Multimorbidity is associated with risk of incident venous thromboembolism – A nationwide proof-of-concept study by Jonatan Ahrén, MirNabi Pirouzifard, Björn Holmquist, Jan Sundquist, Kristina Sundquist, Bengt Zöller

“…Conclusion: This study demonstrated proof-of-concept that multimorbidity is a novel dose-graded predictor for VTE. …”
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A systematic literature review on combined seawater desalination and reverse electrodialysis: Evaluating its technological readiness and potential for full-commercialization by Marijn T. van Geet, Janina Fuchs

“…It is concluded that these main barriers might cause the eco-innovation to fall victim to the so-called ''Valley of Death,'' a funding gap between the proof of concept within academia and the adoption of the technology by the industry on a commercial scale. …”
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Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

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Christ's crucifixion as a medico-historical event by Francois P. Retief, Louise Cilliers

“…There is no reason to consider this as proof of a functioning blood circulation indicating apparent rather than true death. …”
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Complete positivity order and relative entropy decay by Li Gao, Marius Junge, Nicholas LaRacuente, Haojian Li

“…For classical Markov semigroups, this gives a short proof that every sub-Laplacian of a Hörmander system on a compact manifold satisfies a modified log-Sobolev inequality uniformly for scalar and matrix-valued functions. …”
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Features of the Application of the Amnesty Institution under the Laws of the Russian Empire (1845-1917) by G. G. Dedurin, D. G. Zavrichko

“…The reasons for the abolition of punishment could be the following: incurable illness or death of the accused, reconciliation of the parties, the statute of limitations for the crime and pardon. …”
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Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts by Stefania Niada, Chiara Giannasi, Alice Gualerzi, Giuseppe Banfi, Anna Teresa Brini

“…The proosteogenic effect of DF secretome was validated in vitro on human primary osteoblasts, providing a proof of concept of its osteoinductive potential. …”
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Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitot... by Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar

“…With this proof of concept, we tried to explore the potential of selective GABAA receptor agonists or positive allosteric modulators (diazepam and phenobarbitone sodium) and GABAA level enhancer (sodium valproate) for management of MS by screening them for their activity in experimental autoimmune encephalomyelitis (EAE) model in rats and cuprizone-induced demyelination model in mice. …”
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Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia by Qi Zhou, Yongyu Guan, Pingping Zhao, Huiyuan Chu, Yaming Xi

“…In addition, gilteritinib or GSK-J4 monotherapy increases reactive oxygen species (ROS) production, and the combination has a synergistic effect, accelerating leukemic cell death. Our study provides proof that the combined therapy of gilteritinib and GSK-J4 has a synergistic antileukemic effect on FLT3-ITD+ AML.…”
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DEPEND study protocol: early detection of patients with pancreatic cancer – a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as scr... by Christopher D Byrne, Sam Wilding, Paul Remi Afolabi, Declan McDonnell, Victoria Goss, Jocelyn Walters, Zaed Z Hamady

“…Introduction Pancreatic cancer (PC) is the fifth leading cause of cancer-related death in the UK. The incidence of PC is increasing, with little or no improvement in overall survival and the best chance for long-term survival in patients with PC relies on early detection and surgical resection. …”
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A new and automated risk prediction of coronary artery disease using clinical endpoints and medical imaging-derived patient-specific insights: protocol for the retrospective GeoCAD... by Louisa Jorm, Daniel Moses, Dona Adikari, Ramtin Gharleghi, Shisheng Zhang, Arcot Sowmya, Sze-Yuan Ooi, Susann Beier

“…Introduction Coronary artery disease (CAD) is the leading cause of death worldwide. More than a quarter of cardiovascular events are unexplained by current absolute cardiovascular disease risk calculators, and individuals without clinical risk factors have been shown to have worse outcomes. …”
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Imaging Flow Cytometric Identification of Chromosomal Defects in Paediatric Acute Lymphoblastic Leukaemia by Ana P. A. Simpson, Carly E. George, Henry Y. L. Hui, Ravi Doddi, Rishi S. Kotecha, Kathy A. Fuller, Wendy N. Erber

“…Acute lymphoblastic leukaemia is the most common childhood malignancy that remains a leading cause of death in childhood. It may be characterised by multiple known recurrent genetic aberrations that inform prognosis, the most common being hyperdiploidy and t(12;21) <i>ETV6::RUNX1</i>. …”
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Адам и Ева как прообраз Нового Адама и Новой Евы (по учению святителя Иринея Лионского, Тертуллиана и святителя Викторина Петавийского). К вопросу о теории рекапитуляции в раннехри... by Nikolay A. Khandoga

“…As a result, instead of the death of Adam and Eve and their descendants (by bodily birth), humanity received immortality, starting with New Adam and New Eve and their descendants (by spiritual birth). …”
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Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control by Helena Escuin-Ordinas, Ignacio Melero, Marisol Quintero, Jose Luis Perez-Gracia, Maite Alvarez, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Paloma Sanchez-Mateos, Inmaculada Rodríguez López, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Eneko Garate-Soraluze, Victor Diaz Pascual, Leire Arbea Moreno

“…BO-112 and focal irradiation were used to make the proof-of-concept for local immunotherapy plus radiation therapy combinations.Methods Murine transplantable tumor cell lines (TS/A, MC38 and B16-OVA) were used to show increased immunogenic features under irradiation, as well as in bilateral tumor models in which only one of the lesions was irradiated or/and injected with BO-112. …”
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A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response by Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster

“…Background &amp; Aims: Hepatocellular carcinoma (HCC) is the third-leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC are hampered by the absence of authentic tractable systems recapitulating the heterogeneity of HCC tumors in patients and the tumor microenvironment (TME). …”
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Stability Analysis of a Multigroup Epidemic Model with General Exposed Distribution and Nonlinear Incidence Rates by Ling Zhang, Jingmei Pang, Jinliang Wang

“…For a simpler case that assumes an identical natural death rate for all groups, and with a gamma distribution for exposed distribution is considered. …”
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Jinbei oral liquid for idiopathic pulmonary fibrosis: a randomized placebo-controlled trial by Aijun Zhang, Kangkang Han, Fangfang Chen, Xiao Chen, Jun Wang, Yikai Niu, Zhaoqiu Hu, Chunyan Zheng, Liping Han, Zhaoqing Meng, Liangzong Zhang, Qingcui Xu, Cuixiang Yu, Wei Zhang, Quanguo Li, Ningning Tao, Weixiang Kong, Fei Liu, Min Wang, Juanjuan Jiang, Honglin Li, LongBin Pang, Huaichen Li

“…A double-blind, multicenter, randomized, proof-of-concept trial was conducted to assess the efficacy of oral JBOL 40 ml and Corbrin Capsules 1 g compared to a placebo and Corbrin Capsules in patients with idiopathic pulmonary fibrosis (IPF). …”
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Improved estimates for extinction probabilities and times to extinction for populations of tsetse (Glossina spp) by Damian, Kajunguri, Elisha B., Are, John W., Hargrove

“…The original derivation was partially heuristic and provided no proofs for inductive results. We provide these proofs, together with a more compact way of reaching the same results. …”
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Construction of a Practical Oriented Tool for Evaluating the Ability of Community Medical Staff to Provide Hospice Care Services and Its Reliability and Validity by SHA Jingjing, JING Limei, DING Tongjiu, XIN Yurong, TANG Lan, LI Shuijing

“…Conclusion In this study, it proofs that the questionnaire tool for evaluating the ability of community health service center medical staff is scientific, reliability, and validity, and can be used to evaluate the various abilities of community general practitioners in hospice care services.…”
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