The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis by Shi-Hong Su, Xue-Qian Cai, Yong-Huai Li, Ai-Hui Xu, Qian Huang, Hua Niu, Qing-Hai You, Geng-Yun Sun

“…Methods We genotyped ten single nucleotide polymorphisms (SNPs) in ERAP1, ERAP2 genes among 497 PTB patients and 502 controls by SNPscan technique. Additionally, we detected the ERAP1, ERAP2 genes methylation levels in 98 PTB patients and 97 controls through Illumina Hiseq platform. …”
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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Testosterone production and spermatogenesis were detected at different time points through various tests. …”
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Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group by Laura Massaro, Annamaria Iagnocco, Florenzo Iannone, Corrado Campochiaro, Maria De Santis, Ilaria Cavazzana, Piero Ruscitti, Roberto Giacomelli, Rosario Foti, Lorenzo Dagna, Giovanna Cuomo, Giacomo De Luca, Francesco Caso, Ilenia Di Cola, Clodoveo Ferri, Vincenzo Raimondo, Francesco Ursini, Veronica Brusi, Giuseppe Varcasia, Roberta Pellegrini, Domenico Olivo, Giuseppe Murdaca, Carlo Selmi, Olga Addimanda, Erika Pigatto, Francesca Francioso, Rossella De Angelis, Jacopo Ciaffi, Luana Mancarella, Marcella Visentini, Francesca Motta, Virginia Caira, Alberto Lo Gullo, Caterina Naclerio, Elena Marchetti, Sebastiano Lorusso, Jessica Luppino, Roberta Foti, Massimo Reta

“…No differences were detected in the percentage of patients diagnosed with connective tissue diseases (CTD 19.7% vs 20.7%, p=0.837) or vasculitis (6.6% vs 9.0%, p=0.467). …”
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Study on exhaled volatile organic compounds identifying cognitive fatigue induced by N-back task in healthy young adults by Xiaoyu Zhang, Xiaoyan Dong, Qiang Huang, Zhe Liu, Qin Wang

“…Exhaled VOCs were collected and detected using a Bio-VOC sampler and Thermal Desorption Gas Chromatography-Mass Spectroscopy method. …”
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Relationship between caries indexes and obesity in a sample of Puerto Rican adolescents by Lydia M. Lopez del Valle, Mariely Nieves-Plaza, Sona Rivas-Tumanyan, Rosana Hanke-Herrero

“…Each participant received dental exams for caries using the criteria of the International Caries Detection and Assessment System (ICDAS), had his or her body mass index (BMI) determined, and took a 19-item risk factor questionnaire. …”
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh by Muntasir Alam, Md Saiful Islam, M. Ishrat Jahan, Arpita Shyama Deb, Afruna Rahman, Zahidul Islam, Atique Iqbal Chowdhury, Kazi Munisul Islam, Mohammad Zahid Hossain, Dilruba Ahmed, Shams El Arifeen, Emily S. Gurley, Mustafizur Rahman

“…Key L. monocytogenes virulence genes facilitating the crossing of the placental barrier, including full-length inlA, LIPI-1, and LIPI-3, were detected. The isolate was closely related to clinical L. monocytogenes isolates, as determined by GrapeTree based on cgMLST. …”
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Prevalence and risk factors of postpartum depression, general depressive symptoms, anxiety and stress (PODSAS) among mothers during their 4-week postnatal follow-up in five public... by Boon How Chew, Subashini Ambigapathy, Saidatul Akmar Mohammad Redzuan, Priyasini Suntharalingam, Thenmoli Palaniyappan, Venotha Ganasan, Puteri Normalina Megat Abu Bakar, Paream Kaur, Lili Zuryani Marmuji, V Paranthaman

“…Findings from this study will be used to identify the needs for early screening and detection, encourage development of interventions to reduce its occurrence and support mothers with PODSAS.Methods and analysis This cross-sectional study will recruit 459 postpartum mothers during their 4-week postnatal follow-up in five selected public health clinics in Perak from September 2019 to May 2020. …”
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis by Peng Zou, Tianjing Li, Zixuan Cao, Erwan Yang, Mingdong Bao, Haofuzi Zhang, Zhuoyuan Zhang, Dan Liu, Min Zhang, Xiangyu Gao, Junmiao Ge, Xiaofan Jiang, Zhicheng Tian, Peng Luo

“…In order to deeply investigate this scientific issue, we constructed a high-altitude hypoxic TBI model at different altitudes and used animal behavioral assessments (Modified neurological severity score, rotarod test, elevated plus maze test) as well as histopathological analyses (brain gross specimens, brain water content, Evans blue content, hypoxia inducible factor-1α, Hematoxylin-Eosin staining and ROS detection) to reveal its underlying principles and characteristics. …”
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Serum CXCL12 and S100A12 levels in peripheral blood fluid and their correlation with severity in patients with knee osteoarthritis by LijiangTao, Minjuan He, Yisheng Lu, Jie Zheng, Yili Ye

“…The levels of CXCL12 and S100A12 in PB and SF were detected by enzyme-linked immunosorbent assay (Elisa). …”
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Virtual online consultations: advantages and limitations (VOCAL) study by Trisha Greenhalgh, Joe Wherton, Sara Shaw, Charles Gutteridge, Emma Byrne, Isabel Hodkinson, Shanti Vijayaraghavan, Desirée Campbell-Richards, Satya Bhattacharya, Philippa Hanson, Seendy Ramoutar, Anna Collard, Joanne Morris

