The Evidence of Cooperative Binding of a Ligand to G4 DNA by A. G. Kudrev

Get full text

Telomere DNA in the insect order Dermaptera and the first evidence for the non-canonical telomeric motif TTCGG in Arthropoda by Vladimir A. Lukhtanov

Get full text

Genetic Evidence for Geographic Structure within the  Neanderthal Population by Rogers, Alan R.

Get full text

Genetic Evidence of Killer Whale Predation on White Sharks in Australia by Isabella M. M. Reeves, Andrew R. Weeks, Alison V. Towner, Rachael Impey, Jessica J. Fish, Zach S. R. Clark, Paul A. Butcher, Lauren Meyer, David M. Donnelly, Charlie Huveneers, Nicky Hudson, Adam D. Miller

“…Genomic analyses performed on swabs taken from the bite wounds confirmed the presence of killer whale DNA in the major bite area, while the other bites were embedded with genetic material from the scavenging broadnose sevengill shark (Notorynchus cepedianus). …”
Get full text

The impact of parameter variation in the quantification of forensic genetic evidence by Camila Costa, Carolina Figueiredo, Sandra Costa, Paulo Miguel Ferreira, António Amorim, Lourdes Prieto, Nádia Pinto

“…The weight of the evidence depends on several parameters regarding the population and sample-related analytical factors, the latter in a greater number when the DNA amount is considered. …”
Get full text

Experimental Evidence of Rapidly Decaying Environmental DNA Highlights Infection Risk from Two Major Amphibian Pathogens by Joseph D. Trafford, Trenton W. J. Garner, David J. Murrell, Julia J. Day

Get full text

Genetic evidence for the causal effects of air pollution on the risk of respiratory diseases by Yanjuan Wu, Yuting Zhang, Jingcun Wang, Qiming Gan, Xiaofen Su, Sun Zhang, Yutong Ding, Xinyan Yang, Nuofu Zhang, Kang Wu

Get full text

The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia by Haoran Jia, Ye Liu, Tingting Zhao, Dexing Wang, Meng Du, Weiwei Wang

Get full text

New Species of Empidinae (Diptera) from San Rossore National Park, Italy, with the First Report on Leg Polymorphism in the Genus <i>Hilara</i> Meigen and Their DNA Barcoding Evidence by Miroslav Barták, Milan Kozánek, Antonio Belcari, Andrea Š. Tóthová

Get full text

Increased interferon I signaling, DNA damage response and evidence of T-cell exhaustion in a patient with combined interferonopathy (Aicardi-Goutières Syndrome, AGS) and cohesinopathy (Cornelia de Lange Syndrome, CdLS) by Sorina Boiu, Nikolaos Paschalidis, George Sentis, Theodora Manolakou, Andrianos Nezos, Manolis Gialitakis, Maria Grigoriou, Erato Atsali, Melpomeni Giorgi, Argirios Ntinopoulos, Clio Mavragani, Periklis Makrythanasis, Dimitrios T. Boumpas, Aggelos Banos

Get full text

An Overview of DNA Repair in Amyotrophic Lateral Sclerosis by Fabio Coppedè

“…After a brief description of the evidence of DNA damage in ALS, this paper focuses on the available data on DNA repair activity in ALS neuronal tissue and disease animal models. …”
Get full text

Differential Toxicity of DNA Adducts of Mitomycin C by Jill Bargonetti, Elise Champeil, Maria Tomasz

“…This review focuses on differential biological effects of individual adducts in various mammalian cell cultures, observed in the authors' laboratories. Evidence is reviewed that various adducts are capable of inducing different cell death pathways in cancer cells.This evidence is derived from a parallel study of MC and its derivatives 2,7-diaminomitosene (2,7-DAM) which is the main metabolite of MC and forms two mono-adducts with DNA, and decarbamoyl mitomycin C (DMC), which alkylates and cross-links DNA, predominantly with a chirality opposite to that of the DNA adducts of MC. 2,7-DAM is not cytotoxic and does not activate the p53 pathway while MC and DMC are cytotoxic and able to activate the p53 pathway. …”
Get full text

Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…Despite its reputation as a radioresistant tumour, there is evidence to support a role for radiotherapy in patients with melanoma and we summarise current clinical practice. …”
Get full text

Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. …”
Get full text

The role of DNA methylation in the disorders of bone metabolism by B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva, R. I. Khusainova

“…The purpose of this review is to compile and systematize data on the role of DNA methylation in bone metabolism in normal and pathological conditions, in the formation of osteoporosis, and to assess achievements and trends in this field of research and technologies for studying DNA methylation.…”
Get full text

Genome-Wide Analysis of DNA Methylation in Human Amnion by Jinsil Kim, Mitchell M. Pitlick, Paul J. Christine, Amanda R. Schaefer, Cesar Saleme, Belén Comas, Viviana Cosentino, Enrique Gadow, Jeffrey C. Murray

“…This work provides preliminary evidence that DNA methylation changes in the amnion may be at least partially involved in the physiological process of labor and the etiology of preterm birth and suggests that DNA methylation profiles, in combination with other biological data, may provide valuable insight into the mechanisms underlying normal and pathological pregnancies.…”
Get full text

MicroRNAs in the DNA Damage/Repair Network and Cancer by Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

“…Recently, increasing evidence has suggested that microRNAs take actively part in the regulation of the DNA damage/repair network. …”
Get full text

Herpes Simplex Virus Latency: The DNA Repair-Centered Pathway by Jay C. Brown

“…Here I describe the basic features of the DNA repair-centered pathway and discuss some of the experimental evidence supporting it. …”
Get full text

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease by Yajing Huang, Jingwei Chi, Fanxiang Wei, Yue Zhou, Yihai Cao, Yangang Wang

“…Existing evidence indicates that changes in mtDNA copy number in blood and urine reflect mitochondrial dysfunction and the severity of DKD. …”
Get full text

Liberties of the genome: insertions of mitochondrial DNA fragments into nuclear genome by M. V. Golubenko, V. P. Puzyrev

“…To date, evidence has been obtained that the occurrence of new mtDNA insertions in the nuclear genome is a seldom but not exceptionally rare event. …”
Get full text