Mia Maria, Amukti Danang Prasetyaning, Irham Lalu Muhammad, Yuliani Sapto, Adikusuma Wirawan, Khairi Sabiah, Darmawi Darmawi, Chong Rockie, Ates Ilker, Singh Dilpreet, Chavan Aditya Ashok

“…The data was then screened using SNPnexus to detect potentially protein-damaging variants. Furthermore, the gene expression of these variants was analysed using the GTEx portal. …”
Get full text

Analisis Perilaku Entitas untuk Pendeteksian Serangan Internal Menggunakan Kombinasi Model Prediksi Memori dan Metode PCA by Rahmat - Budiarto, Yanif Dwi Kuntjoro

“…External attacks can be prevented using firewalls, anti-virus software, and special software for intruder and malware detection. This study intention is to build a model for analyzing entity behavior using a memory prediction model and uses the principal component analysis (PCA) as a feature selection method and implement it to detect cyber-attacks and anomalies involving insiders. …”
Get full text

Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Conditional deletion of Nrf2 in CD8TILs abrogates mTORC1 activation and antitumor immunity by Met. …”
Get full text

Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…Consistent with the role of these proteins in BMC assembly and metabolism, deletion of eutN, eutL/eutM1/eutM2, or eutL/eutM1/eutM2/eutN not only affected BMC formation but also ethanolamine utilization, causing cell growth defects with ethanolamine as a nutrient. …”
Get full text

Perbandingan Prediksi Penggunaan Listrik dengan Menggunakan Metode Long Short Term Memory (LSTM) dan Recurrent Neural Network (RNN) by Nurfatima Selle, Novanto Yudistira, Candra Dewi

“…Perbandingan antar RNN dan LSTM menghasilkan LSTM mampu menghasilkan kinerja yang lebih baik pada penggunaan deret waktu yang lebih panjang.   Abstract Electrical energy has become one of the most important needs and helped human life nowadays. …”
Get full text

Investigation of the dose and structure effects of lipid oxidation products aldehydes on the generation of heterocyclic amines: A case study of 2-amino-1-methyl-6-phenylimidazo [4,... by Mantong Zhao, Zhongyuan Liu, Mengyin Zha, Ying Sun, Haohao Shi, Xueying Zhang, Chuan Li, Guanghua Xia

“…It was observed the aldehydes that contribute to thiobarbituric acid reactive substances (TBARS) value significantly promoted PhIP generation (p < 0.05). The defat treatment of fresh fish tissue significantly reduced the PhIP formation in pan-fried products (p < 0.05). …”
Get full text

Prediksi Produksi Biofarmaka Menggunakan Model Fuzzy Time Series dengan Pendekatan Percentage Change dan Frequency Based Partition by Dwi Ekasari Harmadji, Solikhin Solikhin, Uky Yudatama, Agus Purwanto

“…Saat ini belum dijumpai studi peramalan deret waktu untuk memprediksi produksi biofarmaka dengan tingkat akurasi baik. …”
Get full text

Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
Get full text

Segmentasi Citra X-Ray Dada Menggunakan Metode Modifikasi Deeplabv3+ by Rima Tri Wahyuningrum, Maughfirotul Jannah, Budi Dwi Satoto, Amillia Kartika Sari, Anggraini Dwi Sensusiati

“…As an alternative, radiographic images such as chest x-rays and CT scans can help detect this. Radiographic images, especially x-rays, need processing to be able to make a diagnosis. …”
Get full text

Kontrol Level Kecepatan Kipas Melalui Deteksi Gestur Jari Tangan Menggunakan MediaPipe dan Faster-RCNN by Muhammad Aldi Fakhruddin, Heri Pratikno, Musayyanah, Weny Indah Kusumawati

“…The results of the average accuracy test detection of finger gestures using the MediaPipe at a distance of 10 cm (37%), a distance of 50 cm (70%), a distance of 100 cm (54.7%), and a distance of 175 cm (63.3%). …”
Get full text

A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence by Hennart, Mélanie, Crestani, Chiara, Bridel, Sébastien, Armatys, Nathalie, Brémont, Sylvie, Carmi-Leroy, Annick, Landier, Annie, Passet, Virginie, Fonteneau, Laure, Vaux, Sophie, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain

