The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update by Lucas Bouys, Anna Vaczlavik, Isadora P. Cavalcante, Florian Violon, Anne Jouinot, Annabel Berthon, Patricia Vaduva, Stéphanie Espiard, Karine Perlemoine, Peter Kamenicky, Marie-Christine Vantyghem, Antoine Tabarin, Gérald Raverot, Cristina L. Ronchi, Ulrich Dischinger, Martin Reincke, Maria C. Fragoso, Constantine A. Stratakis, Albain Chansavang, Eric Pasmant, Bruno Ragazzon, Jérôme Bertherat, for the COMETE and ENSAT Networks

“…Results 146 different germline variants (110 previously published and 36 novel) are identified, including 46% missense substitutions, 45% truncating variants, 3% affecting splice sites, 4% in-frame variants and 2% large deletions. In addition to the germline events, somatic 16p loss-of-heterozygosity and 104 different somatic events are described. …”
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Frequency and Risk Factors of Advanced Neoplasia in Korean Inflammatory Bowel Disease Patients with Low-grade Dysplasia by Kyeong Ok Kim, Dong Hyun Kim, Soo-Kyung Park, Division of Gastroenterology, Department of Internal Medicine and Inflammatory Bowel Disease Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Chang Kyun Lee, IBD Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)

“…Background/Aims: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient. …”
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Investigating the effect of synthetic cobalt and nickel oxide nanoparticles on the growth and physiology of Mungbean (Vigna radiata L.) seedlings, and exploring tunable magnetism s... by Anjali Joshi, Simranjeet Kaur, Pargat Singh, Havneet Singh, Keya Dharamvir, Harsh Nayyar, Gaurav Verma

“…This study examines the dual effects of cobalt oxide (CoO) and nickel oxide (NiO) nanoparticles on Mungbean (Vigna radiata L.) seedlings, emphasizing their biological responses and magnetic properties for detection and monitoring applications. Seeds were treated with CoO and NiO nanoparticles at concentrations of 50 and 100 mg/L and cultivated under controlled conditions. …”
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Frequency of BK virus genotypes in patients with colorectal cancer by Mahsa Javadi, Gholamabbas Kaydani, Roya Pirmoradi, Abdolhassan Talaiezadeh, Azadeh Haghi Navand, Mohammad Karimi Baba Ahmadi, Manoochehr Makvandi

“…Materials and Methods: This investigation encompassed 50 specimens of colorectal adenocarcinoma tumors, 50 adjacent tissues, and 40 urine samples, with patients having a mean age of 61 years ± 12.4 years. The detection of BK virus DNA VP1 gene and genotyping were carried out through nested-PCR and sequencing techniques. …”
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Comparison of clinical metagenomics with 16S rDNA Sanger sequencing for the bacteriological diagnosis of culture-negative samples by Camille d’Humières, Skerdi Haviari, Marie Petitjean, Laurène Deconinck, Signara Gueye, Nathan Peiffer-Smadja, Lynda Chalal, Naima Beldjoudi, Geoffrey Rossi, Yann Nguyen, Charles Burdet, Ségolène Perrineau, Diane Le Pluart, Roza Rahli, Michael Thy, Piotr Szychowiak, Xavier Lescure, Véronique Leflon-Guibout, Victoire de Lastours, Etienne Ruppé

“…Clinical metagenomics (CMg), i.e. the sequencing of a sample’s entire nucleic acids, may allow for the identification of bacteria not detected by conventional methods. Here, we tested the performance of CMg compared to 16S rDNA sequencing (Sanger) in 50 patients with suspected bacterial infection but negative cultures. …”
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Residential Indoor and Outdoor PM Measured Using Low-cost Monitors during the Heating Season in Monroe County, NY by Andrea R. Ferro, Naděžda Zíková, Mauro Masiol, Gursumeeran P. Satsangi, Thomas Twomey, David C. Chalupa, David Q. Rich, Philip K. Hopke