“…Data will be analysed and synthesised using a sociotechnical framework developed from structuration theory.Ethics approval City Road and Hampstead NHS Research Ethics Committee, 9 December 2014, reference 14/LO/1883.Planned outputs We plan outputs for 5 main audiences: (1) academics: research publications and conference presentations; (2) service providers: standard operating procedures, provisional operational guidance and key safety issues; (3) professional bodies and defence societies: summary of relevant findings to inform guidance to members; (4) policymakers: summary of key findings; (5) patients and carers: ‘what to expect in your virtual consultation’.Discussion The research literature on video consultations is sparse. …”
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Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association by V. T. Ivashkin, N. D. Yushchuk, I. V. Mayev, Tatyana L Lapina, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, A. S. Trukhmanov, A. A. Sheptulin, Ye. K. Baranskaya, O. S. Lyashenko, K. V. Ivashkin

“…At the present time several laboratory methods for diagnosis of Clostridial infection exist: fecal ELISA test for toxins A and B, PCR, test for C. difficile glutamate dehydrogenase. Detection of densely adhered to underlying mucosa greenish or creamy deposits (pseudomembranes) is the endoscopical marker of severe C. difficile-associated disease i.e. pseudomembranous colitis. …”
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A novel approach to skin disease segmentation using a visual selective state spatial model with integrated spatial constraints by Yu Bai, Hai Zhou, Hongjie Zhu, Shimin Wen, Binbin Hu, Haotian Li, Huazhang Wang, Daji Ergu, Fangyao Liu

“…Automated techniques for skin lesion segmentation assist dermatologists in early detection and ongoing monitoring of various skin diseases, ultimately improving patient outcomes and reducing healthcare costs. …”
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Unraveling the depth-dependent causal dynamics of methanogenesis and methanotrophy in a high-latitude fen peatland by Shuai Yang, Jinyun Tang, Zhen Li, Kunxiaojia Yuan, Qiong Wu, Kuang-Yu Chang, Suzanne B Hodgkins, Rachel M Wilson, Qing Zhu, Robert F Grant, William J Riley, Scott R Saleska, Virginia I Rich, Ruth K Varner

“…Next, to explore the vertical heterogeneity in CH _4 cycling, we applied the PCMCI/PCMCI+ causal detection framework with a bootstrap aggregation method to the modeling results, characterizing causal relationships among regulating factors (e.g. temperature, microbial biomass, soil substrate concentrations) through acetoclastic methanogenesis, hydrogenotrophic methanogenesis, and methanotrophy, across three depth intervals (0–10 cm, 10–20 cm, 20–30 cm). …”
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Clinical Characteristics During and After COVID‐19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China by Haoling Tang, Zhiwei Chen, Tianquan Huang, Pingping Yu, Qiao Tang, Yue Qiu, Yunling Xue, Jing Tang, Nan Cai, Hong Ren, Mingli Peng, Peng Hu

“…Results A total of 1101 HCWs were included, with SARS‐CoV‐2 infection detected in 78.20% (861/1101) during the observation period. …”
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Genomic characterization of Achromobacter genogroup 20 and identification of a potential species-specific marker by Mariana Papalia, Rocio Stucchi, Valeria Alexander, Liliana Clara, Mariángeles Visus, Gabriel Gutkind, Marcela Radice

“…The genome included coding sequences for three putative β-lactamases (one new OXA type-class D β -lactamase and two new class C), 32 efflux pump proteins, two aminoglycoside-modifying enzymes and a dihydropteroate synthase; also, substitutions in parC and parE were detected. The OXA enzyme, designated OXA-1238 (PP446293), differs from OXA-114a by 85 amino acids, with 69% identity. …”
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Socioeconomic position and breast cancer screening use in Chile: A population-based study by Camilo Guerrero-Nancuante, Pamela Eguiguren, Isabel Abarca-Baeza, Isabel Guzmán, María Luisa Garmendia

“…Background: Breast cancer screening is crucial for the early detection of the disease. Although several studies have examined the relationship between socioeconomic factors and mammography use, the impact of socioeconomic position (SEP) in countries undergoing demographic and epidemiological transitions—marked by a rising cancer incidence—and passive breast cancer screening programs in the search of the target population remains understudied. …”
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Quantitative assessment of colour fundus photography in hyperopia children based on artificial intelligence by Yuan Zhang, Yingting Zhu, Zhirong Wang, Yue Xiao, Yehong Zhuo, Zhidong Li, Guitong Ye, Jianqi Chen, Ruiyu Luo, Rui Xie, Jinan Zhan

“…Fundus parameters, such as optic disc area and mean vessel diameter, were automatically and quantitatively detected using AI. Significant variables (p<0.05) in the univariate analysis were included in a stepwise multiple linear regression.Results Overall, 324 children were included, 172 with low and 152 with moderate-to-high hyperopia. …”
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Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Within the cheese clade, we identified three genetically differentiated populations and we detected footprints of recombination and admixture. …”
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Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer’s disease: transcriptomics combined with machine learning analysis by Meiling Wang, Aojie He, Yubing Kang, Zhaojun Wang, Yahui He, Kahleong Lim, Chengwu Zhang, Li Lu

“…In conclusion, this study detected changes in intercellular communication between endothelial cells and pericytes in the middle temporal gyrus and identified four novel feature genes related to middle temporal gyrus and vascular functioning in patients with Alzheimer’s disease. …”
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Nomograms based on ratio indexes to predict severity and prognosis in immune checkpoint inhibitors-related myocarditis: a retrospective analysis by Zhenli Li, Tiezhu Yao, Guang Liu, Zhengkun Guan, Jing Liu, Ling Guo, Jingtao Ma

“…The nomogram-based models of ratio indexes could provide a potential choice for early detection and monitor of the severe ICI-M and subsequent MACEs. …”
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