Does Baseline Serum Androgen Levels Have an Impact on Ovulation Induction Cycle Outcomes by Using Clomifene Citrate among Infertile Women with Polycystic Ovary Syndrome? A Retrospe... by Serkan Kahyaoglu, Muzeyyen Gulnur Ozaksit, Gozde Karacan Duman, Deniz Ozturk Atan, Inci Kahyaoğlu, Meryem Kuru Pekcan, Ozlem Moraloglu Tekin

“…CONCLUSION: Lower or higher levels of androgenic milieu within the ovaries result in defective folliculogenesis and ovulation failure. Increased serum levels of free testosterone which is a proxy for ovarian androgen production might be a detrimental factor for clinical pregnancy rates of women with polycystic ovary syndrome by impairing proper folliculogenesis. …”
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CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions by Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

“…On the contrary, the loss of Thr495 phosphorylation by the phosphorylation-defective mutant DUB3 T495A, the cancer-related mutant DUB3 D496H and CK2 inhibition failed to deubiquitinate and stabilize YAP1 effectively. …”
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Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stress by Purva V. Gade, Angela Victoria Rojas Rivera, Layla Hasanzadah, Sofie Strompf, Thomas Raymond Philipson, Matthew Gadziala, Atharva Tyagi, Arnav Bandam, Rithvik Gabbireddy, Fatah Kashanchi, Amanda Haymond, Lance A. Liotta, Marissa A. Howard

“…Mitophagy is a critically important survival mechanism in which toxic, aged, or defective mitochondria are segregated into mitophagosomes, which shuttle the damaged mitochondrial segments to the lysosome and proteasome for destruction. …”
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Breg Cells in Celiac Disease Isolated or Associated to Hashimoto’s Thyroiditis by Maria Giulia Santaguida, Ilenia Gatto, Giorgio Mangino, Camilla Virili, Ilaria Stramazzo, Poupak Fallahi, Alessandro Antonelli, Patrizia Gargiulo, Giovanna Romeo, Marco Centanni

“…In conclusion, celiac disease, isolated and even more when associated with HT, determines a peculiar behavior of Breg cells which are increased in number but possibly functionally defective. Furthermore, the association CD + HT was characterized by a reduction of Breg memory subsets as compared with the isolated disorders. …”
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Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cells Combined with Normothermic Machine Perfusion Repairs Bile Duct Injury in a Rat Model of DCD Liver Transplantation via A... by Xuan Tian, Huan Cao, Longlong Wu, Weiping Zheng, Mengshu Yuan, Xiang Li, Hongli Song, Zhongyang Shen

“…A large number of regenerative cells appeared at the injured site, and the defective bile duct epithelium was restored. Dilatation of peribiliary glands (PBGs), proliferation of PBG cells, high expression of vascular endothelial growth factor (VEGF), and increased proportion of bile duct progenitor cells with stem/progenitor cells biomarkers were observed. …”
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Non3 is an essential Drosophila gene required for proper nucleolus assembly by E. N. Andreyeva, A. A. Ogienko, A. A. Yushkova, J. V. Popova, G. A. Pavlova, E. N. Kozhevnikova, A. V. Ivankin, M. Gatti, A. V. Pindyurin

“…The strongest lethal allele (Non3∆600) is a genetically null allele that carries a large deletion of the gene and exhibits early lethality when homozygous. …”
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Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy by Kun Wang, Yingying Zhang, Zhaoming Su, Bei Wang, Yuanyang Zhou, Xiaochu Tong, Chengying Xie, Xiaomin Luo, Sulin Zhang, Mingyue Zheng

“…Methods We consider CDC42 and its downstream binding and effector proteins as a gene set, as mutations in these components could lead to defective CDC42 function. To elucidate the biomarker function of mutations within the CDC42 gene set, we curated a comprehensive discovery dataset that included seven ICI treatment cohorts. …”
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The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis by Marianne G. Pouwer, Suvi E. Heinonen, Margareta Behrendt, Anne-Christine Andréasson, Arianne van Koppen, Aswin L. Menke, Elsbet J. Pieterman, Anita M. van den Hoek, J. Wouter Jukema, Brendan Leighton, Ann-Cathrine Jönsson-Rylander, Hans M. G. Princen

“…E3L and E3L.GK+/− mice developed NASH with severe inflammation and fibrosis which, however, was not altered by introduction of the defective GK phenotype, whereas mild kidney pathology with tubular vacuolization was present in all three phenotypes. …”
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Increased Fas and Bcl-2 Expression on Peripheral Blood T and B Lymphocytes from Juvenile-Onset Systemic Lupus Erythematosus, but not from Juvenile Rheumatoid Arthritis and Juvenile... by Bernadete L. Liphaus, Maria H. B. Kiss, Solange Carrasco, Claudia Goldenstein-Schainberg