“…While the accuracy of LCMs is inconsistent and source dependent, the LCMs provided reasonable precision for estimating indoor/outdoor (I/O) ratios based on laboratory and field testing, understanding the relationship between indoor sources and concentration, and comparing PM concentrations across residences for the detected size range (0.5–3 µm). The indoor PM2.5 concentration pattern showed clear morning and evening peaks as well as higher indoor concentrations during the weekends when people are typically at home. …”
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Experimental study of the effects of siestas on the nocturnal sleep quality and thermal comfort levels under thermoneutral environment in summer by Huili Yu, Xue Zhao, Liping Chen, Xiaohui Tian, Shimin Liang, Songtao Hu

“…Higher DA concentration was also detected in the siesta group after the nocturnal sleep. …”
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Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study by Biling Gan, Lei Wu, Shunan Zhou, Zhihong Chen, Fan Wu, Lianqun Xu, Zhenrong Chen, Honghui Ma, Peijia He, Dan Fang, Ning Shi

“…This study provides a bibliometric overview of these therapeutic combinations, evaluating their development and impact.MethodsA rigorous selection process was applied to relevant literature from Web of Science, followed by in-depth bibliometric analyses— including timeline visualization, burst detection, and co-occurrence analysis—using CiteSpace and VOSviewer. …”
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Comparing the diagnosis accuracy and efficacy of presepsin (sCD14) and nCD64 in neonatal sepsis: A systematic review and meta-analysis by Amit Kumar Mittal, Mamta Patel, Dolat Singh Shekhawat, Pratibha Singh, Kuldeep Singh

“…Objective: To evaluate and compare the diagnostic accuracy and clinical utility of sCD14 and nCD64 in detecting neonatal sepsis. Methods: A systematic review and meta-analysis were conducted, including studies that assessed the sensitivity, specificity, and overall diagnostic performance of sCD14 and nCD64. …”
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Highly efficient assessment and selective determination of pancreatic cancer biomarker CA-19-9 using co-electrodeposited MXene-AgNPs nanocomposite by Mahsa Mirzayi, Balal Khalilzadeh, Sattar Akbari Nakhjavani, Rahim Mohammad-Rezaei

“…We believe that our fabricated sensor can be the plan of diseases management program due to affordable rapid and label free detection of a targeted biomarkers.…”
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Emission Characteristics of Volatile Organic Compounds from Typical Coal Utilization Sources: A Case Study in Shanxi of Northern China by Yang Xu, Hualong Yu, Yulong Yan, Lin Peng, Rumei Li, Cheng Wang, Zhiyong Li

“…In this study, we investigated the profiles; benzene, toluene, ethylbenzene, and xylene (BTEX) ratios; ozone formation potential (OFP); and secondary organic aerosol (SOA) formation potential of VOCs generated by coal-utilizing steel plants, power plants, coking plants, and residential stoves in northern China. Among the detected VOCs, the results identified 1-butene as the most abundant species for both the power plants (36.7%) and the residential stoves (41.7%) as well as a significant contributor at the steel plants (7.3%), and alkenes, alkanes, and aromatics composed the largest groups for the power plants (42.0%) and residential stoves (60.2%); steel plants (59.2%); and coking plants (66.1%), respectively. …”
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Aircraft Measurements of Physicochemical Evolution of Atmospheric Aerosols in Air Pollution Plumes over a Megacity and Suburban Areas by Taehyun Park, Yongjoo Choi, Jinsoo Choi, Junyoung Ahn, Jinsoo Park, Yonghwan Lee, Jihee Ban, Gyutae Park, Seokwon Kang, Kyunghoon Kim, Beom-Keun Seo, Jongho Kim, Soobog Park, Hyunjae Kim, HaEun Jeon, Taehyoung Lee

“…Finally, flights investigating the distributions of pollutants in the central, upwind, and downwind SMA regions generally detected high levels of oxidation downwind as well as different aerosol masses between the low and high altitudes. …”
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Predicting Neoplastic Gallbladder Polyps: The Role of Current Surgical Indications and Preoperative Images by Ik Hyun Jo, Chang Nyol Paik, Hong Geun Ahn, Dong Do You, Jae Hyun Han, Hyun A Kim

