Understanding cancer from an evolutionary perspective: high-risk reprogramming of genome-damaged stem cells by Vladimir F. Niculescu

“…Oxygen-sensitive germline and stem cells suffer DNA double-strand breaks due to stress and oxygen ranges reminiscent of ancestral hyperoxia, leading to cell senescence. …”
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Evaluation of the microenvironment formed by interferon-β by Mai Yamagishi, Mai Yamagishi, Yutaka Hori, Nobutake Suzuki, Nobutake Suzuki, Yu Peng, Yu Peng, Yoshie Harada, Takashi Funatsu, Osamu Ohara, Yoshitaka Shirasaki, Yoshitaka Shirasaki

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RLS-associated MEIS transcription factors control distinct processes in human neural stem cells by Volker Kittke, Chen Zhao, Daniel D. Lam, Philip Harrer, Wojciech Krezel, Barbara Schormair, Konrad Oexle, Juliane Winkelmann

“…By separate knockout and overexpression of MEIS1 and MEIS2 in human neural stem cells, we find they control specific sets of target genes, associated with distinct biological processes. …”
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ErbB4 as a Potential Molecular Target in the Treatment of Esophageal Squamous Cell Cancers by Ke Zhao, Bao-Jun Chen, Zhi-Guo Chen

“…Additionally, miRNA-140-5p had marked effect on the DNA synthesis and caspase 3/7 activity in comparison to control cells. …”
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Isolation, characterization and therapeutic efficacy of lytic bacteriophage ZK22 against Salmonella Typhimurium in mice by Yihong Sun, Qing Qu, Yanhua Huang, Shuo Zhou, Hua Xiang, Wei Wang

“…Typhimurium was 10− 2 (PFU/cell), with an incubation period of around 10 min and the burst size of 393 PFU/cell. …”
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Cell-free fat extract improves embryo development and clinical outcomes in older women with previous in-vitro fertilization failure by Xiaowei Zhou, Hanfei Zhu, Jingru Duan, Lan Xia, Shen Zhao, Huihui Xu, Xian Wu, Xiaoling Wang, Bufang Xu, Yi Cao, Aijun Zhang

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Greater residential greenness is associated with reduced epigenetic aging in adults by Andrey I. Egorov, Shannon M. Griffin, Jo Klein, Wei Guo, Jennifer N. Styles, Jason Kobylanski, Mark S. Murphy, Elizabeth Sams, Edward E. Hudgens, Timothy J. Wade

“…Epigenetic age acceleration (EAA) is a composite biomarker of biological aging based on DNA methylation measurements; it is predictive of morbidity and mortality. …”
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MicroRNAs Expression Profile in MN1-Altered Astroblastoma by Francesca Gianno, Evelina Miele, Claudia Sabato, Elisabetta Ferretti, Simone Minasi, Francesca Romana Buttarelli, Debora Salerno, Natalia Pediconi, Giuseppe Rubens Pascucci, Francesca Guerrieri, Andrea Ciolfi, Simone Pizzi, Maura Massimino, Veronica Biassoni, Elisabetta Schiavello, Marco Gessi, Sofia Asioli, Angela Mastronuzzi, Antonio d’Amati, Giuseppina Catanzaro, Elisabetta Viscardi, David Capper, Felice Giangaspero, Manila Antonelli

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Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells by Dingbo Zhang, Fiona Parth, Laura Matos da Silva, Teng-Cheong Ha, Axel Schambach, Jens Boch

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Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability by Petr Smirnov, Moritz J. Przybilla, Milena Simovic-Lorenz, R. Gonzalo Parra, Hana Susak, Manasi Ratnaparkhe, John KL. Wong, Verena Körber, Jan-Philipp Mallm, George Philippos, Martin Sill, Thorsten Kolb, Rithu Kumar, Nicola Casiraghi, Konstantin Okonechnikov, David R. Ghasemi, Kendra Korinna Maaß, Kristian W. Pajtler, Anna Jauch, Andrey Korshunov, Thomas Höfer, Marc Zapatka, Stefan M. Pfister, Wolfgang Huber, Oliver Stegle, Aurélie Ernst

