Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression by Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An

“…The OMp showed reduced TNF-α, IL-12, and NO production as well as defective phagocytosis activity compared to nondiabetic controls; however, there was no significant difference with IL-6 production. …”
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The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis by Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

“…Remarkably, exogenous addition of laminin-511 reduced endothelial cell rounding, restored cell attachment and reversed the defective migration caused by mycolactone. Hence supplementing mycolactone-depleted extracellular matrix may be a future therapeutic avenue, to improve wound healing rates.…”
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Descriptive Investigation of Strongyloidiasis Infection and Characterization of Strongyloides stercoralis Using Morphological and Molecular-Based Methods by Nayana Gunathilaka, Nilmini Chandrasena, Tharaka Wijerathna, Yoshito Fuji, Deepa Gunasekara, Ruwan Prasanna Gunatilaka, Ranjan Premaratna

“…Diagnosis of this infection is important because of its potential to cause fatal hyperinfection syndrome or disseminated infections in those with defective cellular immunity. Parasitological methods based on faecal microscopy and culture often fail to detect low-intensity infections. …”
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Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1 by Jiraporn Ousingsawat, Khaoula Talbi, Hilario Gómez-Martín, Anne Koy, Alberto Fernández-Jaén, Hasan Tekgül, Esra Serdaroğlu, Juan Darío Ortigoza-Escobar, Rainer Schreiber, Karl Kunzelmann

“…Methods We applied electrophysiology, Ca2+ measurements and cell biological methods to analyze the molecular mechanisms that lead to aberrant intracellular Ca2+ signals and defective activation of K+ channels in patients heterozygous for the ANO3 variants. …”
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Environmental Enrichment Induces Changes in Long-Term Memory for Social Transmission of Food Preference in Aged Mice through a Mechanism Associated with Epigenetic Processes by Simona Cintoli, Maria Cristina Cenni, Bruno Pinto, Silvia Morea, Alessandro Sale, Lamberto Maffei, Nicoletta Berardi

“…We found that only EE mice successfully performed the remote memory recall task, showed neuronal activation in OFC, assessed with c-fos immunohistochemistry and early tagging of OFC, assessed with histone H3 acetylation, suggesting a defective system consolidation and early OFC tagging in aged mice which are ameliorated by EE.…”
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Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability by Wang Cong, Wang Xiangchong, Zhang Yiyi, Mi Yuan, Han Yanxue, Zhi Yaxin, Zhao Ran, Cui Nanqi, Ma Qianli, Zhang Huaxing, Xue Dazhong, Qiao Ruoyang, Han Jiabing, Yu Yulou, Li Jiaxuan, Shaiea Mohammed, Liu Demin, Gu Guoqiang, Wang Chuan

“…However, following Fgf13 deletion, interstitial fibrosis is decreased, ejection fraction and fractional shortening are increased, and heart mass is decreased, compared with those in the TAC group. …”
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Albino lethal 13, a chloroplast‐imported protein required for chloroplast development in rice by Xiaoqiong Guo, Chunli Wang, Qian Zhu, Wenhua Dongchen, Xiaoling Zhang, Wei Li, Hui Zhang, Cui Zhang, Zar Ni Naing Nant Nyein, Mengting Li, Lijuan Chen, Dongsun Lee

“…In our investigation, we identified a rice mutant with defective chloroplasts in rice (Oryza sativa L.), named albino lethal 13 (osal13), which displayed a distinct albino phenotype in leaves, ultimately resulting in seedling lethality. …”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…RTS iPSC-derived osteoblasts showed defective osteogenic differentiation and gain of in vitro tumorigenic ability. …”
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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…We observed epigenetic control of this reversible memory of generational PAH stress in F1 PAH-tolerant embryos. We detected a bivalent domain in the CYP1A promoter enhancer comprising both activating and repressive histone post-translational modifications. …”
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Plant diversity and transcriptional variability assessed by retrotransposon-based molecular markers by R. N. Kalendar, K. S. Aizharkyn, O. N. Khapilina, A. A. Amenov, D. S. Tagimanova

