Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

“…Methods In vitro and in vivo experiments, RNA‐seq, CO‐IP and proteomic analysis, combined with single‐cell RNA‐seq datasets were used to reveal the upstream and downstream mechanisms involved. …”
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Modeling Climate‐Driven Vegetation Changes Under Contrasting Temperate and Arid Conditions in the Mediterranean Basin by Marco Bianchini, Mohamed Tarhouni, Matteo Francioni, Marco Fiorentini, Chiara Rivosecchi, Jamila Msadek, Abderrazak Tlili, Farah Chouikhi, Marina Allegrezza, Giulio Tesei, Paola Antonia Deligios, Roberto Orsini, Luigi Ledda, Maria Karatassiou, Athanasios Ragkos, Paride D'Ottavio

“…MaxEnt emerged as the most reliable algorithm for small presence‐only datasets, effectively predicting habitat suitability. …”
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Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia by Rong Lin, Rong Lin, XiaoYing Weng, XiaoYing Weng, Liang Lin, Liang Lin, XuYang Hu, XuYang Hu, ZhiYan Liu, ZhiYan Liu, Jing Zheng, Jing Zheng, FenFang Shen, FenFang Shen, Rui Li, Rui Li

“…Differentially expressed mtPCD genes were identified as potential biomarkers from the GSE10588 and GSE98224 datasets and subsequently validated. Hub genes were determined using support vector machine, least absolute shrinkage and selection operator, and Boruta based on consistent expression profiles. …”
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Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…Results ERBB2 mRNA amplification was found in HCC datasets, and its expression was downregulated in high grade HCC with a worse overall survival. …”
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Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts by Atsuki Fukada, Yasunori Enomoto, Ryo Horiguchi, Yoichiro Aoshima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Takafumi Suda, Toshihide Iwashita

“…The transcriptome profile of ITGA8+ fibroblasts in adult mouse lungs, evaluated through two independent single-cell RNA-seq datasets, consistently showed higher expression of Tcf21 and Plin2, which are canonical markers of lipofibroblasts. …”
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Risk factors affecting polygenic score performance across diverse cohorts by Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie

“…Machine learning models (neural networks) increased relative model R2 (mean 23%) across datasets. Finally, creating PGSBMI directly from GxAge genome-wide association studies effects increased relative R2 by 7.8%. …”
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TPDTNet: Two-Phase Distillation Training for Visible-to-Infrared Unsupervised Domain Adaptive Object Detection by Siyu Wang, Xiaogang Yang, Ruitao Lu, Shuang Su, Bin Tang, Tao Zhang, Zhengjie Zhu

“…Extensive experiments are conducted on three optical-to-infrared datasets, and the experimental results show that our TPDTNet method achieves state-of-the-art results relative to those of the baseline model.…”
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Perbedaan Efektivitas Parasetamol Oral Dengan Tramadol Oral Sebagai Tatalaksana Nyeri Pasca Operasi Transurethral Resection of The Prostate by Ismail Muhammad, Alvarino Alvarino, Nasman Puar, Hafni Bachtiar

“…Postoperative pain due to trauma TURP (resection of prostate tissue), irritation foley catheters and catheter traction after TURP surgery on the wound. …”
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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…A more comprehensive understanding and study of the mechanisms of AVF maturation is urgently needed.Methods and results In this study, we downloaded the publicly available datasets (GSE119296 and GSE220796) from the Gene Expression Omnibus (GEO) and merged them for subsequent analysis. …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England by Derek G Cook, Frank J Kelly, Iain M Carey, H Ross Anderson, David P Strachan, Richard W Atkinson, Sean D Beevers, David Dajnak, John Gulliver

“…Objective To investigate whether the incidence of dementia is related to residential levels of air and noise pollution in London.Design Retrospective cohort study using primary care data.Setting 75 Greater London practices.Participants 130 978 adults aged 50–79 years registered with their general practices on 1 January 2005, with no recorded history of dementia or care home residence.Primary and secondary outcome measures A first recorded diagnosis of dementia and, where specified, subgroups of Alzheimer’s disease and vascular dementia during 2005–2013. …”
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Predicting cardiovascular outcomes in Chinese patients with type 2 diabetes by combining risk factor trajectories and machine learning algorithm: a cohort study by Qi Huang, Xiantong Zou, Zhouhui Lian, Xianghai Zhou, Xueyao Han, Yingying Luo, Shuohua Chen, Yanxiu Wang, Shouling Wu, Linong Ji