“…Genomic sequencing can inform on transmission routes and genotypes of concern, but currently, no standard approach exists to detect clinically important genomic features and to interpret emergence in the global C. diphtheriae population framework. …”
Get full text

Benefits of a second tandem flight phase between two successive satellite altimetry missions for assessing instrumental stability by M. Ablain, N. Lalau, B. Meyssignac, R. Fraudeau, A. Barnoud, G. Dibarboure, A. Egido, C. Donlon

“…Nevertheless, it is only feasible to detect instrumental drifts in the global mean sea level exceeding 1.0 to 1.5 mm yr<span class="inline-formula">⁻¹</span> due to the brief duration of the tandem phase (9 to 12 months). …”
Get full text

Editorial by Daniel Halliday

“…On the other hand, there are reasons to defend intergenerational wealth transfers as a means through which families can retain important assets, like a cherished home, and so that parents can exercise a degree of partiality towards their offspring or other chosen recipients. …”
Get full text

Psychosocial risks and mental health of health and social care workers in the context of the COVID-19 pandemic by Nadia Vilahur Chiaraviglio

“…Further investment is necessary to ensure decent work conditions in all professions in the sector. …”
Get full text

A Candidate High-velocity Exoplanet System in the Galactic Bulge by Sean K. Terry, Jean-Philippe Beaulieu, David P. Bennett, Aparna Bhattacharya, Jon Hulberg, Macy J. Huston, Naoki Koshimoto, Joshua W. Blackman, Ian A. Bond, Andrew A. Cole, Jessica R. Lu, Clément Ranc, Natalia E. Rektsini, Aikaterini Vandorou

“…The ∼10 yr baseline between the microlensing event and the Keck follow-up observations allows us to detect the faint candidate lens host (star) at K = 22.3 mag and confirm the distant lens system interpretation. …”
Get full text

Pearls on a String: Dark and Bright Galaxies on a Strikingly Straight and Narrow Filament by M. Arabsalmani, S. Roychowdhury, B. Schneider, V. Springel, E. Le Floc’h, F. Bournaud, A. Burkert, J.-C. Cuillandre, P.-A. Duc, E. Emsellem, D. Galárraga-Espinosa, E. Pian, F. Renaud, M. A. Zwaan

“…We study the cold H i gas in a 1.3 Mpc section of the filament through H i 21 cm emission line observations and detect 11 H i sources, many more than expected from the H i mass function in a similar volume. …”
Get full text

ASKAP Observations of the Radio Shell in the Composite Supernova Remnant G310.6-1.6 by Wenhui Jing, Jennifer L. West, Xiaohui Sun, Wasim Raja, Xianghua Li, Lingxiao Dang, Ping Zhou, Miroslav D. Filipović, Andrew M. Hopkins, Roland Kothes, Sanja Lazarević, Denis Leahy, Emil Lenc, Yik Ki Ma, Cameron L. Van Eck

“…We report the observations of the radio shell of the supernova remnant (SNR) G310.6–1.6 at 943 MHz from the Evolutionary Map of the Universe (EMU) and the Polarization Sky Survey of the Universe’s Magnetism (POSSUM) surveys by using the Australian Square Kilometre Array Pathfinder (ASKAP). We detect polarized emission from the central pulsar wind nebula (PWN) with rotation measures varying from –696 rad m ^−2 to –601 rad m ^−2 . …”
Get full text

Comparative functional analysis of a new CDR1-like ABC transporter gene in multidrug resistance and virulence between Magnaporthe oryzae and Trichophyton mentagrophytes by Jing Wang, Chenwen Xiao, Shuang Liang, Muhammad Noman, Yingying Cai, Zhen Zhang, Xueming Zhu, Rongyao Chai, Haiping Qiu, Zhongna Hao, Yanli Wang, Jiaoyu Wang, Guolian Bao, Guochang Sun, Fucheng Lin

“…Moreover, MoCDR1 also rescued the defects in drug sensitivity and virulence of ΔTmcdr1. …”
Get full text

The sport and Lithuanian national identity by Ingvaras Butautas, Rasa Čepaitienė

“…Paradoxically, Lithuanians fancy themselves due to basketball victories, but perhaps they are better known for football defeats. In opposition to the rest of Europe, basketball truly is the most popular sport in Lithuania, yet till now, nobody has tried to analyze the historical and socio-cultural reasons for such a phenomenon in a more thorough way.  …”
Get full text