Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer by Yongzhi Wu, Chengen Deng, Zigui Huang, Yongqi Huang, Chuanbin Chen, Mingjian Qin, Zhen Wang, Fuhai He, Shenghai Liu, Rumao Zhong, Jun Liu, Chenyan Long, Jungang Liu, Weizhong Tang, Xiaoliang Huang

“…Furthermore, using transcriptome data from 23 CRC patients, we constructed an immune cell infiltration matrix to deeply explore the biological functions associated with LNM. …”
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Rescuing vascular dysfunction in dorsal pancreatic arteries prevents tacrolimus-induced glucose metabolism disorder in mice by Lingyan Fei, Honghong Wang, Dongliang Zhao, Xiaohua Wang, Jizhen Ren, Lanyun Liu, Chun Tang, Yan Lei, Qingqing Wang, Yuanpeng Nie, Yang Liu, Na Li, Ming Zhong, Nan Xu, Jin Wei, Pontus B. Persson, Andraes Patzak, Pratik H. Khedkar, Zhihua Zheng, Shan Jiang

“…Up to 33.6% of solid organ transplantation patients receiving Tac treatment develop hyperglycemia; however, the underlying mechanisms remain poorly understood. …”
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Clinical association of body symptoms and primary dysmenorrhea among young and middle-aged women: an observational study by Tzyy-Guey Tseng, Che-Yen Kuan, Yun-Ping Lo, Yun-Shiuan Chuang, Yun-Shiuan Chuang, Yun-Shiuan Chuang, Chun-Ying Lee, Chun-Ying Lee, Yi-Ting Lin, Yi-Ting Lin, Yi-Ting Lin, Ing-Luen Shyu, Ing-Luen Shyu, Ing-Luen Shyu, Ming-Tsang Wu, Ming-Tsang Wu, Ming-Tsang Wu, Chi-Jung Tai, Chi-Jung Tai, Chi-Jung Tai, Chi-Jung Tai

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Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospectiv... by Pei-xin Tan, Lin-xin Wu, Shuang Ma, Shi-jing Wei, Tai-hang Wang, Bing-chen Wang, Bing-bing Fu, Jia-shuo Yang, Qing Zhao, Qing Zhao, Li Sun, Yi Liu, Tao Yan

“…Least absolute shrinkage and selection operator (LASSO) regression in combination with multivariate Cox and logistic regression were employed to identify the main impact indicators of relapse-free survival (RFS) and depression. The developed predictive model was evaluated using calibration plots, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). …”
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Optimizing treatment for depression in primary care using psychotherapy versus antidepressant medication in a low-resource setting: protocol for the OptimizeD randomized controlled... by Julia R. Pozuelo, Anuja Lahiri, Rahul S. P. Singh, Arvind Kushwah, Mimansa Khanduri, Akanksha Shukla, Azaz Khan, Sruthi G., Varun Shende, Yashika Parashar, Yashwant K. Mehra, Anant Bhan, Ronald C. Kessler, Daisy R. Singla, John A. Naslund, Karmel W. Choi, Pim Cuijpers, Robert DeRubeis, Mohammad M. Herzallah, Chunling Lu, Jordan W. Smoller, Tyler J. VanderWeele, Abhijit R. Rozatkar, Tamonud Modak, Michelle Melwyn Joel, Debasis Biswas, Shubham Atal, Umay Kulsum, Steven D. Hollon, Vikram Patel

“…Using machine learning, we will attempt to develop a precision treatment rule that leverages baseline clinical, psychological, cognitive, socioeconomic, and biological data to predict which treatment is most likely to achieve remission for each patient. …”
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Allometric equations model for estimating an above and below ground biomass of dipterocarp forest in the tropics by I. Heriansyah, Luthfy Abdullah , J.S. Rahajoe, R. Susanti, Y. Lisnawati, Subarudi , R. Dewi, Darwo , Mawazin , Abdurachman , Karmilasanti , N. Wakhid, D. Wicaksono, R. Effendi, A.S. Yunianto, M.A. Qirom, N. Mindawati

“…Many allometric equations have been developed for estimating the forest biomass in tropical región. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…However, markedly downregulation of the mRNA level of pro-inflammatory cytokine il-1β (p < 0.05) was observed in 0.05 and 0.3T23 groups, compared with the control. 16S rRNA sequencing analysis data on gut microbiota indicated that supplementation of T23 at lower levels (0.05, 0.1 and 0.2) resulted in a remarkable elevation of the abundance of phylum Firmicutes and reduced the abundance of Proteobacteria, and the ratio of (Firmicutes +Bacteroidota +Fusobacteria) /Proteobacteria. …”
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Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure by Lorna Swan, Gruschen R Veldtman, Hubert W Vliegen, Philippine Kiès, Filip Zemrak, Amanda Hunter, Anastasia D Egorova, Monique RM Jongbloed, J Wouter Jukema, Simon T MacDonald, Niki L Walker, Ali N Zaidi, Madelien V Regeer, Bart JA Mertens, Ralph ML Neijenhuis, Ari M Cedars

