Non-pharmaceutical interventions and epigenetic aging in adults: Protocol for a scoping review. by Alina Liebich, Shenglin Zheng, Theresa Schachner, Jacqueline Mair, Mia Jovanova, Falk Müller-Riemenschneider, Tobias Kowatsch

“…Several non-pharmaceutical interventions can lower the risk of NCDs, including common mental disorders (CMDs), and may slow down biological aging, as evidenced by outcome markers such as epigenetic clocks. …”
Get full text

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice by Meng Li, Min Xu, Jichang Li, Lili Chen, Dongwei Xu, Ying Tong, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia

“…We further demonstrated that Alda-1 treatment could activate AMPK and autophagy and that AMPK activation was required for Alda-1-mediated autophagy enhancement. …”
Get full text

The nutritional evaluation of forage-based mixed rations in New Zealand using an in vitro gas production technique. 1: analytical survey by N.D. Meads, R. Tahmasbi, N. Jantasila

“…The results showed an average total gas production (TGP) of 129.82 ml/g dry matter (DM), 78.6% true digestibility (TDMD), 125.06 mg/g DM microbial biomass (MB), 20.16 g CH4/kg DM, and 12.8 MJME/kg DM. …”
Get full text

Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway by Chuan Lv, Can Wu, Yue-hong Zhou, Ying Shao, Guan Wang, Qiu-yue Wang

“…Conversely, LA at a higher concentration (1.0 mmol/L) inhibited high glucose-induced rat mesangial cell proliferation, entry of cell cycle into S phase, and extracellular matrix exertion, as well as phosphorylation of mTOR, p70S6K, and 4E-BP1 but enhanced the activity of AMPK. However, these effects disappeared when AMPK activity was inhibited with CaMKK inhibitor STO-609. …”
Get full text

A Citrus bergamia Extract Decreases Adipogenesis and Increases Lipolysis by Modulating PPAR Levels in Mesenchymal Stem Cells from Human Adipose Tissue by Debora Lo Furno, Adriana Carol Eleonora Graziano, Rosanna Avola, Rosario Giuffrida, Vincenzo Perciavalle, Francesco Bonina, Giuliana Mannino, Venera Cardile

“…Moreover, the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), adipocytes fatty acid-binding protein (A-FABP), adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), monoglyceride lipase (MGL), 5′-adenosine monophosphate-activated protein kinase (AMPK)α1/2, and pAMPKα1/2 was evaluated by Western blot analysis and the release of glycerol by colorimetric assay. …”
Get full text

Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells by Mohamed Elfeky, Ryuji Kaede, Yuko Okamatsu-Ogura, Kazuhiro Kimura

“…In conclusion, our results indicate that adiponectin suppresses HMGB1 release by LPS through an AMPK-mediated and HO-1-dependent IL-10-independent pathway.…”
Get full text

Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress by Xiaomeng Tang, Jingjing Ning, Yilin Zhao, Shuyun Feng, Lujing Shao, Tiantian Liu, Huijie Miao, Yucai Zhang, Chunxia Wang

“…Compound C (CC), an inhibitor of AMP-activated protein kinase (AMPK) activation, was used to confirm the roles of AMPK activation in FGF19-mediated hepatoprotective effects. …”
Get full text

བྱིས་ པའི་ མནོལ་ སྐྲ་ ལེན་ པའི་ སྐོར་ གྱི་ ངོ་ སྤྲོད་ ཆེ་ ལོང་ ཙམ།... by Lhamokyab Noyontsang

“…In Amdo (north-eastern Tibet), the ceremony called “the removal of the impure hair” refers to the first cutting of a child’s hair. …”
Get full text

Nutritive value of cattle manure vermicast and its effect on in vitro ruminal gas production by Aminu Nasiru, Abdul Razak Alimon, Norli Ismail, Mahamad Hakimi Ibrahim

“…Results of in vitro gas production and rumen fermentation profiles from this study indicated that inclusion of CMV reduced gas production and DMD; however, it increased PF48, with no significant changes in MCP. …”
Get full text

Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…Duchenne muscular dystrophy (DMD), an X-linked neuromuscular disorder, characterised by progressive immobility, chronic inflammation and premature death, is caused by the loss of the mechano-transducing signalling molecule, dystrophin. …”
Get full text

A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse by Craig Robert Wright, Giselle Larissa Allsopp, Alex Bernard Addinsall, Natasha Lee McRae, Sofianos Andrikopoulos, Nicole Stupka

“…Given that SEPS1 is highly expressed in skeletal muscle, we investigated whether the genetic reduction of Seps1 exacerbated inflammation in the mdx mouse. F1 male mdx mice with a heterozygous Seps1 deletion (mdx:Seps1−/+) were generated. …”
Get full text

