Log odds of positive lymph nodes compared to positive lymph node ratio and number of positive lymph nodes in prognostic modeling for patients with NSCLC undergoing lobectomy or tot... by Qiming Huang, Shai Chen, Zhenjie Li, Longren Wu, Dongliang Yu, Linmin Xiong

“…The SHAP (SHapley Additive exPlanations) analysis of the XGBoost model demonstrated that the LODDS exhibited the highest SHAP values (0.25) for predicting overall survival in patients, consistently outperforming the LNR and the number of nPLN across both training and validation datasets.ConclusionsCompared to the nPLN and LNR staging systems, LODDS demonstrates superior prognostic power for patients with stage I–IIIA NSCLC undergoing lobectomy or pneumonectomy. …”
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Novel image registration algorithm for scene-matching navigation by Hongrui YANG, Qiju ZHU, Peixian CAO, Hao GU, Dongdong ZHAO

“…Our framework has been rigorously evaluated across diverse multimodal image pairs, including optical–optical, optical–SAR, and optical–hyperspectral datasets. Our algorithm has been compared with current state-of-the-art image registration methods, including traditional feature–based approaches such as DSOG, histogram of oriented phase congruency (HOPC), and radiation-variation insensitive feature transform (RIFT), as well as deep learning–based techniques such as Loftr and Superpoint. …”
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Enhancing predictive accuracy for urinary tract infections post-pediatric pyeloplasty with explainable AI: an ensemble TabNet approach by Hongyang Wang, Junpeng Ding, Shuochen Wang, Long Li, Jinqiu Song, Dongsheng Bai

“…This ensemble approach mitigates the dependency of machine learning models on feature engineering while addressing the issue of overfitting in deep learning-based models like TabNet, particularly in the context of small medical datasets. By improving prediction accuracy, this model supports proactive interventions, reduces postoperative infections and re-obstruction rates, enhances pyeloplasty outcomes, and alleviates health and economic burdens. …”
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Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…Methods This study utilized clinical neuroblastoma samples from 20 patients and 1310 cases from four public datasets to investigate SLC1A5 expression, biological function, and prognostic significance. …”
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Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering by Maria K. Jaakkola, Maria Rantala, Anna Jalo, Teemu Saari, Jaakko Hentilä, Jatta S. Helin, Tuuli A. Nissinen, Olli Eskola, Johan Rajander, Kirsi A. Virtanen, Jarna C. Hannukainen, Francisco López-Picón, Riku Klén

“…First, we excluded methods that were computationally too demanding for the large datasets from human total-body PET scanners. These criteria filtered out most of the commonly used approaches, leaving only two clustering methods, k-means and Gaussian mixture model (GMM), for further analyses. …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…Data procurement encompassed transcriptomic and clinical datasets from HCC patients, sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) repositories. …”
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Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis by Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

“…Our study introduces a quantitative description of the fundamental parameters characterizing the maintenance and evolution of T-cell subsets with age, based on a comprehensive integration of available organ-specific and systems-level flow cytometry datasets. Overall, it provides the most up-to-date view of physiological T-cell dynamics and its variance and may be used as a consistent reference for gaining further mechanistic understanding of the human immune status in health and disease.…”
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Role of stability analysis and waste discharge concentration of ternary hybrid nanofluid in a non-Newtonian model with slip boundary conditions by Nurhana Mohamad, Shuguang Li, Umair Khan, Anuar Ishak, Ali Elrashidi, Mohammed Zakarya

“…Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.…”
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Genome skimming provides evidence to accept two new genera (Apiaceae) separated from the Peucedanum s.l. by Bo-Ni Song, Chang-Kun Liu, Chang-Kun Liu, Jiao-Jiao Deng, Wei-Yan Tan, Song-Dong Zhou, Xing-Jin He

“…Therefore, we conducted a comprehensive taxonomic revision of taxa within the polyphyletic Peucedanum s.l. genus in this study.MethodsWe used two molecular datasets (103 plastomes and 43 nrDNA sequences) generated by genome skimming to reconstructed a reliable phylogenetic framework with high support and resolution. …”
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Question–Answer Methodology for Vulnerable Source Code Review via Prototype-Based Model-Agnostic Meta-Learning by Pablo Corona-Fraga, Aldo Hernandez-Suarez, Gabriel Sanchez-Perez, Linda Karina Toscano-Medina, Hector Perez-Meana, Jose Portillo-Portillo, Jesus Olivares-Mercado, Luis Javier García Villalba

“…Machine Learning (ML)-based approaches aim to overcome these limitations but encounter challenges related to scalability and adaptability due to their reliance on large labeled datasets and their limited alignment with the requirements of secure development teams. …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…Many of these genes are absent in published cnidarian and myxozoan datasets and appear to be specific to S. molnari; they may therefore represent potential innovations enabling Sphaerospora to exploit the host’s blood system. …”
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EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B by Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng

“…Methods Bioinformatic analyses were conducted to identify genes overexpressed in PCa tissues using The Cancer Genome Atlas (TCGA) and GEO datasets. Western blotting and immunohistochemistry assays were applied to determine the expression levels of euchromatic histone lysine methyltransferase 2 (EHMT2), pT232‐Aurora B and Cullin 3 (CUL3). …”
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Needs Assessment and Tailored Training Pilot for Emergency Care Clinicians in the Prehospital Setting in Rwanda by Naz Karim, Jeanne D’Arc Nyinawankusi, Mikaela S. Belsky, Pascal Mugemangango, Zeta Mutabazi, Catalina Gonzalez Marques, Angela Y. Zhang, Janette Baird, Jean Marie Uwitonze, Adam C. Levine

“…Linked prehospital and hospital care datasets allowed for evaluation of patient outcomes and prehospital process indicators that included training skill application, airway intervention, intravenous fluid administration, and glucose administration. …”
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Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…We analyzed tissue-based bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) datasets from COPD and non-COPD patients, sourced from the Gene Expression Omnibus (GEO) database. …”
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Comprehensive overview of genotype distribution and prevalence of human papillomavirus in cervical lesions by Yang Liu, Chengquan Zhao, Tiannan Wang, Yuhong Ye, Terrel Jones, Xianxu Zeng

“…The distribution of HR-HPV in severe squamous lesions is complex, involving many HR-HPV genotypes in addition to HPV16, while the distribution of HR-HPV genotypes in endocervical glandular lesions is mainly limited in HPV18 and HPV16.Large datasets from China have identified the three most common HR-HPV genotypes in this population as stratified by diagnostic category: HPV52, HPV16, HPV58 in histologically negative cases and cervical intraepithelial neoplasia 1 (CIN1); HPV16, HPV52, HPV58 in CIN2/3; HPV16, HPV58, HPV52 or HPV18 in squamous cell carcinoma (SCC); HPV16, HPV18 and HPV52 in endocervical adenocarcinoma in situ (AIS), invasive adenocarcinoma, as well as mixed squamous and glandular lesions. …”
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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

“…Objective To evaluate the impact of the ‘Getting it Right First Time’ (GIRFT) national improvement programme in orthopaedics, which started in 2012.Design Mixed-methods study comprising statistical analysis of linked national datasets (National Joint Registry; Hospital Episode Statistics; Patient-Reported Outcomes); economic analysis and qualitative case studies in six National Health Service (NHS) Trusts.Setting NHS elective orthopaedic surgery in England.Participants 736 088 patients who underwent primary hip or knee replacement at 126 NHS Trusts between 1 April 2009 and 31 March 2018, plus 50 NHS staff.Intervention Improvement bundle including ‘deep dive’ visits by senior clinician to NHS Trusts, informed by bespoke set of routine performance data, to discuss how improvements could be made locally.Main outcome measures Number of procedures conducted by low volume surgeons; use of uncemented hip implants in patients >65; arthroscopy in year prior to knee replacement; hospital length of stay; emergency readmissions within 30 days; revision surgery within 1 year; health-related quality of life and functional status.Results National trends demonstrated substantial improvements beginning prior to GIRFT. …”
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Prevalence and determinants of clustering of adverse lifestyle behaviors among 35 – 75 years old residents at high cardiovascular disease risk in Hebei province: an analysis of dat... by Yuejing QIAO, Yuhuan LIU, Lijuan TANG, Dongsheng JIANG, Xiaoli LIU, Ze CUI

“…MethodsInformation on 29 721 residents aged 35 – 75 years who were considered at high risk of CVD was collected from the datasets of the CVD Early Detection and Comprehensive Intervention Project, which was conducted in 11 sites in Hebei province from 2018 to 2021. …”
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Fetal cardiac function in pregnancy affected by congenital heart disease: protocol for a multicentre prospective cohort study by Anna Erenbourg, Tracie Barber, Vera Cecotti, Stefano Faiola, Ilaria Fantasia, Tamara Stampaljia, Hagai Avnet, Beata Radzymińska-Chruściel, Neama Meriki, Alec Welsh

“…After adjustments allowing for patient exclusions or incomplete datasets, a total of 330 healthy singleton pregnancies and 165 diagnosed with CHD will be recruited. …”
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Acceptable Postvoid Residual Urine Volume after Vaginal Delivery and Its Association with Various Obstetric Parameters by Wen Sze Choe, Beng Kwang Ng, Ixora Kamisan Atan, Pei Shan Lim

“…If the bladder volume was 500 ml or more, an indwelling catheter would be inserted and kept for 24 hours. Results. …”
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Association between terminal pleural elastance and radiographic lung re-expansion after therapeutic thoracentesis in patients with symptomatic pleural effusion: a post-hoc analysis... by Fabien Maldonado, Michael Lester, Otis B Rickman, Lance J Roller, Sameer K Avasarala, James M Katsis, Robert J Lentz

“…Objectives Recurrent symptomatic effusions can be durably managed with pleurodesis or placement of indwelling pleural catheters. Recent pleurodesis trials have largely relied on lung re-expansion on post-thoracentesis radiograph as an inclusion criterion rather than pleural elastance as determined by manometry, which is an important predictor of successful pleurodesis. …”
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