Cognition and experience of surgical incisions in patients undergoing laparoscopic surgery with enhanced recovery after surgery protocol: A qualitative study by Hongxia Xu, Yihong Xu, Gongjie Shi, Jiaqi Lu, Liping Zhu, Guibing He, Xiao Liang

“…Semi-structured interviews, covering physical function, social function, emotional function, self and others’ acceptance, and confidence in the nature and treatment of the disease, were audio-recorded and transcribed verbatim and guided by a thematic framework co-developed by surgeons, nurses, and psychologists. The data were analyzed via the framework method to identify themes related to incision experiences. …”
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Acute cannabis intoxication among the paediatric population by Ginevra Malta, Giuseppe Davide Albano, Gianluca Lavanco, Anna Brancato, Carla Cannizzaro, Antonina Argo, Simona Contorno, Fulvio Plescia, Stefania Zerbo

“…The pharmacokinetics of cannabinoid ingestion in children are significantly influenced by the immaturity of their gastrointestinal tract and metabolic enzyme systems, resulting in altered oral bioavailability. Clinical data indicate that Δ9-tetrahydrocannabinol (THC)-related effects in paediatricpaediatric patients typically emerge within 2 hours of ingestion, with more severe symptoms developing within 4 hours. …”
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The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights by Peicheng Jiang, Zhifeng Jiang, Su Li, Su Li, Ye-Xiong Li, Yuqiong Chen, Xinyan Li

“…Moreover, a GLS-DSBr (double strand break repair) prognostic model was developed using machine learning with data from 2,066 LUAD patients.ResultsIn vitro and in vivo experiments demonstrated that GLS silence inhibited DSB repair and promoted ferroptosis, therefore enhancing radiosensitivity. …”
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Predicting the risk of postoperative avascular necrosis in patients with talar fractures based on an interpretable machine learning model by Jian Zhang, Jian Zhang, Jian Zhang, Jihai Xu, Jihai Xu, Jiapei Yu, Jiapei Yu, Jiapei Yu, Hong Chen, Hong Chen, Xin Hong, Songou Zhang, Xin Wang, Xin Wang, Chengchun Shen, Chengchun Shen, Chengchun Shen

“…Multidimensional data encompassing demographic characteristics, fracture-related variables, surgery-related parameters, and follow-up information were collected. …”
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Multivariate predictive model of the therapeutic effects of metoprolol in paediatric vasovagal syncope: a multi-centre studyResearch in context by Yaxi Cui, Jing Zhang, Yuwen Wang, Ying Liao, Keyu Liu, Wenrui Xu, Shu Wu, Chufan Sun, Chunyu Zhang, Qingyou Zhang, Ping Liu, Yuli Wang, Yanjun Deng, Chen Shen, Yao Lin, Hong Cai, Juan Zhang, Runmei Zou, Ping Liu, Shuo Wang, Hongfang Jin, Lin Shi, Cheng Wang, Junbao Du

“…Univariate analysis and logistic regression were used to select the candidate predictors. …”
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Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations by Alejandro Álvarez‐Bustos, Helio José Coelho‐Junior, Riccardo Calvani, Leocadio Rodriguez‐Mañas, Matteo Tosato, Matteo Cesari, Antonio Cherubini, Alfonso J. Cruz‐Jentoft, Pálmi V. Jónsson, Fabrizia Lattanzio, Marcello Maggio, Regina Roller‐Wirnsberger, Ingrid Rýznarová, Annemie M. W. J. Schols, Cornel C. Sieber, Alan J. Sinclair, Anna Skalska, Timo Strandberg, Achille Tchalla, Eva Topinková, Bruno Vellas, Stephan vonHaehling, Francesco Landi, Emanuele Marzetti, for the SPRINTT consortium

“…Methods This is a secondary analysis of an evaluator blinded, randomised controlled trial, developed in 16 clinical sites across 11 European countries, from January 2016 to 31 October 2019. …”
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Impact of a pain education program for people with spinal cord injury who experience neuropathic pain by Nicholas P. Cherup, Kimberly D. Anderson, Marlon L. Wong, Gabriel E. Fernandez, Linda E. Robayo, Kathryn Roach, Roberta Vastano, Eva Widerstrom-Noga, Eva Widerstrom-Noga