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Evaluating an intervention to promote access to mental healthcare for low language proficient migrants and refugees across Europe (MentalHealth4All): study protocol for a pretest–p... by Fang Wang, Mike Mösko, Demi Krystallidou, Yuhui Chen, Liza G G van Lent, Saskia Hanft-Robert, Ilaria Galasso, Barbara Schouten, Antoon Cox, Sona Hodakova, Chiara Rao, Koen Kerremans, Raquel Lázaro Gutiérrez, Özlem Temizöz, Dalia Mankauskienė, Łucja Biel, Emilio Di Maria, Julia van Weert, Melanie de Looper, Gian Hernandez, Gaukhar Orkashbayeva, Tobias Kleineidam, Angeliki Tsoukaneli, Mehmet Uygun, Ily Hollebeke, Beatrice Bünsch, Leon Köchel, Mia Mengtong Li, Mara Morelli, Stefania Muzi, Cecilia Serena Pace, Carlotta Gualco, Nijolė Maskaliūnienė, Katarzyna Czarnocka-Gołębiewska, Urszula Okulska-Łukawska, Argnieszka Biernacka, Aleksandra Kalata-Zawłocka, Agnieszka Słopień, Natalia Pytlińska, Monika Šavelová, Andrej Birčák, Daniela Müglová, Carmen Valero Garcés, Carmen Pena Díaz, Elena Alcalde Peñalver, Cristina Álvaro Aranda, Silvia Damianova Radeva, Sabine Braun, Jaleh Delfani, Graham Hieke, Elena Davitti, Constantin Orasan, Lieven Buysse

“…Secondary outcomes (measured at T2) are: actual usage of the platform (ie, tracking data), perceived ease of use, usefulness of content, comprehensibility of information, attractiveness of content and emotional support. …”
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Antibiotic susceptibility patterns of Salmonella isolates from clinical, food, and environmental sources in Addis Ababa and surrounding towns, Ethiopia by Abebe M. Aga, Demise Mulugeta, Dassalegn Muleta, Adugna Abdi Woldesemayat, Abera Motuma, Musin Kelel, Bilise Wakitole, Shambel Tadesse, Zinash Teferi, Fanos Tadesse Woldemariyam, Serkadis Oljira, Henok Ferede, Natnael Berihun, Samson Girma, Dereje Nigussie, Mesfin Tafesse Gemeda

“…This study provides a comprehensive analysis of Salmonella isolates from clinical, food, and environmental samples in Addis Ababa and nearby towns, offering current data on antimicrobial resistance patterns. …”
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Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…This study utilizes 96 variables of seasonal time series data that affect the management quality index within the bank productivity framework, one of the critical indicators for assessing the health of the banking system. …”
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Radiomic Model Associated with Tumor Microenvironment Predicts Immunotherapy Response and Prognosis in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma by Jie Sun, Xuewei Wu, Xiao Zhang, Weiyuan Huang, Xi Zhong, Xueyan Li, Kaiming Xue, Shuyi Liu, Xianjie Chen, Wenzhu Li, Xin Liu, Hui Shen, Jingjing You, Wenle He, Zhe Jin, Lijuan Yu, Yuange Li, Shuixing Zhang, Bin Zhang

“…A combined model was constructed by integrating clinical and radiomic data. A radiomic interpretability study was performed with whole slide images (WSIs) stained with hematoxylin and eosin (H&E) and immunohistochemistry (IHC). …”
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CARI Guideline: Evidence-Based Recommendations for Balanced Electrolyte Solutions to Improve Kidney Transplant Outcomes by Colm O’Reilly, David Tunnicliffe, Allan Blackley, Michael Collins, Emmy O’Neill, Siah Kim, Karthik Venkataraman, Emily See, Ross Francis

“…This guideline seeks to synthesize the available evidence and make recommendations for the Australian and New Zealand care by a multidisciplinary working group, including consumers with lived experience of kidney transplantation.A recently published systematic review and meta-analysis of randomized controlled trials (RCTs), including data from the BEST Fluids trial, evaluating balanced electrolyte solutions versus normal saline in kidney transplants was identified and absolute effects were determined using baseline risks of SONG Transplant Core outcomes from either national registries or event rates in the control arms of the included trials. …”
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Lessons from the PROTECT-CH COVID-19 platform trial in care homes by Philip M Bath, Jonathan Ball, Matthew Boyd, Heather Gage, Matthew Glover, Maureen Godfrey, Bruce Guthrie, Jonathan Hewitt, Robert Howard, Thomas Jaki, Edmund Juszczak, Daniel Lasserson, Paul Leighton, Val Leyland, Wei Shen Lim, Pip Logan, Garry Meakin, Alan Montgomery, Reuben Ogollah, Peter Passmore, Philip Quinlan, Caroline Rick, Simon Royal, Susan D Shenkin, Clare Upton, Adam L Gordon