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Novel Genomic Aberrations in Testicular Germ Cell Tumors by Array-CGH, and Associated Gene Expression Changes by Rolf I. Skotheim, Reija Autio, Guro E. Lind, Sigrid M. Kraggerud, Peter W. Andrews, Outi Monni, Olli Kallioniemi, Ragnhild A. Lothe

“…Introduction: Testicular germ cell tumors of adolescent and young adult men (TGCTs) generally have near triploid and complex karyotypes. …”
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A Calorimetric Characterization of Cr(VI)-Reducing Arthrobacter oxydans at Different Phases of the Cell Growth Cycle by Nugzar G. Bakradze, Marina K. Abuladze, Victor M. Sokhadze, Nina V. Asatiani, Nelly A. Sapojnikova, Tamara M. Kartvelishvili, Emma N. Namchevadze, Nelly Y. Tsibakhashvili, Leila V. Tabatadze, Lia V. Lejava, Hoi-Ying Holman

“…In this paper we introduce a new concept of thermal spectrum of the endothermic melting of complex biological systems (e.g., proteins, nucleic acids, ribosomes, membrane structures) in intact cells. …”
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Two Novel 30K Proteins Overexpressed in Baculovirus System and Their Antiapoptotic Effect in Insect and Mammalian Cells by Wei Yu, Qing Li, Yuhua Yao, Yanping Quan, Yaozhou Zhang

“…Both Slp and Lsp-t significantly enhanced the viability and suppressed DNA fragmentation in H2O2 treated BmN and HUVEC cells. …”
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Computational problems of analysis of short next generation sequencing reads by R. te Boekhorst, F. M. Naumenko, N. G. Orlova, E. R. Galieva, A. M. Spitsina, I. V. Chadaeva, Y. L. Orlov, I. I. Abnizova

“…Short read next generation sequencing (NGS) has significant impacts on modern genomics, genetics, cell biology and medicine, especially on meta-genomics, comparative genomics, polymorphism detection, mutation screening, transcriptome profiling, methylation profiling, chromatin remodelling and many more applications. …”
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Combinatorial Cytotoxic Effects of Gelam Honey and 5-Fluorouracil against Human Adenocarcinoma Colon Cancer HT-29 Cells In Vitro by Syed Ahmad Tajudin T-Johari, Fatimah Hashim, Wan Iryani Ismail, Abdul Manaf Ali

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PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress by Chujie Chen, Jinyan He, Weixian Huang, Dong Xu, Zhaohui Li, Anqi Yang

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The use of premature chromosome condensation to study in interphase cells the influence of environmental factors on human genetic material by Vasiliki I. Hatzi, Georgia I. Terzoudi, Christina Paraskevopoulou, Vasilios Makropoulos, Demetrios P. Matthopoulos, Gabriel E. Pantelias

“…The PCC has been successfully used in problems involving cell cycle analysis, diagnosis and prognosis of human leukaemia, assessment of interphase chromosome malformations resulting from exposure to radiation or chemicals, as well as elucidation of the mechanisms underlying the conversion of DNA damage into chromosomal damage. …”
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Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study by Simona Tarantino, Annalisa Bianco, Mariafrancesca Cascione, Alessandra Carlà, Lia Fiamà, Riccardo Di Corato, Livia Giotta, Paolo Pellegrino, Anna Paola Caricato, Rosaria Rinaldi, Valeria De Matteis

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SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

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PPARγ Regulates Genes Involved in Triacylglycerol Synthesis and Secretion in Mammary Gland Epithelial Cells of Dairy Goats by Hengbo Shi, Jun Luo, Jiangjiang Zhu, Jun Li, Yuting Sun, Xianzi Lin, Liping Zhang, Dawei Yao, Huaiping Shi

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