“…Despite the availability of various treatments, many report inadequate pain relief, and various side effects.ObjectiveThe primary purpose of the current study was to explore participants’ perspectives on a brief, four-week virtual pain education program and second to evaluate any effects on pain and psychosocial factors.MethodsThis study included 36 participants with SCI who experienced moderate to severe neuropathic pain and explored their perspectives on the pain program using qualitative interviews and evaluated a small set of self-reported pain outcomes.ResultsThe analysis and coding of the qualitative interview data resulted in two primary overarching themes: Benefits of pain education and Content and delivery of pain education. …”
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Circulating B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus by Joanna Kosałka-Węgiel, Bogdan Jakieła, Radosław Dziedzic, Mamert Milewski, Andżelika Siwiec-Koźlik, Lech Zaręba, Stanisława Bazan-Socha, Marek Sanak, Jacek Musiał, Mariusz Korkosz

“…Finally, the percentage of plasmablasts correlated with SLE duration (r = 0.42, <i>p</i> = 0.016). In the follow-up analysis, during a median observation of 5 years, 5 out of the initially 23 inactive SLE patients developed a disease flare. …”
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Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches by Xuemin Fu, Luling Wu, Luling Wu, Jingna Xun, Benno Pütz, Zhihang Zheng, Yanpeng Li, Yanpeng Li, Yinzhong Shen, Hongzhou Lu, Jun Chen, Bertram Müller-Myhsok

“…Although improved risk stratification and tailored clinical management are urgently needed to enhance patient survival, such strategies remain limited.MethodsWe analyzed clinical and immunological data from 98 HIV-related cryptococcosis cases, employing machine learning techniques to model disease severity and predict survival outcomes. …”
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Top 10 palliative care research priorities in France: a 3-step, mixed-methods protocol (AXEPRO study) by Stéphane Sanchez, Guillaume Economos, Fiona Ecarnot, Cecile Barbaret, Raphaëlle Habert-Dantigny, Héloïse Rouze, Doan Huynh, Roseline Huynh, Caroline Tête, Martin Julier-Costes, Valérie Amouroux-Gorsse, Isabelle Lavault, Justine Bret

“…Following the guidance from the James Lind Alliance and the UK public consultation (‘Palliative and End of Life Care Research Priorities Project’), we developed a 3-step protocol aimed at prioritising 10 unanswered questions in palliative care (PC) research in France, from the viewpoint of patients, volunteers, healthcare professionals and family caregivers.Methods and analysis To identify unanswered questions in PC (stage 1), an unstructured questionnaire will be used. …”
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Identity in turmoil: Investigating the morally injurious dimensions of minority stress by Andrew A. Nicholson, Sandhya Narikuzhy, Jakub Wolf, Mina Pichtikova, Magdalena Siegel, James Mirabelli, Taylor Hatchard, Niki Hosseini-Kamkar, Ella Bawagan, Sophia L. Roth, Christina Mutschler, Ruth A. Lanius, Fardous Hosseiny, Kristen Eckstrand, Brigitte Lueger-Schuster

“…Qualitative themes were extracted and then converged with MIES scores to investigate differential thematic presentations based on the quantitative intensity of SGM-related PMIEs.Results: Data analysis indicated four core themes related to moral injury among SGMs: shame (internalizing stigma), guilt, betrayal/loss of trust, and attachment injuries (rejection, altered sense-of-self, and social cognition). …”
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MRI-based risk factors for intensive care unit admissions in acute neck infections by Jari-Pekka Vierula, Harri Merisaari, Jaakko Heikkinen, Tatu Happonen, Aapo Sirén, Jarno Velhonoja, Heikki Irjala, Tero Soukka, Kimmo Mattila, Mikko Nyman, Janne Nurminen, Jussi Hirvonen

“…Objectives: We assessed risk factors and developed a score to predict intensive care unit (ICU) admissions using MRI findings and clinical data in acute neck infections. …”
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Efficacy and safety of robot-assisted laparoscopic sacral fixation for the treatment of pelvic organ prolapse by Liu Xiaodong, Wang Jiawen, Meng Lingfeng, Zhao Shuangyi, Zhou Yunhe, Chu Xin, Wu Jianye, Zhang Yaoguang