“…Results We initiated the trial including protocol, approvals, insurance, website, database, data algorithms, intervention selection and training materials. …”
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Efficacy of a Personalized Mobile Health Intervention (BedTime) to Increase Sleep Duration Among Short-Sleeping Patients With Type 2 Diabetes: Protocol for a Pilot Randomized Contr... by Yuki Ban, Kayo Waki, Ryohei Nakada, Akihiro Isogawa, Kengo Miyoshi, Hironori Waki, Shunsuke Kato, Hideaki Sawaki, Takashi Murata, Yushi Hirota, Shuichiro Saito, Seiji Nishikage, Atsuhito Tone, Mayumi Seno, Masao Toyoda, Shinichi Kajino, Kazuki Yokota, Yuya Tsurutani, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe

“…The intervention period concluded on December 6, 2024, and the observation period ended on February 26, 2025, with 70 participants completing the observation period. The data analysis is currently underway, and results are expected to be published in July 2025. …”
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Mitochondrial DNA Polymorphisms of Peripheral Blood Mononuclear Cells Associated with Sustained Ventricular Tachycardia in Patients with Cardioverter-Defibrillator Implantation Ind... by Tariel Atabekov, Viacheslav Korepanov, Sergey Krivolapov, Mikhail Khlynin, Sergey Afanasiev, Maria Golubenko, Roman Batalov, Sergey Popov

“…Based on our data, we developed a risk model for SVT. …”
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Influence of the biophosphomag preparation and biologically active substances from milk thistle seeds (Silybum marianum) on the metabolism of lymphocytes and their functional featu... by Petro Fedyshyn, Olga Pavliuk, Ivan Stupak, Taisa Dovbynchuk, Yulia Pysmenna, Volodymyr Liashenko, Natalia Senchylo, Serhii Holopura, Liliia Kalachniuk, Liudmyla Garmanchuk

“…According to preliminary data, the preparations exhibit choleretic activity and help stabilize liver and digestive functions. …”
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How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies by Lin Hu, Jiayuan Li, Zihuan Tang, Peng Gong, Zongqi Chang, Chen Yang, Tianpei Ma, Shuang Jiang, Chunxia Yang, Tao Zhang

“…China Health and Nutrition Survey (CHNS) was used to develop Klemera-Doubal method-biological age (KDM-BA), and the validation analysis was performed in UK Biobank (UKB) and Hongguang Elderly Health Examination Cohort (HEHEC). …”
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A microRNA signature that correlates with cognition and is a target against cognitive decline by Md Rezaul Islam, Lalit Kaurani, Tea Berulava, Urs Heilbronner, Monika Budde, Tonatiuh Pena Centeno, Vakthang Elerdashvili, Maria‐Patapia Zafieriou, Eva Benito, Sinem M Sertel, Maria Goldberg, Fanny Senner, Janos L Kalman, Susanne Burkhardt, Anne Sophie Oepen, Mohammad Sadman Sakib, Cemil Kerimoglu, Oliver Wirths, Heike Bickeböller, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Nicoleta‐Carmen Cosma, Klaus Fliessbach, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Luca Kleinedam, Christoph Laske, Coraline D Metzger, Matthias H Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris S. Rauchmann, Nina Roy, Anja Schneider, Annika Spottke, Eike J Spruth, Stefan Teipel, Maike Tscheuschler, Michael Wagner, Jens Wiltfang, Emrah Düzel, Frank Jessen, Delcode Study Group, Silvio O Rizzoli, Wolfram‐Hubertus Zimmermann, Thomas G Schulze, Peter Falkai, Farahnaz Sananbenesi, Andre Fischer

“…In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3‐microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. …”
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Utilization of agricultural waste to reduce enteric methane emissions on livestock in tropical environment by Sulistyo ., Pranoto ., E. Mahajoeno, S.H. Pranolo, A. Sofyan, H. Herdian, B. Haryanto, R.H. Praptana

“…The methane, nitrous oxide, and carbon dioxide contents were analyzed using gas chromatography. Data on nutrient content and digestibility of dry matter and organic matter were analyzed using analysis of variance, and the estimated greenhouse gas emissions were calculated using the ideal gas equation approach.FINDINGS: The quality of the feed formula influences the amountof greenhouse gases emission produced by enteric fermentation processes. …”
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