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161
Attentional Phenotypes for the Analysis of Higher Mental Function
Published 2002-01-01“…DNA from cheek swabs of subjects who performed the task are then used to examine candidate polymorphisms in genes related to the transmitters. …”
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162
Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown
Published 2012-01-01“…., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. …”
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163
Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison
Published 2012-01-01“…Indeed, convincing experimental and clinical evidence underline the key role of oxidative stress in several tumor aspects thus affecting several characteristics of cancer cells. …”
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164
NF-κB-Specific Suppression in Cardiomyocytes Unveils Aging-Associated Responses in Cardiac Tissue
Published 2025-01-01“…Echocardiography showed evidence of eccentric hypertrophy, and both diastolic and systolic dysfunction in 3M mice. …”
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165
Descriptive Investigation of Strongyloidiasis Infection and Characterization of Strongyloides stercoralis Using Morphological and Molecular-Based Methods
Published 2020-01-01“…The multiplex PCR performed on DNA extracted from stool elicited the expected band at 129 bp on gel electrophoresis of the PCR yield providing molecular evidence of intestinal strongyloidiasis. …”
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166
Brigatinib treatment in a patient with advanced NSCLC with XPO1-ALK fusion: a case report
Published 2025-01-01“…In this case report, we provide evidence of a novel ALK fusion, XPO1-ALK (intergenic), identified by next-generation DNA sequencing in a patient with advanced lung cancer. …”
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167
Mitochondria as a Potential Regulator of Myogenesis
Published 2013-01-01“…For example, mitochondrial mass/volume, mtDNA copy number, and mitochondrial respiration are markedly increased after the onset of myogenic differentiation. …”
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168
Pathological Significance of Mitochondrial Glycation
Published 2012-01-01“…The formation of glycation adducts within cells can have severe functional consequences such as inhibition of protein activity and promotion of DNA mutations. Although several lines of evidence suggest that there are specific mitochondrial targets of glycation, and mitochondrial dysfunction itself has been implicated in disease and ageing, it is unclear if glycation of biomolecules specifically within mitochondria induces dysfunction and contributes to disease pathology. …”
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169
Role of aspirin in cancer prevention
Published 2024-01-01“…Aspirin [1], also known as acetylsalicylic acid, is a common non-steroidal anti-inflammatory drug (NSAID). The available evidence shows that aspirin can effectively prevent and treat diseases such as rectal, gastric, ovarian, prostate, and lung cancer. …”
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170
Current Views of Torque Teno Virus (TTV) in Liver Diseases
Published 2020-09-01“…We review published evidence on the torque teno virus (TT virus, TTV), which was discovered in the late of the 20th century.Key points. …”
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171
Protective effect of exercise on animals with sepsis: a systematic review of the existing literature
Published 2025-02-01“…However, in preclinical studies, there was no systematic evidence to summarize the effects of exercise training on sepsis. …”
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172
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173
Three new asexual Kirschsteiniothelia species from Guizhou Province, China
Published 2025-02-01“…Based on distinct morphological characteristics and molecular phylogenetic evidence, we describe three new species: Kirschsteiniothelia guizhouensis, K. weiningensis, and K. xishuiensis. …”
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174
Heterogeneous Chromosomal Aberrations in Intraductal Breast Lesions Adjacent to Invasive Carcinoma
Published 2000-01-01“…There is evidence that breast cancer is a heterogeneous disease phenotypically as well as molecular biologically. …”
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175
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression
Published 2015-06-01“…nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR). nc886 is transcribed by RNA polymerase III (Pol III) and is intriguingly the first case of a Pol III gene whose expression is silenced by CpG DNA hypermethylation in several types of cancer. …”
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176
Targeting Toll-Like Receptors for Treatment of SLE
Published 2010-01-01“…Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. …”
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177
Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review
Published 2022-01-01“…A search for scientific evidence was carried out in electronic databases (MEDLINE/PubMed, SciELO). …”
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178
Pittsburgh as a High Risk Population: The Potential Savings of a Personalized Dental Care Plan
Published 2016-01-01“…Objectives. Little evidence exists for the current standard of two annual preventative care visits. …”
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179
Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Published 2018-01-01“…Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications. …”
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180
Effects of endocrine disrupting chemicals, blood metabolome, and epigenetics on breast cancer risk: A multi-dimensional mendelian randomization study
Published 2025-02-01“…The study also examines the 1400 blood metabolome as potential mediators and explores EDCs-associated DNA methylation changes as potential factors, with a focus on European populations. …”
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