“…Defective regulation of apoptosis may play a role in the development of autoimmune diseases. …”
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Soviet Russia/the USSR and transformation of the international relations system in the first half of the 1920s by E. V. Romanova

“…The author shows that, despite the prominence of ideological conflict in the development of the IR system that emerged after the First World War, continuous tensions both between the defeated and the victors and among the latter urged the political and military elites of Western states to consider the Soviet Russia as a situational partner even under the Bolsheviks rule. …”
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Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…Abstract Congenital heart disease (CHD) is a prevalent condition characterized by defective heart development, causing premature death and stillbirths among infants. …”
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Combined Open-Slot and Monopole 8 × 8 High-Isolation Broadband MIMO Antenna System for Sub-6 GHz Terminals by Jie Guo, Shaoqing Zhang, Chong-Zhi Han, Liang Zhang

“…Moreover, the isolation of two closely placed antenna elements is achieved by the parasitic strip-loading technique and defective ground techniques. Due to the decoupling techniques used in the 8 × 8 MIMO antenna system, the average isolation has been optimized from 13.2 dB to 21.9 dB and the total efficiency of each antenna element has been improved from a worst 20% to over 45%. …”
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Localization of rust resistance genes in old local Russian flaxes by methods of classical genetics by S. N. Kutuzova, E. A. Porokhovinova, N. B. Brutch, A. V. Pavlov

“…Flax rust, a disease  that  destroyed a significant portion  of the yield before  the creation  of resistant varieties, is currently defeated, but it can cause new outbreaks as identical resistance genes  are used in breeding. …”
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Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…In the context of endocrine disorders, molecular therapy is particularly effective in modulating pathogenic mechanisms such as defective insulin signaling, beta-cell dysfunction and hormonal imbalances. …”
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Depletion of key gut bacteria predicts disrupted bile acid metabolism in inflammatory bowel disease by Daniel Peterson, Christopher Weidenmaier, Sonia Timberlake, Rotem Gura Sadovsky

“…These un-isolated clades of BA-transforming bacteria merit further research; as beyond their prevalence in the human population, we found some cases in which they engrafted in IBD patients who had undergone fecal microbiota transplantation and experienced a clinical response.IMPORTANCEIn this paper, we identify specific bacteria that perform an important metabolic function in the human gut and demonstrate that in the guts of a large subset of patients with IBD, these bacteria are missing and the function is defective. This is a rare example where the correlation between the absence of specific bacteria and the dysfunction of metabolism is directly observed, not in mice nor in the lab, but in physiologic microbial communities in the human gut. …”
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Model systems of human immunodef iciency virus (HIV-1) for in vitro eff icacy assessment of candidate vaccines and drugs against HIV-1 by N. B. Rudometova, D. N. Shcherbakov, A. P. Rudometov, A. A. Ilyichev, L. I. Karpenko

“…Pseudotyped viruses have defective genomes restricting their replication to a single cycle, which renders them harmless compared to infectious viruses. …”
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Low SAR compact wideband/dual-band semicircular slot antenna structures for sub-6 GHz 5G wireless applications by Reham W. Abd-Elsalam, Hussein E. Seleem, Mostafa M. Abd-Elnaby, Amr H. Hussein

“…To minimize the antenna size and control the bandwidth, a semicircle-defected ground structure is etched beneath the radiating patch. …”
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Optimization of Truck Platoon Size in Freeway Diverging Areas Based on Comprehensive Performance Evaluation by Zhifa Yang, Zongyao Li, Zhuo Yu, Wencai Sun, Jingjing Tian

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Engineering Design of a Mechanical Decladder for Spent Nuclear Rod-Cuts by Young-Hwan Kim, Yung-Zun Cho, Young-Soon Lee, Jin-Mok Hur

“…The mechanical decladder is an apparatus for separating and recovering fuel material and cladding tubes by horizontally slitting the cladding tube of a fuel rod and a defective irradiated fuel rod. In this study, we address the engineering design of the mechanical decladder for the pretesting of rod-cut slitting. …”
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A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside by A. A. Ostanin, S. S. Kirikovich, E. V. Dolgova, А. S. Proskurina, E. R. Chernykh, S. S. Bogachev

“…The role of DBP in the resistance of organism against a number of diseases is supported by the increased risk of a variety of severe illnesses (amyotrophic lateral sclerosis, colorectal cancer etc.) in patients deficient for GcMAF due to homozygosity for defective DBP alleles. In this review, we also will examine in detail the current data i) on the structure and functions of DBP, as the main precursor of GcMAF, ii) on the main mechanisms of GcMAF anticancer effect, iii) on the tumor strategy for neutralizing GcMAF activity, iv) on the results of GcMAF clinical trials in various cancers; and will discuss the available controversies regarding the positioning of GcMAF as an effective antitumor drug.…”
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