TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and often lethal malignancy, requiring the development of enhanced therapeutic approaches. The DNA damage response (DDR) pathway is frequently altered during PDAC development, leading to an increased occurrence of DNA damage. …”
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Natural selection and evolution: evolving concepts by Andre J. van Wijnen, Eric Lewallen

“…Current evolutionary models incorporate different adaptive and non-adaptive processes based on molecular genetic changes and how DNA is modified over time in unicellular species, or in germline versus somatic cells in metazoan species. …”
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Epigenetic and gene regulatory functions of small RNAs by Cecere, Germano

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Regulatory roles of RNA binding proteins in the Hippo pathway by Shuchang Peng, Chenglin Li, Yanwen He, Lei Xue, Xiaowei Guo

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A multiplex method for rapidly identifying viral protease inhibitors by Seo Jung Hong, Samuel J Resnick, Sho Iketani, Ji Won Cha, Benjamin Alexander Albert, Christopher T Fazekas, Ching-Wen Chang, Hengrui Liu, Shlomi Dagan, Michael R Abagyan, Pavla Fajtová, Bruce Culbertson, Brooklyn Brace, Eswar R Reddem, Farhad Forouhar, J Fraser Glickman, James M Balkovec, Brent R Stockwell, Lawrence Shapiro, Anthony J O’Donoghue, Yosef Sabo, Joel S Freundlich, David D Ho, Alejandro Chavez

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Spontaneous and environment induced genomic alterations in yeast model by Ke-Jing Li, Lei Qi, Ying-Xuan Zhu, Min He, Qian Xiang, Dao-Qiong Zheng

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Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp by Chung-Min Kang, Hyunok Kim, Je Seon Song, Byung-Jai Choi, Seong-Oh Kim, Han-Sung Jung, Seok-Jun Moon, Hyung-Jun Choi

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Streptomyces learnhanii sp. nov., unveiling a Mangrove-Derived Novel “Modern Actinobacteria” in Malaysia by Jodi Woan-Fei Law, Vengadesh Letchumanan, Kar-Wai Hong, Sunny Hei Wong, Nurul Syakima Ab Mutalib, Ya-Wen He, Kok-Gan Chan, Loh Teng-Hern Tan

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Streptomyces griseiviridis sp. nov., a Novel “Modern Actinobacteria” isolated from Malaysia Mangrove Soil by Jodi Woan Fei Law, Loh Teng-Hern Tan, Vengadesh Letchumanan, Kar-Wai Hong, Hooi-Leng Ser, Bey-Hing Goh, Nurul Syakima Ab Mutalib, Kok-Gan Chan, Learn-Han Lee

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Comparison of Stemness and Gene Expression between Gingiva and Dental Follicles in Children by Chung-Min Kang, Seong-Oh Kim, Mijeong Jeon, Hyung-Jun Choi, Han-Sung Jung, Jae-Ho Lee

“…Comparative gene expression profiles were collected using cDNA microarray. The expression of development, chemotaxis, mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSs) related genes was assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). …”
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Re-evaluating evidence for giant genomes in amoebae by Daniel Barzilay, João P. B. Alcino, Giulia M. Ribeiro, Alfredo L. P. Sousa, Daniel J. G. Lahr

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An Insight of Vitamin E as Neuroprotective Agents by Hui-Min Yap, Kwan-Liang Lye

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Development of a Semiconductor Sequencing-based Panel for Screening Individuals with Lynch Syndrome by Ryia-Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Janice Khor Sheau Sean, Sazuita Saidin, Mohd Ridhwan Abd Razak, Isa Md. Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal

“…The sensitivity and specificity of the identified mutations were determined by sequencing the serially diluted DNA from two human cancer cell lines, HCT 116 and LN-18. …”
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Molecular profiling and detection methods of microRNA in cancer research by Nurul-Syakima Ab Mutalib, Imilia Ismail, Hooi-Leng Ser

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Crosslinked Decellularized Porcine Pericardium as a Substrate for Conjunctival Reconstruction by Fangyuan Chen, Jingyue Deng, Lishi Luo, Ying Zhu, Yuying Dong, Yuanting Yang, Rijia Zhang, Jian Chen, Qing Zhou

“…Through animal models of conjunctiva defect model, the DPP-Asp-hEGF revealed a closed, multilayer epithelium with an equal amount of goblet cells and no indication for conjunctival scarring after 28 days, compared to amniotic membrane (AM) groups and sham groups. …”
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Free radicals and their impact on health and antioxidant defenses: a review by Nisansala Chandimali, Seon Gyeong Bak, Eun Hyun Park, Hyung-Jin Lim, Yeong-Seon Won, Eun-Kyung Kim, Sang-Ik Park, Seung Jae Lee

“…Oxidative stress results in the damage of critical biomolecules like DNA, proteins, and lipids, contributing to the pathogenesis of various diseases. …”
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Association of dopamine receptor D2 -141C insertion/deletion and dopamine beta-hydroxylase 19 bp insertion/deletion polymorphisms with schizophrenia: A case-control study in the ea... by Boukhenaf Yasmina, Sariyah Ayachi Ouarda, Achou Rayene, Iness Bernou Amina, Zohra Madoui Fatima, Sifi Karima, Larbi Rezgoun Mohamed

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Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression by Sofiia Melnyk, Marc Stierhof, Dmytro Bratiichuk, Franziska Fries, Rolf Müller, Yuriy Rebets, Andriy Luzhetskyy, Bohdan Ostash

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TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton by Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood

“…TGFβ is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. …”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

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