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IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3
Published 2025-02-01Get full text
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Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation
Published 2025-02-01Get full text
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Understanding Disease Susceptibility through Population Genomics
Published 2012-12-01“…A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are associated with the expression phenotypes have been identified, first in Epstein-Barr virus-transformed lymphoblastoid cell lines and later expanded to other cell and tissue types. …”
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胚胎干细胞分化为表皮样细胞的基因表达谱差异研究
Published 2012-01-01“…Pathway分析显示,与DNA复制(DNA replication)通路相关的差异基因有23个;与蛋白酶体(Proteasome)通路相关的24个;剪接体(spliceosome)通路相关有47个;细胞周期(Cell cycle)相关的有44个。…”
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The Comet Assay for the Evaluation of Genotoxic Potential of Landfill Leachate
Published 2012-01-01“…Genotoxic assessment of landfill leachate before and after biological treatment was conducted with two human cell lines (Me45 and NHDF) and Daphnia magna somatic cells. …”
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Role of sirtuins in epigenetic regulation and aging control
Published 2024-04-01“…Changes in the SIRT activity in human cells can also be considered a marker of aging and are involved in the genesis of various agedependent disorders. …”
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Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma
Published 2025-01-01“…Furthermore, we examined the correlation between CTF1 expression and tumor prognosis, DNA methylation patterns, m6A-related genes, potential biological functions, the immune microenvironment, and genes associated with immune checkpoints. …”
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IL-6–174 G/C transversion might decrease male infertility risk: A case-control study
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Transcriptome profiling revealed multiple circadian rhythm-related genes associated with common gynecological cancers
Published 2025-01-01“…BackgroundStudies have shown that more than half of the human genome expression is affected by circadian rhythms, which includes genes involved in cell cycle control, DNA repair and apoptosis that are critical in cancer biology. …”
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Efficacy of Larimichthys crocea TASOR protein-derived peptide FAM286 against Staphylococcus aureus
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TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6
Published 2021-01-01“…Notably, TEX10 might regulate carcinoma cell proliferating process and metastasis via XRCC6, thereby controlling the signaling of Wnt/β-catenin and DNA repair channel. …”
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Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking
Published 2021-12-01“…In addition, molecular docking was conducted between the core targets and the active ingredients of <italic>Coptis chinensis</italic> to verify the binding ability between the active ingredients and the core targets.Results① A total of 14 active ingredients of <italic>Coptis chinensis</italic>, 189 targets for the treatment of type 2 diabetes mellitus were screened out, among which 136 potential targets were identified, including 20 core targets (degree≥12), 137 signaling pathways with significant significance. ② Gene Ontology (GO) functional enrichment analysis showed that, the biological processes (BP) involved in the predicted target of <italic>Coptis chinensis</italic> in the treatment of type 2 diabetes mellitus involved gland development, epithelial cell proliferation, regulation of DNA-binding transcription factor activity, oxidative stress and apoptosis response to lipopolysaccharide, etc. …”
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Comprehensive pan-cancer analysis reveals NTN1 as an immune infiltrate risk factor and its potential prognostic value in SKCM
Published 2025-01-01“…The results suggested that NTN1 might be involved in crucial biological processes and pathways related to cancer development and progression, including cell adhesion, axon guidance, immune response, and various signaling pathways. …”
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CD63 Promotes Hemocyte-Mediated Phagocytosis in the Clam, Paphia undulata
Published 2016-01-01Get full text
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