Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry by Yiwei Chen, Yiwei Chen, Jiali Lin, Detong Shi, Yu Miao, Yu Miao, Feng Xue, Feng Xue, Kexin Liu, Kexin Liu, Xiaotao Wang, Changqing Zhang, Changqing Zhang

“…This study aims to integrate URG expression data with machine learning (ML) to identify biomarkers that improve diagnosis and prognosis in the early stages of OA.MethodsOA single-cell RNA sequencing datasets were collected from the GEO database. Single-cell analysis was performed to investigate the composition and relationships of chondrocytes in OA. …”
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Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas by Junhao Zhang, Lingbo Li, Aiwei Tang, Chucheng Wang, Yupeng Wang, Yongqi Hu, Guangting He, Guangting He, Wangjun Liao, Wangjun Liao, Wangjun Liao, Rui Zhou

“…Additional glioma-specific datasets (Chinese Glioma Genome Atlas, GlioVis, GSE43378, and GSE182109) were also collected to validate the transcriptional characteristics of HATs and HDACs in gliomas. …”
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Derivation and validation of a clinical predictive model for longer duration diarrhea among pediatric patients in Kenya using machine learning algorithms by Billy Ogwel, Vincent H. Mzazi, Alex O. Awuor, Caleb Okonji, Raphael O. Anyango, Caren Oreso, John B. Ochieng, Stephen Munga, Dilruba Nasrin, Kirkby D. Tickell, Patricia B. Pavlinac, Karen L. Kotloff, Richard Omore

“…While all models showed good prediction capability, the random forest model achieved the best performance (AUC [95% Confidence Interval]: 83.0 [78.6–87.5] and 71.0 [62.5–79.4]) on the development and temporal validation datasets, respectively. While the random forest model showed slight deviations from perfect calibration, these deviations were not statistically significant (Brier score = 0.17, Spiegelhalter p-value = 0.219). …”
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First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer by Juan Sempere-Valverde, Juan Sempere-Valverde, Eva Aylagas, Vitaly Syomin, Vitaly Syomin, Marcos A. L. Teixeira, Glafira D. Kolbasova, Glafira D. Kolbasova, Sofía Ruiz-Velasco, Sahar Chebaane, Arthur Anker, João Curdia, Ronald Cadiz, Dylan M. Cottrell, Andrea Desiderato, Luiz F. Andrade, Chakkiath Paul Antony, Carolina Bocanegra-Castano, Matilde Marzucchi, Angelo Poliseno, Doaa Baker, Basmah Alabdulaziz, Flor Torres, Ameer A. Eweida, Ameer A. Eweida, Susana Carvalho, Susana Carvalho

“…The environmental characteristics of each site were obtained by deploying temperature data loggers and through an environmental risk assessment.ResultsCommunity patterns observed from the PhQd and bulk DNA datasets revealed a clear separation of two sites within Sharma lagoon from the remaining sites. …”
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Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors by Qiang Wang, Qing Yi, Wei Xiong, Rui Duan, Jianfei Qian, Liuling Xiao, Miao Xian, Pan Su, Chuanchao Zhang, Yabo Li, Ling Zhong, Chengyun Zheng

“…Gene expression levels in human MM were analyzed using Gene Expression Omnibus public datasets.Results We found that programmed cell death protein 1 (PD-1) antibody treatment had a therapeutic effect in 5TGM1 mice; it was ineffective in Vk*MYC mice. …”
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Prevalence and characterization of IncQ1α-mediated multi-drug resistance in Proteus mirabilis Isolated from pigs in Kunming, Yunnan, China by Hongmei Liu, Hongmei Liu, Hongmei Liu, Na Xia, Fanan Suksawat, Bundit Tengjaroenkul, Yue Hu, Xiaofeng Zhou, Xiaojiang Li, Cuiqin Huang, Yinli Bao, Qiong Wu, Chunrong Zhang, Sunpetch Angkititrakul, Bin Xiang, Xin Wu

“…A comparison with 126 public genome datasets confirmed this association.…”
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Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report by Lei Cai, Qing Lv, Ronghua Ma, Wei Liu, Yalun Guan, Zhongqiang Huang, Qingyu Liu, Yunfeng Li, Shuhua Liu, Ge Li, Yu Zhang

“…A thorough correlation analysis was conducted on the transcriptome and proteome expression data, revealing a significant positive correlation between the two datasets. A total of eight genes and proteins with high expression levels were identified as common to both the transcriptome and proteome. …”
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Mitral Annular Plane Systolic Excursion (MAPSE) as a Predictor of Atrial Fibrillation Recurrence in Patients after Pulmonary Vein Isolation by Jan Alatic, David Suran, Damijan Vokac, Franjo Husam Naji

“…Introduction. Catheter ablation (CA) with pulmonary vein isolation (PVI) has become widely used in the past years for the treatment of atrial fibrillation (AF). …”
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The Development of Simple Scoring System to Predict Urinary Tract Infection (UTI) in Patients with Stroke by In-Hui Pak, Se-Ryong Han, Chol-Ho Sin, Hyo-Song Kim, Un-Ryong Rim

“…The variables with significant difference between the non-UTI group and the UTI group were age (non-UTI versus UTI, 56.4 ± 7.2 vs. 59.0 ± 12.8; p<0.001), female (244 (24.2) vs. 176 (36.1), p<0.001), 300 ≦ SI (smoking index) (16 (2.4) vs. 48 (12.0), p<0.001), alcohol > 25 g/d (292 (29.0) vs. 184 (37.7), p<0.001), poststroke hyperglycemia (120 (10.3) vs. 163 (33.4), p<0.001), indwelling of urinary catheter (157 (15.6) vs. 351 (72.0), p<0.001), GCS (Glasgow Coma Scale) on admission (11.2 ± 3.9 vs. 8.5 ± 4.0, p=0.038), and WFNS (World Federation of Neurosurgeons) (in subarachnoid hemorrhage) on admission (2.9 ± 1.7 vs. 3.5 ± 1.5, p<0.001). …”
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Digging for clues: Stick tools used for honey digging in a second community of ‘forest fragment chimpanzees’ outside the Budongo and Bugoma Forests, Uganda by Matthew R. McLennan, Georgia A. Lorenti, Simon Mugenyi, Jonan Muganzi, Jacqueline Rohen