Bibliometric analysis of trends in dental management of the children with Autism Spectrum Disorder (ASD) by Kanwalpreet Kaur, Ravinder S. Saini, Syed Altafuddin Quadri, Gustavo Vicentis Oliveira Fernandes, Anna Avetisyan, Seyed Ali Mosaddad, Artak Heboyan

Get full text

Breastfeeding support as predictors of sustainable breastfeeding practices of nursing mothers with common mental disorders in tertiary hospital nurseries in Nigeria: a cross sectio... by Michael Abel Alao, Olayinka Rasheed Ibrahim, Sakiru Abiodun Yekinni, Sikirat Adetoun Sotimehin, Udochukwu Michael Diala, Datonye Christopher Briggs, Aishatu Zaidu Musa, Zainab Oluwatosin Imam, Esther Oluwatoyin Famutimi, Adedeji Abiodun Idris, Adaeze C. Ayuk, Kenechukwu Kosisochukwu Iloh, Chioma Laura Odimegwu, Ayomide Toluwanimi Adeyemi, Patricia F. Medupin, Yetunde C. Adeniyi, Kenechi Ogbodo Nnamani, Olukemi Oluwatoyin Tongo

“…Across Nigeria's six geopolitical zones, there was an inverse relationship between optimal breastfeeding support and the proportion of mothers with CMDs. The northern zone provided better breastfeeding support and had fewer CMDs than the southern region of the country. …”
Get full text

Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in a Child with Myelodysplastic Neoplasm with Complex Karyotype and ETV6 Variant: Challenges in Treatment by Elaiza Almeida Antônio de Kós, Viviane Lamim Lovatel, Rita de Cássia Barbosa Tavares, Gerson Moura Ferreira, Bernadete Evangelho Gomes, Ana Paula Silva Bueno, Elaine Sobral da Costa, Teresa de Souza Fernandez

“…Due to the rarity of childhood MDS (cMDS), there are few studies showing the impact of cytogenetic alterations and genetic variants on outcomes of allo-HSCT, mainly focusing on clonal chromosomal evolution (CCE) during relapse post-transplant. …”
Get full text

Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation by Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang, Ping Zhao

“…Western blot results suggested that nuciferine increased AMPK and PKC phosphorylation levels in skeletal muscle and liver, and enhanced GLUT4 expression in skeletal muscle. …”
Get full text

Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…In vitro studies with bone marrow-derived macrophage (BMDM), RAW264.7, and THP-1 cells further demonstrated Blimp-1 promotes M2 polarization and modulates key metabolic pathways. …”
Get full text

A study of disability and socio-economic impact of mental morbidities from the state of Madhya Pradesh, India by Vijender Singh, Roshan F. Sutar, Suruchi Gupta, Abhijit P. Pakhare, Arun M. Kokane, B. A. Aravind, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, Girish N. Rao

“…Conclusion: We report a substantial magnitude of disability in social, work, and family life domains. Participants having CMDs, female gender, and those non-working had more disabilities and would require targeted interventions.…”
Get full text

Predictors of sickness absence among employees with common mental disorders in Sweden– a longitudinal study by Anna Frantz, Anna Toropova, Iben Axén, Gunnar Bergström, Anna Finnes, Elisabeth Björk Brämberg

“…The results highlight the importance of addressing specific workplace factors when designing interventions aimed at decreasing sickness absence for employees on sickness absence due to CMDs. The results could be used to inform a dialogue between healthcare personnel and employees on sickness absence due to CMDs, and to serve as basis for a structured inventory to assist healthcare personnel in addressing workplace factors.…”
Get full text

Amplitude Modulation Depth Coding Method for SSVEP-Based Brain–Computer Interfaces by Ruxue Li, Zhenyu Wang, Xi Zhao, Guiying Xu, Honglin Hu, Ting Zhou, Tianheng Xu

“…A 36-target paradigm based on AMDC strategy was designed and evaluated in terms of user experience and classification performance in Experiment 2. …”
Get full text

Exploring seasonal dynamics of sea spray aerosol bioactivity: Insights into molecular effects on human bronchial epithelial cells by Zixia Liu, Emmanuel Van Acker, Maarten De Rijcke, Filip Van Nieuwerburgh, Colin Janssen, Jana Asselman

“…We found that SSA exposure influenced the expression of genes involved in critical signaling pathways: mTOR, PI3K, Akt, and NF-κB were downregulated, while AMPK was upregulated. Downregulation of mTOR, PI3K, Akt, and NF-κB potentially indicates a protective response against tumor-promoting and inflammatory signals, whereas upregulation of AMPK may confer a beneficial effect on metabolic regulation. …”
Get full text