Real-world enrollment for a prospective clinico-genomic database using a pragmatic technology-enabled platform by Alexia Exarchos, Ariel B. Bourla, Maneet Kaur, Katja Schulze, Sophia Maund, Yi Cao, Yihua Zhao, Elizabeth H. Williams, Sarah C. Gaffey, Richard Zuniga, Shaily Lakhanpal, Vladan Antic, Michelle Doral, Johanna Sy, Neal J. Meropol, Anne C. Chiang

“…Background: Discovery and incorporation of predictive and prognostic biomarkers enhance outcomes for patients with cancer. Clinico-genomic datasets, which retrospectively link real-world clinical data to tumor sequencing data, are important resources for biomarker research, which has historically relied on robust research infrastructures exclusive to large academic centers. …”
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Economic and relationship-strengthening intervention to reduce alcohol use in couples living with HIV in Malawi: a study protocol for a randomised controlled trial of Mlambe by Torsten B Neilands, Lynae A Darbes, James Mkandawire, Derek S Brown, Fred M Ssewamala, Judith A Hahn, Amy A Conroy, Nancy Mulauzi, Scott Tebbetts

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Harmonizing population health data into OMOP common data model: a demonstration using COVID-19 sero-surveillance data from Nairobi Urban Health and Demographic Surveillance System by Michael Ochola, Sylvia Kiwuwa-Muyingo, Tathagata Bhattacharjee, David Amadi, Maureen Ng’etich, Damazo Kadengye, Henry Owoko, Boniface Igumba, Jay Greenfield, Jim Todd, Agnes Kiragga, Agnes Kiragga

“…The target OMOP CDM can now be used to analyze the prevalence of COVID-19 antibodies in the Nairobi Urban HDSS population.ResultsWe successfully mapped the Nairobi Urban HDSS COVID-19 sero-surveillance data to the OMOP CDM. The standardized dataset included information on demographics, COVID-19 symptoms, vaccination, and COVID-19 antibody test results.ConclusionsThe OMOP CDM is a valuable tool for harmonizing observational health data. …”
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Preharvest Factors Affecting Quality on “Abate Fetel” Pears: Study of Superficial Scald with Multivariate Statistical Approach by Alessandro Bonora, Enrico Muzzi, Cristiano Franceschini, Alexandra Boini, Gianmarco Bortolotti, Kushtrim Bresilla, Giulio Demetrio Perulli, Melissa Venturi, Luigi Manfrini, Luca Corelli Grappadelli

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Cardiovascular Protection of Nephropathic Male Patients by Oral Food Supplements by Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Silvia Urciuoli, Anna Pietroboni Zaitseva, Georgia Wilson Jones, Nicola Di Daniele, Annalisa Romani

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Screening of Anti-Inflammatory Components of Qin Jin Hua Tan Tang by a Multivariate Statistical Analysis Approach for Spectrum-Effect Relationships by Feipeng Duan, Yisheng Li, Meizhen Zhao, Tianyong Hu, Xinquan Pan, Yue Feng, Fang Ma, Shuqi Qiu, Yiqing Zheng

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Reinforcement Learning-Based Generative Security Framework for Host Intrusion Detection by Yongsik Kim, Su-Youn Hong, Sungjin Park, Huy Kang Kim

“…We verified the proposed framework using the system call log datasets: ADFA-LD, LID-DS 2021 dataset. The proposed framework demonstrated a high accuracy rate of 96.5% average when faced with different attacks. …”
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In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders by Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye

“…Methods Transcriptome profiles of PD (dataset number: GSE205450, obtained from postmortem putamen and caudate samples from forty controls and thirty-five PD patients) were retrieved from the Gene Expression Omnibus (GEO) database. …”
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Corneal nerve abnormalities in early-stage diabetic retinopathy evaluated by corneal confocal microscopy by Yi Zhou, Xiangchen Li, Suhan Shi, Ziwei Guo, Beibei Shan, Linlin Xu, Yixiao Li, Jianxin Guo

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Response surface methodology and adaptive neuro-fuzzy inference system for adsorption of reactive orange 16 by hydrochar by J. Oliver Paul Nayagam, K. Prasanna

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Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome by Catello Vollono, Giacomo Della Marca, Elisa Testani, Anna Losurdo, Daniela Virdis, Diana Ferraro, Valerio Brunetti, Paolo M. Rossini, Domenica Le Pera, Salvatore Mazza, Massimiliano Valeriani

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A Novel CRYBB2 Stopgain Mutation Causing Congenital Autosomal Dominant Cataract in a Chinese Family by Yu Zhou, Yaru Zhai, Lulin Huang, Bo Gong, Jie Li, Fang Hao, Zhengzheng Wu, Yi Shi, Yin Yang

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Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators by Jianping Deng, Zicong Wu, Chen Chen, Zhenling Zhao, Yifei Li, Zhengquan Su, Yiguang Lin, Yifei Wang, Zhiping Wang

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Co-producing a safe mobility and falls informatics platform to drive meaningful quality improvement in the hospital setting: a mixed-methods protocol for the insightFall study by Ben Glampson, Clare Leon-Villapalos, Erik Mayer, Rachael Lear, Phoebe Averill, Catalina Carenzo, Rachel Tao, Robert Latchford

“…Exploratory analysis of a preliminary static dataset will examine the variety (structured/unstructured), veracity (accuracy/completeness) and value (clinical utility) of the data. …”
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The effectiveness of providing training and ongoing support to foster cultural humility in volunteers serving as mentors to youth of color: a mixed-methods study protocol by Bernadette Sánchez, Amy J. Anderson, Carla Herrera, David L. DuBois, Kay Thursby Bourke, Jean K. Sack, So Jung Lee, Karen Burchwell, Lidia Y. Monjaras-Gaytan, Yesenia Garcia-Murillo

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An ensemble machine learning-based performance evaluation identifies top In-Silico pathogenicity prediction methods that best classify driver mutations in cancer by Subrata Das, Vatsal Patel, Shouvik Chakravarty, Arnab Ghosh, Anirban Mukhopadhyay, Nidhan K. Biswas

“…Methods The study used a dataset from 502 HNSC patients, classifying mutations based on 299 known high-confidence cancer driver genes. …”
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A comparison of drug‐eluting stent and coronary artery bypass grafting in mildly to moderately ischemic heart failure by Kun Wang, Le Wang, Hongliang Cong, Jingxia Zhang, Yuecheng Hu, Yingyi Zhang, Rui Zhang, Wenyu Li, Wei Qi

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Mechanically powered negative pressure dressing reduces surgical site infection after stoma reversal by Brian Williams, MD, Aubrey Swinford, MD, Jordan Martucci, MD, Johnny Wang, MD, Jordan R. Wlodarczyk, MD, Abhinav Gupta, MD, Kyle G. Cologne, MD, Sarah E. Koller, MD, Christine Hsieh, MD, Marjun P. Duldulao, MD, Joongho Shin, MD

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Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve by Julia Schwarz, Franziska Zistler, Adriana Usheva, Anika Fix, Sebastian Zinn, Juliana Zimmermann, Franziska Knolle, Franziska Knolle, Gerhard Schneider, Rachel Nuttall

“…In this study we aimed to investigate whether BFR modulates the association between age-related brain changes and cognitive performance across a broad range of cognitive domains.MethodsAn open-access neuroimaging and behavioral dataset (n = 301 healthy participants, 18–89 years) was analyzed. …”
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Association between blood test indicators and atrial fibrillation in elderly patients aged 65 and above in the Central Jiangsu region: a cross-sectional study by Hao Liang, Shuai Zhang, Ye Zhu

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