Novel primers improve species delimitation in Cercospora by Mounes Bakhshi, Mahdi Arzanlou, Asadollah Babai-ahari, Johannes Z. Groenewald, Pedro W. Crous

“…To this end, 145 Cercospora isolates from the Iranian mycobiota together with 25 additional reference isolates preserved in the Westerdijk Fungal Biodiversity Institute were subjected to an eight-gene (ITS, tef1, actA, cmdA, his3, tub2, rpb2 and gapdh) analysis. Results from this study provided new insights into DNA barcoding in Cercospora, and revealed gapdh to be a promising gene for species delimitation when supplemented with cmdA, tef1 and tub2. …”
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Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease by Brandon Zimmerman, Leslie A. Dakin, Anne Fortier, Evanthia Nanou, Angelo Blasio, James Mann, Howard Miller, Marissa Fletcher, Tiansheng Wang, Suganthini Nanthakumar, Gizelle McCarthy, Caline Matar, Prachi Matsye, Guanyu Wang, Phillip Snyder, Kevin Daniel, Harsha Swamy, Kelly Sullivan, Franklin Bright, Audrey Powers, Kevin J. Gagnon, Fan Lu, Steven Paula, Suvarna Khare-Pandit, Larry Henry, Martine Hamel, Francois Denis, Olivier Nicolas, Niresh Hariparsad, Shyamesh Kumar, Jennifer Proctor, Timothy Senter, Brinley Furey, Mark E. Bunnage

“…These preclinical data, combined with clinical data from our previously published phase 2 proof-of-concept study, support the potential of APOL1 channel inhibition for the treatment of AMKD.…”
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Punicalagin prevents obesity-related cardiac dysfunction through promoting DNA demethylation in mice by Shengjie Pei, Run Liu, Qingqing Ma, Peng Jiang, Xin He, Zhongshi Qi, Jiacheng Fang, Xu Yang, Zirui Yao, Xiaoqian Liu, Xianfeng Jing, Lei Chen, Duo Li

“…In conclusion, PU up-regulated TETs enzyme activities and TET2 protein stability through alleviating mitochondrial dysfunction and activating AMPK, so as to promote DNA demethylation, thus preventing obesity-related cardiac dysfunction.…”
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Bone Mineral Density, TBS, and Body Composition Indexes in Ukrainian Men with Parkinson’s Disease by Vladyslav Povoroznyuk, Maryna Bystrytska, Nataliia Grygorieva, Iryna Karaban, Nina Karasevich

“…Also, we established significantly decreased lower extremities BMD indexes, but not upper extremities, spine, and trunk BMDs in PD males. …”
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TMEM101 expression and its impact on immune cell infiltration and prognosis in hepatocellular carcinoma by Lingyun Kuang, Yilin Pang, Quangang Fang

“…Comparative analysis with four established HCC diagnostic biomarkers (AFP, EFNA3, MDK, and SMYD5) using ROC curve and time-dependent ROC curves demonstrated the diagnostic potential of TMEM101 in HCC. …”
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Genome-wide association study of myofiber type composition traits in a yellow-feather broiler population by Chengyu Fan, Yanju Shan, Ming Zhang, Yunjie Tu, Gaige Ji, Xiaojun Ju, Jingting Shu, Yifan Liu

“…We annotated several candidate genes, including DMD, KLF7, CREB1, EFCAB11, GADD45A, GSTT1, and GSTT1L, which are related to myofiber type composition. …”
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Protein Level and Infantile Diarrhea in a Postweaning Piglet Model by Jing Gao, Jie Yin, Kang Xu, Hui Han, ZeMin Liu, ChenYu Wang, TieJun Li, YuLong Yin

“…In addition, the Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway (P<0.01) was inhibited in the HP group. …”
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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

“…Mechanistically, Apelin-MSC-EXOs delivered miR-34a-5p into injured cardiomyocytes, thereby ameliorating cardiomyocyte pyroptosis via regulation of the HMGB1/AMPK axis. These cardioprotective effects were partially abrogated by downregulation of miR-34a-5p in Apelin-MSC-EXOs.Conclusion: Our study revealed miR-34a-5p as a key component of Apelin-MSC-EXOs that protected against SMD via mediation of the HMGB1/AMPK signaling pathway. …”
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Prostate cancer cells elevate glycolysis and G6PD in response to caffeic acid phenethyl ester-induced growth inhibition by Tzu-Ping Lin, Pei-Chun Chen, Ching-Yu Lin, Bi-Juan Wang, Ying-Yu Kuo, Chien-Chih Yeh, Jen-Chih Tseng, Chieh Huo, Cheng-Li Kao, Li-Jane Shih, Jen-Kun Chen, Chia-Yang Li, Tzyh-Chyuan Hour, Chih-Pin Chuu

