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The Spectrum of Anti-Chromatin/Nucleosome Autoantibodies: Independent and Interdependent Biomarkers of Disease
Published 2014-01-01“…This review will focus on immunoassays that utilize chromatin components, their clinical relationships, and newer evidence implicating HMG proteins and DNA neutrophil extracellular traps (NETs) as important players in systemic autoimmune rheumatic diseases.…”
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Association of Toll-Like Receptor 2 (TLR2) Expression in Placenta and Intrauterine Exposure to Hepatitis B Virus
Published 2022-01-01“…We performed enzyme-linked immunoadsorbent assay of HBeAg, HBsAg titer, Anti-HBs, and Anti-HBc to 59 HBsAg-positive pregnant women and identified HBV DNA using nested PCR in their cord blood during delivery for evidence of exposure to HBV DNA. …”
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124
The Role of Epigenetic in Dental and Oral Regenerative Medicine by Different Types of Dental Stem Cells: A Comprehensive Overview
Published 2022-01-01“…A wide range of host and environmental factors influence stem cell differentiation and differentiation commitment, of which epigenetic regulation is critical. Several lines of evidence have shown that epigenetic modification of DNA and DNA-correlated histones are necessary for determining cells’ phenotypes and regulating stem cells’ pluripotency and renewal capacity. …”
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125
Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts
Published 2025-02-01“…P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cells by TERT. …”
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126
Albinism in the Ancient Mediterranean World
Published 2021-05-01“… The discovery of DNA in the 20th century and recent biomedical research into the human genome in Southern Africa have shed much light on the diag-nostic, epidemiological, and sociological aspects of albinism. …”
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127
Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions
Published 2024-09-01“…While there is strong evidence that epigenetic alterations, consisting of changes in DNA methylation, histone modifications, and non-coding RNAs, play a crucial role in breast cancer initiation and development, additional research is warranted to elucidate the safety profile of long-term interventions involving epigenetic drugs and to validate the role of epigenetic markers in disease diagnosis, prognosis, and personalised treatment. …”
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128
Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing.
Published 2025-01-01“…Our results provide biochemical evidence that the HIV-1 capsid lattice conceals the genome from cGAS and that chemical or physical disruption of the viral core can expose HIV-1 DNA and activate innate immune signaling.…”
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129
Genomic data suggest parallel dental vestigialization within the xenarthran radiation
Published 2023-08-01Get full text
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130
Transcultural Diabetes Nutrition Algorithm: A Malaysian Application
Published 2013-01-01“…The initial evidence-based global tDNA template was designed for simplicity, flexibility, and cultural modification. …”
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131
Human Papillomavirus Detection in Head and Neck Squamous Cell Carcinomas at a Tertiary Hospital in Sub-Saharan Africa
Published 2019-01-01“…HPV-DNA was detected in 18% of the HNSCC cases, with 17 being HPV-16 and 1 dual infection with HPV-16 and HPV-18. …”
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132
Genetics and Epigenetics of Parkinson's Disease
Published 2012-01-01“…In addition, increasing evidence suggests that epigenetic mechanisms, such as DNA methylation, histone modifications, and small RNA-mediated mechanisms, could regulate the expression of PD-related genes.…”
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133
An Effective and Safe Maize Seed Chipping Protocol Using Clipping Pliers With Applications in Small-Scale Genotyping and Marker-Assisted Breeding
Published 2025-02-01“…For three of the methods, seed-based DNA was of comparable quality to DNA extracted from leaf punches. …”
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134
Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas
Published 2002-01-01“…In IDH lesions loss of heterozygosity (LOH) at various loci could be identified, and comparative genomic hybridization (CGH) and fluorescence in situhybridization (FISH) studies delivered evidence for DNA amplification on chromosomal region 20q13 in the early stage of IDH. …”
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135
Behavioral phenotyping of Kaiso-deficient mice
Published 2015-12-01“…Kaiso is a methyl DNA-binding protein, which participates in the epigenetic regulation of gene expression. …”
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136
Significance of Apoptosis in the Process of Tumorigenesis in Colorectal Mucosa and Adenomas in FAP Patients
Published 1997-01-01“…The existence of subdiploid apoptotic cells was derived from DNA and/or DNA/protein patterns. In a follow‐up group, the mucosa is characterised by a balance between proliferation (S % + G2M % = 19) and apoptotic cells (% = 17). …”
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137
The Transcultural Diabetes Nutrition Algorithm: A Canadian Perspective
Published 2014-01-01“…The Transcultural Diabetes Nutrition Algorithm (tDNA) is a clinical tool designed to facilitate implementation of therapeutic lifestyle recommendations for people with or at risk for type 2 diabetes. …”
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138
Role of Helicobacter pylori in the Pathogenesis of Gastric Carcinoma and Progression of Lymphoid Nodules to Lymphoma
Published 1999-01-01“…A model for gastric carcinogenesis is proposed in which H pylori causes cell proliferation, and the risk of DNA damage is increased, leading to inadequate repair and malignant transformation. …”
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The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis
Published 2023-01-01“…There is an increasing amount of evidence that suggests that epigenetic aberrations, including deoxyribonucleic acid (DNA) methylation, play a definite role in the pathogenesis of endometriosis. …”
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Detection of Human Papillomavirus Type 2 Related Sequence in Oral Papilloma
Published 1998-01-01“…We analysed the genetical and histopathological evidence for HPV type 2 infection in three oral papillomas. …”
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