Synthesis and Characterisation of Copper(II) Complexes with Tridentate NNO Functionalized Ligand: Density Function Theory Study, DNA Binding Mechanism, Optical Properties, and Biol... by Madhumita Hazra, Tanushree Dolai, Akhil Pandey, Subrata Kumar Dey, Animesh Patra

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SOD1 Is Essential for the Viability of DT40 Cells and Nuclear SOD1 Functions as a Guardian of Genomic DNA by Eri Inoue, Keizo Tano, Hanako Yoshii, Jun Nakamura, Shusuke Tada, Masami Watanabe, Masayuki Seki, Takemi Enomoto

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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…Aim:  demonstration of basic molecular biological, metabolic and immunological effects of fecal microbiota transplantation (FMT), on the example of a rare case of acute graft-versus-host disease (GVHD) with intestinal damage in a patient after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Materials and methods. …”
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Rapid Multi-Well Evaluation of Assorted Materials for Hydrogel-Assisted Giant Unilamellar Vesicle Production: Empowering Bottom-Up Synthetic Biology by Cherng-Wen Darren Tan, Magdalena Schöller, Eva-Kathrin Ehmoser

“…Giant unilamellar vesicles (GUVs) are versatile cell models in biomedical and environmental research. …”
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3-Hydroxyanthranic acid inhibits growth of oral squamous carcinoma cells through growth arrest and DNA damage inducible alpha by Guifang Gan, Xinxia Zhou, Qiaoping Zheng, Xianfu Gao, Xu Chen, Han Zhang, Jinghao Liu, Zhaopeng Shi, Fuxiang Chen

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PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cells by Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo Shiotani

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A concept of natural genome reconstruction. Part 2. Effect of extracellular double-stranded DNA fragments on hematopoietic stem cells by V. S. Ruzanova, S. G. Oshikhmina, A. S. Proskurina, G. S. Ritter, S. S. Kirikovich, E. V. Levites, Y. R. Efremov, T. V. Karamysheva, M. I. Meschaninova, A. L. Mamaev, O. S. Taranov, A. S. Bogachev, S. V. Sidorov, S. D. Nikonov, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, E. V. Dolgova, S. S. Bogachev

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Non-thermal plasma as promising anti-cancer therapy against bladder cancer by inducing DNA damage and cell cycle arrest by Jojanneke Stoof, Zakaria Kalmoua, Ana Sobota, Ruud H. Brakenhoff, Marijke Stigter, Thang V. Pham, Sander R. Piersma, Alex Henneman, Tonny Lagerweij, Richard de Goeij-de Haas, R. Jeroen A. van Moorselaar, Connie R. Jimenez, Irene V. Bijnsdorp

“…This is induced via upregulation of cell cycle checkpoint signalling and DNA damage repair pathways using LC-M/MS-based phospho-proteomics. …”
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Immunodeficiency, Centromeric Instability, and Facial Dysmorphism (ICF) Syndrome: How HSCT alters the impairment of the DNA methylation process by Wojciech Homa, Joanna Wanat, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Aleksandra Warunek, Gabriela Gronowicz, Michał Chról, Weronika Zielińska

“…Advances in molecular biology and genetics enabled insights into the DNA methylation machinery, which allowed us to gain a more precise understanding of the pathogenesis of ICF and also opened up opportunities for the development of new therapeutic options. …”
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Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts by Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao

“…COUP‐TFII augmented endothelialization and inhibited calcification in decellularized allografts by modulating the Ang1/Tie2/PI3K/AKT signaling pathway that dictates the fate of Sca‐1+ stem/progenitor cells. Heparin‐polyethyleneimine nanoparticles (HEPI) are prepared as COUP‐TFII pDNA nanocarriers (COUP‐TFII@HPEI) and used to modify decellularized allografts, achieving long‐term and stable overexpression of COUP‐TFII. …”
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Effects of the auxin-dependent degradation of the cohesin and condensin complexes on the repair of distant DNA double-strand breaks in mouse embryonic stem cells by A. V. Smirnov, A. S. Ryzhkova, A. M. Yunusova

“…Cohesin knockdown was recently shown to stimulate frequencies of genomic deletions produced by distant paired DSBs, but does not affect DNA repair of a single or close DSBs. We examined how auxin-inducible protein degradation of Rad21 (cohesin) or Smc2 (condensins I+II) changes the frequencies of rearrangements between paired distant DSBs in mouse embryonic stem cells (mESCs). …”
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Calcium hydroxide nanoparticles induce cell death, genomic instability, oxidative stress and apoptotic gene dysregulation on human HepG2 cells by Hanan R. H. Mohamed, Esraa H. Ibrahim, Shahd E. E. Shaheen, Nesma O. E. Hussein, Ayman Diab, Gehan Safwat

“…However, limited information exists regarding their effects on genomic DNA integrity and their potential to induce apoptosis in normal and cancerous human cell lines. …”
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Lunasin peptide promotes lysosome-mitochondrial mediated apoptosis and mitotic termination in MDA-MB-231 cells by Yuqiong Hao, Huimin Guo, Yechun Hong, Xin Fan, Yumei Su, Xiushi Yang, Guixing Ren

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Potential of Co(II) and Cd(II) chelates of N′-(3-fluorobenzoyl)benzo[d]thiazole-2-carbohydrazide: Structural aspects, binding interactions, biological and molecular docking studies... by K. Srilaxmi, B. Sireesha

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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Here, we review the wide-ranging roles of physiological DSBs and the emerging network of their multilateral regulation to consider how the cell is able to harness DNA breaks as a critical biochemical tool.…”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

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Differential Toxicity of DNA Adducts of Mitomycin C by Jill Bargonetti, Elise Champeil, Maria Tomasz

“…This review focuses on differential biological effects of individual adducts in various mammalian cell cultures, observed in the authors' laboratories. …”
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Radiotherapy for Melanoma: More than DNA Damage by Susanne J. Rogers, Emsad Puric, Brigitte Eberle, Niloy R. Datta, Stephan B. Bodis

“…It has long been known that radiation causes not only DNA strand breaks, apoptosis, and necrosis, but also immunogenic modulation and cell death through the induction of dendritic cells, cell adhesion molecules, death receptors, and tumour-associated antigens, effectively transforming the tumour into an individualised vaccine. …”
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RNA Splicing: A New Player in the DNA Damage Response by Silvia C. Lenzken, Alessia Loffreda, Silvia M. L. Barabino

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Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment by Giulia Gerini, Alice Traversa, Fabrizio Cece, Matteo Cassandri, Paola Pontecorvi, Simona Camero, Giulia Nannini, Enrico Romano, Francesco Marampon, Mary Anna Venneri, Simona Ceccarelli, Antonio Angeloni, Amedeo Amedei, Cinzia Marchese, Francesca Megiorni

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