“…ROS level decreased 48 h after treatment with CAPE. Co-treatment of AMPK inhibitor with CAPE exhibited additive growth inhibition on PCa cells. …”
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To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents by Isaac Arbeláez-Quintero, Mauricio Palacios

“…Its mechanism of action has not been elucidated, but metformin pleiotropic effects involve actions in addition to glycemic control. AMPK activation has been described as one of the pharmacological mechanisms that explain the action of metformin and that lead to neuroprotective effects. …”
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Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy by Yuan-qiao Xu, Yanjiao Chen, Jia-xin Xing, Jun Yao

“…We discussed the molecular underpinnings of the effects of EE, including modulation of key signaling pathways such as extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), and AMPK/SIRT1, which were implicated in neuroprotection and synaptic plasticity. …”
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A szürke OSINT gyanús? by István Solti

“…Érték: A magyar büntetőjog egyes tényállási elemeinek tanulmányozásával mutat ki olyan elkövetési módokat, amik az információgyűjtés bűntetőjogi minősítését alapozhatják meg. …”
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Research progress on free fatty acid receptors and bronchial asthma by Fangxin Cao, Na Lin, Juntao Lin, Gai Yang, Xintong Wang

“…FFARs can affect the occurrence and progression of asthma through β-arrestins, RhoA/ROCK1, PLC/IP3, MAPK, AMPK and other pathways. This article reviews the research progress on the role of FFARs in bronchial asthma, with the aim of providing a reference for their use as new targets for the treatment of bronchial asthma.…”
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Common Mental Disorders in Brazilian Graduate Students by Nayara Paula Fernandes Martins Molina, Assis do Carmo Pereira Junior, Gabriela Di Donato, Marina Aleixo Diniz Rezende, Maria Olívia Barboza Zanetti, Vanderlei José Haas, Adriana Inocenti Miasso

“…This study is aimed at ascertaining the prevalence and predictors of common mental disorders (CMD) among Brazilian graduate students (N=5266) during the COVID-19 pandemic. …”
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Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells. by Eric Cheng, Ran Lu, Abigail R Gerhold

“…Correspondingly, we show that caloric restriction, which delays GSPC mitosis and compromises mitotic fidelity, does not act via the canonical insulin signaling pathway, and instead requires AMP-activated kinase (AMPK). Together this work demonstrates that GSPC mitosis is influenced by at least two genetically separable signaling pathways and highlights the importance of signaling networks for proper stem and progenitor cell mitosis in vivo.…”
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Mechanisms of Agricultural Land Transfer Influence on the Urban Settlement Intention of Rural Floating Population in China by Yu Xie, Yin Yao, Bingbing Zhang, Xiongying Chen, Xinyu Wang, Tsang-Kai Hung, Zijun Wang

“…Based on data from the 2017 China Migrants Dynamic Survey (CMDS), this paper explores the mechanism of the impact of agricultural land transfer on the urban settlement intention of rural floating population by constructing a structural equation modeling and bootstrap test. …”
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THE REVIEW OF SNACK BAR FROM CHIA - MOCAF AS AN ANTIDIABETIC FOOD by Saskia Revinka Maharani, Vega Yoesepa Pamela, Septariawulan Kusumasari

“…Chia seed flour has been shown to increase AMPK expression, while mocaf can increase insulin sensitivity in type 2 diabetes mellitus.…”
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CRISPR-Cas9 in Cardiovascular Medicine: Unlocking New Potential for Treatment by Klaudia Bonowicz, Dominika Jerka, Klaudia Piekarska, Janet Olagbaju, Laura Stapleton, Munirat Shobowale, Andrzej Bartosiński, Magdalena Łapot, Yidong Bai, Maciej Gagat

“…This article examines the potential of CRISPR-Cas9 in the treatment of various CVDs, including atherosclerosis, arrhythmias, cardiomyopathies, hypertension, and Duchenne muscular dystrophy (DMD). The technology’s ability to correct single-gene mutations with high precision and efficiency positions it as a groundbreaking tool in cardiovascular therapy. …”
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Nutrient availability in tropical soils fertilized with sewage sludge and natural phosphate by Rodinei Facco Pegoraro, Jefferson Rodrigo Teixeira Silva, Leidivan Almeida Frazão, Regynaldo Arruda Sampaio, Silvana Ferreira Bicalho, Verônica Aparecida Santos Ferreira Soares

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Insulin-Sensitizing Properties of Decoctions from Leaves, Stems, and Roots of <i>Cucumis prophetarum</i> L. by Zewdie Mekonnen, Giuseppe Petito, Getasew Shitaye, Gianluca D’Abrosca, Belete Adefris Legesse, Sisay Addisu, Maurizio Ragni, Antonia Lanni, Roberto Fattorusso, Carla Isernia, Lara Comune, Simona Piccolella, Severina Pacifico, Rosalba Senese, Gaetano Malgieri, Solomon Tebeje Gizaw

“…Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and impaired beta-cell secretory function. …”
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