“…This study examined the accuracy of surgical indications commonly used in clinical practice for detecting neoplastic polyps and investigated further clues for predicting neoplastic polyps. …”
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Riverine microplastic discharge along the southern Black Sea coast of Türkiye by Yahya Terzi, Rafet Çağrı Öztürk, Ahmet Raif Eryaşar, İlhan Yandi, Ahmet Şahin, Fatih Yılmaz, Kenan Gedik, Sedat Gündoğdu

“…While no significant differences in MP characteristics were detected between basins (NMDS and ANOSIM), this study emphasizes rivers as major pathways for MP pollution in the Black Sea. …”
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Non-small cell lung cancer and the tumor microenvironment: making headway from targeted therapies to advanced immunotherapy by Anna De Lucia, Lucia Mazzotti, Lucia Mazzotti, Anna Gaimari, Anna Gaimari, Matteo Zurlo, Roberta Maltoni, Claudio Cerchione, Sara Bravaccini, Angelo Delmonte, Lucio Crinò, Patricia Borges de Souza, Luigi Pasini, Fabio Nicolini, Fabrizio Bianchi, Manel Juan, Hugo Calderon, Chiara Magnoni, Chiara Magnoni, Luca Gazzola, Luca Gazzola, Paola Ulivi, Massimiliano Mazza

“…Over the past decades, significant progress has been made in the understanding of non-small cell lung cancer (NSCLC) biology and tumor progression mechanisms, resulting in the development of novel strategies for early detection and wide-ranging care approaches. Since their introduction, over 20 years ago, targeted therapies with tyrosine kinase inhibitors (TKIs) have revolutionized the treatment landscape for NSCLC. …”
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Using machine learning models to plan HIV services: Emerging opportunities in design, implementation and evaluation by T Dzinamarira, E Mbunge, I Chingombe, D F Cuadros, E Moyo, I Chitungo, G Murewanhema, B Muchemwa, G Rwibasira, O Mugurungi, G Musuka, H Herrera

“…However, barriers such as lack of engagement, limited availability of early HIV-infection detection tools, high rates of HIV/sexually transmitted infections (STIs), barriers to access antiretroviral therapy, lack of innovative resource optimisation and distribution strategies, and poor prevention services for vulnerable populations still exist and substantially affect the attainment of the UNAIDS 95-95-95 targets. …”
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PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma by San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang

“…Prothrombin induced by vitamin K absence II (PIVKA-II) is more sensitive for HCC detection, though its role in systemic therapy remains underexplored. …”
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Development of a respiratory virus risk model with environmental data based on interpretable machine learning methods by Shuting Shi, Haowen Lin, Leiming Jiang, Zhiqi Zeng, ChuiXu Lin, Pei Li, Yinghua Li, Zifeng Yang

“…The data was collected from 31 regions in China between 2016 and 2021, encompassing pathogen detection, air quality indices, and meteorological measurements. …”
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Evaluating ChatGPT-4's performance on oral and maxillofacial queries: Chain of Thought and standard method by Kaiyuan Ji, Zhihan Wu, Jing Han, Guangtao Zhai, Guangtao Zhai, Jiannan Liu

“…With the continuous advancement of Artificial Intelligence technologies, particularly the application of generative pre-trained transformers like ChatGPT-4, there is potential to enhance public awareness of the prevention and early detection of these diseases. This study evaluated the performance of ChatGPT-4 in addressing oral and maxillofacial disease questions using standard approaches and the Chain of Thought (CoT) method, aiming to gain a deeper understanding of its capabilities, potential, and limitations.Materials and methodsThree experts, drawing from their extensive experience and the most common questions in clinical settings, selected 130 open-ended questions and 1,805 multiple-choice questions from the national dental licensing examination. …”
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<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…Feces of patients with diarrhea are sampled for C. difficile toxin detection. Nowadays there are several laboratory diagnostic tests for Clostridial infection: testing for C. difficile glutamate dehydrogenase, enzyme-linked immunoassay, polymerase chain reaction for toxigenic strain of C. difficile. …”
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