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2241
Myogenic differentiation markers in muscle tissue after aerobic training
Published 2025-01-01“…The review delves into the intricate molecular mechanisms underlying the regulation of MDFs following aerobic training, elucidating the role of key signaling pathways including the MAPK/ERK, PI3K/Akt, and AMPK pathways, among others. These pathways play pivotal roles in orchestrating the expression and activity of MDFs, ultimately influencing muscle adaptation and regeneration. …”
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2242
Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution
Published 2020-01-01“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
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2243
Collaborative Learning melalui Jump Rope Game pada Kemampuan Motorik Sosial Emosional Anak
Published 2024-07-01“…Penelitian ini bertujuan untuk melihat pengaruh Model Collaborative Learning melalui Jump Rope Game terhadap Kemampuan Motorik Kasar dan Sosial Emosional Amak Usia lima sampai enam tahun. Berdasarkan hasil observasi, ditemukan permasalahan kurangnya perkembangan yang signifikan terutama dalam kegiatan pembelajaran yang menarik dan menyenangkan bagi anak. …”
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2244
Systems Biology Profiling of AMD on the Basis of Gene Expression
Published 2013-01-01“…Moreover, clades and nodal synapomorphies did not support the classical AMD phenotypes as valid transcriptomal genotypes. …”
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2245
Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma
Published 2025-01-01Subjects: Get full text
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2246
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
Published 2025-01-01“…Elevated mitochondria Ca2+ further activates the Ca2+/CaM-dependent protein kinase kinase β (CaMKKβ)-AMP-activated protein kinase (AMPK)-dynamin-related protein 1 (DRP1) signaling pathway, which interacts with mitochondrial fission protein 1 (FIS1) and mitochondrial dynamics proteins of 49 kDa (MiD49) to promote mitochondrial fission. …”
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2247
Macrophage to neuron communication via extracellular vesicles in neuropathic pain conditions
Published 2025-01-01“…EV-mediated transfer of miR-155 suppresses phosphatase Ship1 expression and increases cytokine interleukin-6 (IL-6) contents. Intrathecal-injected BMDM-derived EVs accumulate in lumbar DRG and EVs containing miR-155 antagomir result in Ship1 upregulation, Il6 downregulation in neurons in concomitance to attenuation of neuropathic mechanical hypersensitivity. …”
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2248
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2249
Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages
Published 2025-01-01“…Moreover, the MHCIIloCD11bhi bone marrow-derived DC (BMDC) subset was identified to be the most responsive DC subset to SBA treatment. …”
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2250
Lactiplantibacillus plantarum improves the growth performance and meat quality of broilers by regulating the cecal microbiota and metabolites
Published 2025-01-01“…The lipid metabolism-related gene expressions in the liver showed that Lp treatments increased the expression of AMPK, CPT-1α, PPARα, ATGL and also decreased the expression of PPARγ, SREBP-1c, ACC, FAS, LPL, and SCD. …”
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2251
Arginine–NO pathway modulated energy metabolism in the hepatopancreas and muscle of female Litopenaeus vannamei
Published 2025-03-01“…The findings showed that the levels of nos, cgmp, ampk (a, b, c), genes involved in glucose metabolism, lipid metabolism and amino acid metabolism were inhibited. …”
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2252
(+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats
Published 2012-01-01“…We also observed a marked reduction in respiratory quotient (RQ) along with a corresponding induction of hepatic AMPK in rodents provided (+)-Z-BDDA. Collectively, these findings indicate that (+)-Z-BDDA partially attenuated obesity and associated pathologies through increased resting energy expenditure and fatty acid utilization. …”
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2253
Metabolic Reprograming of Macrophages: A New Direction in Traditional Chinese Medicine for Treating Liver Failure
Published 2024-01-01“…A comprehensive literature review revealed that several signaling pathways may regulate macrophage polarization through energy metabolism, including phosphatidyl-inositol 3-kinase/protein kinase B (PI3K/AKT), mammalian target of rapamycin (mTOR)/hypoxia-inducible factor 1α (HIF-1α), nuclear factor-κB (NF-κB), and AMP-activated protein kinase (AMPK), which exhibit crosstalk with one another. …”
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2254
Identification of Hypoxia Signature to Assess the Tumor Immune Microenvironment and Predict Prognosis in Patients with Ovarian Cancer
Published 2021-01-01“…Gene sets related to the high hypoxia risk group were associated with signaling pathways of cell cycle, MAPK, mTOR, PI3K-Akt, VEGF, and AMPK. Conclusion. The hypoxia risk model could serve as an independent prognostic indicator and reflect overall immune response intensity in the OC microenvironment.…”
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2255
Yogurt-derived Lactobacillus plantarum Q16 alleviated high-fat diet-induced non-alcoholic fatty liver disease in mice
Published 2022-09-01“…Meanwhile, L. plantarum Q16 also improved hepatic energy metabolism by regulating FGF21/adiponectin/AMPKα/PGC-1α signaling pathway. Metagenomic analysis also discovered that L. plantarum Q16 increased species diversity and richness of intestinal microbiota, promoted proliferation of beneficial commensals and suppressed the growth of endotoxin-producing microorganisms in the colon of HFD-fed mice. …”
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2256
Morpho-phylogenetic evidence reveals novel hyphomycetous fungi on medicinal plants in Southwestern China
Published 2025-01-01“…These taxa were characterised and identified based on morphological and culture characteristics, coupled with phylogenetic analyses of combined sequences of calmodulin (cmdA), the internal transcribed spacer region of ribosomal DNA (ITS), nuclear large subunit ribosomal DNA (LSU), RNA polymerase second-largest subunit (rpb2), the translation elongation factor 1-alpha (tef1-α), and β-tubulin (tub2). …”
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2257
Single-cell RNA sequencing elucidates cellular plasticity in esophageal small cell carcinoma following chemotherapy treatment
Published 2025-01-01“…Further analysis highlighted dynamic interactions between tumor cells andimmune cells, with significant changes detected in key signaling pathways, suchas TIGIT-PVR and MDK-SDC4. This study elucidates the complex dynamics of cellplasticity in SCCE following chemotherapy, providing new insights and identifyingpotential therapeutic targets to enhance treatment efficacy.…”
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2258
AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis
Published 2025-02-01“…Finally, AdipoRon primarily exerted its effects through restoring the balance of myocardial fatty acid intake, transport, and oxidation via the downstream AMPKα or PPARα signaling pathways. The protective effects of AdipoRon in HFpEF mice were reversed by compound C and GW6471, inhibitors of AMPKα and PPARα, respectively. …”
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2259
Faktor determinan risiko kardiometabolik pada remaja usia 15-18 tahun
Published 2024-07-01“…Cardiometabolic risks were classified using Cardiometabolic Disease Staging (CMDS), waist circumference was measured with Medline, physical activity was measured using a Physical Activity Questionnaire for Adolescents (PAQA), and blood pressure was measured with a sphygmomanometer. …”
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2260
Genetics of aging and longevity
Published 2016-09-01“…These trends include heterochromatin recovery, retrotransposition suppression, aneuploidy elimination; restoring the acidity of lysosomes; telomere elongation; suppression of chronic inflammation; elimination of protein cross-links; elimination of senescent cells; recovery of NAD+ levels; inhibition of mTOR, S6K, TGF-β, AT1; controlled activation of the ”longevity program” genes FOXO, AMPK, PGC1α, NRF2.…”
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