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The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo...
Published 2025-01-01“…Epigenetics are heritable reversible changes in gene expression that occur without any changes in the nuclear DNA sequence or DNA copy number. Primary Objective i. …”
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DNA Damage Induced by Alkylating Agents and Repair Pathways
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Simple and Fail-safe Method to Transform Miniprep Escherichia coli Strain K12 Plasmid DNA Into Viable Agrobacterium tumefaciens EHA105 Cells for Plant Genetic Transformation
Published 2025-01-01“…The optimized method minimizes DNA degradation and maximizes uptake by Agrobacterium cells, making it a reproducible and accessible protocol for various genetic engineering applications. …”
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The relative biologic effectiveness versus linear energy transfercurve as an output-input relation for linear cellular systems
Published 2009-05-01“…These systems internal state parameters represent parts of a biochemical network within a cell. Although multiple biochemical parts may well be involved, the shape of the RBE-LET curve is reproduced when only three system parameters are related to three biochemical parts: the molecular machinery for DNA double strand break repair; the molecular pathways for handling oxidative stress; and the radiolytic products of the cellular water. …”
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EPIGENETICS TODAY AND TOMORROW
Published 2015-01-01“…DNA methylation in eukaryotes is species- and tissue (cell) specific. …”
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Herpes Simplex Virus Latency: The DNA Repair-Centered Pathway
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Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases?
Published 2012-01-01Get full text
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Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease
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PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells
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Synthetic transmembrane DNA receptors enable engineered sensing and actuation
Published 2025-02-01“…Upon the input of external signals, the DNA receptors can form dimers on the cell surface triggered by configuration changes, leading to a series of downstream cascade events including communication between donor and recipient cells, gene transcription regulation, protein level control, and cell apoptosis. …”
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Topical Mitomycin C and Radiation Induce Conjunctival DNA-Polyploidy
Published 2001-01-01“…Conclusion: Measurements of DNA‐content revealed euploid polyploidisation of morphological suspicious but benign squamous cells which is the biologic correlate of well known secondary morphologic changes following topical chemotherapy and/or radiation. …”
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Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Published 2010-01-01“…The bulky DNA adducts, which usually have complex structure, are particularly important because of their biological relevance. …”
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Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction
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Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy
Published 2025-01-01“…Abstract Initially, it was believed that glycolysis and DNA damage repair (DDR) were two distinct biological processes that independently regulate tumor progression. …”
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