The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

“…This agent mediates its effects through several mechanisms, including the reduction of reactive oxygen species (ROS) and oxidative stress-induced damage, as well as the modulation of subcellular signaling pathways such as AMPK, AKT/mTOR, and NF-κB. These pathways are involved in cellular senescence and inflammation, and their modulation can improve cell function and help prevent disease. …”
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Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential by Panting Wang, Panting Wang, Zixi Li, Yixuan Song, Bowei Zhang, Chaofeng Fan, Chaofeng Fan

“…Conversely, it can promote M2 polarization or suppress M1 polarization by inhibiting the NF-κB signaling pathway or activating the PI3K/Akt and AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. …”
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Rotavirus VP6 Adjuvant Effect on Norovirus GII.4 Virus-Like Particle Uptake and Presentation by Bone Marrow-Derived Dendritic Cells In Vitro and In Vivo by Kirsi Tamminen, Suvi Heinimäki, Timo Vesikari, Vesna Blazevic

“…The adjuvant effect of VP6 on GII.4 VLP presentation and NoV-specific immune response induction by BMDC in vivo was also studied. Intracellular staining demonstrated that BMDCs internalized both antigens, but VP6 more efficiently than NoV VLPs. …”
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A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide by Angelo Santoro, Antonio Ricci, Manuela Rodriquez, Michela Buonocore, Anna Maria D’Ursi

“…The results suggest that the synthetic tetrahydrocurcumin (THC) derivative interacts with the amyloid peptide in all the systems presented, while cyclocurcumin (CYC) and bisdemethoxycurcumin (BMDC) only interact when the peptide is in a less stable conformation. …”
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Risk assessment of complex organoarsenic species in food by EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Lars Barregård, Diane Benford, Eugenia Dogliotti, Kevin Francesconi, Jose Ángel Gómez Ruiz, Hans Steinkellner, Tanja Schwerdtle

“…For AsB, no reference point (RP) could be derived because of insufficient toxicity data. AsB did not show adverse effects in the two available repeat dose toxicity tests in rodents. …”
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Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats by Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu

“…In addition, mechanism studies showed that SCGH improved glucose metabolism via activating the IRS/Akt signaling pathway, and promoted lipid metabolism via activating the AMPK signaling pathway. In summary, these findings suggested that SCGH have potential anti-diabetic effects by improving insulin resistance and lipid metabolism disorders.…”
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Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin by Chunlan Yan, Zhihao Zhang, Liqun Ma, Xinyi Xu, Muhammad Azhar, Xianju Huang, Jianxun Shi, Jun Li

“…Further investigation suggested that WVBF modulates the signal transductions of the IRS1/PI3K/AKT/GLUT4 and AMPK pathways. These f indings demonstrate potentials of WVBF in the treatment of T2DM and possible mechanisms for its hepatoprotective activities.…”
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Heme Oxygenase 1/Peroxisome Proliferator-Activated Receptor Gamma Pathway Protects Intimal Hyperplasia and Mitigates Arteriovenous Fistula Dysfunction by Regulating Oxidative Stres... by Tingfei Xie, Yunpeng Xu, Lecai Ji, Xiaolu Sui, Aisha Zhang, Yanzi Zhang, Jihong Chen

“…These DEmRNAs were significantly enriched in the PPAR signaling pathway, AMPK signaling pathway, glucagon signaling pathway, IL-17 signaling pathway, and Toll-like receptor signaling pathway. …”
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Inferring transcriptomic dynamics implicated in odor fatty acid accumulation in adipose tissue of Hulun Buir sheep from birth to market by Yechan Zhao, Zhangyan Li, Huimin Ou, Zhiliang Tan, Jinzhen Jiao

“…Furthermore, DEGs involved in lipid metabolism and branch-chain amino acid degradation pathways exhibited surge in expression at mid-fattening vs. weaning, with acetyl-CoA and branched-chain-CoA as intermediates, and driven by regulation of PPAR and AMPK signaling pathways. Overall, our findings provided novel insight into the critical time window and pivotal candidate genes of OFA synthesis in the adipose tissue, which will assist with the targeted development of nutritional strategies to inhibit OFA accumulation of lambs.…”
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Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease by Wenhao Chen, Wanliang Yang, Bin Meng, Xingkun Wang, Heng Duan, Qian Xu, Hao Li

“…PDK4 silencing promoted NPCS proliferation, decreased the levels of the proinflammatory factors, and suppressed ferroptosis. …”
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Survey on the development of mimic defense in cyberspace:from mimic concept to “mimic+” ecology by Hailong MA, Liang WANG, Tao HU, Yiming JIANG, Yanze QU