“…[Methods] A retrospective analysis was conducted on the clinical data of 17 female patients with pelvic organ prolapse who underwent robot-assisted laparoscopic sacral fixation at Beijing Hospital between September 2019 and June 2023. …”
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Historical water environment changes in Chagan Lake (mid-19th to mid-20th century) inferred from sedimentary diatom records by Fengyang Sui, Fengyang Sui, Xinxin Du, Henglin Xiao, Henglin Xiao, Shuying Zang, Hongkuan Hui, Qi Lv, Yan Liu, Nannan Zhang, Yawen Fan

“…Although pH values and salinity thresholds remained stable, the nutrient status developed towards eutrophication after the 1950s. Sedimentological data further indicated accelerated sedimentation rates (0.34 cm·yr−1 pre-1950s vs. 1.31 cm·yr−1 post-1980s) and notable changes in grain-size characteristics, attributable to combined anthropogenic erosion, hydrological engineering, and climatic influences. …”
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Comparative child mental health and academic outcomes after primary school teachers deliver task-shifted mental health care in India by Priscilla Giri, Molly M. Lamb, Venessa C. Fuentes, Arpana Thapa, Surekha Bhattarai, Choden Dukpa, Catherine C. Shrestha, Setareh Ekhteraei, Juliana L. Vanderburg, Breanna Windsor, Abhishek K. Rauniyar, Karen Hampanda, Bradley N. Gaynes, Rinzi Lama, Michael Matergia, Christina M. Cruz

“…We conducted a pragmatic, mixed methods, post hoc analysis using data from 2019 of an open trial of Tealeaf running in parallel with the all-EUC first step of a stepped wedge cluster randomized controlled trial (SW-CRCT). …”
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National Health Policy and factors predicting its implementation at the local level in Nepal: an exploratory cross-sectional study by Dipendra Khadka, Dipendra Khadka, Dipendra Khadka, Zhang Xinyi, Zhang Xinyi, Zhang Mengjie, Zhang Mengjie, Rajan Bhusal, Chichen Zhang, Chichen Zhang

“…This study evaluated the implementation status, challenges, and opportunities of the NHP at the local level in Nepal.Materials and methodsA descriptive cross-sectional study was conducted in the Lumbini province among 166 health workers selected through simple random sampling. Data were collected from October 10 to November 15, 2024, using a structured questionnaire developed in Nepali through literature review and expert consultations. …”
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A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma by Xuyan Zhao, Hanxiao Cui, Mingjing Zhou, Xueting Ren, Zihao Li, Peinan Liu, Danni Zhao, Shuai Lin, Huafeng Kang

“…However, its relationship with prognosis, tumour microenvironment (TME), and treatment response in KIRC remains unclear.Method Expression profiles and clinical data were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus databases. …”
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Stress adaptation under in vitro evolution influences survival and metabolic phenotypes of clinical and environmental strains of Vibrio cholerae El-Tor by Nana Eghele Adade, Stephen Dela Ahator, Inmaculada García-Romero, Macarena Algarañás, Vincent Appiah, Miguel A. Valvano, Samuel Duodu

“…Mutations in genes encoding EAL and HD-GYP domain-containing proteins correlated with increased biofilm formation and different colony morphotypes. The combined analysis of the metabolic and genomic data pointed to pathways implicated in stress survival. …”
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The effects on clinical characteristics, potential factors and outcomes in SAPHO patients during the COVID-19 epidemic by Minhui Su, Haixu Jiang, Shengyan Liu, Pengfei Shen, Dinghua Zhou, Keqiang Zhu, Zixi Huang, Chen Li, Meiling Li

“…The associated effect factors were displayed in the case of previous tonsillectomy using multivariate analysis and Firth’s penalized likelihood. JAK inhibitor use (p = 0.025) and pneumonia (p = 0.011) were more likely to develop in patients with a history of tonsillectomy.ConclusionDisease activity was inversely correlated with JAK inhibitor use in SAPHO patients with COVID-19 during the pandemic. …”
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Effects of different corticotomy approaches on anterior retraction with clear aligners: a finite element study by Hongyu Hou, Fang Yang, Hong He, Fang Hua, Zhengguo Cao, Hui Xiong

“…Methods Based on research criteria, one volunteer was selected(24 years old, male) and cone beam computed tomography (CBCT) data were obtained. Finite element models were constructed using reverse engineering, including maxillary dentition without first premolars, maxilla, periodontal ligaments (PDLs), attachments, and aligners. …”
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