“…Methods We included 16,378 patients from the Kailuan cohort, splitting them into training and testing datasets. Using baseline characteristics and changes over a four-year observation period, we developed the ML-CVD-C (Machine Learning Cardiovascular Disease in Chinese) score to predict 10-year cardiovascular risk, including cardiovascular death, nonfatal myocardial infarction, and stroke. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs). …”
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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma by Liuyan Chen, Lvying Wu, Minying Tang, Yuanhang Cheng, Kuanyin Wang, Jianan Zhang, Wenyi Deng, Lingfeng Zhu, Jin Chen

“…Methods We utilized external datasets and bioinformatics analyses to investigate the significance of DBF4 in ccRCC. …”
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New Insights into the Role of Inflammatory Pathways and Immune Cell Infiltration in Sleep Deprivation-Induced Atrial Fibrillation: An Integrated Bioinformatics and Experimental Stu... by Liang J, Tang B, Shen J, Rejiepu M, Guo Y, Wang X, Shao S, Guo F, Wang Q, Zhang L

“…The objective of this research was to pinpoint the shared molecular routes responsible for SD-induced AF and investigate possible treatment targets.Methods: Utilizing bioinformatics, we examined two transcriptome datasets from the Gene Expression Omnibus (GEO) database to pinpoint genes with differential expression (DEGs) common to SD and AF. …”
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Trends and distribution patterns of infant mortality and maternal HIV positivity in South Africa: A decade review (2007 - 2016) by M Makhele, N Ledibane, H Ramatsoma, A Musekiwa

“…Line charts with descriptive statistics were used to detail trends in IMRs, and multiple logistic regression models were used to identify risk factors for infant mortality in the 2007 and 2016 CS datasets. Spearman’s rank-order correlation (rho) was used to correlate infant mortality with data from the 2007 ANCHSS. …”
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Digital Gaming and Subsequent Health and Well-Being Among Older Adults: Longitudinal Outcome-Wide Analysis by Atsushi Nakagomi, Kazushige Ide, Katsunori Kondo, Koichiro Shiba

“…Consequently, we used 2 datasets for analysis. We applied targeted maximum likelihood estimation to estimate the population average treatment effects, with Bonferroni correction used to adjust for multiple testing. …”
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Snow depth estimation on leadless landfast ice using Cryo2Ice satellite observations by M. Saha, J. Stroeve, J. Stroeve, D. Isleifson, J. Yackel, V. Nandan, V. Nandan, J. C. Landy, H. M. Lam

“…Moreover, the proposed methodology for getting snow depth over leadless landfast sea ice needs to be validated using in situ datasets in other landfast sea ice regions in the Arctic.…”
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Pressurised water flow in fractured permafrost rocks revealed by borehole temperature, electrical resistivity tomography, and piezometric pressure by M. Offer, M. Offer, S. Weber, S. Weber, M. Krautblatter, I. Hartmeyer, M. Keuschnig

“…To overcome the lack of a quantitative assessment, we combine datasets of rock temperature measured in two deep boreholes (2016–2023), with electrical resistivity tomography measurements repeated monthly in 2013 and 2023; the site-specific temperature–resistivity relation determined in the laboratory with samples from the study area; and borehole piezometer data. …”
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Enhancing Semi-Supervised Learning With Concept Drift Detection and Self-Training: A Study on Classifier Diversity and Performance by Jose L. M. Perez, Roberto S. M. Barros, Silas G. T. C. Santos

“…These classifiers were combined with several detectors and tested on a total of 84 artificial and five real-world datasets. The experiments were conducted with 15% and 30% of labeled data, the main percentages addressed in this research, while 100% was used to provide additional grounding in some cases. …”
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Investigating Smartphone-Based Sensing Features for Depression Severity Prediction: Observation Study by Yannik Terhorst, Eva-Maria Messner, Kennedy Opoku Asare, Christian Montag, Christopher Kannen, Harald Baumeister

“…All analyses were pooled across the imputed datasets according to Rubin’s rule. ResultsA total of 107 participants were included in the study. …”
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