“…Our study also showed that chimpanzees in Mairirwe compete with humans for this underground resource, with local people using machetes to excavate the bee nests. Our data suggest that tool-assisted honey digging may be a foraging behaviour common to chimpanzees inhabiting riverine forest fragments outside the Budongo and Bugoma forests. …”
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Empowering Nursing Practices: Enhancing Patient Care Through Knowledge, Attitude and Practice Towards Urinary Catheterisation in Taicang City by Lihong Zhang, Hong Zhang, Yaxuan Wang, Hui Li, Ting Liu, Jingjing Qian, Chi Wang

“…Partial correlation analysis adjusted for age, gender, department, working experience and experience in treating patients with catheter‐associated urinary tract infections also showed positive correlations among KAP. …”
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Correlation between uterine microbiota and pregnancy outcomes of embryo transfer in overweight and obese women by Ying Yan, Ying Li, Lingling Wu, Yuxuan Zhang, Hong Guo, Yazhong Ji

“…Microbial samples were collected from the catheter tips and analyzed using RNA Ribosomal 16S.ResultsIn 45 women, the β-human chorionic gonadotropin (β-hCG) positivity rate and clinical pregnancy rate 10-12 days after embryo transfer were higher in the Con group. …”
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The latest diagnostic methods for esophageal and gastric examinations. High-resolution manometry is now available in Ukraine by Yu.M. Stepanov, N.V. Prolom, S.O. Tarabarov

“…One of the main advantages of HR manometry is accurate diagnosis of functional esophageal disorders due to the use of special catheters with numerous sensors located at a short distance from each other (about 1 cm). …”
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Epidemiology, Clinical Characteristics and Treatment Outcomes of Acinetobacter baumannii Infection at a Regional Hospital in Thailand by Sakulkonkij P, Bruminhent J

“…Risk factors for acquiring multidrug-resistant (MDR) pathogens included previous hospitalization or antibiotic use and the presence of an indwelling urinary catheter, which was common in both survived and deceased groups. …”
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Human health risk from groundwater consumption: A case study in the Apaaso-Tafo Community in the Bono East Region of Ghana by Emmanuel Okyere, Ethel Bentil, Nana Adwoa Kusi-Addai, Lawson Mensah

“…The authorities should also monitor GW quality regularly and respond to changes in quality with the appropriate intervention such as issuing ‘boil-before-drinking’ notices to consumers or encouraging parents to provide bottled and sachet water for their young children. Future research with an increased number of communities, sample size and sampling frequency should also be conducted to enhance the generalisability of these findings.…”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Method: The identified targets’ expression profiles were determined at the mRNA and protein levels using The Breast Cancer Gene-Expression Miner v5.0 (bcGen-ExMiner v5.0) and The Human Protein Atlas datasets, respectively. A gene signature composed of the specifically designated genes was constructed, and its association with different breast cancer molecular subtypes was investigated through the Gene expression-based Outcome for Breast Cancer (GOBO) online tool. …”
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Explainable AI in Diagnostic Radiology for Neurological Disorders: A Systematic Review, and What Doctors Think About It by Yasir Hafeez, Khuhed Memon, Maged S. AL-Quraishi, Norashikin Yahya, Sami Elferik, Syed Saad Azhar Ali

“…<b>Results:</b> Forty-seven studies were summarized and tabulated with information about the XAI technology and datasets employed, along with performance accuracies. …”
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Synthesizing field plot and airborne remote sensing data to enhance national forest inventory mapping in the boreal forest of Interior Alaska by Pratima Khatri-Chhetri, Hans-Erik Andersen, Bruce Cook, Sean M. Hendryx, Liz van Wagtendonk, Van R. Kane

“…To achieve this goal, we compared the performance of two advanced modeling approaches, the convolutional neural network (CNN) and the XGBoost model. Our datasets included field and high-resolution topographic metrics including elevation, slope, aspect, and solar radiation and canopy height derived from lidar (1 m) and 44 vegetation indices derived from high-resolution (1 m) visible to near infrared (VNIR) hyperspectral data collected by NASA Goddard's Lidar, Hyperspectral and Thermal Imager (G-LiHT) sensor. …”
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Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer by Jingmin Che, Bo Chen, Xusheng Wang, Baoe Liu, Cuixiang Xu, Huxia Wang, Jingying Sun, Qing Feng, Xiangrong Zhao, Zhangjun Song

“…A combination of PD-L1 inhibitors and DLG5 RNA interference techniques was used, along with various methods including cell counting kit-8 (CCK-8), colony formation, wound healing, transwell migration, reverse transcription-quantitative real-time PCR (RT-qPCR), immunofluorescence, immunohistochemical staining (IHC), expression analysis from datasets and western blotting. These methods were employed to evaluate changes in cell proliferation, migration, and the expression levels of PD-L1 and DLG5. …”
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Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…While some results are promising, not all NITs demonstrate substantial accuracy, highlighting the need for validation with larger datasets. Future research should concentrate on studying the thresholds of NITs and enhancing the clarity of methodological reporting.Keywords: NAFLD, NIT, obesity, NMA, diagnostic…”
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