“…A high proportion of the retroelements have lost their autonomous transposition ability, either by point mutations and/or deletions, many of them seem to embody defective elements with deletions. …”
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Distinct gut microbial signature and altered short chain fatty acid metabolism at disease onset in a rat preclinical model of superimposed preeclampsia by Moumen M. Alhasan, María S. Landa, Silvia I. García, Roman G. Gerlach, Hani Harb, Fabian B. Fahlbusch, Melanie L. Conrad, Gabriela Barrientos

“…In this study, we assessed the gut microbiome in a rat model of superimposed preeclampsia to characterize the microbial signature associated with defective placentation processes identified at the preclinical disease stage. …”
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Partial Discharge Localization of Gas-Insulated Switchgear via Electromagnetic Time Reversal Enhanced by Windowed Phase Spectrum Cross-Correlation Criterion by Zongyao Wang, Yuan Yan, Lei Jin, Zixing Xu, Shuangzan Ren, Yanliang He, Saike Yang, Hongjie Li

“…Accordingly, this paper proposes an improved EMTR method for PD localization of GIS based on dual-sensor detection and phase spectrum cross-correlation analysis. …”
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KLJUČNI FAKTORI KOJI UTIČU NA RAZVOJ POLITIČKOG SISTEMA REPUBLIKE SRBIJE by Ratko Ljubojević, Slobodan Petrović

“…Ovi spoljni faktori refleksivno usmeravaju svoja interna političko-sociološka dešavanja na tok života i odvijanja sveukupnih društvenih procesa u Republici Srbiji. Efekte tih dešavanja osećamo intenzitetom kojim deskriptivna svest ne može da perceptuje. …”
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LEGAL INSTITUTE OF MOBILIZATION AND SOCIAL RESPONSIBILITY: THEORETICAL AND LEGAL ASPECTS OF INTERACTION AND MUTUAL INFLUENCE by Iryna Kirieieva

“…In addition, it is emphasized that mobilization and civic responsibility are one of the key components of successful defense of the Motherland. Summary  of  the  main  results  of  the  study. …”
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Monitoring process of developing system for providing temperature, air supply and filtration of transported control modules by A. A. Girchenko, A. A. Rumyantsev, A. A. Kazantsev, D. I. Bukhanets, A. V. Timoshenko, A. A. Murashev

“…The article presents an approach to formalizing the process of creating a system for providing temperature, air supply and filtration (TAFS) of transported control modules of aerospace defense complexes. The use of line graphs to control the creation of such systems has recently shown its inconsistency and requires improvement in terms of how to manage the processes of creating such systems. …”
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The influence of locus of control, coping strategies and time perspective on post-traumatic growth in survivors with primary breast cancer by Alexandra-Cristina Paunescu, Marina Kvaskoff, Cyrille Delpierre, Lidia Delrieu, Guillemette Jacob, Myriam Pannard, Marie Préau

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Impact of Charge on Strange Compact Stars in Rastall Theory by Malick Sallah, Muhammad Sharif

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Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension by Mentari Putri Pratami, Mentari Putri Pratami, Wawan Sujarwo, Miftahul Huda Fendiyanto, Ratna Yuniati, Ifan Rizky Kurniyanto, Nuniek Widiayani, Mahmoud F. Seleiman, Nawab Ali, Muhammad Fuad Anshori

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Analysis of Collective Behavior and the Psychology of the Masses. Case: October–2019, Ecuador by M. Espín, L. Vallejo, M. Gavilanez

“…The results of the investigation identified causes of the collective protests to decree 883 pronounced by the Ecuadorian government, whose effect was a series of collective behaviors, according to the psychology of the masses; these were: imitation, acting as followers, looking for affection or acceptance, frustration, repressed and controlled emotions, emotional contagion, feeling protected, defending their rights and being heard. In addition, the indigenous behavior identified included leadership, perseverance, solidarity, union, the formation of a new generation of leaders, the use of digital media, and the Andean worldview on the participation of the family clan and death. …”
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Occurrence of Equatorial Plasma Bubbles during Intense Magnetic Storms by Chao-Song Huang

“…In this study, we present the measurements of the ion density and velocity in the evening equatorial ionosphere by the Defense Meteorological Satellite Program (DMSP) satellites during 22 intense magnetic storms. …”
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