“…Build upon the dynamic-heterogeneous-redundant architecture for multi-body execution, multi-mode ruling and multi-dimension reconstruction, cyberspace mimic defense (CMD) uses uncertain system to deal with the uncertain threat to cyberspace ubiquity.The evolution of CMD over the past 8 years were reviewed systematically from the vertical, horizontal, current, developing and future perspectives.From the vertical perspective, the development process of CMD from concept to theory and practice was summarized.From the horizontal view, it elaborated the core structure DHR (dynamical heterogeneous redundancy) of CMD, the principles based on CMD’s three major theorems, safety gains and performance costs.A comparison was conducted between CMD and five other active defense technologies, namely intrusion tolerance, moving target defense, zero trust architecture, trusted computing and computer immunology.From the current perspective, it reviewed the implementation elements, performance, system architecture, heterogeneous strategies, scheduling strategies, voting strategies and other common technology patterns and characteristics of 11 types of main existing mimic products including mimicry router, mimicry processor, mimicry DNS server and mimicry cloud platform.From the developing perspective, it explored the “mimic+” AICDS (Mimic + AI/IoT/Cloud/Data/SDN) symbiotic ecology with respect to 5 types of new technologies, namely artificial intelligence, Internet of things, cloud computing, big data and software-defined network, and proposed the corresponding technology junctions and cross research value.From the future perspective, it looked into the future mimicry baseline 2.0 product ecology, “mimic +5G/6G”, “mimic + edge computing”,“mimic + cloud” and “mimic + blockchain” application scenarios.Besides, 4 types of challenges faced by CMD in the future were analyzed and summarized, including escape space of multi-mode decision attack, mutual restriction of heterogeneous and synchronous, difficult balance between security and function, and limited transformation space of existing endogenous security components.…”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Special attention was given to the various pathways involved, pointing out the ability of the phytoagents to hinder the deleterious ones (especially those leading to, driven by, or associated with TGF-β activation, SREBP, Smad, MAPK, PKC, NF-κB, NLRP3 inflammasome, and caspase), to promote the protective ones (PPAR-α, PPAR-γ, EP4/Gs/AC/cAMP, Nrf2, AMPK, and SIRT1), and to favorably modulate those with potentially dual effect (PI3K/Akt). …”
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二甲双胍改善多囊卵巢综合征大鼠胰岛素敏感性的机制

“…【结论】 二甲双胍改善PCOS 大鼠胰岛素抵抗和肝脏脂肪沉积,可能与其激活肝脏组织AMPK通路和降低内质网应激水平有关?…”
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Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy by Yuyang Wang, Hailing Zhao, Qian Wang, Xuefeng Zhou, Xiaoguang Lu, Tongtong Liu, Yongli Zhan, Ping Li

“…In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy. …”
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Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway by Rumeng Ding, Quancheng Kan, Ting Wang, Ran Xiao, Yanan Song, Duolu Li

“…The ability of ginsenoside Rh2 to inhibit TNBC cell proliferation was further confirmed by attenuating the activation of the IL-6/JAK2/STAT3 apoptosis pathway and reducing the expression of protein kinases AMPK-α1 and PKA-Cα.ConclusionBased on network analysis and experimental validation, our findings demonstrate that ginsenoside Rh2 regulates TNBC proliferation and apoptosis through suppression of the IL-6/JAK2/STAT3 pathway, both in vitro and in vivo. …”
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The gut-liver axis mechanism of increased susceptibility to non-alcoholic fatty disease in female offspring rats with prenatal caffeine exposure by Qian Wang, Xiaoqian Lu, Wen Hu, Cong Zhang, Kexin Liu, Kai Tong, Kaiqi Chen, Hui Wang

“…In vivo and in vitro experiments confirmed that sodium butyrate (NaB) supplementation could reduce hepatic lipid accumulation through MCT1/GPR109A-AMPK, thereby effectively decreasing the susceptibility to NAFLD in the PCE female offspring rats.…”
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Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome by Rosalie Matico, Karolien Grauwen, Dhruv Chauhan, Xiaodi Yu, Irini Abdiaj, Suraj Adhikary, Ine Adriaensen, Garcia Molina Aranzazu, Jesus Alcázar, Michela Bassi, Ellen Brisse, Santiago Cañellas, Shubhra Chaudhuri, Francisca Delgado, Alejandro Diéguez-Vázquez, Marc Du Jardin, Victoria Eastham, Michael Finley, Tom Jacobs, Ken Keustermans, Robert Kuhn, Josep Llaveria, Jos Leenaerts, Maria Lourdes Linares, Maria Luz Martín, Rosa Martín-Pérez, Carlos Martínez, Robyn Miller, Frances M Muñoz, Michael E Muratore, Amber Nooyens, Laura Perez-Benito, Mathieu Perrier, Beth Pietrak, Jef Serré, Sujata Sharma, Marijke Somers, Javier Suarez, Gary Tresadern, Andres A Trabanco, Dries Van den Bulck, Michiel Van Gool, Filip Van Hauwermeiren, Teena Varghese, Juan Antonio Vega, Sameh A Youssef, Matthew J Edwards, Daniel Oehlrich, Nina Van Opdenbosch

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Surfactin alleviated hyperglycaemia in mice with type 2 diabetes induced by a high-fat diet and streptozotocin by Xiaoyu Chen, Hongyuan Zhao, Fanqiang Meng, Libang Zhou, Zhaoxin Lu, Yingjian Lu

Subjects: “…Type 2 diabetes mellitus (T2DM)…”
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Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition by Yongkang Liu, Fan Yang, Sijing Wan, Xianzhong Wang, Liwen Guan, Yan Li, Caidi Xu, Binghua Xie, Shigui Wang, Xiao-Ling Tan, Bin Tang

“…The overlapping DEGs were implicated in various biological processes, including protein metabolism, fatty acid metabolism, AMPK signaling, mTOR signaling, insulin/insulin-like growth factor signaling (IIS), the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and the cellular process of meiosis in oocytes. …”
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Astragalin and rutin restore gut microbiota dysbiosis, alleviate obesity and insulin resistance in high-fat diet-fed C57BL/6J mice by Muni Swamy Ganjayi, Karunakaran Reddy Sankaran, Balaji Meriga, Ruchika Bhatia, Shikha Sharma, Kanthi Kiran Kondepudi

“…The mRNA expressions of CCAAT/enhancer binding protein-α (C/EBP-α), sterol regulatory element-binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor-γ (PPAR-γ), acetyl-CoA carboxylase (ACC), adipocyte protein 2 (aP2), and fatty acid synthase (FAS) were downregulated (P < 0.05) and the protein expression of PPAR-γ was downregulated while adenosine 5’ monophosphate-activated protein kinase (AMPK) was phosphorylated in CAR-treated HFD-fed mice compared to the HFD control group. …”
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