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Integrated and streamlined microfluidic device for molecular diagnosis of pathogen through direct PCR amplification
Published 2025-01-01“…Direct PCR, which enables direct DNA amplification from biological samples without the need for DNA extraction and purification, streamlines the device architecture and transforms it into a more user-friendly form. …”
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443
Microsatellite instability and somatic gene variant profile in solid organ tumors
Published 2024-05-01Get full text
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444
Identification of Differentially Expressed lncRNAs in a CpG ODN-Activated Macrophage
Published 2020-01-01“…A series of inflammatory cytokines are produced and released to eliminate pathogens. CpG DNA is an immune stimulator recognized by TLR9, subsequently inducing inflammatory responses in macrophages. …”
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445
Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury
Published 2021-01-01“…HMGB1 is a ubiquitous nuclear DNA-binding protein whose biological function depends on posttranslational modifications, its redox state, and its cellular localization. …”
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446
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Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer
Published 2025-01-01“…This analysis uncovered their substantial impact on critical biological processes and molecular functions, such as cyclin-dependent protein kinase activity, mitotic DNA damage checkpoint signalling, stress-activated MAPK cascade, regulation of extrinsic apoptotic signalling pathway, and positive regulation of cell adhesion. …”
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448
An integrated method for taxonomic identif ication of microorganisms
Published 2020-07-01“…For accurate species-level identification of microorganisms, researchers today increasingly use a combination of standard microbiological cultivation and visual observation methods with molecular biological and genetic techniques that help distinguish between species and strains of microorganisms at the level of DNA or RNA molecules. …”
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449
18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns
Published 2013-01-01“…Conventional 18F-FDG-PET imaging is of limited usefulness for imaging Glioblastoma Multiforme (GBM) due to high levels of glucose uptake by normal brain and the resultant signal-to-noise intensity. 18F-Fluorothymidine (FLT) in contrast has shown promise for imaging GBM, as thymidine is taken up preferentially by proliferating cells. These studies were undertaken to investigate the effectiveness of 18F-FLT-PET in a GBM mouse model, especially after radiation therapy (RT), and its correlation with useful biomarkers, including proliferation and DNA damage. …”
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450
Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens
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451
Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1...
Published 2019-06-01“…It has high repeat sequence with 9.3% and DNA methylation existence in the genome. The 46.34 Mb genomes contained 14,091 predicted genes, which of 13,135 were annotated. …”
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452
Histopathological and Immunohistochemical Evaluation of African Swine Fever Pigs in Bali Province
Published 2024-12-01“…African Swine Fever (ASF) is a disease affecting pigs, caused by a double-stranded DNA virus that is not transmissible to humans or other animals. …”
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453
Alphaherpesvirus in Pets and Livestock
Published 2025-01-01“…Herpesviruses are a group of DNA viruses capable of infecting multiple mammalian species, including humans. …”
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454
Characteristics of the monkeypox virus isolate obtained from the first patient in Russia and its sensitivity to 7-[N-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo-[3.2.2.0...
Published 2024-12-01“…The disease was confirmed by PCR followed by determination of the nucleotide sequence of viral DNA by sequencing. Isolation of the new MPXV strain from clinical samples was carried out in Vero E6 cells. …”
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455
Production and bioactivity test of recombinant protein common carp growth hormone
Published 2011-01-01“… This study aimed to produce recombinant growth hormone (rGH) protein of common carp (Cyprinus carpio) and evaluate its bioactivity. DNA fragment encoding mature GH protein of common carp (mCcGH) was amplified by polymerase chain reaction (PCR) method and PCR products were then ligated into pCold I to generate pCold I-mCcGH protein expression vector. …”
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456
A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment
Published 2025-02-01“…In the immune TME, the immune effector cells such as dendritic cells (DCs), M1-like tumor-associated macrophages (M1-TAMs), and T cells are inhibited. …”
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457
THE EFFECT OF QUERCETIN ON MORPHOLOGICAL AND BIOCHEMICAL CHANGES IN RAT LIVER UNDER 270TH DAY CENTRAL DEPRIVATION OF LUTEINIZING HORMONE SYNTHESIS
Published 2022-04-01“…Peroxynitrite and superoxide anion radical are powerful oxidants that can damage biological polymers (DNA, proteins and biological membranes) and lead to the development of oxidative-nitrosative stress.…”
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458
Molecular techniques for cancer diagnostics
Published 2024-01-01“… Cancer cells differ from healthy tissues in their biological makeup. …”
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459
Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis
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460